IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

PLoS Pathogens

Volumn 12, Issue 2, 2016, Pages

  Naujoks, Jan ^a   Tabeling, Christoph ^a   Dill, Brian D ^b,j   Hoffmann, Christine ^c   Brown, Andrew S ^d   Kunze, Mareike ^a   Kempa, Stefan ^e   Peter, Andrea ^a   Mollenkopf, Hans Joachim ^f   Dorhoi, Anca ^f   Kershaw, Olivia ^g   Gruber, Achim D ^g   Sander, Leif E ^a   Witzenrath, Martin ^a   Herold, Susanne ^h   Nerlich, Andreas ^a   Hocke, Andreas C ^a   van Driel, Ian ^d   Suttorp, Norbert ^a   Bedoui, Sammy ^d   Hilbi, Hubert ^c,i   Trost, Matthias ^b   Opitz, Bastian ^a   more..

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^g FREIE UNIVERSITÄT BERLIN   (Germany)

^h JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

ⁱ UNIVERSITY OF ZURICH   (Switzerland)

^j ROCKEFELLER UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERFERON; ITACONIC ACID; PROTEOME; HYDROLYASE; IRG1 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SUCCINIC ACID DERIVATIVE;

ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CELL DEATH; CELL ISOLATION; CELL VACUOLE; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE ONTOLOGY; GENE SILENCING; GENETIC TRANSFECTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOBLOTTING; IRG1 GENE; KRUSKAL WALLIS TEST; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOUSE; MULTIDRUG RESISTANCE; MYCOBACTERIUM; NONHUMAN; PNEUMONIA; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA; STAPHYLOCOCCUS AUREUS; TIME-LAPSE VIDEO MICROSCOPY; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DISEASE MODEL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; METABOLISM; MICROBIOLOGY; MITOCHONDRION; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HYDRO-LYASES; IMMUNITY, INNATE; INTERFERONS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, IMMUNOLOGICAL; PROTEOME; REACTIVE OXYGEN SPECIES; SUCCINATES; VACUOLES;

EID: 84959498218     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005408     Document Type: Article

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