Hemoglobin-induced neuronal degeneration in the hippocampus after neonatal intraventricular hemorrhage

Brain Research

Volumn 1635, Issue , 2016, Pages 86-94

  Garton, Thomas P ^a   He, Yangdong ^a   Garton, Hugh J L ^a   Keep, Richard F ^a   Xi, Guohua ^a   Strahle, Jennifer M ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

^c Department of Neurosurgery ^*  (United States)

Author keywords

CD163; Deferoxamine; Hemoglobin; Hippocampus; Intraventricular hemorrhage; Neuron

Indexed keywords

CD163 ANTIGEN; DEFEROXAMINE; HEMOGLOBIN; MESSENGER RNA; NEURON SPECIFIC ENOLASE; STRESS ACTIVATED PROTEIN KINASE; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; BRAIN SIZE; CELL DEATH; CONTROLLED STUDY; ENDOCYTOSIS; HEMOGLOBIN INDUCED HIPPOCAMPUS NEURONAL DEGENERATION; HIPPOCAMPAL CA1 REGION; HYDROCEPHALUS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; NEONATAL INTRAVENTRICULAR HEMORRHAGE; NERVE CELL DEGENERATION; NEUROIMAGING; NEWBORN; NEWBORN DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CEREBRAL HEMORRHAGE; DEFEROXAMINE; HEMOGLOBINS; HIPPOCAMPUS; HYDROCEPHALUS; INJECTIONS, INTRAVENTRICULAR; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE;

EID: 84959530084     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.12.060     Document Type: Article

References (41)

1. F. Chen JNK-induced apoptosis, compensatory growth, and cancer stem cells Cancer Res. 72 2012 379 386
2. K.J. Collard Iron homeostasis in the neonate Pediatrics 123 2009 1208 1216
3. H.J. Cui, and et al. Efficacy of deferoxamine in animal models of intracerebral hemorrhage: A systematic review and stratified meta-analysis PLoS One 10 2015 e0127256
4. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
5. D.N. Dhanasekaran, and E.P. Reddy JNK signaling in apoptosis Oncogene 27 2008 6245 6251
6. I.Y. Eyüpoglu, and et al. Identification of neuronal cell death in a model of degeneration in the hippocampus Brain Res. Brain Res. Protoc. 11 2003 1 8
7. J. Galea, and et al. The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage J. Neurochem. 121 2012 785 792
8. P. Georgiadis, and et al. Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage Stroke 39 2008 3378 3388
9. M. Gram, and et al. Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation J. Neuroinflamm. 10 100 2013 1 13
10. M. Gram, and et al. Extracellular hemoglobin-mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage J. Neuroinflamm. 11 200 2014 1 15
11. M. Heron, and et al. Annual summary of vital statistics: 2007 Pediatrics 125 2010 4 15
12. K. Holfelder, and et al. De novo expression of the hemoglobin scavenger receptor CD163 by activated microglia is not associated with hemorrhages in human brain lesions Histol. Histopathol. 26 2011 1007 1017
13. Y. Jiang, and et al. Thrombin-receptor activation and thrombin-induced brain tolerance J. Cereb. Blood Flow Metab. 22 2002 404 410
14. M. Kristiansen, and et al. Identification of the haemoglobin scavenger receptor Nature 409 2001 198 201
15. S.K. Law, and et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily Eur. J. Immunol. 23 1993 2320 2325
16. J.Y. Lee, and et al. Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury J. Cereb. Blood Flow Metab. 30 2010 1793 1803
17. M. Lewis, and M. Bendersky Cognitive and motor differences among low birth weight infants: Impact of intraventricular hemorrhage, medical risk, and social class Pediatrics 83 1989 187 192
18. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
19. J. Lok, and et al. Intracranial hemorrhage: Mechanisms of secondary brain injury Acta Neurochir. Suppl. 111 2011 63 69
20. H. Meng, and et al. Deferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition Brain Res. 1602 2015 44 52
21. S.K. Moestrup, and H.J. Møller CD163: A regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response Ann. Med. 36 2004 347 354
22. B.P. Murphy, and et al. Posthaemorrhagic ventricular dilatation in the premature infant: Natural history and predictors of outcome Arch. Dis. Child. Fetal Neonatal Ed. 87 2002 F37 F41
23. T. Nakamura, and et al. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage J. Neurosurgery 100 2004 672 678
24. W. Ni, M. Okauchi, T. Hatakeyama, Y. Gu, R.F. Keep, G. Xi, and Y. Hua Deferoxamine reduces intracerebral hemorrhage-induced white matter damage in aged rats Exp. Neurol. 272 2015 128 134 (Epub 2015 March) 10.1016/j.expneurol.2015.02.035
25. E.S. Papadakis, and et al. The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway FEBS Lett. 580 2006 1320 1326
26. G. Papazisis, and et al. Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia Pharmacol. Res. 57 2008 73 78
27. M.M.J. Polfliet, and et al. The rat macrophage scavenger receptor CD163: Expression, regulation and role in inflammatory mediator production Immunobiology 211 2006 419 425
28. M. Ramani, and et al. Neurodevelopmental impairment following neonatal hyperoxia in the mouse Neurobiol. Dis. 50 2013 69 75
29. R.F. Regan, and S.S. Panter Neurotoxicity of hemoglobin in cortical cell culture Neurosci. Lett. 153 1993 219 222
30. C.A. Schaer, and et al. Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin Circ. Res. 99 2006 943 950
31. D.J. Schaer, and et al. Gating the radical hemoglobin to macrophages: The anti-inflammatory role of CD163, a scavenger receptor Antioxid. Redox Signal. 9 2007 991 999
32. S. Song, and et al. A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: Effects of deferoxamine on hemoglobin-induced neuronal death Stroke 38 2007 2861 2863
33. J.M. Strahle, and et al. Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage Neurosurgery 75 2014 696 706
34. H. Van Gorp, and et al. Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy Mol. Immunol. 47 2010 1650 1660
35. K.R. Wagner, and et al. Heme and iron metabolism: Role in cerebral hemorrhage J. Cereb. Blood Flow Metab. 23 2003 629 652
36. J. Wang, and S. Dore Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage Brain 130 2007 1643 1652
37. P. Wang, S.W. You, Y.J. Yang, and et al. Systemic injection of low-dose lipopolysaccharide fails to break down the blood-brain barrier or activate the TLR4-MyD88 pathway in neonatal rat brain Int. J. Mol. Sci. 15 6 2014 10101 10115
38. C.R. Weston, and R.J. Davis The JNK signal transduction pathway Curr. Opin. Cell Biol. 19 2007 142 149
39. O.T. Wolf, and et al. Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI Brain Res. Brain Res. Protoc. 10 2002 41 46
40. P. Zhang, and et al. Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats Brain Dev. 37 2015 747 752
41. A. Zlotnik, and et al. Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats Anesthesiology 116 2012 73 83