Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats

Brain and Development

Volumn 37, Issue 8, 2015, Pages 747-752

  Zhang, Peng ^a   Cheng, Guoqiang ^a   Chen, Longxia ^a   Zhou, Wenhao ^a   Sun, Jinqiao ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Brain; Hypoxia ischemia; Neonate; Toll like receptor 2; Toll like receptor 4

Indexed keywords

TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TLR2 PROTEIN, RAT; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY LIGATION; COGNITION; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; LEARNING; LEFT COMMON CAROTID ARTERY; NEWBORN; NONHUMAN; OXYGEN BREATHING; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BIOSYNTHESIS; DISEASE MODEL; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84939268147     PISSN: 03877604     EISSN: 18727131     Source Type: Journal    
DOI: 10.1016/j.braindev.2014.12.001     Document Type: Article

References (20)

1. Lawn J.E., Kerber K., Enweronu-Laryea C., Cousens S. 3.6 million neonatal deaths - what is progressing and what is not?. Semin Perinatol 2010, 34:371-386.
2. Mwaniki M.K., Atieno M., Lawn J.E., Newton C.R. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet 2012, 379:445-452.
3. Hedtjärn M., Mallard C., Hagberg H. Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia. J Cereb Blood Flow Metab 2004, 24:1333-1351.
4. Kaisho T., Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006, 117:979-987.
5. Uematsu S., Akira S. Toll-like receptors and innate immunity. J Mol Med 2006, 84:712-725.
6. Wang Y.C., Lin S., Yang Q.W. Toll-like receptors in cerebral ischemic inflammatory injury. J Neuroinflamm 2011, 8:134.
7. Chen C.J., Kono H., Golenbock D., Reed G., Akira S., Rock K.L. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007, 13:851-856.
8. Tang S.C., Arumugam T.V., Xu X., Cheng A., Mughal M.R., Jo D.G., et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 2007, 104:13798-13803.
9. Winters L., Winters T., Gorup D., Mitrečić D., Curlin M., Križ J., et al. Expression analysis of genes involved in TLR2-related signaling pathway: inflammation and apoptosis after ischemic brain injury. Neuroscience 2013, 238:87-96.
10. Zwagerman N., Plumlee C., Guthikonda M., Ding Y. Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol Res 2010, 32:123-126.
11. Stridh L., Smith P.L., Naylor A.S., Wang X., Mallard C. Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia. Neuroinflammation 2011, 8:45.
12. Stridh L., Mottahedin A., Johansson M.E., Valdez R.C., Northington F., Wang X., et al. Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia. J Neurosci 2013, 33:12041-12051.
13. Sun J., Zhou W., Sha B., Yang Y. Ischemia induced neural stem cell proliferation and differentiation in neonatal rat involved vascular endothelial growth factor and transforming growth factor-beta pathways. Brain Dev 2010, 32:191-200.
14. Kong Y., Le Y. Toll-like receptors in inflammation of the central nervous system. Int Immunopharmacol 2011, 11:1407-1414.
15. Marsh B.J., Williams-Karnesky R.L., Stenzel-Poore M.P. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience 2009, 158:1007-1020.
16. Yang Q.W., Li J.C., Lu F.L., Wen A.Q., Xiang J., Zhang L.L., et al. Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab 2008, 28:1588-1596.
17. Lv M., Liu Y., Zhang J., Sun L., Liu Z., Zhang S., et al. Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience 2011, 176:162-172.
18. Hyakkoku K., Hamanaka J., Tsuruma K., Shimazawa M., Tanaka H., Uematsu S., et al. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focalcerebral ischemia. Neuroscience 2010, 171:258-267.
19. Qiu J., Xu J., Zheng Y., Wei Y., Zhu X., Lo E.H., et al. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke 2010, 41:2077-2082.
20. Ziegler G., Harhausen D., Schepers C., Hoffmann O., Röhr C., Prinz V., et al. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun 2007, 359:574-579.