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Volumn 7, Issue 2, 2016, Pages 89-92

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; MATRIX METALLOPROTEINASE; TIGHT JUNCTION PROTEIN;

EID: 84959543227     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-016-0447-9     Document Type: Editorial
Times cited : (59)

References (38)
  • 2
    • 84941175340 scopus 로고    scopus 로고
    • American heart association/american stroke association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • COI: 1:CAS:528:DC%2BC2MXhs1Sis7jF, PID: 26123479
    • Powers WJ, Derdeyn CP, Biller J, Coffey CS, Hoh BL, Jauch EC, et al. American heart association/american stroke association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(10):3020–35.
    • (2015) Stroke , vol.46 , Issue.10 , pp. 3020-3035
    • Powers, W.J.1    Derdeyn, C.P.2    Biller, J.3    Coffey, C.S.4    Hoh, B.L.5    Jauch, E.C.6
  • 3
    • 84941189036 scopus 로고    scopus 로고
    • Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection
    • COI: 1:CAS:528:DC%2BC2MXhsVKitLrK, PID: 26314402
    • Lapchak PA. Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection. Transl Stroke Res. 2015;6(5):345–54.
    • (2015) Transl Stroke Res , vol.6 , Issue.5 , pp. 345-354
    • Lapchak, P.A.1
  • 4
    • 84937513897 scopus 로고    scopus 로고
    • Stroke neurologist’s perspective on the new endovascular trials
    • PID: 25944328
    • Grotta JC, Hacke W. Stroke neurologist’s perspective on the new endovascular trials. Stroke. 2015;46(6):1447–52.
    • (2015) Stroke , vol.46 , Issue.6 , pp. 1447-1452
    • Grotta, J.C.1    Hacke, W.2
  • 5
    • 85052608663 scopus 로고    scopus 로고
    • Blood–brain barrier function in intracerebral hemorrhage
    • COI: 1:STN:280:DC%2BD1cjps1yrtQ%3D%3D, PID: 19066086
    • Keep RF, Xiang J, Ennis SR, Andjelkovic A, Hua Y, Xi G, et al. Blood–brain barrier function in intracerebral hemorrhage. Acta Neurochir Suppl. 2008;105:73–7.
    • (2008) Acta Neurochir Suppl , vol.105 , pp. 73-77
    • Keep, R.F.1    Xiang, J.2    Ennis, S.R.3    Andjelkovic, A.4    Hua, Y.5    Xi, G.6
  • 6
    • 84905858029 scopus 로고    scopus 로고
    • Vascular disruption and blood–brain barrier dysfunction in intracerebral hemorrhage
    • PID: 25120903
    • Keep RF, Zhou N, Xiang J, Andjelkovic AV, Hua Y, Xi G. Vascular disruption and blood–brain barrier dysfunction in intracerebral hemorrhage. Fluids Barriers CNS. 2014;11:18.
    • (2014) Fluids Barriers CNS , vol.11 , pp. 18
    • Keep, R.F.1    Zhou, N.2    Xiang, J.3    Andjelkovic, A.V.4    Hua, Y.5    Xi, G.6
  • 7
    • 84923103035 scopus 로고    scopus 로고
    • Thrombin-induced cerebral hemorrhage: role of protease-activated receptor-1
    • COI: 1:CAS:528:DC%2BC3sXhsFWmtLvN, PID: 24323711
    • Cheng Y, Xi G, Jin H, Keep RF, Feng J, Hua Y. Thrombin-induced cerebral hemorrhage: role of protease-activated receptor-1. Transl Stroke Res. 2014;5(4):472–5.
    • (2014) Transl Stroke Res , vol.5 , Issue.4 , pp. 472-475
    • Cheng, Y.1    Xi, G.2    Jin, H.3    Keep, R.F.4    Feng, J.5    Hua, Y.6
  • 8
    • 84893807007 scopus 로고    scopus 로고
    • Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema
    • COI: 1:CAS:528:DC%2BC3sXhvVyhsrzE, PID: 24323726
    • Khanna A, Kahle KT, Walcott BP, Gerzanich V, Simard JM. Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema. Transl Stroke Res. 2014;5(1):3–16.
    • (2014) Transl Stroke Res , vol.5 , Issue.1 , pp. 3-16
    • Khanna, A.1    Kahle, K.T.2    Walcott, B.P.3    Gerzanich, V.4    Simard, J.M.5
  • 9
    • 12844259450 scopus 로고    scopus 로고
    • Telemedicine for safe and extended use of thrombolysis in stroke: the telemedic pilot project for integrative stroke care (TEMPiS) in Bavaria
    • COI: 1:CAS:528:DC%2BD2MXmtVWhtw%3D%3D, PID: 15625294
    • Audebert HJ, Kukla C, Von Clarmann Claranau S, Kuhn J, Vatankhah B, Schenkel J, et al. Telemedicine for safe and extended use of thrombolysis in stroke: the telemedic pilot project for integrative stroke care (TEMPiS) in Bavaria. Stroke. 2005;36(2):287–91.
    • (2005) Stroke , vol.36 , Issue.2 , pp. 287-291
    • Audebert, H.J.1    Kukla, C.2    Von Clarmann Claranau, S.3    Kuhn, J.4    Vatankhah, B.5    Schenkel, J.6
  • 10
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood–brain barrier and white matter components after cerebral ischemia
    • COI: 1:STN:280:DC%2BD3MritFGluw%3D%3D, PID: 11567062
    • Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood–brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001;21(19):7724–32.
    • (2001) J Neurosci , vol.21 , Issue.19 , pp. 7724-7732
    • Asahi, M.1    Wang, X.2    Mori, T.3    Sumii, T.4    Jung, J.C.5    Moskowitz, M.A.6
  • 11
    • 84863230646 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood–brain barrier damage in early ischemic stroke stage
    • COI: 1:CAS:528:DC%2BC38XjslKjtLY%3D, PID: 22378877
    • Liu J, Jin X, Liu KJ, Liu W. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood–brain barrier damage in early ischemic stroke stage. J Neurosci. 2012;32(9):3044–57.
    • (2012) J Neurosci , vol.32 , Issue.9 , pp. 3044-3057
    • Liu, J.1    Jin, X.2    Liu, K.J.3    Liu, W.4
  • 12
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • COI: 1:CAS:528:DC%2BD2sXkvFyntLo%3D, PID: 16850029
    • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007;27(4):697–709.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.4 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 13
    • 84925543483 scopus 로고    scopus 로고
    • Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke
    • COI: 1:CAS:528:DC%2BC2cXitV2gtLvM, PID: 25476155
    • Reuter B, Rodemer C, Grudzenski S, Meairs S, Bugert P, Hennerici MG, et al. Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke. Transl Stroke Res. 2015;6(2):156–9.
    • (2015) Transl Stroke Res , vol.6 , Issue.2 , pp. 156-159
    • Reuter, B.1    Rodemer, C.2    Grudzenski, S.3    Meairs, S.4    Bugert, P.5    Hennerici, M.G.6
  • 14
    • 79951922143 scopus 로고    scopus 로고
    • Engaging neuroscience to advance translational research in brain barrier biology
    • COI: 1:CAS:528:DC%2BC3MXitVOnsb4%3D, PID: 21331083
    • Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011;12(3):169–82.
    • (2011) Nat Rev Neurosci , vol.12 , Issue.3 , pp. 169-182
    • Neuwelt, E.A.1    Bauer, B.2    Fahlke, C.3    Fricker, G.4    Iadecola, C.5    Janigro, D.6
  • 15
    • 84874478286 scopus 로고    scopus 로고
    • Blood–brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions
    • COI: 1:CAS:528:DC%2BC3sXjsl2jsbw%3D, PID: 23468865
    • Krueger M, Hartig W, Reichenbach A, Bechmann I, Michalski D. Blood–brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions. PLoS One. 2013;8(2), e56419.
    • (2013) PLoS One , vol.8 , Issue.2
    • Krueger, M.1    Hartig, W.2    Reichenbach, A.3    Bechmann, I.4    Michalski, D.5
  • 16
    • 84899967644 scopus 로고    scopus 로고
    • Stepwise recruitment of transcellular and paracellular pathways underlies blood–brain barrier breakdown in stroke
    • COI: 1:CAS:528:DC%2BC2cXmsVCht7w%3D, PID: 24746419
    • Knowland D, Arac A, Sekiguchi KJ, Hsu M, Lutz SE, Perrino J, et al. Stepwise recruitment of transcellular and paracellular pathways underlies blood–brain barrier breakdown in stroke. Neuron. 2014;82(3):603–17.
    • (2014) Neuron , vol.82 , Issue.3 , pp. 603-617
    • Knowland, D.1    Arac, A.2    Sekiguchi, K.J.3    Hsu, M.4    Lutz, S.E.5    Perrino, J.6
  • 17
    • 84959498881 scopus 로고    scopus 로고
    • Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice, J Cereb Blood Flow Metab
    • Nahirney PC, Reeson P, Brown CE. Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice. J Cereb Blood Flow Metab. 2015.
    • (2015) Brown CE
    • Nahirney, P.C.1    Reeson, P.2
  • 18
    • 84955446823 scopus 로고    scopus 로고
    • Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
    • Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X et al. Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury. Nat Commun. 2016;7:10523. doi:10.1038/ncomms10523
    • (2016) Nat Commun , vol.7 , pp. 10523
    • Shi, Y.1    Zhang, L.2    Pu, H.3    Mao, L.4    Hu, X.5    Jiang, X.6
  • 19
    • 0037786965 scopus 로고    scopus 로고
    • Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins
    • COI: 1:CAS:528:DC%2BD3sXks1Kms70%3D, PID: 12775580
    • Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296–304.
    • (2003) Circ Res , vol.92 , Issue.12 , pp. 1296-1304
    • Lin, T.1    Zeng, L.2    Liu, Y.3    DeFea, K.4    Schwartz, M.A.5    Chien, S.6
  • 20
    • 78649467527 scopus 로고    scopus 로고
    • Pericytes regulate the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC3cXht1yjs7jF, PID: 20944627
    • Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, et al. Pericytes regulate the blood–brain barrier. Nature. 2010;468(7323):557–61.
    • (2010) Nature , vol.468 , Issue.7323 , pp. 557-561
    • Armulik, A.1    Genove, G.2    Mae, M.3    Nisancioglu, M.H.4    Wallgard, E.5    Niaudet, C.6
  • 21
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood–brain barrier integrity during embryogenesis
    • COI: 1:CAS:528:DC%2BC3cXht1yjs7bI, PID: 20944625
    • Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood–brain barrier integrity during embryogenesis. Nature. 2010;468(7323):562–6.
    • (2010) Nature , vol.468 , Issue.7323 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 22
    • 84928893681 scopus 로고    scopus 로고
    • Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity
    • PID: 24583950
    • Yao Y, Chen ZL, Norris EH, Strickland S. Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun. 2014;5:3413.
    • (2014) Nat Commun , vol.5 , pp. 3413
    • Yao, Y.1    Chen, Z.L.2    Norris, E.H.3    Strickland, S.4
  • 23
    • 84897564199 scopus 로고    scopus 로고
    • Capillary pericytes regulate cerebral blood flow in health and disease
    • COI: 1:CAS:528:DC%2BC2cXlsFyis7k%3D, PID: 24670647
    • Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014;508(7494):55–60.
    • (2014) Nature , vol.508 , Issue.7494 , pp. 55-60
    • Hall, C.N.1    Reynell, C.2    Gesslein, B.3    Hamilton, N.B.4    Mishra, A.5    Sutherland, B.A.6
  • 24
    • 84929839390 scopus 로고    scopus 로고
    • Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells
    • COI: 1:CAS:528:DC%2BC2MXhtleqsLjE, PID: 25694098
    • Nakagomi T, Kubo S, Nakano-Doi A, Sakuma R, Lu S, Narita A, et al. Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells. Stem Cells. 2015;33(6):1962–74.
    • (2015) Stem Cells , vol.33 , Issue.6 , pp. 1962-1974
    • Nakagomi, T.1    Kubo, S.2    Nakano-Doi, A.3    Sakuma, R.4    Lu, S.5    Narita, A.6
  • 25
    • 84944462988 scopus 로고    scopus 로고
    • Mechanisms underlying astrocyte endfeet swelling in stroke
    • COI: 1:STN:280:DC%2BC28zhtlGgug%3D%3D, PID: 26463917
    • Xiang J, Tang Y, Li C, Su EJ, Lawrence DA, Keep RF. Mechanisms underlying astrocyte endfeet swelling in stroke. Acta Neurochir Suppl. 2016;121:19–22.
    • (2016) Acta Neurochir Suppl , vol.121 , pp. 19-22
    • Xiang, J.1    Tang, Y.2    Li, C.3    Su, E.J.4    Lawrence, D.A.5    Keep, R.F.6
  • 26
    • 84905388735 scopus 로고    scopus 로고
    • Oligodendrocyte precursor cells support blood–brain barrier integrity via TGF-beta signaling
    • PID: 25078775
    • Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, et al. Oligodendrocyte precursor cells support blood–brain barrier integrity via TGF-beta signaling. PLoS One. 2014;9(7), e103174.
    • (2014) PLoS One , vol.9 , Issue.7
    • Seo, J.H.1    Maki, T.2    Maeda, M.3    Miyamoto, N.4    Liang, A.C.5    Hayakawa, K.6
  • 28
    • 84941317563 scopus 로고    scopus 로고
    • Intercellular cross-talk in intracerebral hemorrhage
    • COI: 1:CAS:528:DC%2BC2MXmsFeitLk%3D, PID: 25863131
    • Egashira Y, Hua Y, Keep RF, Xi G. Intercellular cross-talk in intracerebral hemorrhage. Brain Res. 2015;1623:97–109.
    • (2015) Brain Res , vol.1623 , pp. 97-109
    • Egashira, Y.1    Hua, Y.2    Keep, R.F.3    Xi, G.4
  • 29
    • 84905586728 scopus 로고    scopus 로고
    • Evaluation of the protective potential of brain microvascular endothelial cell autophagy on blood–brain barrier integrity during experimental cerebral ischemia-reperfusion injury
    • PID: 25070048
    • Li H, Gao A, Feng D, Wang Y, Zhang L, Cui Y, et al. Evaluation of the protective potential of brain microvascular endothelial cell autophagy on blood–brain barrier integrity during experimental cerebral ischemia-reperfusion injury. Transl Stroke Res. 2014;5(5):618–26.
    • (2014) Transl Stroke Res , vol.5 , Issue.5 , pp. 618-626
    • Li, H.1    Gao, A.2    Feng, D.3    Wang, Y.4    Zhang, L.5    Cui, Y.6
  • 30
    • 84921362221 scopus 로고    scopus 로고
    • Longitudinal assessment of imatinib’s effect on the blood–brain barrier after ischemia/reperfusion injury with permeability MRI
    • COI: 1:CAS:528:DC%2BC2cXhsVWksrjL, PID: 25146090
    • Merali Z, Leung J, Mikulis D, Silver F, Kassner A. Longitudinal assessment of imatinib’s effect on the blood–brain barrier after ischemia/reperfusion injury with permeability MRI. Transl Stroke Res. 2015;6(1):39–49.
    • (2015) Transl Stroke Res , vol.6 , Issue.1 , pp. 39-49
    • Merali, Z.1    Leung, J.2    Mikulis, D.3    Silver, F.4    Kassner, A.5
  • 31
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • COI: 1:CAS:528:DC%2BC3MXos1Srsrw%3D, PID: 21738161
    • Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17(7):796–808.
    • (2011) Nat Med , vol.17 , Issue.7 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 32
    • 84943579915 scopus 로고    scopus 로고
    • Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke
    • PID: 26148976
    • Gliem M, Krammes K, Liaw L, van Rooijen N, Hartung HP, Jander S. Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia. 2015;63(12):2198–207.
    • (2015) Glia , vol.63 , Issue.12 , pp. 2198-2207
    • Gliem, M.1    Krammes, K.2    Liaw, L.3    van Rooijen, N.4    Hartung, H.P.5    Jander, S.6
  • 33
    • 84924096827 scopus 로고    scopus 로고
    • Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery
    • PID: 25889169
    • Yang Y, Salayandia VM, Thompson JF, Yang LY, Estrada EY, Yang Y. Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery. J Neuroinflammation. 2015;12:26.
    • (2015) J Neuroinflammation , vol.12 , pp. 26
    • Yang, Y.1    Salayandia, V.M.2    Thompson, J.F.3    Yang, L.Y.4    Estrada, E.Y.5    Yang, Y.6
  • 34
    • 84891353994 scopus 로고    scopus 로고
    • Remote ischemic perconditioning is effective after embolic stroke in ovariectomized female mice
    • COI: 1:CAS:528:DC%2BC2cXhvVejtg%3D%3D, PID: 24385308
    • Hoda MN, Bhatia K, Hafez SS, Johnson MH, Siddiqui S, Ergul A, et al. Remote ischemic perconditioning is effective after embolic stroke in ovariectomized female mice. Transl Stroke Res. 2014;5(4):484–90.
    • (2014) Transl Stroke Res , vol.5 , Issue.4 , pp. 484-490
    • Hoda, M.N.1    Bhatia, K.2    Hafez, S.S.3    Johnson, M.H.4    Siddiqui, S.5    Ergul, A.6
  • 35
    • 84905582293 scopus 로고    scopus 로고
    • Recombinant T cell receptor ligand treatment improves neurological outcome in the presence of tissue plasminogen activator in experimental ischemic stroke
    • COI: 1:CAS:528:DC%2BC2cXhtVantbfE, PID: 24953050
    • Zhu W, Libal NL, Casper A, Bodhankar S, Offner H, Alkayed NJ. Recombinant T cell receptor ligand treatment improves neurological outcome in the presence of tissue plasminogen activator in experimental ischemic stroke. Transl Stroke Res. 2014;5(5):612–7.
    • (2014) Transl Stroke Res , vol.5 , Issue.5 , pp. 612-617
    • Zhu, W.1    Libal, N.L.2    Casper, A.3    Bodhankar, S.4    Offner, H.5    Alkayed, N.J.6
  • 36
    • 84895607012 scopus 로고    scopus 로고
    • Hyperglycemia, acute ischemic stroke, and thrombolytic therapy
    • COI: 1:CAS:528:DC%2BC2cXktVWnu74%3D, PID: 24619488
    • Hafez S, Coucha M, Bruno A, Fagan SC, Ergul A. Hyperglycemia, acute ischemic stroke, and thrombolytic therapy. Transl Stroke Res. 2014;5(4):442–53.
    • (2014) Transl Stroke Res , vol.5 , Issue.4 , pp. 442-453
    • Hafez, S.1    Coucha, M.2    Bruno, A.3    Fagan, S.C.4    Ergul, A.5
  • 37
    • 84905579766 scopus 로고    scopus 로고
    • Effect of clot aging and cholesterol content on ultrasound-assisted thrombolysis
    • COI: 1:CAS:528:DC%2BC2cXhvV2msro%3D, PID: 24488442
    • Zhou Y, Murugappan SK, Sharma VK. Effect of clot aging and cholesterol content on ultrasound-assisted thrombolysis. Transl Stroke Res. 2014;5(5):627–34.
    • (2014) Transl Stroke Res , vol.5 , Issue.5 , pp. 627-634
    • Zhou, Y.1    Murugappan, S.K.2    Sharma, V.K.3
  • 38
    • 84870781275 scopus 로고    scopus 로고
    • The vascular neural network—a new paradigm in stroke pathophysiology
    • COI: 1:CAS:528:DC%2BC38XhvVSqtL%2FL, PID: 23070610
    • Zhang JH, Badaut J, Tang J, Obenaus A, Hartman R, Pearce WJ. The vascular neural network—a new paradigm in stroke pathophysiology. Nat Rev Neurol. 2012;8(12):711–6.
    • (2012) Nat Rev Neurol , vol.8 , Issue.12 , pp. 711-716
    • Zhang, J.H.1    Badaut, J.2    Tang, J.3    Obenaus, A.4    Hartman, R.5    Pearce, W.J.6


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