Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients

Mitochondrion

Volumn 28, Issue , 2016, Pages 8-15

  Kallianpur, Kalpana J ^a   Gerschenson, Mariana ^a   Mitchell, Brooks I ^a   LiButti, Daniel E ^a   Umaki, Tracie M ^a   Ndhlovu, Lishomwa C ^a   Nakamoto, Beau K ^a,b   Chow, Dominic C ^a   Shikuma, Cecilia M ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b STRAUB CLINIC AND HOSPITAL   (United States)

Author keywords

Atrophy; Brain; Neuroinflammation; Oxidative stress; Pallidum; ROS

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIRETROVIRUS AGENT; MITOCHONDRIAL DNA; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; BRAIN SIZE; BRAIN VENTRICLE DILATATION; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GLOBUS PALLIDUS; GRAY MATTER; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LATERAL BRAIN VENTRICLE; MALE; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OXIDATIVE STRESS; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ATROPHY; CHEMISTRY; COMPLICATION; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY;

ADULT; ATROPHY; CROSS-SECTIONAL STUDIES; DEOXYGUANOSINE; DNA DAMAGE; DNA, MITOCHONDRIAL; FEMALE; GRAY MATTER; HIPPOCAMPUS; HIV INFECTIONS; HUMANS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84960337972     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2016.02.006     Document Type: Article

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