Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage

Stroke

Volumn 39, Issue 12, 2008, Pages 3378-3388

  Georgiadis, Paraskevi ^a   Xu, Hongmin ^a   Chua, Caroline ^a   Hu, Furong ^a   Collins, Lee ^a   Huynh, Chau ^a   Lagamma, Edmund F ^a   Ballabh, Praveen ^a  

^a WESTCHESTER MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Axonal damage; GM hemorrhage intraventricular hemorrhage; Inflammation; Microglia; Neurobehavioral testing; Neutrophil

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLYCEROL;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; AUTOPSY; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN VENTRICLE; CELL INFILTRATION; CESAREAN SECTION; COGNITION; CONTROLLED STUDY; EXPERIMENTAL MODEL; GERMINAL MATRIX HEMORRHAGE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; INFANT; MICROGLIA; NEOCORTEX; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE FIBER; NEUROFILAMENT; NEUROLOGIC EXAMINATION; NEUTROPHIL; NEWBORN; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RABBIT; WALKING DIFFICULTY; ANIMAL; ANIMAL BEHAVIOR; BRAIN; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; ECHOGRAPHY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; NERVE DEGENERATION; PATHOLOGY; PREGNANCY; PSYCHOLOGICAL ASPECT; SINGLE BLIND PROCEDURE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BEHAVIOR, ANIMAL; BRAIN; CEREBRAL HEMORRHAGE; CEREBRAL VENTRICLES; DISEASE MODELS, ANIMAL; FEMALE; GESTATIONAL AGE; GLYCEROL; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INJECTIONS, INTRAPERITONEAL; MICROGLIA; NERVE DEGENERATION; NEUTROPHILS; PREGNANCY; PREMATURE BIRTH; RABBITS; SINGLE-BLIND METHOD;

EID: 58149345068     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.510883     Document Type: Article

References (30)

1. The vermont-oxford trials network: Very low birth weight outcomes for 1990. Investigators of the vermont-oxford trial network database project. Pediatrics. 1993;91:540 -545.
2. Heuchan AM, Evans N, Henderson Smart DJ, Simpson JM. Perinatal risk factors for major intraventricular haemorrhage in the australian and new zealand neonatal network, 1995-97. Arch Dis Child Fetal Neonatal Ed. 2002;86:F86-F90.
3. Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: An overview: Structure, regulation, and clinical implications. Neurobiol Dis. 2004;16:1-13.
4. Antoniuk S, da Silva RV. [periventricular and intraventricular hemorrhage in the premature infants]. Rev Neurol. 2000;31:238-243.
5. Kenny JD, Garcia-Prats JA, Hilliard JL, Corbet AJ, Rudolph AJ. Hyper-carbia at birth: A possible role in the pathogenesis of intraventricular hemorrhage. Pediatrics. 1978;62:465-467.
6. Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M. Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 2007;13:477-485.
7. Braun AXH, Kocherlakota P, Siegel D, Ungvari Z, Csiszar A, Nedergaard M, Ballabh P. Paucity of pericytes in germinal matrix vasculature. J Neurosci. 2007;27:12012-12024.
8. Del Bigio MR, Yan HJ, Buist R, Peeling J. Experimental intracerebral hemorrhage in rats. Magnetic resonance imaging and histopathological correlates. Stroke. 1996;27:2312-2319; discussion 2319-2320.
9. Fischer EG, Lorenzo AV, Landis WJ, Welch K, Ofori-Kwakye SK, Dorval B, Hodgens KJ, Kerr CS. Vasculature to the germinal matrix in rabbit pups. J Neurosurg. 1986;64:650-656.
10. Sotrel A, Lorenzo AV. Ultrastructure of blood vessels in the ganglionic eminence of premature rabbits with spontaneous germinal matrix hemorrhages. J Neuropathol Exp Neurol. 1989;48:462-482.
11. Lorenzo AV, Welch K, Conner S. Spontaneous germinal matrix and intraventricular hemorrhage in prematurely born rabbits. J Neurosurg. 1982;56:404-410.
12. Ment LR, Stewart WB, Duncan CC, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. J Neurosurg. 1982;57:219-223.
13. Goddard J, Lewis RM, Armstrong DL, Zeller RS. Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model. J Pediatr. 1980;96:1057-1060.
14. Xue M, Balasubramaniam J, Buist RJ, Peeling J, Del Bigio MR. Periven-tricular/intraventricular hemorrhage in neonatal mouse cerebrum. J Neuropathol Exp Neurol. 2003;62:1154-1165.
15. Conner ES, Lorenzo AV, Welch K, Dorval B. The role of intracranial hypotension in neonatal intraventricular hemorrhage. J Neurosurg. 1983; 58:204-209.
16. Luttrell CN, Finberg L. Hemorrhagic encephalopathy induced by hyper-natremia. I. Clinical, laboratory, and pathological observations. AMA Arch Neurol Psychiatry. 1959;81:424-432.
17. Aronowski J, Hall CE. New horizons for primary intracerebral hemorrhage treatment: Experience from preclinical studies. Neurol Res. 2005; 27:268-279.
18. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529-534.
19. Derrick M, Luo NL, Bregman JC, Jilling T, Ji X, Fisher K, Gladson CL, Beardsley DJ, Murdoch G, Back SA, Tan S. Preterm fetal hypoxia-is-chemia causes hypertonia and motor deficits in the neonatal rabbit: A model for human cerebral palsy? J Neurosci. 2004;24:24-34.
20. Shennan AH, Bewley S. Why should preterm births be rising? Bmj. 2006;332:924-925.
21. Welch K. The intracranial pressure in infants. J Neurosurg. 1980;52: 693-699.
22. Volpe JJ. Neurology of Newborn. 2001 (ed 4) In: Intracranial Hemorrhage: Subdural, Primary, Subarachnoid, Intracerebellar, Intraventricu-lar and Miscellaneous. pp 407. WB Saunders Company, Philadelphia.
23. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: New opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999; 19:819-834.
24. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci. 2001;2:734-744.
25. Singleton RH, Povlishock JT. Identification and characterization of heterogeneous neuronal injury and death in regions of diffuse brain injury: Evidence for multiple independent injury phenotypes. J Neurosci. 2004; 24:3543-3553.
26. Barun S, Ertoy D, Dilekoz E, Muftuoglu S, Erten Y, Sucak G, Bali M, Tekeli N, Sarioglu Y, Ercan ZS. Effects of amifostine on glycerol-pretreated rabbit kidneys. Basic Clin Pharmacol Toxicol. 2005;97: 168-173.
27. Wolfert AI, Oken DE. Glomerular hemodynamics in established glycerol-induced acute renal failure in the rat. J Clin Invest. 1989;84:1967-1973.
28. Finckh ES. The indirect action of subcutaneous injections of glycerol on the renal tubules in the rat. J Pathol Bacteriol. 1959;78:197-202.
29. Berger C, Sakowitz OW, Kiening KL, Schwab S. Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. Stroke. 2005;36:e4-e6.
30. Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. Neuroscience. 2004;129:1021-1029.