메뉴 건너뛰기




Volumn 4, Issue 4, 2015, Pages 249-260

Mendelian randomization studies of biomarkers and type 2 diabetes

Author keywords

Biomarkers; Epidemiology; Genome wide association; Mendelian randomization; Study; Type 2 diabetes

Indexed keywords

ADIPONECTIN; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BETA CAROTENE; BILIRUBIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; DIMETHYLGLYCINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LINOLEOYL COENZYME A DESATURASE; LIPOPROTEIN A; MACROPHAGE MIGRATION INHIBITION FACTOR; MICRORNA; RESISTIN; SEX HORMONE BINDING GLOBULIN; TRIACYLGLYCEROL; URIC ACID; VITAMIN D; VITAMIN D BINDING PROTEIN;

EID: 84959374672     PISSN: None     EISSN: 20493614     Source Type: Journal    
DOI: 10.1530/EC-15-0087     Document Type: Article
Times cited : (20)

References (59)
  • 2
    • 84893411408 scopus 로고    scopus 로고
    • Identification of relevant biomarkers for type 2 diabetes
    • Abbasi A, Stolk RP & Bakker SJ. Identification of relevant biomarkers for type 2 diabetes. Lancet. Diabetes & Endocrinology 2014 2 106–107. (doi:10.1016/S2213-8587(14)70005-1)
    • (2014) Lancet. Diabetes & Endocrinology , vol.2 , pp. 106-107
    • Abbasi, A.1    Stolk, R.P.2    Bakker, S.J.3
  • 3
    • 84858433338 scopus 로고    scopus 로고
    • Biomarkers in diabetes: Hemoglobin A1c, vascular and tissue markers
    • Lyons TJ & Basu A. Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers. Translational Research 2012 159 303–312. (doi:10.1016/j.trsl.2012.01.009)
    • (2012) Translational Research , vol.159 , pp. 303-312
    • Lyons, T.J.1    Basu, A.2
  • 4
    • 37549025830 scopus 로고    scopus 로고
    • Mendelian randomisation studies of type 2 diabetes: Future prospects
    • Sandhu MS, Debenham SL, Barroso I & Loos RJ. Mendelian randomisation studies of type 2 diabetes: future prospects. Diabetologia 2008 51 211–213. (doi:10.1007/s00125-007-0903-x)
    • (2008) Diabetologia , vol.51 , pp. 211-213
    • Sandhu, M.S.1    Debenham, S.L.2    Barroso, I.3    Loos, R.J.4
  • 9
    • 1942436221 scopus 로고    scopus 로고
    • Mendelian randomization: Prospects, potentials, and limitations
    • Smith GD & Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. International Journal of Epidemiology 2004 33 30–42. (doi:10.1093/ije/dyh132)
    • (2004) International Journal of Epidemiology , vol.33 , pp. 30-42
    • Smith, G.D.1    Ebrahim, S.2
  • 10
    • 84943354221 scopus 로고    scopus 로고
    • Using published data in Mendelian randomization: A blueprint for efficient identification of causal risk factors
    • Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG & EPICInterAct Consortium. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. European Journal of Epidemiology 2015 30 543–552. (doi:10.1007/ s10654-015-0011-z)
    • (2015) European Journal of Epidemiology , vol.30 , pp. 543-552
    • Burgess, S.1    Scott, R.A.2    Timpson, N.J.3    Davey Smith, G.4    Thompson, S.G.5
  • 18
    • 84895492184 scopus 로고    scopus 로고
    • Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: A Mendelian randomization effect
    • Chung CM, Lin TH, Chen JW, Leu HB, Yin WH, Ho HY, Sheu SH, Tsai WC, Chen JH, Lin SJ et al. Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect. Diabetes/Metabolism Research and Reviews 2014 30 232–240. (doi:10.1002/dmrr.2481)
    • (2014) Diabetes/Metabolism Research and Reviews , vol.30 , pp. 232-240
    • Chung, C.M.1    Lin, T.H.2    Chen, J.W.3    Leu, H.B.4    Yin, W.H.5    Ho, H.Y.6    Sheu, S.H.7    Tsai, W.C.8    Chen, J.H.9    Lin, S.J.10
  • 19
    • 84859238629 scopus 로고    scopus 로고
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
    • Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikainen LP et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics 2012 8 e1002607. (doi:10.1371/journal.pgen.1002607)
    • (2012) Plos Genetics , vol.8
    • Dastani, Z.1    Hivert, M.F.2    Timpson, N.3    Perry, J.R.4    Yuan, X.5    Scott, R.A.6    Henneman, P.7    Heid, I.M.8    Kizer, J.R.9    Lyytikainen, L.P.10
  • 20
    • 79952400252 scopus 로고    scopus 로고
    • Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance
    • De Silva NM, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN, Shields B, Knight BA et al. Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes 2011 60 1008–1018. (doi:10.2337/db10-1317)
    • (2011) Diabetes , vol.60 , pp. 1008-1018
    • De Silva, N.M.1    Freathy, R.M.2    Palmer, T.M.3    Donnelly, L.A.4    Luan, J.5    Gaunt, T.6    Langenberg, C.7    Weedon, M.N.8    Shields, B.9    Knight, B.A.10
  • 22
    • 84863229728 scopus 로고    scopus 로고
    • Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population
    • Gan W, Guan Y, Wu Q, An P, Zhu J, Lu L, Jing L, Yu Y, Ruan S, Xie D et al. Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population. American Journal of Clinical Nutrition 2012 95 626–632. (doi:10.3945/ajcn.111.025684)
    • (2012) American Journal of Clinical Nutrition , vol.95 , pp. 626-632
    • Gan, W.1    Guan, Y.2    Wu, Q.3    An, P.4    Zhu, J.5    Lu, L.6    Jing, L.7    Yu, Y.8    Ruan, S.9    Xie, D.10
  • 23
    • 37549070669 scopus 로고    scopus 로고
    • Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: Results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002
    • Herder C, Klopp N, Baumert J, Muller M, Khuseyinova N, Meisinger C, Martin S, Illig T, Koenig W & Thorand B. Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002. Diabetologia 2008 51 276–284. (doi:10.1007/s00125-007-0800-3)
    • (2008) Diabetologia , vol.51 , pp. 276-284
    • Herder, C.1    Klopp, N.2    Baumert, J.3    Muller, M.4    Khuseyinova, N.5    Meisinger, C.6    Martin, S.7    Illig, T.8    Koenig, W.9    Thorand, B.10
  • 24
    • 84889824353 scopus 로고    scopus 로고
    • Association of homocysteine with type 2 diabetes: A meta-analysis implementing Mendelian randomization approach
    • Huang T, Ren J, Huang J & Li D. Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach. BMC Genomics 2013 14 867. (doi:10.1186/1471-2164-14-867)
    • (2013) BMC Genomics , vol.14
    • Huang, T.1    Ren, J.2    Huang, J.3    Li, D.4
  • 25
    • 84906039863 scopus 로고    scopus 로고
    • Associations of common variants in methionine metabolism pathway genes with plasma homocysteine and the risk of type 2 diabetes in Han Chinese
    • Huang T, Sun J, Chen Y, Xie H, Xu D & Li D. Associations of common variants in methionine metabolism pathway genes with plasma homocysteine and the risk of type 2 diabetes in Han Chinese. Journal of Nutrigenetics and Nutrigenomics 2014 7 63–74. (doi:10.1159/000365007)
    • (2014) Journal of Nutrigenetics and Nutrigenomics , vol.7 , pp. 63-74
    • Huang, T.1    Sun, J.2    Chen, Y.3    Xie, H.4    Xu, D.5    Li, D.6
  • 26
    • 84925298675 scopus 로고    scopus 로고
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis
    • Interleukin 1 Genetics C. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet. Diabetes & Endocrinology 2015 3 243–253. (doi:10.1016/S2213-8587(15)00034-0)
    • (2015) Lancet. Diabetes & Endocrinology , vol.3 , pp. 243-253
    • Interleukin 1 Genetics, C.1
  • 29
    • 84885954764 scopus 로고    scopus 로고
    • Lipoprotein(A) concentrations, isoform size, and risk of type 2 diabetes: A Mendelian randomisation study
    • Kamstrup PR & Nordestgaard BG. Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: a Mendelian randomisation study. Lancet. Diabetes & Endocrinology 2013 1 220–227. (doi:10.1016/S2213-8587(13)70064-0)
    • (2013) Lancet. Diabetes & Endocrinology , vol.1 , pp. 220-227
    • Kamstrup, P.R.1    Nordestgaard, B.G.2
  • 30
    • 78651287448 scopus 로고    scopus 로고
    • Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Kroger J, Zietemann V, Enzenbach C, Weikert C, Jansen EH, Doring F, Joost HG, Boeing H & Schulze MB. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. American Journal of Clinical Nutrition 2011 93 127–142. (doi:10.3945/ajcn.110.005447)
    • (2011) American Journal of Clinical Nutrition , vol.93 , pp. 127-142
    • Kroger, J.1    Zietemann, V.2    Enzenbach, C.3    Weikert, C.4    Jansen, E.H.5    Doring, F.6    Joost, H.G.7    Boeing, H.8    Schulze, M.B.9
  • 31
    • 84908336306 scopus 로고    scopus 로고
    • The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: A Mendelian randomization study
    • Leong A, Rehman W, Dastani Z, Greenwood C, Timpson N, Langsetmo L, Berger C, Metastroke, Fu L, Wong BY et al. The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study. PLoS Medicine 2014 11 e1001751. (doi:10.1371/journal.pmed.1001751)
    • (2014) Plos Medicine , vol.11
    • Leong, A.1    Rehman, W.2    Dastani, Z.3    Greenwood, C.4    Timpson, N.5    Langsetmo, L.6    Berger, C.7    Metastroke, F.L.8    Wong, B.Y.9
  • 35
    • 84872770236 scopus 로고    scopus 로고
    • A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome
    • Peters KE, Beilby J, Cadby G, Warrington NM, Bruce DG, Davis WA, Davis TM, Wiltshire S, Knuiman M, McQuillan BM et al. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. BMC Medical Genetics 2013 14 15. (doi:10.1186/ 1471-2350-14-15)
    • (2013) BMC Medical Genetics , vol.14 , Issue.15
    • Peters, K.E.1    Beilby, J.2    Cadby, G.3    Warrington, N.M.4    Bruce, D.G.5    Davis, W.A.6    Davis, T.M.7    Wiltshire, S.8    Knuiman, M.9    McQuillan, B.M.10
  • 36
    • 80054096937 scopus 로고    scopus 로고
    • No evidence for a causal link between uric acid and type 2 diabetes: A Mendelian randomisation approach
    • Pfister R, Barnes D, Luben R, Forouhi NG, Bochud M, Khaw KT, Wareham NJ & Langenberg C. No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach. Diabetologia 2011 54 2561–2569. (doi:10.1007/s00125-011-2235-0)
    • (2011) Diabetologia , vol.54 , pp. 2561-2569
    • Pfister, R.1    Barnes, D.2    Luben, R.3    Forouhi, N.G.4    Bochud, M.5    Khaw, K.T.6    Wareham, N.J.7    Langenberg, C.8
  • 37
    • 80055060938 scopus 로고    scopus 로고
    • Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: Evidence of causal association from population studies
    • Pfister R, Sharp S, Luben R, Welsh P, Barroso I, Salomaa V, Meirhaeghe A, Khaw KT, Sattar N, Langenberg C et al. Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies. PLoS Medicine 2011 8 e1001112. (doi:10.1371/journal.pmed.1001112)
    • (2011) Plos Medicine , vol.8
    • Pfister, R.1    Sharp, S.2    Luben, R.3    Welsh, P.4    Barroso, I.5    Salomaa, V.6    Meirhaeghe, A.7    Khaw, K.T.8    Sattar, N.9    Langenberg, C.10
  • 38
    • 84868143292 scopus 로고    scopus 로고
    • Pancreatic b-cell function and type 2 diabetes risk: Quantify the causal effect using a Mendelian randomization approach based on meta-analyses
    • Song Y, Yeung E, Liu A, Vanderweele TJ, Chen L, Lu C, Liu C, Schisterman EF, Ning Y & Zhang C. Pancreatic b-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Human Molecular Genetics 2012 21 5010–5018. (doi:10.1093/hmg/dds339)
    • (2012) Human Molecular Genetics , vol.21 , pp. 5010-5018
    • Song, Y.1    Yeung, E.2    Liu, A.3    Vanderweele, T.J.4    Chen, L.5    Lu, C.6    Liu, C.7    Schisterman, E.F.8    Ning, Y.9    Zhang, C.10
  • 39
    • 80053405321 scopus 로고    scopus 로고
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
    • Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 60 2624–2634. (doi:10.2337/db11-0415)
    • (2011) Diabetes , vol.60 , pp. 2624-2634
    • Strawbridge, R.J.1    Dupuis, J.2    Prokopenko, I.3    Barker, A.4    Ahlqvist, E.5    Rybin, D.6    Petrie, J.R.7    Travers, M.E.8    Bouatia-Naji, N.9    Dimas, A.S.10
  • 40
    • 84879203883 scopus 로고    scopus 로고
    • PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4
    • Trombetta M, Bonetti S, Boselli ML, Miccoli R, Trabetti E, Malerba G, Pignatti PF, Bonora E, Del Prato S & Bonadonna RC. PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4. Acta Diabetologica 2013 50 401–408. (doi:10.1007/s00592-012-0443-9)
    • (2013) Acta Diabetologica , vol.50 , pp. 401-408
    • Trombetta, M.1    Bonetti, S.2    Boselli, M.L.3    Miccoli, R.4    Trabetti, E.5    Malerba, G.6    Pignatti, P.F.7    Bonora, E.8    Del Prato, S.9    Bonadonna, R.C.10
  • 41
    • 84922461670 scopus 로고    scopus 로고
    • Affection of single-nucleotide polymorphisms inmiR-27a,miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people
    • Wang TT, Chen YJ, Sun LL, Zhang SJ, Zhou ZY & Qiao H. Affection of single-nucleotide polymorphisms inmiR-27a,miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people. Chinese Medical Journal 2015 128 533–539. (doi:10.4103/0366-6999.151112)
    • (2015) Chinese Medical Journal , vol.128 , pp. 533-539
    • Wang, T.T.1    Chen, Y.J.2    Sun, L.L.3    Zhang, S.J.4    Zhou, Z.Y.5    Qiao, H.6
  • 43
    • 84906824359 scopus 로고    scopus 로고
    • WalkerMet al. Genetic evidence for a normalweight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes
    • Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, WalkerMet al. Genetic evidence for a normalweight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes 2014 63 4369–4377. (doi:10.2337/db14-0318)
    • (2014) Diabetes , vol.63 , pp. 4369-4377
    • Yaghootkar, H.1    Scott, R.A.2    White, C.C.3    Zhang, W.4    Speliotes, E.5    Munroe, P.B.6    Ehret, G.B.7    Bis, J.C.8    Fox, C.S.9
  • 49
    • 29944439735 scopus 로고    scopus 로고
    • Messenger molecules and cell death: Therapeutic implications
    • Sedlak TW & Snyder SH. Messenger molecules and cell death: therapeutic implications. Journal of the American Medical Association 2006 295 81–89. (doi:10.1001/jama.295.1.81)
    • (2006) Journal of the American Medical Association , vol.295 , pp. 81-89
    • Sedlak, T.W.1    Snyder, S.H.2
  • 50
    • 73249127018 scopus 로고    scopus 로고
    • Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote musclemitochondrial biogenesis and prevent obesity
    • Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T et al. Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote musclemitochondrial biogenesis and prevent obesity. Diabetes 2009 58 2880–2892. (doi:10.2337/db09-0393)
    • (2009) Diabetes , vol.58 , pp. 2880-2892
    • Miyashita, K.1    Itoh, H.2    Tsujimoto, H.3    Tamura, N.4    Fukunaga, Y.5    Sone, M.6    Yamahara, K.7    Taura, D.8    Inuzuka, M.9    Sonoyama, T.10
  • 51
    • 33748477872 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: The SLIM study
    • Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, de Bruin TW & Blaak EE. Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia 2006 49 2392–2401. (doi:10.1007/s00125-006-0383-4)
    • (2006) Diabetologia , vol.49 , pp. 2392-2401
    • Corpeleijn, E.1    Feskens, E.J.2    Jansen, E.H.3    Mensink, M.4    Saris, W.H.5    De Bruin, T.W.6    Blaak, E.E.7
  • 54
    • 42449163324 scopus 로고    scopus 로고
    • Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
    • Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie O & Ueland PM. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. Journal of Nutrition 2008 138 914–920.
    • (2008) Journal of Nutrition , vol.138 , pp. 914-920
    • Konstantinova, S.V.1    Tell, G.S.2    Vollset, S.E.3    Nygard, O.4    Bleie, O.5    Ueland, P.M.6
  • 56
    • 34047213327 scopus 로고    scopus 로고
    • Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. American
    • Sheikh K, Camejo G, Lanne B, Halvarsson T, Landergren MR & Oakes ND. Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. American Journal of Physiology. Endocrinology and Metabolism 2007 292 E1157–E1165. (doi:10.1152/ajpendo.00254.2006)
    • (2007) Journal of Physiology. Endocrinology and Metabolism , vol.292 , pp. E1157-E1165
    • Sheikh, K.1    Camejo, G.2    Lanne, B.3    Halvarsson, T.4    Landergren, M.R.5    Oakes, N.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.