Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Translational Stroke Research

Volumn 5, Issue 4, 2014, Pages 484-490

  Hoda, Md Nasrul ^a,b,c,d   Bhatia, Kanchan ^b   Hafez, Sherif S ^b   Johnson, Maribeth H ^a   Siddiqui, Shahneela ^b   Ergul, Adviye ^b,c,d   Zaidi, Syed Kashif ^e   Fagan, Susan C ^b,c,d   Hess, David C ^b,c  

^a AUGUSTA UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Embolic stroke; IV tPA thrombolysis; Remote ischemic conditioning; Stroke

Indexed keywords

FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL; BRAIN CORTEX; C57BL MOUSE; FEMALE; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC PRECONDITIONING; MOUSE; MULTIMODALITY CANCER THERAPY; OVARIECTOMY; STROKE; VASCULARIZATION;

ANIMALS; CEREBRAL CORTEX; COMBINED MODALITY THERAPY; FEMALE; FIBRINOLYTIC AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC PRECONDITIONING; MICE; MICE, INBRED C57BL; OVARIECTOMY; STROKE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84891353994     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-013-0318-6     Document Type: Article

References (28)

1. Hess DC, Hoda MN, Bhatia K. Remote limb preconditioning and postconditioning: will it translate into a promising treatment for acute stroke? Stroke; J Cereb Circ. 2013;44:1191–7.
2. Hossmann KA. Pathophysiological basis of translational stroke research. Folia neuropathologica/Association of Polish Neuropathologists and Medical Research Centre. Pol Acad Sci. 2009;47:213–27.
3. Hossmann KA. The two pathophysiologies of focal brain ischemia: implications for translational stroke research. Journal of cerebral blood flow and metabolism. Off J Int Soc Cereb Blood Flow Metab. 2012;32:1310–6.
4. Siegel C, Turtzo C, McCullough LD. Sex differences in cerebral ischemia: possible molecular mechanisms. J Neurosci Res. 2010;88:2765–74.
5. Persky RW, Turtzo LC, McCullough LD. Stroke in women: disparities and outcomes. Curr Cardiol Rep. 2010;12:6–13.
6. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. Journal of cerebral blood flow and metabolism. Off J Int Soc Cereb Blood Flow Metab. 2005;25:502–12.
7. Albers GW, Goldstein LB, Hess DC, Wechsler LR, Furie KL, Gorelick PB, et al. Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies. Stroke; J Cereb Circ. 2011;42:2645–50.
8. Meng W, Wang X, Asahi M, Kano T, Asahi K, Ackerman RH, et al. Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism. Off J Int Soc Cereb Blood Flow Metab. 1999;19:1316–21.
9. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, et al. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke; J Cereb Circ. 2012;43:2794–9.
10. Hoda MN, Li W, Ahmad A, Ogbi S, Zemskova MA, Johnson MH, et al. Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke. Exp Transl Stroke Med. 2011;3:16.
11. Li W, Prakash R, Kelly-Cobbs AI, Ogbi S, Kozak A, El-Remessy AB, et al. Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes. 2010;59:228–35.
12. Yuan HJ, Zhu XH, Luo Q, Wu YN, Kang Y, Jiao JJ, et al. Noninvasive delayed limb ischemic preconditioning in rats increases antioxidant activities in cerebral tissue during severe ischemia-reperfusion injury. J Surg Res. 2012;174:176–83.
13. Dm R, Ve H, Ge T, Mo J, Sd K. Remote ischemic preconditioning reduces thrombus formation in the rat. JTH: Journal of thrombosis and haemostasis; 2012.
14. Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, et al. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood. 2009;114:3329–34.
15. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006;12:441–5.
16. Choudhri TF, Hoh BL, Solomon RA, Connolly Jr ES, Pinsky DJ. Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice. Stroke; J Cereb Circ. 1997;28:2296–302.
17. Hoda MN, Singh I, Singh AK, Khan M. Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat. J Neuroinflammation. 2009;6:21.
18. Liu R, Liu Q, He S, Simpkins JW, Yang SH. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther. 2010;332:1006–12.
19. Santizo RA, Xu HL, Galea E, Muyskens S, Baughman VL, Pelligrino DA. Combined endothelial nitric oxide synthase upregulation and caveolin-1 downregulation decrease leukocyte adhesion in pial venules of ovariectomized female rats. Stroke; J Cereb Circ. 2002;33:613–6.
20. Cipolla MJ, Godfrey JA, Wiegman MJ. The effect of ovariectomy and estrogen on penetrating brain arterioles and blood-brain barrier permeability. Microcirculation. 2009;16:685–93.
21. Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med. 2009;15:1031–7.
22. De Silva DA, Fink JN, Christensen S, Ebinger M, Bladin C, Levi CR, et al. Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET). Stroke; J Cereb Circ. 2009;40:2872–4.
23. Soares BP, Tong E, Hom J, Cheng SC, Bredno J, Boussel L, et al. Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients. Stroke; J Cereb Circ. 2010;41:e34–40.
24. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79:1853–61.
25. Liu F, Li Z, Li J, Siegel C, Yuan R, McCullough LD. Sex differences in caspase activation after stroke. Stroke; J Cereb Circ. 2009;40:1842–8.
26. McElroy JF, Wade GN. Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats. Physiol Behav. 1987;39:361–5.
27. Rocca WA, Grossardt BR, Miller VM, Shuster LT, Brown Jr RD. Premature menopause or early menopause and risk of ischemic stroke. Menopause. 2012;19:272–7.
28. McCarthy AM, Menke A, Ouyang P, Visvanathan K. Bilateral oophorectomy, body mass index, and mortality in U.S. women aged 40 years and older. Cancer Prev Res (Phila). 2012;5:847–54.