The effect of forced exercise on knee joints in Dio2-/- mice: Type II iodothyronine deiodinasedeficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

Annals of the Rheumatic Diseases

Volumn 75, Issue 3, 2016, Pages 571-577

  Bomer, Nils ^a,b   Cornelis, Frederique M F ^c   Ramos, Yolande F M ^a   Den Hollander, Wouter ^a   Storms, Lies ^c   Van Der Breggen, Ruud ^a   Lakenberg, Nico ^a   Slagboom, P Eline ^a,b,d   Meulenbelt, Ingrid ^a,d   Lories, Rik J L ^c,e  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Integrated Research on Developmental Determinants of Ageing and Longevity (IDEAL)   (Netherlands)

^c SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^d Netherlands Genomics Initiative   (Netherlands)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; DEIODINASE IODOTHYRONINE TYPE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; IODOTHYRONINE; UNCLASSIFIED DRUG; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; CTGF GENE; CTNNB1 GENE; DISEASE SEVERITY; EGFR GENE; EXERCISE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HISTOPATHOLOGY; HOMEOSTASIS; KNEE MENISCUS; KNOCKOUT MOUSE; MALE; MECHANICAL STRESS; MEF2C GENE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRG4 GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RUNNING; SYNOVITIS; WILD TYPE; ANIMAL; ARTICULAR CARTILAGE; C57BL MOUSE; DNA MICROARRAY; GENETICS; KNEE; KNEE OSTEOARTHRITIS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CARTILAGE, ARTICULAR; GENE EXPRESSION PROFILING; IODIDE PEROXIDASE; KNEE JOINT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS, KNEE; PHYSICAL CONDITIONING, ANIMAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL;

EID: 84960117079     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206608     Document Type: Article

References (40)

1. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet 1918;377:2115-26.
2. Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 2012;64:1697-707.
3. Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther 2009;11:224.
4. Haq I, Murphy E, Dacre J. Osteoarthritis. Postgrad Med J 2003;79:377-83.
5. Aigner T, Rose J, Martin J, et al. Aging theories of primary osteoarthritis: from epidemiology to molecular biology. Rejuvenation Res 2004;7:134-45.
6. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646-56.
7. Meulenbelt I, Min JL, Bos S, et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008;17:1867-75.
8. Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 2004;101:9757-62.
9. Miyamoto Y, Mabuchi A, Shi D, et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet 2007;39:529-33.
10. Miyamoto Y, Shi D, Nakajima M, et al. Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat Genet 2008;40:994-8.
11. Southam L, Chapman K, Loughlin J. Genetic association analysis of BMP5 as a potential osteoarthritis susceptibility gene. Rheumatology (Oxford) 2003;42:911-12.
12. Evangelou E, Valdes AM, Castano-Betancourt MC, et al. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Ann Rheum Dis 2013;72:1264-5.
13. Reynard LN, Loughlin J. The genetics and functional analysis of primary osteoarthritis susceptibility. Expert Rev Mol Med 2013;15:e2.
14. Cornelis FM, Luyten FP, Lories RJ. Functional effects of susceptibility genes in osteoarthritis. Discov Med 2011;12:129-39.
15. Meulenbelt I, Bos SD, Chapman K, et al. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. Ann Rheum Dis 2011;70:164-7.
16. Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol 2011;7:43-9.
17. Bomer N, den Hollander W, Ramos YFM, et al. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis. Ann Rheum Dis 2015;74:1571-9.
18. Bos SD, Bovee JV, Duijnisveld BJ, et al. Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis 2012;71:1254-8.
19. Karlsson C, Dehne T, Lindahl A, et al. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010;18:581-92.
20. Ijiri K, Zerbini LF, Peng H, et al. Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum 2008;58:2075-87.
21. Nagase H, Nagasawa Y, Tachida Y, et al. Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats. Osteoarthritis Cartilage 2013;21:514-23.
22. Schneider MJ, Fiering SN, Pallud SE, et al. Targeted Disruption of the Type 2 Selenodeiodinase Gene (DIO2) Results in a Phenotype of Pituitary Resistance to T4. Mol Endocrinol 2001;15:2137-48.
23. Szklarczyk D, Franceschini A, Kuhn M, et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 2011;39:D561-8.
24. Bassett JH, Boyde A, Howell PG, et al. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. Proc Natl Acad Sci USA 2010;107:7604-9.
25. Ramos YF, den Hollander W, Bovee JV, et al. Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study. PLoS ONE 2014;9:e103056.
26. Ruan MZC, Erez A, Guse K, et al. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med 2013;5:176ra34.
27. Arnold MA, Kim Y, Czubryt MP, et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell 2007;12: 377-89.
28. Mackie EJ, Ahmed YA, Tatarczuch L, et al. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 2008;40:46-62.
29. Omoto S, Nishida K, Yamaai Y, et al. Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis Cartilage 2004;12:771-8.
30. Shepard J, Jeong JW, Maihle N, et al. Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther 2013;15:R60.
31. Davidson ENB, Vitters EL, Mooren FM, et al. Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage. Arthritis Rheum 2006;54:1653-61.
32. Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008;4:550-6.
33. Linglart A, Maupetit-Méhouas S, Silve C. GNAS-related loss-of-function disorders and the role of imprinting. Horm Res Paediatr 2013;79:119-29.
34. Bastepe M, Weinstein LS, Ogata N, et al. Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci USA 2004;101:14794-9.
35. Taniguchi N, Carams B, Hsu E, et al. Expression patterns and function of chromatin protein HMGB2 during Mesenchymal stem cell differentiation. J Biol Chem 2011;286:41489-98.
36. Burns K, Duggan B, Atkinson EA, et al. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 1994;367: 476-80.
37. Li H, Zhang XY, Wu TJ, et al. Endoplasmic reticulum stress regulates rat mandibular cartilage thinning under compressive mechanical stress. J Biol Chem 2013;288:18172-83.
38. Sekiya I, Vuoristo JT, Larson BL, et al. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci 2002;99: 4397-402.
39. Dy P, Smits P, Silvester A, et al. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 2010;341:346-59.
40. Reppe S, Rian E, Jemtland R, et al. Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells. J Bone Miner Res 2000;15:2402-12.