Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

Organic Letters

Volumn 18, Issue 5, 2016, Pages 1028-1031

  Wang, Shengzheng ^a,b   Jiang, Yan ^a   Wu, Shanchao ^a   Dong, Guoqiang ^a   Miao, Zhenyuan ^a   Zhang, Wannian ^a   Sheng, Chunquan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; OXINDOLE; PROTEIN MDM2; PROTEIN P53; SPIRO COMPOUND;

CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; STEREOISOMERISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CATALYSIS; DRUG DISCOVERY; INDOLES; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-MDM2; SPIRO COMPOUNDS; STEREOISOMERISM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84960080789     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/acs.orglett.6b00155     Document Type: Article

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