Inhibition of plasminogen activator inhibitor- 1 attenuates transforming growth factor- β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to myofibroblasts

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Omori, Keitaro ^a   Hattori, Noboru ^a   Senoo, Tadashi ^a   Takayama, Yusuke ^a   Masuda, Takeshi ^a   Nakashima, Taku ^a   Iwamoto, Hiroshi ^a   Fujitaka, Kazunori ^a   Hamada, Hironobu ^b   Kohno, Nobuoki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; BENZOXAZOLE DERIVATIVE; BLEOMYCIN; BLEOMYCIN A5; DICARBOXYLIC ACID; SK-216;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIMARY CELL CULTURE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; LUNG ALVEOLUS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY FIBROSIS;

AGED; ANIMALS; BENZOXAZOLES; BLEOMYCIN; CELL DIFFERENTIATION; CELL LINE; DICARBOXYLIC ACIDS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBROBLASTS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MYOFIBROBLASTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PULMONARY ALVEOLI; PULMONARY FIBROSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84959441198     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148969     Document Type: Article

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