NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

Leukemia

Volumn 30, Issue 2, 2016, Pages 473-483

  Jayavelu, A K ^a   Muller J P ^a   Bauer, R ^a   Bohmer S A ^a   Lassig J ^a   Cerny Reiterer, S ^b   Sperr, W R ^b   Valent, P ^b   Maurer, B ^b,c   Moriggl, R ^b,c   Schroder K ^d   Shah, A M ^e   Fischer, M ^a   Scholl, S ^a   Barth, J ^d,f   Oellerich, T ^d   Berg, T ^d   Serve, H ^d   Frey, S ^g   Fischer, T ^g   Heidel, F H ^g   Bohmer F D ^a   more..

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d GOETHE UNIVERSITY   (Germany)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; MESSENGER RNA; ONCOPROTEIN; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; STAT5 PROTEIN; CD135 ANTIGEN; FLT3 PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN; PTPRJ PROTEIN, HUMAN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA; MAJOR CLINICAL STUDY; MOLECULAR MECHANICS; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ACUTE MYELOID LEUKEMIA; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL CULTURE; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TANDEM REPEAT;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; FMS-LIKE TYROSINE KINASE 3; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NADPH OXIDASE; PROTEIN TYROSINE PHOSPHATASES; REACTIVE OXYGEN SPECIES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; TANDEM REPEAT SEQUENCES;

EID: 84959374191     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.234     Document Type: Article

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