메뉴 건너뛰기




Volumn 94, Issue 3, 2015, Pages 251-256

The protective effect of vildagliptin in chronic experimental cyclosporine A-induced hepatotoxicity

Author keywords

Apoptosis; Cyclosporine; Inflammation; Oxidative stress; Vildagliptin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CATALASE; CYCLOSPORIN A; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; SERUM ALBUMIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; VILDAGLIPTIN; ADAMANTANE; ANTIOXIDANT; CYCLOSPORIN; NITRILE; PROTECTIVE AGENT; PYRROLIDINE DERIVATIVE;

EID: 84959346321     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2015-0336     Document Type: Article
Times cited : (16)

References (41)
  • 1
    • 0037099176 scopus 로고    scopus 로고
    • Relationship between the activation of heat shock factor and the suppression of nuclear factor-_B activity in rat hepatocyte cultures treated with cyclosporine A
    • Andres, D., Diez-Fernandez, C., Castrillo, A., and Cascales, M. 2002. Relationship between the activation of heat shock factor and the suppression of nuclear factor-_B activity in rat hepatocyte cultures treated with cyclosporine A. Biochem. Pharmacol. 64(2): 247–256. doi:10.1016/S0006-2952(02)01115-2.
    • (2002) Biochem. Pharmacol , vol.64 , Issue.2 , pp. 247-256
    • Andres, D.1    Diez-Fernandez, C.2    Castrillo, A.3    Cascales, M.4
  • 2
    • 84904540452 scopus 로고    scopus 로고
    • Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats
    • Apaijai, N., Chinda, K., Palee, S., Chattipakorn, S., and Chattipakorn, N. 2014. Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PLoS One, 9(7): e102374. doi:10.1371/journal.pone.0102374.
    • (2014) Plos One , vol.9 , Issue.7
    • Apaijai, N.1    Chinda, K.2    Palee, S.3    Chattipakorn, S.4    Chattipakorn, N.5
  • 3
    • 84876847293 scopus 로고    scopus 로고
    • Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats
    • Avila Dde, L., Araujo, G.R., Silva, M., Miranda, P.H., Diniz, M.F., Pedrosa, M.L., et al. 2013. Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Arch. Med. Res. 44(3): 194–202. doi:10.1016/j.arcmed.2013.03.004.
    • (2013) Arch. Med. Res , vol.44 , Issue.3 , pp. 194-202
    • Avila Dde, L.1    Araujo, G.R.2    Silva, M.3    Miranda, P.H.4    Diniz, M.F.5    Pedrosa, M.L.6
  • 5
    • 33749834648 scopus 로고    scopus 로고
    • DPP-4 inhibitors and their potential role in the management of type-2 diabetes
    • Barnett, A. 2006. DPP-4 inhibitors and their potential role in the management of type-2 diabetes. Int. J. Clin. Pract. 60(11): 1454–1470. doi:10.1111/j.1742-1241. 2006.01178.x.
    • (2006) Int. J. Clin. Pract , vol.60 , Issue.11 , pp. 1454-1470
    • Barnett, A.1
  • 6
    • 84894488315 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart
    • Chinda, K., Sanit, J., Chattipakorn, S., and Chattipakorn, N. 2014. Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart. Diab. Vasc. Dis. Res. 11(2): 75–83. doi:10.1177/1479164113516134.
    • (2014) Diab. Vasc. Dis. Res , vol.11 , Issue.2 , pp. 75-83
    • Chinda, K.1    Sanit, J.2    Chattipakorn, S.3    Chattipakorn, N.4
  • 7
    • 35948979743 scopus 로고    scopus 로고
    • Cell signaling in oxidative stress-induced liver injury
    • Czaja, M.J. 2007. Cell signaling in oxidative stress-induced liver injury. Semin. Liver Dis. 27(4): 378–389. doi:10.1055/s-2007-991514.
    • (2007) Semin. Liver Dis , vol.27 , Issue.4 , pp. 378-389
    • Czaja, M.J.1
  • 9
    • 0024389669 scopus 로고
    • Effect of cyclosporin on rat liver and kidney glutathione content
    • Duruibe, V.A., Okonmah, A., and Blyden, G.T. 1989. Effect of cyclosporin on rat liver and kidney glutathione content. Pharmacology, 39(4): 205–212. doi:10. 1159/000138599.
    • (1989) Pharmacology , vol.39 , Issue.4 , pp. 205-212
    • Duruibe, V.A.1    Okonmah, A.2    Blyden, G.T.3
  • 10
    • 23944482985 scopus 로고    scopus 로고
    • Melatonin protects against lead-induced hepatic and renal toxicity in male rats
    • El-Sokkary, G.H., Abdel-Rahman, G.H., and Kamel, E.S. 2005. Melatonin protects against lead-induced hepatic and renal toxicity in male rats. Toxicology, 213(1–2): 25–33. doi:10.1016/j.tox.2005.05.003.
    • (2005) Toxicology , vol.213 , Issue.12 , pp. 25-33
    • El-Sokkary, G.H.1    Abdel-Rahman, G.H.2    Kamel, E.S.3
  • 11
    • 0023263612 scopus 로고
    • Action of cyclosporine on mitochondrial calcium fluxes
    • Fournier, N., Ducet, G., and Crevat, A. 1987. Action of cyclosporine on mitochondrial calcium fluxes. J. Bioenerg. Biomembr. 19(3): 297–303. doi:10.1007/BF00762419.
    • (1987) J. Bioenerg. Biomembr , vol.19 , Issue.3 , pp. 297-303
    • Fournier, N.1    Ducet, G.2    Crevat, A.3
  • 12
    • 0031925072 scopus 로고    scopus 로고
    • Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells
    • Gaetaniello, L., Fiore, M., de Filippo, S., Pozzi, N., Tamasi, S., and Pignata, C. 1998. Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells. Hepatology, 27(4): 934–942. doi:10.1002/hep.510270407.
    • (1998) Hepatology , vol.27 , Issue.4 , pp. 934-942
    • Gaetaniello, L.1    Fiore, M.2    De Filippo, S.3    Pozzi, N.4    Tamasi, S.5    Pignata, C.6
  • 13
    • 0029892265 scopus 로고    scopus 로고
    • Determination of the kinetic parameters for the “suicide substrate” inactivation of bovine liver catalase by hydrogen peroxide
    • Ghadermarzi, M., and Moosavi-Movahedi, A.A. 1996. Determination of the kinetic parameters for the “suicide substrate” inactivation of bovine liver catalase by hydrogen peroxide. J. Enzyme Inhib. 10(3): 167–175. doi:10.3109/14756369609030310.
    • (1996) J. Enzyme Inhib , vol.10 , Issue.3 , pp. 167-175
    • Ghadermarzi, M.1    Moosavi-Movahedi, A.A.2
  • 14
    • 84871229656 scopus 로고    scopus 로고
    • The protective effects of omega 3 fatty acids and sesame oil against cyclosporine A-induced nephrotoxicity
    • Goksu Erol, A.Y., Avcı, G., Sevimli, A., Ulutas, E., and Ozdemir, M. 2013. The protective effects of omega 3 fatty acids and sesame oil against cyclosporine A-induced nephrotoxicity. Drug Chem. Toxicol. 36(2): 241–248. doi:10.3109/01480545.2012.710627.
    • (2013) Drug Chem. Toxicol , vol.36 , Issue.2 , pp. 241-248
    • Goksu Erol, A.Y.1    Avcı, G.2    Sevimli, A.3    Ulutas, E.4    Ozdemir, M.5
  • 15
    • 0035723325 scopus 로고    scopus 로고
    • CD26: A multifunctional integral membrane and secreted protein of activated lymphocytes
    • Gorrell, M.D., Gysbers, V., and McCaughan, G.W. 2001. CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand. J. Immunol. 54(3): 249–264. doi:10.1046/j.1365-3083.2001.00984.x.
    • (2001) Scand. J. Immunol , vol.54 , Issue.3 , pp. 249-264
    • Gorrell, M.D.1    Gysbers, V.2    McCaughan, G.W.3
  • 16
    • 84876523499 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4: A key player in chronic liver disease. World
    • Itou, M., Kawaguchi, T., Taniguchi, E., and Sata, M. 2013. Dipeptidyl peptidase-4: a key player in chronic liver disease. World J. Gastroenterol. 19(15): 2298–2306. doi:10.3748/wjg.v19.i15.2298.
    • (2013) J. Gastroenterol , vol.19 , Issue.15 , pp. 2298-2306
    • Itou, M.1    Kawaguchi, T.2    Taniguchi, E.3    Sata, M.4
  • 17
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • Jiang, X., and Wang, X. 2004. Cytochrome C-mediated apoptosis. Annu. Rev. Biochem. 73: 87–106. doi:10.1146/annurev.biochem.73.011303.073706.
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 18
    • 42149184731 scopus 로고    scopus 로고
    • Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats
    • Josephine, A., Nithya, K., Amudha, G., Veena, C.K., Preetha, S.P., and Varalakshmi, P. 2008. Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats. BMC Pharmacol. 8: 4. doi:10.1186/1471-2210-8-4.
    • (2008) BMC Pharmacol , vol.8 , pp. 4
    • Josephine, A.1    Nithya, K.2    Amudha, G.3    Veena, C.K.4    Preetha, S.P.5    Varalakshmi, P.6
  • 19
    • 0033670282 scopus 로고    scopus 로고
    • The beneficial effect of melatonin for cyclosporine hepatotoxicity in rats
    • Kwak, C.S., and Mun, K.C. 2000. The beneficial effect of melatonin for cyclosporine hepatotoxicity in rats. Transplant. Proc. 32(7): 2009–2010. doi:10.1016/S0041-1345(00)01535-9.
    • (2000) Transplant. Proc , vol.32 , Issue.7 , pp. 2009-2010
    • Kwak, C.S.1    Mun, K.C.2
  • 20
    • 84880640200 scopus 로고    scopus 로고
    • Use of antioxidants to prevent cyclosporine a toxicity
    • Lee, J. 2010. Use of antioxidants to prevent cyclosporine a toxicity. Toxicol. Res. 26(3): 163–170. doi:10.5487/TR.2010.26.3.163.
    • (2010) Toxicol. Res , vol.26 , Issue.3 , pp. 163-170
    • Lee, J.1
  • 21
    • 84862944057 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats
    • Liu, W.J., Xie, S.H., Liu, Y.N., Kim, W., Jin, H.Y., Park, S.K., et al. 2012. Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats. J. Pharmacol. Exp. Ther. 340(2): 248–255. doi:10.1124/jpet.111. 186866.
    • (2012) J. Pharmacol. Exp. Ther , vol.340 , Issue.2 , pp. 248-255
    • Liu, W.J.1    Xie, S.H.2    Liu, Y.N.3    Kim, W.4    Jin, H.Y.5    Park, S.K.6
  • 22
    • 79751492851 scopus 로고    scopus 로고
    • NF-κB in the liver-linking injury, fibrosis and hepatocellularcarcinoma
    • Luedde, T., and Schwabe, R.F. 2011. NF-κB in the liver-linking injury, fibrosis and hepatocellularcarcinoma. Nat. Rev. Gastroenterol. Hepatol. 8(2): 108–118. doi: 10.1038/nrgastro.2010.213.
    • (2011) Nat. Rev. Gastroenterol. Hepatol , vol.8 , Issue.2 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 23
    • 0028305735 scopus 로고
    • Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: Differing effects of cyclosporine and FK 506
    • McCashland, T.M., Donovan, J.P., Amelsberg, A., Rossi, S.S., Hofmann, A.F., Shaw, B.W., Jr., and Quigley, E.M. 1994. Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: differing effects of cyclosporine and FK 506. Hepatology, 19(6): 1381–1389. doi:10.1002/hep. 1840190611.
    • (1994) Hepatology , vol.19 , Issue.6 , pp. 1381-1389
    • McCashland, T.M.1    Donovan, J.P.2    Amelsberg, A.3    Rossi, S.S.4    Hofmann, A.F.5    Shaw, B.W.6    Quigley, E.M.7
  • 24
    • 0029876386 scopus 로고    scopus 로고
    • Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice
    • Mentzel, S., Dijkman, H.B., Van Son, J.P., Koene, R.A., and Assmann, K.J. 1996. Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice. J. Histochem. Cytochem. 44(5): 445–461. doi:10.1177/44.5.8627002.
    • (1996) J. Histochem. Cytochem , vol.44 , Issue.5 , pp. 445-461
    • Mentzel, S.1    Dijkman, H.B.2    Van Son, J.P.3    Koene, R.A.4    Assmann, K.J.5
  • 25
    • 84886735895 scopus 로고    scopus 로고
    • Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes
    • Miyagawa, K., Kondo, T., Goto, R., Matsuyama, R., Ono, K., Kitano, S., et al. 2013. Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes. Cardiovasc. Diabetol. 12: 160. doi:10.1186/1475-2840-12-160.
    • (2013) Cardiovasc. Diabetol , vol.12 , pp. 160
    • Miyagawa, K.1    Kondo, T.2    Goto, R.3    Matsuyama, R.4    Ono, K.5    Kitano, S.6
  • 26
    • 0032125182 scopus 로고    scopus 로고
    • Inhibition of biliary glutathione secretion by cyclosporine A in the rat: Possible mechanisms and role in the cholestasis induced by the drug
    • Moran, D., De Buitrago, J.M., Fernandez, E., Galan, A.I., Munoz, M.E., and Jimenez, R. 1998. Inhibition of biliary glutathione secretion by cyclosporine A in the rat: possible mechanisms and role in the cholestasis induced by the drug. J. Hepatol. 29(1): 68–77. doi:10.1016/S0168-8278(98)80180-3.
    • (1998) J. Hepatol , vol.29 , Issue.1 , pp. 68-77
    • Moran, D.1    De Buitrago, J.M.2    Fernandez, E.3    Galan, A.I.4    Munoz, M.E.5    Jimenez, R.6
  • 27
    • 0030051609 scopus 로고
    • Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore and cyclosporine A-sensitive channel
    • Nicolli, A., Basso, E., Petronilli, V., Wenger, R.M., and Bernard, P. 1995. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore and cyclosporine A-sensitive channel. J. Biol. Chem. 271(4): 2185–2192.
    • (1995) J. Biol. Chem , vol.271 , Issue.4 , pp. 2185-2192
    • Nicolli, A.1    Basso, E.2    Petronilli, V.3    Wenger, R.M.4    Bernard, P.5
  • 28
    • 3142604803 scopus 로고    scopus 로고
    • Cyclosporine A and adverse effects on organs: Histochemical studies
    • Rezzani, R. 2004. Cyclosporine A and adverse effects on organs: histochemical studies. Prog. Histochem. Cytochem. 39(2): 85–128. doi:10.1016/j.proghi.2004. 04.001.
    • (2004) Prog. Histochem. Cytochem , vol.39 , Issue.2 , pp. 85-128
    • Rezzani, R.1
  • 29
    • 0034942355 scopus 로고    scopus 로고
    • Melatonin antagonises the cyclosporine A immunosuppressive effects in rat thymuses
    • Rezzani, R., Rodella, L., and Bianchi, R. 2001. Melatonin antagonises the cyclosporine A immunosuppressive effects in rat thymuses. Int. Immunopharmacol. 1(8): 1615–1619. doi:10.1016/S1567-5769(01)00077-7.
    • (2001) Int. Immunopharmacol , vol.1 , Issue.8 , pp. 1615-1619
    • Rezzani, R.1    Rodella, L.2    Bianchi, R.3
  • 30
    • 20444488772 scopus 로고    scopus 로고
    • Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver
    • Rezzani, R., Buffoli, B., Rodella, L., Stacchiotti, A., and Bianchi, R. 2005. Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. Int. Immunopharmacol. 5(9): 1397–1405. doi:10.1016/j.intimp.2005.03.021.
    • (2005) Int. Immunopharmacol , vol.5 , Issue.9 , pp. 1397-1405
    • Rezzani, R.1    Buffoli, B.2    Rodella, L.3    Stacchiotti, A.4    Bianchi, R.5
  • 31
    • 0026535636 scopus 로고
    • The restoration of ATP synthesis may explain the protective effect of calcium antagonist against cyclosporine A nephrotoxicity
    • Salducci, M.D., Chauvet-Monges, A.M., Berland, Y., Dussol, B., Elsen, R., and Crevat, A. 1992. The restoration of ATP synthesis may explain the protective effect of calcium antagonist against cyclosporine A nephrotoxicity. Life Sci. 50(26): 2053–2058. doi:10.1016/0024-3205(92)90571-6.
    • (1992) Life Sci , vol.50 , Issue.26 , pp. 2053-2058
    • Salducci, M.D.1    Chauvet-Monges, A.M.2    Berland, Y.3    Dussol, B.4    Elsen, R.5    Crevat, A.6
  • 32
    • 0028135549 scopus 로고
    • Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity
    • Serino, F., Grevel, J., Napoli, K.L., Kahan, B.D., and Strobel, H.W. 1994. Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity. Transplant. Proc. 26(5): 2869–2870.
    • (1994) Transplant. Proc , vol.26 , Issue.5 , pp. 2869-2870
    • Serino, F.1    Grevel, J.2    Napoli, K.L.3    Kahan, B.D.4    Strobel, H.W.5
  • 33
    • 0033405266 scopus 로고    scopus 로고
    • Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis
    • Shihab, F.S., Andoh, T.F., Tanner, A.M., Yi, H., and Bennett, W.M. 1999. Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. Kidney Int. 56(6): 2147–2159. doi:10.1046/j.1523-1755.1999. 00794.x.
    • (1999) Kidney Int , vol.56 , Issue.6 , pp. 2147-2159
    • Shihab, F.S.1    Oh, T.F.2    Tanner, A.M.3    Yi, H.4    Bennett, W.M.5
  • 34
    • 84879044408 scopus 로고    scopus 로고
    • What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?
    • Tarantino, G., and Finelli, C. 2013. What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome? World J. Gastroenterol. 19(22): 3375–3384. doi:10.3748/wjg.v19.i22.3375.
    • (2013) World J. Gastroenterol , vol.19 , Issue.22 , pp. 3375-3384
    • Tarantino, G.1    Finelli, C.2
  • 35
    • 79955700474 scopus 로고    scopus 로고
    • Circulating levels of cytochrome C, gammaglutamyl transferase, triglycerides and unconjugated bilirubin inoverweight/obese patients with nonalcoholic fatty liver disease
    • Tarantino, G., Colao, A., Capone, D., Conca, P., Tarantino, M., and Grimaldi, E. 2011a. Circulating levels of cytochrome C, gammaglutamyl transferase, triglycerides and unconjugated bilirubin inoverweight/obese patients with nonalcoholic fatty liver disease. J. Biol. Regul. Homeost. Agents, 25(1): 47–56.
    • (2011) J. Biol. Regul. Homeost. Agents , vol.25 , Issue.1 , pp. 47-56
    • Tarantino, G.1    Colao, A.2    Capone, D.3    Conca, P.4    Tarantino, M.5    Grimaldi, E.6
  • 36
    • 84455162004 scopus 로고    scopus 로고
    • Serum Bcl2 concentrations in overweightobese subjects with nonalcoholic fatty liver disease
    • Tarantino, G., Scopacasa, F., Colao, A., Capone, D., Tarantino, M., Grimaldi, E., et al. 2011b. Serum Bcl2 concentrations in overweightobese subjects with nonalcoholic fatty liver disease. World J. Gastroenterol. 17(48): 5280–5288. doi:10.3748/wjg.v17.i48.5280.
    • (2011) World J. Gastroenterol , vol.17 , Issue.48 , pp. 5280-5288
    • Tarantino, G.1    Scopacasa, F.2    Colao, A.3    Capone, D.4    Tarantino, M.5    Grimaldi, E.6
  • 37
    • 84926297509 scopus 로고    scopus 로고
    • Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat
    • Vavrinec, P., Henning, R.H., Landheer, S.W., Wang, Y., Deelman, L.E., van Dokkum, R.P., et al. 2014. Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat. Curr. Vasc. Pharmacol. 12(6): 836–844. doi:10.2174/15701611113116660151.
    • (2014) Curr. Vasc. Pharmacol , vol.12 , Issue.6 , pp. 836-844
    • Vavrinec, P.1    Henning, R.H.2    Landheer, S.W.3    Wang, Y.4    Deelman, L.E.5    Van Dokkum, R.P.6
  • 38
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei, M.C., Zong, W.X., Cheng, E.H., Lindsten, T., Panoutsakopoulou, V., Ross, A.J., et al. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science, 292(5517): 727–730. doi:10.1126/science.1059108.
    • (2001) Science , vol.292 , Issue.5517 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3    Lindsten, T.4    Panoutsakopoulou, V.5    Ross, A.J.6
  • 39
    • 0023621231 scopus 로고
    • A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats
    • Wixson, S.K., White, W.J., Hughes, H.C., Jr., Lang, C.M., and Marshall, W.K. 1987. A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Lab. Anim. Sci. 37(6): 726–730.
    • (1987) Lab. Anim. Sci , vol.37 , Issue.6 , pp. 726-730
    • Wixson, S.K.1    White, W.J.2    Hughes, H.C.3    Lang, C.M.4    Marshall, W.K.5
  • 40
    • 84920606469 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice
    • Wu, Y.J., Guo, X., Li, C.J., Li, D.Q., Zhang, J., Yang, Y., et al. 2015. Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism, 64(2): 226–235. doi:10.1016/j.metabol.2014.08.006.
    • (2015) Metabolism , vol.64 , Issue.2 , pp. 226-235
    • Wu, Y.J.1    Guo, X.2    Li, C.J.3    Li, D.Q.4    Zhang, J.5    Yang, Y.6
  • 41
    • 0034333125 scopus 로고    scopus 로고
    • The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice
    • Zhu, W., and Fung, P.C. 2000. The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice. Free Radic. Biol. Med. 29(9): 870–880. doi:10.1016/S0891-5849(00)00396-8.
    • (2000) Free Radic. Biol. Med , vol.29 , Issue.9 , pp. 870-880
    • Zhu, W.1    Fung, P.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.