Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1181-1188

  Kumari, Garima ^a   Nutan, ^b   Modi, Manoj ^b   Gupta, Satish K ^b   Singh, Ramendra K ^a,c  

^a UNIVERSITY OF ALLAHABAD   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Anti HIV; MTT assay; NNRTIs; Oxindoles; SAR; Stereoselective synthesis

Indexed keywords

2 (CHLOROMETHYL) 5' (TRIFLUOROMETHOXY)SPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (CHLOROMETHYL) 5' METHYLSPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (CHLOROMETHYL) 5' NITROSPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (CHLOROMETHYL)SPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (HYDROXYMETHYL) 5' (TRIFLUOROMETHOXY)SPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (HYDROXYMETHYL) 5' METHYLSPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (HYDROXYMETHYL) 5' NITROSPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; 2 (HYDROXYMETHYL)SPIRO[CYCLOPROPANE 1,3' INDOL] 2'(1'H)ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; HISTIDINE; LYSINE; OXINDOLE; RHODIUM DERIVATIVE; RNA DIRECTED DNA POLYMERASE; TYROSINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLOPROPANATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ACETATES; ANTI-HIV AGENTS; CATALYSIS; CELL LINE; CELL SURVIVAL; CYCLOPROPANES; HIV-1; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS; RHODIUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79952280115     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.037     Document Type: Article

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