Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 9, 2016, Pages E1152-E1161

  Stevers, Loes M ^a   Lam, Chan V ^a   Leysen, Seppe F R ^a   Meijer, Femke A ^a   Van Scheppingen, Daphne S ^a   De Vries, Rens M J M ^a   Carlile, Graeme W ^b   Milroy, Lech G ^a   Thomas, David Y ^b   Brunsveld, Luc ^a   Ottmann, Christian ^a,c  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Disordered protein; Multivalency; Protein protein interaction

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FUSICOCCIN A; NATURAL PRODUCT; PROTEIN 14 3 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; IN VITRO STUDY; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; AMINO ACID SEQUENCE; CALORIMETRY; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; BINDING SITES; CALORIMETRY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA;

EID: 84959472285     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516631113     Document Type: Article

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