Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

PLoS Neglected Tropical Diseases

Volumn 10, Issue 2, 2016, Pages

  Fonseca Silva, Fernanda ^a   Inacio, Job D F ^a   Canto Cavalheiro, Marilene M ^a   Menna Barreto, Rubem F S ^a   Almeida Amaral, Elmo E ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALBUMIN; APIGENIN; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; CREATININE; GLOBULIN; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; UREA; ANTIPRURITIC AGENT;

AMASTIGOTE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG MECHANISM; IC50; LEISHMANIA AMAZONENSIS; MACROPHAGE; MOUSE; NONHUMAN; PARASITE LOAD; PROTEIN BLOOD LEVEL; SKIN LEISHMANIASIS; SPECTROFLUOROMETRY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; FEMALE; HUMAN; IMMUNOLOGY; LEISHMANIA; LEISHMANIASIS, CUTANEOUS; MALE; PARASITOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRECLINICAL STUDY;

ANIMALS; ANTIPRURITICS; APIGENIN; AUTOPHAGY; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; LEISHMANIA; LEISHMANIASIS, CUTANEOUS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; REACTIVE OXYGEN SPECIES;

EID: 84959501824     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004442     Document Type: Article

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