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Volumn 51, Issue 66, 2015, Pages 13113-13116
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Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation
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Author keywords
[No Author keywords available]
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Indexed keywords
ANTINEOPLASTIC AGENT;
CASPASE;
CHROMAN DERIVATIVE;
NUTLIN 3;
OXINDOLE;
PROTEIN MDM2;
PROTEIN P21;
PROTEIN P53;
SPIRO COMPOUND;
SPIROOXINDOLE DERIVATIVE;
UNCLASSIFIED DRUG;
INDOLE DERIVATIVE;
ANTIPROLIFERATIVE ACTIVITY;
APOPTOSIS;
ARTICLE;
ASYMMETRIC CATALYSIS;
ASYMMETRIC SYNTHESIS;
CANCER INHIBITION;
CELL CYCLE ARREST;
CELL PROLIFERATION;
CHIRALITY;
CONTROLLED STUDY;
DRUG EFFICACY;
DRUG POTENCY;
DRUG SYNTHESIS;
ENANTIOSELECTIVITY;
HUMAN;
HUMAN CELL;
MCF 7 CELL LINE;
MICHAEL ADDITION;
MOLECULAR DOCKING;
PROTEIN PROTEIN INTERACTION;
SIGNAL TRANSDUCTION;
STRUCTURE ACTIVITY RELATION;
CATALYSIS;
CELL CYCLE CHECKPOINT;
CHEMICAL STRUCTURE;
CHEMISTRY;
DRUG EFFECTS;
METABOLISM;
PROTEIN CONFORMATION;
SYNTHESIS;
ANTINEOPLASTIC AGENTS;
APOPTOSIS;
CATALYSIS;
CELL CYCLE CHECKPOINTS;
CELL PROLIFERATION;
CHEMISTRY TECHNIQUES, SYNTHETIC;
CHROMANS;
HUMANS;
INDOLES;
MCF-7 CELLS;
MODELS, MOLECULAR;
PROTEIN CONFORMATION;
PROTO-ONCOGENE PROTEINS C-MDM2;
TUMOR SUPPRESSOR PROTEIN P53;
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EID: 84938852043
PISSN: 13597345
EISSN: 1364548X
Source Type: Journal
DOI: 10.1039/c5cc04968g Document Type: Article |
Times cited : (84)
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References (50)
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