Recognition of an intra-chain tandem 14-3-3 binding site within PKCe

EMBO Reports

Volumn 10, Issue 9, 2009, Pages 983-989

  Kostelecky, Brenda ^a   Saurin, Adrian T ^a   Purkiss, Andrew ^a   Parker, Peter J ^a,b   McDonald, Neil Q ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN 14 3 3; PROTEIN KINASE C EPSILON;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; GENE ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; STOICHIOMETRY; TANDEM REPEAT; THERMODYNAMICS;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN KINASE C-EPSILON; PROTEIN STRUCTURE, QUATERNARY; THERMODYNAMICS;

PYRONIA TITHONUS;

EID: 69949148383     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.150     Document Type: Article

References (28)

1. Adams PD, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, Moriarty NW, Read RJ, Sacchettini JC, Sauter NK, Terwilliger TC (2002) PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr 58: 1948-1954
2. Bridges D, Moorhead GB (2005) 14-3-3 proteins: A number of functions for a numbered protein. Sci STKE 2005: Re10
3. Delano WL (2002) The PyMOL Molecular Graphics System. Palo Alto, CA USA: Delano Scientific. http://www.pymol.org
4. Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ (2008) The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J 411: 319-331
5. Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60: 2126-2132
6. Fiol CJ, Wang A, Roeske RW, Roach PJ (1990) Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates. J Biol Chem 265: 6061-6065
7. Fuglsang AT, Visconti S, Drumm K, Jahn T, Stensballe A, Mattei B, Jensen ON, Aducci P, Palmgren MG (1999) Binding of 14-3-3 protein to the plasma membrane H(+)-ATPase AHA2 involves the three C-terminal residues Tyr(946)-Thr-Val and requires phosphorylation of Thr(947). J Biol Chem 274: 36774-36780
8. Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC (2005) Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci USA 102: 1222-1227
9. Henriksson ML, Francis MS, Peden A, Aili M, Stefansson K, Palmer R, Aitken A, Hallberg B (2002) A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo. Eur J Biochem 269: 4921-4929
10. Kabsch W (1988) Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector. J Appl Cryst 21: 916-924
11. Kabsch W (1993) Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J Appl Cryst 26: 795-800
12. Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM (2007) Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem 282: 34787-34800
13. Liu D, Bienkowska J, Petosa C, Collier RJ, Fu H, Liddington R (1995) Crystal structure of the zeta isoform of the 14-3-3 protein. Nature 376: 191-194
14. McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni MC, Read RJ (2007) Phaser crystallographic software. J Appl Cryst 40: 658-674
15. Muslin AJ, Tanner JW, Allen PM, Shaw AS (1996) Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84: 889-897
16. Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F (2001) Crystal structure of the 14-3-3zeta:sErotonin N-acetyltransferase complex. A role for scaffolding in enzyme regulation. Cell 105: 257-267
17. Obsil T, Ghirlando R, Anderson DE, Hickman AB, Dyda F (2003) Two 14-3-3 binding motifs are required for stable association of forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry 42: 15264-15272
18. Ottmann C et al (2007) Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+-ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell 25: 427-440
19. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997) Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277: 1501-1505
20. Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC (1998) 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J Biol Chem 273: 16305-16310
21. Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB (1999) Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell 4: 153-166
22. Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ (2008) The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol 10: 891-901
23. Tzivion G, Luo Z, Avruch J (1998) A dimeric 14-3-3 protein is an essential co-factor for Raf kinase activity. Nature 394: 88-92
24. Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD (1998) ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet 19: 175-178
25. Xiao B, Smerdon SJ, Jones DH, Dodson GG, Soneji Y, Aitken A, Gamblin SJ (1995) Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature 376: 188-191
26. Yaffe MB (2002) How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett 513: 53-57
27. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC (1997) The structural basis for 14-3-3:pHosphopeptide binding specificity. Cell 91: 961-971
28. Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T (1998) Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395: 507-510