A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Nature Communications

Volumn 7, Issue , 2016, Pages

  Yuan, Lei ^a   Chan, Gary C ^a   Beeler, David ^a   Janes, Lauren ^a   Spokes, Katherine C ^a   Dharaneeswaran, Harita ^a   Mojiri, Anahita ^b   Adams, William J ^a   Sciuto, Tracey ^a   Garcia Cardeña, Guillermo ^c   Molema, Grietje ^d   Kang, Peter M ^a   Jahroudi, Nadia ^b   Marsden, Philip A ^e,f   Dvorak, Ann ^a   Regan, Erzsébet Ravasz ^a,g   Aird, William C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UNIVERSITY OF TORONTO   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g 931 College Mall   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; VON WILLEBRAND FACTOR; MESSENGER RNA;

CELLS AND CELL COMPONENTS; GENE EXPRESSION; HETEROGENEITY; HOMEOSTASIS; METAZOAN; METHYLATION; NOISE; PHENOTYPE; PROTEIN; RODENT;

ADULT; ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CAPILLARY; CELL CULTURE; CELL HETEROGENEITY; CONTROLLED STUDY; CORONARY ARTERY; DNA METHYLATION; ENDOTHELIUM CELL; GENETICALLY ENGINEERED MOUSE STRAIN; HEART DISEASE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN CORONARY ARTERY ENDOTHELIAL CELL; HUMAN PULMONARY ARTERY ENDOTHELIAL CELL; IN VITRO STUDY; LIFESPAN; MOSAICISM; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; PULMONARY ARTERY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION; 3T3 CELL LINE; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALIA; METAZOA; MUS;

ANIMALS; AORTA; CAPILLARIES; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; ENDOTHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MOSAICISM; NIH 3T3 CELLS; PHENOTYPE; PROMOTER REGIONS, GENETIC; PULMONARY ARTERY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; VON WILLEBRAND FACTOR;

EID: 84959565972     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10160     Document Type: Article

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