A bioassay using intestinal organoids to measure CFTR modulators in human plasma

Journal of Cystic Fibrosis

Volumn 14, Issue 2, 2015, Pages 178-181

  Dekkers, R ^a   Vijftigschild, L A W ^a   Vonk, A M ^a   Kruisselbrink, E ^a   de Winter de Groot, K M ^a   Janssens, H M ^b   van der Ent, C K ^a   Beekman, J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

CFTR; Intestinal organoids; Personalized medicine; Pharmacokinetics; VX 770

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IVACAFTOR; AMINOPHENOL DERIVATIVE; ANTIMUTAGENIC AGENT; QUINOLONE DERIVATIVE;

ARTICLE; BIOASSAY; BLOOD DONOR; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONCENTRATION RESPONSE; CYSTIC FIBROSIS; CYTOPLASM; DRUG BLOOD LEVEL; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE CELL; INTESTINE CRYPT; NORMAL HUMAN; PHARMACODYNAMICS; PLASMA CELL; PROTEIN FUNCTION; TREATMENT RESPONSE; DRUG EFFECTS; DRUG MONITORING; GENETICS; INTESTINE; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

AMINOPHENOLS; ANTIMUTAGENIC AGENTS; BIOLOGICAL ASSAY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG MONITORING; HUMANS; INTESTINES; MUTATION; ORGANOIDS; QUINOLONES; TREATMENT OUTCOME;

EID: 84924227653     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2014.10.007     Document Type: Article

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