DNA demethylation upregulated Nrf2 expression in Alzheimer's disease cellular model

Frontiers in Aging Neuroscience

Volumn 7, Issue JAN, 2016, Pages

  Cao, Huimin ^a   Wang, Li ^b   Chen, Beibei ^a   Zheng, Peng ^a   He, Yi ^a   Ding, Yubin ^a   Deng, Yushuang ^a   Lu, Xi ^a   Guo, Xiuming ^a   Zhang, Yuping ^a   Li, Yu ^a   Yu, Gang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Chongqing Cancer Institute   (China)

Author keywords

Alzheimer's disease; Cellular model; DNA demethylation; NQO1; Nrf2; Oxidative stress

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GLUTATHIONE REDUCTASE; TRANSCRIPTION FACTOR NRF2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; GENE TRANSLOCATION; MOUSE; NONHUMAN; PATHOGENESIS; PROMOTER REGION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84960127525     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00244     Document Type: Article

References (32)

1. Adwan, L., and Zawia, N. H. (2013). Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease. Pharmacol. Ther. 139, 41-50. doi: 10.1016/j.pharmthera.2013.03.010.
2. Bhutani, N., Burns, D. M., and Blau, H. M. (2011). DNA demethylation dynamics. Cell 146, 866-872. doi:10.1016/j.cell.2011.08.042.
3. Bryan, H. K., Olayanju, A., Goldring, C. E., and Park, B. K. (2013). The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation. Biochem. Pharmacol. 85, 705-717. doi:10.1016/j.bcp.2012.11.016.
4. Cervellati, C., Romani, A., Seripa, D., Cremonini, E., Bosi, C., Magon, S., et al. (2014). Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. Biomed. Res. Int. 2014, 309507. doi:10.1155/2014/309507.
5. Clausen, A., Xu, X., Bi, X., and Baudry, M. (2012). Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J. Alzheimers Dis. 30, 183-208. doi:10.3233/jad-2012-111298.
6. Farooqui, A. A., and Horrocks, L. A. (1998). Lipid peroxides in the free radical pathophysiology of brain diseases. Cell. Mol. Neurobiol. 18, 599-608. doi:10.1023/A:1020261600498.
7. Farr, S. A., Ripley, J. L., Sultana, R., Zhang, Z., Niehoff, M. L., Platt, T. L., et al. (2014). Antisense oligonucleotide against GSK-3beta in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic. Biol. Med. 67, 387-395. doi:10.1016/j.freeradbiomed.2013.11.014.
8. Fleming, J. L., Phiel, C. J., and Toland, A. E. (2012). The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease. Curr. Alzheimer Res. 9, 1077-1096. doi:10.2174/156720512803569000.
9. Jo, C., Gundemir, S., Pritchard, S., Jin, Y. N., Rahman, I., and Johnson, G. V. (2014). Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nat. Commun 5, 3496. doi:10.1038/ncomms4496.
10. Joshi, G., Gan, K. A., Johnson, D. A., and Johnson, J. A. (2015). Increased Alzheimer's disease-like pathology in the APP/PS1DeltaE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol. Aging 36, 664-679. doi:10.1016/j.neurobiolaging.2014.09.004.
11. Juttermann, R., Li, E., and Jaenisch, R. (1994). Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl. Acad. Sci. U.S.A. 91, 11797-11801. doi:10.1073/pnas.91.25.11797.
12. Kanninen, K., Heikkinen, R., Malm, T., Rolova, T., Kuhmonen, S., Leinonen, H., et al. (2009). Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 106, 16505-16510. doi:10.1073/pnas.0908397106.
13. Kumar, A., Singh, A., and Ekavali. (2015). A review on Alzheimer's disease pathophysiology and its management: an update. Pharmacol. Rep. 67, 195-203. doi:10.1016/j.pharep.2014.09.004.
14. Li, W., and Kong, A. N. (2009). Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinog. 48, 91-104. doi:10.1002/mc.20465.
15. Liao, J., Karnik, R., Gu, H., Ziller, M. J., Clement, K., Tsankov, A. M., et al. (2015). Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat. Genet. 47, 469-478. doi:10.1038/ng.3258.
16. Lu, H., Liu, X., Deng, Y., and Qing, H. (2013). DNA methylation, a hand behind neurodegenerative diseases. Front. Aging Neurosci. 5:85. doi:10.3389/fnagi.2013.00085.
17. Momparler, R. L. (2005). Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine). Semin. Oncol. 32, 443-451. doi:10.1053/j.seminoncol.2005.07.008.
18. Porcellotti, S., Fanelli, F., Fracassi, A., Sepe, S., Cecconi, F., Bernardi, C., et al. (2015). Oxidative stress during the progression of beta-amyloid pathology in the neocortex of the Tg2576 mouse model of Alzheimer's disease. Oxid. Med. Cell. Longev. 2015, 967203. doi:10.1155/2015/967203.
19. Qiu, Y. Y., Mirkin, B. L., and Dwivedi, R. S. (2002). Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells. Cancer Detect. Prev. 26, 444-453. doi:10.1016/S0361-090X(02)00116-2.
20. Ramsey, C. P., Glass, C. A., Montgomery, M. B., Lindl, K. A., Ritson, G. P., Chia, L. A., et al. (2007). Expression of Nrf2 in neurodegenerative diseases. J. Neuropathol. Exp. Neurol. 66, 75-85. doi:10.1097/nen.0b013e31802d6da9.
21. Schmelz, K., Wagner, M., Dorken, B., and Tamm, I. (2005). 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int. J. Cancer 114, 683-695. doi:10.1002/ijc.20797.
22. Sheng, B., Gong, K., Niu, Y., Liu, L., Yan, Y., Lu, G., et al. (2009). Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: implications for the treatment of Alzheimer's disease. Free Radic. Biol. Med. 46, 1362-1375. doi:10.1016/j.freeradbiomed.2009.02.018.
23. Subramaniam, D., Thombre, R., Dhar, A., and Anant, S. (2014). DNA methyltransferases: a novel target for prevention and therapy. Front Oncol. 4:80. doi:10.3389/fonc.2014.00080.
24. Sultana, R., Perluigi, M., and Butterfield, D. A. (2006). Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid. Redox. Signal. 8, 2021-2037. doi:10.1089/ars.2006.8.2021.
25. Tomobe, K., Shinozuka, T., Kuroiwa, M., and Nomura, Y. (2012). Age-related changes of Nrf2 and phosphorylated GSK-3beta in a mouse model of accelerated aging (SAMP8). Arch. Gerontol. Geriatr. 54, e1-e7. doi:10.1016/j.archger.2011.06.006.
26. Vargas, M. R., Pehar, M., Cassina, P., Martinez-Palma, L., Thompson, J. A., Beckman, J. S., et al. (2005). Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J. Biol. Chem. 280, 25571-25579. doi:10.1074/jbc. M501920200.
27. Williams, T. I., Lynn, B. C., Markesbery, W. R., and Lovell, M. A. (2006). Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. Neurobiol. Aging 27, 1094-1099. doi:10.1016/j.neurobiolaging.2005.06.004.
28. Yang, Y., Jiang, S., Yan, J., Li, Y., Xin, Z., Lin, Y., et al. (2015). An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine Growth Factor Rev. 26, 47-57. doi:10.1016/j.cytogfr.2014.09.002.
29. Yu, S., Khor, T. O., Cheung, K. L., Li, W., Wu, T. Y., Huang, Y., et al. (2010). Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS ONE 5:e8579. doi:10.1371/journal.pone.0008579.
30. Zhang, C., Su, Z. Y., Khor, T. O., Shu, L., and Kong, A. N. (2013). Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem. Pharmacol. 85, 1398-1404. doi:10.1016/j.bcp.2013.02.010.
31. Zhao, Y., and Zhao, B. (2013). Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid. Med. Cell Longev. 2013, 316523. doi:10.1155/2013/316523.
32. Zhou, J., and Seeley, W. W. (2014). Network dysfunction in Alzheimer's disease and frontotemporal dementia: implications for psychiatry. Biol. Psychiatry 75, 565-573. doi:10.1016/j.biopsych.2014.01.020.