Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins

Journal of Medicinal Chemistry

Volumn 55, Issue 15, 2012, Pages 6724-6737

  Abad, Andrés ^a,b   López Pérez, José L ^a   Del Olmo, Esther ^a   García Fernández, Luis F ^c   Francesch, Andrés ^c   Trigili, Chiara ^d   Barasoain, Isabel ^d   Andreu, José M ^d   Fernand Diaz J ^d   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b FACULTAD DE CIENCIAS   (Venezuela)

^c PHARMAMAR S A   (Spain)

^d CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

7 ALPHA (1 HYDROXY 1,1 DIPHENYLMETHYL) EPIPODOPHYLLOTOXIN; 7 ALPHA (2 HYDROXYPROP 2 YL) EPIPODOPHYLLOTOXIN; 7 ALPHA (2 HYDROXYPROP 2 YL) PODOPHYLLOTOXIN; 7 ALPHA [(1R)1 CYCLOHEX 3 ENYL 1 HYDROXYMETHYL] PIPODOPHYLLOTOXIN; 7 ALPHA [(1R)1 HYDROXY 1(3,4 DIMETHOXYPHENYL) ETHYL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(1R)1 HYDROXY 2 METHYL 1 PHENYLPROPYL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(1R)1 HYDROXYBUTYL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(1R)1 HYDROXYETHYL] 2,2,5 TRIMETHYL 1,3 DIOXOLAN 4 YL EPIPODOPHYLLOTOXIN ACETONIDE; 7 ALPHA [(1S)1 CYCLOHEX 3 ENYL 1 HYDROXYMETHYL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(1S)1 HYDROXYBUTYL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(1S)1 HYDROXYETHYL] 2,2,5 TRIMETHYL 1,3 DIOXOLAN 4 YL EPIPODOPHYLLOTOXIN ACETONIDE; 7 ALPHA [(2R)2 HYDROXY 3 METHYLBUT 2 YL] EPIPODOPHYLLOTOXIN; 7 ALPHA [(2S)2 HYDROXY 3 METHYLBUT 2 YL] EPIPODOPHYLLOTOXIN; 7 ALPHA ISOPROPYL 7 DEOXYPODOPHYLLOTOXIN; 7 BETA (1 HYDROXY 1,1 DIPHENYLMETHYL) PODOPHYLLOTOXIN; 7(2 METHYL 1 PHENYL 1 PROPYLIDENE) DEOXYPODOPHYLLOTOXIN; 7(3 METHYL 2 BUTYLIDENE) DEOXYPODOPHYLLOTOXIN; ALDEHYDE; ALKYLIDENE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; DOXORUBICIN; EPIPODOPINACOL; HYDROXYL GROUP; KETONE; PINACOL DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; MICROTUBULE; MICROTUBULE ASSEMBLY; PINACOL REARRANGEMENT; PROTEIN BINDING; PROTEIN INTERACTION; TUMOR CELL;

ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROTUBULES; MODELS, MOLECULAR; PODOPHYLLOTOXIN; STEREOISOMERISM; TUBULIN MODULATORS;

EID: 84864910183     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2017573     Document Type: Article

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