Deferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition

Brain Research

Volumn 1602, Issue C, 2015, Pages 44-52

  Meng, Hui ^a   Li, Fei ^a   Hu, Rong ^a   Yuan, Yikai ^a   Gong, Guoqi ^a   Hu, Shengli ^a   Feng, Hua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Deferoxamine; Hydrocephalus; Intraventricular hemorrhage; Iron chelation; Post hemorrhagic chronic; Wnt signaling pathway

Indexed keywords

DEFEROXAMINE; FERRITIN; WNT1 PROTEIN; WNT3A PROTEIN; IRON; NEUROPROTECTIVE AGENT; WNT1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; BRAIN TISSUE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; HYDROCEPHALUS; IRON CHELATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; BRAIN; CEREBRAL HEMORRHAGE; CHRONIC DISEASE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; MAZE TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

RATTUS;

ANIMALS; BLOTTING, WESTERN; BRAIN; CEREBRAL HEMORRHAGE; CHRONIC DISEASE; DEFEROXAMINE; DISEASE MODELS, ANIMAL; FERRITINS; HYDROCEPHALUS; IMMUNOHISTOCHEMISTRY; IRON; MALE; MAZE LEARNING; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; WNT1 PROTEIN; WNT3A PROTEIN;

EID: 84928005571     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.08.039     Document Type: Article

References (29)

1. Antic, M., Distler, J.H., Distler, O., 2013. Treating skin and lung fibrosis in systemic sclerosis: a future filled with promise?. Curr Opin Pharmacol 13, 455-462.
2. Bhattathiri, P.S., Gregson, B., Prasad, K.S., Mendelow, A.D., 2006. Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the STICH trial. Acta Neurochir. Suppl. 96, 65-68.
3. Brack, A.S., Conboy, M.J., Roy, S., Lee, M., Kuo, C.J., Keller, C., et al., 2007. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317, 807-810.
4. Chen, Z., Gao, C., Hua, Y., Keep, R.F., Muraszko, K., Xi, G., 2011. Role of iron in brain injury after intraventricular hemorrhage. Stroke 42, 465-470.
5. Cheng, J.H., She, H., Han, Y.P., Wang, J., Xiong, S., Asahina, K., et al., 2008. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G39-G49.
6. Cisternas, P., Vio, C.P., Inestrosa, N.C., 2014. Role of wnt signaling in tissue fibrosis, lessons from skeletal muscle and kidney. Curr. Mol. Med. 14, 510-522.
7. Diringer, M.N., Edwards, D.F, Zazulia, A.R., 1998. Hydrocephalus: a previously unrecognized predictor of poor outcome from supratentorial intracerebral hemorrhage. Stroke 29, 1352-1357.
8. Fathke, C., Wilson, L., Shah, K., Kim, B., Hocking, A., Moon, R., et al., 2006. Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol. 7, 4.
9. Gu, Y., Hua, Y., Keep, R.F., Morgenstern, L.B., Xi, G., 2009. Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke 40, 2241-2243.
10. Hanley, D.F., 2009. Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral hemorrhage. Stroke 40, 1533-1538.
11. Hwang, B.Y., Bruce, S.S., Appelboom, G., Piazza, M.A., Carpenter, A.M., Gigante, P.R., et al., 2012. Evaluation of intraventricular hemorrhage assessment methods for predicting outcome following intracerebral hemorrhage. J. Neurosurg. 116, 185-192.
12. Jin, H., Terai, S., Sakaida, I., 2007. The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. J. Gastroenterol. 42, 475-484.
13. Kim, D.S., Oi, S., Hidaka, M., Sato, O., Choi, J.U., 1999. A new experimental model of obstructive hydrocephalus in the rat: the micro-balloon technique. Childs Nerv. Syst. 15, 250-255.
14. Logan, C.Y., Nusse, R., 2004. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810.
15. Massicotte, E.M., Del Bigio, M.R., 1999. Human arachnoid villi response to subarachnoid hemorrhage: possible relationship to chronic hydrocephalus. J. Neurosurg. 91, 80-84.
16. Mayfrank, L., Kissler, J., Raoofi, R., Delsing, P., Weis, J., Kuker, W., et al., 1997. Ventricular dilatation in experimental intraventricular hemorrhage in pigs. Characterization of cerebrospinal fluid dynamics and the effects of fibrinolytic treatment. Stroke 28, 141-148.
17. Miao, C.G., Yang, Y.Y., He, X., Huang, C., Huang, Y., Zhang, L., et al., 2013. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie 95, 2326-2335.
18. Okauchi, M., Hua, Y., Keep, R.F., Morgenstern, L.B., Schallert, T., Xi, G., 2010. Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration. Stroke 41, 375-382.
19. Paul, S., O'Regan St, K., John, A., Stuart, K., Crawford, D., 2013. Interaction of serum ferritin and body mass index in patients with chronic hepatitis B: improved prediction of cirrhosis. Hepatology 57, 2094-2095.
20. Phan, T.G., Koh, M., Vierkant, R.A., Wijdicks, E.F., 2000. Hydrocephalus is a determinant of early mortality in putaminal hemorrhage. Stroke 31, 2157-2162.
21. Selim, M., 2009. Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials. Stroke 40, S90-S91.
22. Strahle, J., Garton, H.J., Maher, C.O., Muraszko, K.M., Keep, R.F., Xi, G., 2012. Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage. Transl. Stroke Res. 3, 25-38.
23. Suzuki, H., Muramatsu, M., Tanaka, K., Fujiwara, H., Kojima, T., Taki, W., 2006. Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage. J. Neurol. 253, 1170-1176.
24. Wan, S., Hua, Y., Keep, R.F., Hoff, J.T., Xi, G., 2006. Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir. Suppl. 96, 199-202.
25. Whitelaw, A., 2001. Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions. Semin. Neonatol. 6, 135-146.
26. Wu, J., Hua, Y., Keep, R.F., Nakamura, T., Hoff, J.T., Xi, G., 2003. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34, 2964-2969.
27. Xi, G., Keep, R.F., Hoff, J.T., 2006. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 5, 53-63.
28. Yoneda, M., Thomas, E., Sumida, Y., Imajo, K., Eguchi, Y., Hyogo, H., et al., 2014. Clinical usage of serum ferritin to assess liver fibrosis in patients with nonalcoholic fatty liver disease: proceed with caution. Hepatol. Res.
29. Zhang, L., Hu, R., Li, M., Li, F., Meng, H., Zhu, G., et al., 2013. Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Neurol. Sci. 34, 639-645.