Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells

Cell Death and Disease

Volumn 4, Issue 3, 2013, Pages

  Zhu, P ^a   Tong, B M K ^b   Wang, R ^a   Chen, J P ^a   Foo, S ^a   Chong, H C ^a   Wang, X L ^a   Ang, G Y ^b   Chiba, S ^b   Tan, N S ^a,c  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b Nanyang Technological University   (Singapore)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Amino endoperoxides; Anoikis; Cancer; Nox4; Reactive oxygen species

Indexed keywords

AMINO ENDOPEROXIDE; CYCLOOXYGENASE 2; ENDOPEROXIDE; HYDROGEN PEROXIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NOX4 PROTEIN, HUMAN; PEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CELL; CANCER CELL CULTURE; CANCER GROWTH; CARCINOMA CELL; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; LYMPH NODE CELL; MOUSE; NONHUMAN; ONE POT SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TREATMENT DURATION; TUMOR VOLUME; ANOIKIS; BREAST TUMOR; CARCINOMA; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METASTASIS; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION; SYNTHESIS; TUMOR CELL LINE;

ANIMALIA;

ANOIKIS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NADPH OXIDASE; NEOPLASM METASTASIS; OXIDATION-REDUCTION; PEROXIDES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875876384     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.68     Document Type: Article

References (42)

1. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 453-458.
2. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904.
3. Fidler IJ. Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemother Pharmacol 1999; 43: S3.
4. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646- 674.
5. Giannoni E, Buricchi F, Grimaldi G, Parri M, Cialdai F, Taddei ML et al. Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. Cell Death Differ 2008; 15: 867-878.
6. Pervaiz S, Clement MV. Superoxide anion: oncogenic reactive oxygen speciesInt J Biochem Cell Biol 2007; 39: 1297-1304.
7. Ferraro D, Corso S, Fasano E, Panieri E, Santangelo R, Borrello S et al. Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene 2006; 25: 3689-3698.
8. Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 1999; 401: 79-82.
9. Zhu P, Tan MJ, Huang RL, Tan CK, Chong HC, Pal M et al. Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell 2011; 19: 401-415.
10. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990; 186: 1-85.
11. Casteel DA. Peroxy natural products. Nat Prod Rep 1992; 9: 289-312.
12. Tang Y, Dong Y, Vennerstrom JL. Synthetic peroxides as antimalarials. Med Res Rev 2004; 24: 425-448.
13. O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides. J Med Chem 2004; 47: 2945-2964.
14. Posner GH, O'Neill PM. Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Acc Chem Res 2004; 37: 397-404.
15. Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM et al. Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. J Biol Chem 2007; 282: 9372-9382.
16. Stockwin LH, Han B, Yu SX, Hollingshead MG, ElSohly MA, Gul W et al. Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction. Int J Cancer 2009; 125: 1266-1275.
17. Ghorai P, Dussault PH, Hu C. Synthesis of spiro-bisperoxyketals. Org Lett 2008; 10: 2401-2404.
18. Harris J, Waetzig S, Woerpel K. Palladium (II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1, 2-dioxanes. Org Lett 2009; 11: 3290-3290.
19. Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, Fabregat I. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res 2009; 69: 7595-7602.
20. Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y et al. NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res 2009; 69: 2647-2654.
21. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
22. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59: 527-605.
23. Wagner BA, Evig CB, Reszka KJ, Buettner GR, Burns CP. Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch Biochem Biophys 2005; 440: 181-190.
24. Yan EB, Unthank JK, Castillo-Melendez M, Miller SL, Langford SJ, Walker DW. Novel method for in vivo hydroxyl radical measurement by microdialysis in fetal sheep brain in utero. J Appl Physiol 2005; 98: 2304-2310.
25. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
26. O'Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncologist 2005; 10: 20-29.
27. Takada N, Watanabe M, Yamada A, Suenaga K, Yamada K, Ueda K et al. Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortislita. J Nat Prod 2001; 64: 356-359.
28. Davies-Coleman MT, Cantrell CL, Gustafson KR, Beutler JA, Pannell LK, Boyd MR. Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species. J Nat Prod 2000; 63: 1411-1413.
29. Efferth T, Benakis A, Romero MR, Tomicic M, Rauh R, Steinbach D et al. Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 2004; 37: 998-1009.
30. Efferth T. Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr Drug Targets 2006; 7: 407-421.
31. Zhang S, Gerhard GS. Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. PloS One 2009; 4: e7472.
32. Babior BM. NADPH oxidase: an update. Blood 1999; 93: 1464-1476.
33. Hsieh CH, Shyu WC, Chiang CY, Kuo JW, Shen WC, Liu RS. NADPH oxidase subunit 4- mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme. PloS One 2011; 6: e23945.
34. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent upregulation of p22phox. J Biol Chem 2011; 286: 7779-7787.
35. Clement M, Pervaiz S. Intracellular superoxide and hydrogen peroxide concentrations: a critical balance that determines survival or death. Redox Rep 2001; 6: 211-214.
36. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst, 1993; 85: 1483-1492.
37. Omenn GS, Goodman G, Thornquist M, Grizzle J, Rosenstock L, Barnhart S et al. The beta-carotene and retinol efficacy trial (CARET) for chemoprevention of lung cancer in high risk populations: smokers and asbestos-exposed workers. Cancer Res 1994; 54: 2038s-2043s.
38. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334: 1145-1149.
39. Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst 1999; 91: 2102-2106.
40. Lam CRI, Tan MJ, Tan SH, Tang MBY, Cheung PCF, Tan NS. TAK1 regulates SCF expression to modulate PKBa activity that protects keratinocytes from ROS-induced apoptosis. Cell Death Differ 2011; 18: 1120-1129.
41. Spasojevic I. Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. Redox Rep 2010; 15: 29-35.
42. Goh YY, Pal M, Chong HC, Zhu P, Tan MJ, Punugu L et al. Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J Biol Chem 2010; 285: 32999-33009.