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Volumn 13, Issue 3, 2016, Pages 150-160

Breakthroughs in the treatment and prevention of Clostridium difficile infection

Author keywords

[No Author keywords available]

Indexed keywords

ACTOXUMAB; BACTERIAL VACCINE; BEZLOTOXUMAB; CADAZOLID; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; CLOSTRIDIUM DIFFICILE VACCINE; FIDAXOMICIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IMMUNOLOGICAL ADJUVANT; METRONIDAZOLE; PLACEBO; PROBIOTIC AGENT; RIDINILAZOLE; SUROTOMYCIN; TOLEVAMER; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; IMMUNOLOGIC FACTOR;

EID: 84959343182     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2015.220     Document Type: Review
Times cited : (128)

References (109)
  • 1
    • 55249105923 scopus 로고    scopus 로고
    • Clostridium difficile-more difficult than ever
    • Kelly, C. P.,&Lamont, J. T. Clostridium difficile-more difficult than ever. N. Engl. J. Med. 359, 1932-1940 (2008
    • (2008) N. Engl. J. Med , vol.359 , pp. 1932-1940
    • Kelly, C.P.1    Lamont, J.T.2
  • 2
    • 84897005978 scopus 로고    scopus 로고
    • Multistate point-prevalence survey of health care-Associated infections
    • Magill, S. S., et al. Multistate point-prevalence survey of health care-Associated infections. N. Engl. J. Med. 370, 1198-1208 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 1198-1208
    • Magill, S.S.1
  • 3
    • 77954581650 scopus 로고    scopus 로고
    • The changing epidemiology of Clostridium difficile infections
    • Freeman, J., et al. The changing epidemiology of Clostridium difficile infections. Clin. Microbiol. Rev. 23, 529-549 (2010
    • (2010) Clin. Microbiol. Rev , vol.23 , pp. 529-549
    • Freeman, J.1
  • 4
    • 84880691277 scopus 로고    scopus 로고
    • Epidemiology of community-Associated Clostridium difficile infection 2009 through 2011
    • Chitnis, A. S., et al. Epidemiology of community-Associated Clostridium difficile infection, 2009 through 2011. JAMA Intern. Med. 173, 1359-1367 (2013
    • (2013) JAMA Intern. Med , vol.173 , pp. 1359-1367
    • Chitnis, A.S.1
  • 5
    • 84898721140 scopus 로고    scopus 로고
    • Clostridium difficile infection among children across diverse US geographic locations
    • Wendt, J. M., et al. Clostridium difficile infection among children across diverse US geographic locations. Pediatrics 133, 651-658 (2014
    • (2014) Pediatrics , vol.133 , pp. 651-658
    • Wendt, J.M.1
  • 6
    • 84902987530 scopus 로고    scopus 로고
    • Pediatric Clostridium difficile infection: 6 year active surveillance in a defined patient population
    • Le Saux, N., et al. Pediatric Clostridium difficile infection: 6 year active surveillance in a defined patient population. Infect. Control Hosp. Epidemiol. 35, 904-906 (2014
    • (2014) Infect. Control Hosp. Epidemiol , vol.35 , pp. 904-906
    • Le Saux, N.1
  • 7
    • 84923775846 scopus 로고    scopus 로고
    • Burden of Clostridium difficile infection in the United States
    • Lessa, F. C., et al. Burden of Clostridium difficile infection in the United States. N. Engl. J. Med. 372, 825-834 (2015
    • (2015) N. Engl. J. Med , vol.372 , pp. 825-834
    • Lessa, F.C.1
  • 8
    • 84884597711 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services Centers for Disease Control and Prevention [online] 2015
    • U.S. Department of Health and Human Services. Antibiotic Resistance Threats in the United States, 2013. Centers for Disease Control and Prevention [online], http://www.cdc.gov/drugresistance/pdf/ar-Threats-2013-508.pdf (2015
    • (2013) Antibiotic Resistance Threats in the United States
  • 9
    • 84863694101 scopus 로고    scopus 로고
    • Burden of Clostridium difficile on the healthcare system
    • Dubberke, E. R.,&Olsen, M. A. Burden of Clostridium difficile on the healthcare system. Clin. Infect. Dis. 55, S88-S92 (2012
    • (2012) Clin. Infect. Dis , vol.55 , pp. S88-S92
    • Dubberke, E.R.1    Olsen, M.A.2
  • 10
    • 79960420811 scopus 로고    scopus 로고
    • The host immune response to Clostridium difficile
    • Kelly, C. P.,&Kyne, L. The host immune response to Clostridium difficile. J. Med. Microbiol. 60, 1070-1079 (2011
    • (2011) J. Med. Microbiol , vol.60 , pp. 1070-1079
    • Kelly, C.P.1    Kyne, L.2
  • 11
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of america (shea) and the infectious diseases society of america (idsa
    • Cohen, S. H., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect. Control Hosp. Epidemiol. 31, 431-455 (2010
    • (2010) Infect. Control Hosp. Epidemiol , vol.31 , pp. 431-455
    • Cohen, S.H.1
  • 12
    • 84875952150 scopus 로고    scopus 로고
    • Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
    • Surawicz, C. M., et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am. J. Gastroenterol. 108, 478-498 (2013
    • (2013) Am. J. Gastroenterol , vol.108 , pp. 478-498
    • Surawicz, C.M.1
  • 13
    • 84887259304 scopus 로고    scopus 로고
    • European Society of Clinical Microbiology and Infectious Diseases: Update of the treatment guidance document for Clostridium difficile infection
    • Debast, S. B., Bauer, M. P.,&Kuijper, E. J. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin. Microbiol. Infect. SUPPL 2, 1-26 (2014
    • (2014) Clin. Microbiol. Infect. Suppl , vol.2 , pp. 1-26
    • Debast, S.B.1    Bauer, M.P.2    Kuijper, E.J.3
  • 14
    • 84872846834 scopus 로고    scopus 로고
    • Committee on Infectious Diseases Clostridium difficile infection in infants and children
    • Committee on Infectious Diseases. Clostridium difficile infection in infants and children. Pediatrics 131, 196-200 (2013
    • (2013) Pediatrics , vol.131 , pp. 196-200
  • 15
    • 84863673580 scopus 로고    scopus 로고
    • Current state of Clostridium difficile treatment options
    • Venugopal, A. A.,&Johnson, S. Current state of Clostridium difficile treatment options. Clin. Infect. Dis. 55, S71-S76 (2012
    • (2012) Clin. Infect. Dis , vol.55 , pp. S71-S76
    • Venugopal, A.A.1    Johnson, S.2
  • 16
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-Associated diarrhea, stratified by disease severity
    • Zar, F. A., Bakkanagari, S. R., Moorthi, K. M.,&Davis, M. B. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-Associated diarrhea, stratified by disease severity. Clin. Infect. Dis. 45, 302-307 (2007
    • (2007) Clin. Infect. Dis , vol.45 , pp. 302-307
    • Zar, F.A.1    Bakkanagari, S.R.2    Moorthi, K.M.3    Davis, M.B.4
  • 17
    • 84905057299 scopus 로고    scopus 로고
    • Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: Results from two multinational, randomized, controlled trials
    • Johnson, S., et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin. Infect. Dis. 59, 345-354 (2014
    • (2014) Clin. Infect. Dis , vol.59 , pp. 345-354
    • Johnson, S.1
  • 18
    • 84856718514 scopus 로고    scopus 로고
    • Fidaxomicin a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infection
    • Venugopal, A. A.,&Johnson, S. Fidaxomicin: a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infection. Clin. Infect. Dis. 54, 568-574 (2012
    • (2012) Clin. Infect. Dis , vol.54 , pp. 568-574
    • Venugopal, A.A.1    Johnson, S.2
  • 19
    • 42049099454 scopus 로고    scopus 로고
    • Safety, tolerance, and pharmacokinetic studies of OPT 80 in healthy volunteers following single and multiple oral doses
    • Shue, Y. K., et al. Safety, tolerance, and pharmacokinetic studies of OPT 80 in healthy volunteers following single and multiple oral doses. Antimicrob. Agents Chemother. 52, 1391-1395 (2008
    • (2008) Antimicrob. Agents Chemother , vol.52 , pp. 1391-1395
    • Shue, Y.K.1
  • 20
    • 7244250115 scopus 로고    scopus 로고
    • Activity of OPT 80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species
    • Credito, K. L.,&Appelbaum, P. C. Activity of OPT 80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species. Antimicrob. Agents Chemother. 48, 4430-4434 (2004
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 4430-4434
    • Credito, K.L.1    Appelbaum, P.C.2
  • 21
    • 9644257232 scopus 로고    scopus 로고
    • In vitro activities of OPT 80 and comparator drugs against intestinal bacteria
    • Finegold, S. M., et al. In vitro activities of OPT 80 and comparator drugs against intestinal bacteria. Antimicrob. Agents Chemother. 48, 4898-4902 (2004
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 4898-4902
    • Finegold, S.M.1
  • 22
    • 84863644993 scopus 로고    scopus 로고
    • Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin reexpression and recurrence of CDI
    • Louie, T. J., et al. Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin reexpression and recurrence of CDI. Clin. Infect. Dis. 55, S132-S142 (2012
    • (2012) Clin. Infect. Dis , vol.55 , pp. S132-S142
    • Louie, T.J.1
  • 24
    • 39349107697 scopus 로고    scopus 로고
    • Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-Associated diarrhea
    • Chang, J. Y., et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-Associated diarrhea. J. Infect. Dis. 197, 435-438 (2008
    • (2008) J. Infect. Dis , vol.197 , pp. 435-438
    • Chang, J.Y.1
  • 25
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • Louie, T. J., et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N. Engl. J. Med. 364, 422-431 (2011
    • (2011) N. Engl. J. Med , vol.364 , pp. 422-431
    • Louie, T.J.1
  • 26
    • 84859007390 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: A double-blind, non-inferiority, randomised controlled trial
    • Cornely, O. A., et al. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect. Dis. 12, 281-289 (2012
    • (2012) Lancet Infect. Dis , vol.12 , pp. 281-289
    • Cornely, O.A.1
  • 27
    • 84863923754 scopus 로고    scopus 로고
    • Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C difficile BI strain
    • Petrella, L. A., et al. Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain. Clin. Infect. Dis. 55, 351-357 (2012
    • (2012) Clin. Infect. Dis , vol.55 , pp. 351-357
    • Petrella, L.A.1
  • 28
    • 80051957059 scopus 로고    scopus 로고
    • Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections
    • Mullane, K. M., et al. Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections. Clin. Infect. Dis. 53, 440-447 (2011
    • (2011) Clin. Infect. Dis , vol.53 , pp. 440-447
    • Mullane, K.M.1
  • 30
    • 84900434000 scopus 로고    scopus 로고
    • Cost-effectiveness of competing strategies for management of recurrent Clostridium difficile infection: A decision analysis
    • Konijeti, G. G., Sauk, J., Shrime, M. G., Gupta, M.,&Ananthakrishnan, A. N. Cost-effectiveness of competing strategies for management of recurrent Clostridium difficile infection: a decision analysis. Clin. Infect. Dis. 58, 1507-1514 (2014
    • (2014) Clin. Infect. Dis , vol.58 , pp. 1507-1514
    • Konijeti, G.G.1    Sauk, J.2    Shrime, M.G.3    Gupta, M.4    Ananthakrishnan, A.N.5
  • 31
    • 84922151992 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of fidaxomicin versus vancomycin in Clostridium difficile infection
    • Nathwani, D., et al. Cost-effectiveness analysis of fidaxomicin versus vancomycin in Clostridium difficile infection. J. Antimicrob. Chemother. 69, 2901-2912 (2014
    • (2014) J. Antimicrob. Chemother , vol.69 , pp. 2901-2912
    • Nathwani, D.1
  • 32
    • 84884222815 scopus 로고    scopus 로고
    • Comparative in vitro activities of SMT19969, a new antimicrobial agent, against Clostridium difficile and 350 gram-positive and gram negative aerobic and anaerobic intestinal flora isolates
    • Goldstein, E. J., Citron, D. M., Tyrrell, K. L.,&Merriam, C. V. Comparative in vitro activities of SMT19969, a new antimicrobial agent, against Clostridium difficile and 350 gram-positive and gram negative aerobic and anaerobic intestinal flora isolates. Antimicrob. Agents Chemother. 57, 4872-4876 (2013
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 4872-4876
    • Goldstein, E.J.1    Citron, D.M.2    Tyrrell, K.L.3    Merriam, C.V.4
  • 33
    • 84928715619 scopus 로고    scopus 로고
    • A randomised Phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections
    • Vickers, R., et al. A randomised Phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections. BMC Infect. Dis. 15, 91 (2015
    • (2015) BMC Infect. Dis , vol.15 , pp. 91
    • Vickers, R.1
  • 35
    • 84866313208 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of CB 183 315, a novel lipopeptide antibiotic for treatment of Clostridium difficile
    • Mascio, C. T., et al. In vitro and in vivo characterization of CB 183, 315, a novel lipopeptide antibiotic for treatment of Clostridium difficile. Antimicrob. Agents Chemother. 56, 5023-5030 (2012
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 5023-5030
    • Mascio, C.T.1
  • 36
    • 84857172297 scopus 로고    scopus 로고
    • In vitro activities of CB 183 315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species
    • Citron, D. M., Tyrrell, K. L., Merriam, C. V.,&Goldstein, E. J. In vitro activities of CB 183, 315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species. Antimicrob. Agents Chemother. 56, 1613-1615 (2012
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 1613-1615
    • Citron, D.M.1    Tyrrell, K.L.2    Merriam, C.V.3    Goldstein, E.J.4
  • 37
    • 84873982271 scopus 로고    scopus 로고
    • Treatment of CDAD with oral CB 183 315: Time to recurrence, relapse and re infection rates compared with vancomycin
    • Chesnel, L., et al. Treatment of CDAD with oral CB 183 315: time to recurrence, relapse and re infection rates compared with vancomycin. Clin. Microbiol. Infect. 18, 380 (2012
    • (2012) Clin. Microbiol. Infect , vol.18 , pp. 380
    • Chesnel, L.1
  • 38
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01597505?term=NCT01597505&rank=1 (2015
    • (2015) ClinicalTrials.gov [Online]
  • 39
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01598311?term=NCT01598311&rank=1 (2015
    • (2015) ClinicalTrials.gov [Online]
  • 40
    • 84959318477 scopus 로고    scopus 로고
    • United States Securities and Exchange Commission
    • United States Securities and Exchange Commission. Form 10 Q. United States Securities and Exchange Commission [online], https://www.sec.gov/Archives/edgar/data/310158/000031015815000053/mrk0630201510q.htm (2015
    • (2015) Form 10 Q. United States Securities and Exchange Commission [Online]
  • 41
    • 84893466318 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections
    • Locher, H. H., et al. In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob. Agents Chemother. 58, 892-900 (2014
    • (2014) Antimicrob. Agents Chemother , vol.58 , pp. 892-900
    • Locher, H.H.1
  • 42
    • 84893515123 scopus 로고    scopus 로고
    • Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections
    • Locher, H. H., et al. Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob. Agents Chemother. 58, 901-908 (2014
    • (2014) Antimicrob. Agents Chemother , vol.58 , pp. 901-908
    • Locher, H.H.1
  • 43
    • 84942850284 scopus 로고    scopus 로고
    • A multicenter, double-blind, randomized, Phase 2 study evaluating the novel antibiotic, cadazolid, in patients with Clostridium difficile infection
    • Louie, T. J., et al. A multicenter, double-blind, randomized, Phase 2 study evaluating the novel antibiotic, cadazolid, in patients with Clostridium difficile infection. Antimicrob. Agents Chemother. 59, 6266-6273 (2015
    • (2015) Antimicrob. Agents Chemother , vol.59 , pp. 6266-6273
    • Louie, T.J.1
  • 44
    • 84977531612 scopus 로고    scopus 로고
    • Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C difficile infection
    • Gerding, D. N., et al. Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection. J. Antimicrob. Chemother. (2015
    • (2015) J. Antimicrob. Chemother
    • Gerding, D.N.1
  • 45
    • 84879764131 scopus 로고    scopus 로고
    • Diagnosis of Clostridium difficile infection: An ongoing conundrum for clinicians and for clinical laboratories
    • Burnham, C. A.,&Carroll, K. C. Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories. Clin. Microbiol. Rev. 26, 604-630 (2013
    • (2013) Clin. Microbiol. Rev , vol.26 , pp. 604-630
    • Burnham, C.A.1    Carroll, K.C.2
  • 46
    • 84929148131 scopus 로고    scopus 로고
    • Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C difficile infection: A randomized clinical trial
    • Gerding, D. N., et al. Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. difficile infection: a randomized clinical trial. JAMA 313, 1719-1727 (2015
    • (2015) JAMA , vol.313 , pp. 1719-1727
    • Gerding, D.N.1
  • 47
    • 84866313203 scopus 로고    scopus 로고
    • Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects
    • Villano, S. A., Seiberling, M., Tatarowicz, W., Monnot Chase, E.,&Gerding, D. N. Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects. Antimicrob. Agents Chemother. 56, 5224-5229 (2012
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 5224-5229
    • Villano, S.A.1    Seiberling, M.2    Tatarowicz, W.3    Monnot Chase, E.4    Gerding, D.N.5
  • 48
    • 84922817126 scopus 로고    scopus 로고
    • The potential of probiotics to prevent Clostridium difficile infection
    • Allen, S. J. The potential of probiotics to prevent Clostridium difficile infection. Infect. Dis. Clin. North Am. 29, 135-144 (2015
    • (2015) Infect. Dis. Clin. North Am. , vol.29 , pp. 135-144
    • Allen, S.J.1
  • 49
    • 84928889861 scopus 로고    scopus 로고
    • Prevention of Clostridium difficile infection with probiotics
    • Evans, C. T.,&Johnson, S. Prevention of Clostridium difficile infection with probiotics. Clin. Infect. Dis. 60, S122-S128 (2015
    • (2015) Clin. Infect. Dis , vol.60 , pp. S122-S128
    • Evans, C.T.1    Johnson, S.2
  • 50
    • 84891816574 scopus 로고    scopus 로고
    • Probiotics for the prevention of Clostridium difficile-Associated diarrhea in adults and children
    • Goldenberg, J. Z., et al. Probiotics for the prevention of Clostridium difficile-Associated diarrhea in adults and children. Cochrane Database Syst. Rev. 5, CD006095 (2013
    • (2013) Cochrane Database Syst. Rev , vol.5 , pp. CD006095
    • Goldenberg, J.Z.1
  • 51
    • 84871349683 scopus 로고    scopus 로고
    • Probiotics for the prevention of Clostridium difficile-Associated diarrhea: A systematic review and meta-Analysis
    • Johnston, B. C., et al. Probiotics for the prevention of Clostridium difficile-Associated diarrhea: a systematic review and meta-Analysis. Ann. Intern. Med. 157, 878-888 (2012
    • (2012) Ann. Intern. Med , vol.157 , pp. 878-888
    • Johnston, B.C.1
  • 52
    • 84885103912 scopus 로고    scopus 로고
    • Probiotics for the prevention of antibiotic-Associated diarrhea and Clostridium difficile infection among hospitalized patients: Systematic review and meta analysis
    • Pattani, R., Palda, V. A., Hwang, S. W.,&Shah, P. S. Probiotics for the prevention of antibiotic-Associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta analysis. Open Med. 7, e56-e67 (2013
    • (2013) Open Med , vol.7 , pp. e56-e67
    • Pattani, R.1    Palda, V.A.2    Hwang, S.W.3    Shah, P.S.4
  • 53
    • 84887390865 scopus 로고    scopus 로고
    • Lactobacilli and bifidobacteria in the prevention of antibiotic-Associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial
    • Allen, S. J., et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-Associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 382, 1249-1257 (2013
    • (2013) Lancet , vol.382 , pp. 1249-1257
    • Allen, S.J.1
  • 54
    • 0037373020 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile colitis: Case series involving 18 patients treated with donor stool administered via a nasogastric tube
    • Aas, J., Gessert, C. E.,&Bakken, J. S. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin. Infect. Dis. 36, 580-585 (2003
    • (2003) Clin. Infect. Dis , vol.36 , pp. 580-585
    • Aas, J.1    Gessert, C.E.2    Bakken, J.S.3
  • 55
    • 0024312284 scopus 로고
    • Bacteriotherapy for chronic relapsing clostridium difficile diarrhoea in six patients
    • Tvede, M.,&Rask-Madsen, J. Bacteriotherapy for chronic relapsing clostridium difficile diarrhoea in six patients. Lancet 333, 1156-1160 (1989
    • (1989) Lancet , vol.333 , pp. 1156-1160
    • Tvede, M.1    Rask-Madsen, J.2
  • 57
    • 84928885767 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for Clostridium difficile infection: A systematic review
    • Drekonja, D., et al. Fecal microbiota transplantation for Clostridium difficile infection: a systematic review. Ann. Intern. Med. 162, 630-638 (2015
    • (2015) Ann. Intern. Med , vol.162 , pp. 630-638
    • Drekonja, D.1
  • 58
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • van Nood, E., et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407-415 (2013
    • (2013) N. Engl. J. Med , vol.368 , pp. 407-415
    • Van Nood, E.1
  • 59
    • 84926417736 scopus 로고    scopus 로고
    • Randomised clinical trial: Faecal microbiota transplantation by colonoscopy versus vancomycin for the treatment of recurrent Clostridium difficile infection
    • Cammarota, G., et al. Randomised clinical trial: faecal microbiota transplantation by colonoscopy versus vancomycin for the treatment of recurrent Clostridium difficile infection. Aliment. Pharmacol. Ther. 41, 835-843 (2015
    • (2015) Aliment. Pharmacol. Ther , vol.41 , pp. 835-843
    • Cammarota, G.1
  • 60
    • 84900418033 scopus 로고    scopus 로고
    • Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: A randomized, open-label, controlled pilot study
    • Youngster, I., et al. Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin. Infect. Dis. 58, 1515-1522 (2014
    • (2014) Clin. Infect. Dis , vol.58 , pp. 1515-1522
    • Youngster, I.1
  • 61
    • 84862309942 scopus 로고    scopus 로고
    • Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection
    • Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J.,&Khoruts, A. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am. J. Gastroenterol. 107, 761-767 (2012
    • (2012) Am. J. Gastroenterol , vol.107 , pp. 761-767
    • Hamilton, M.J.1    Weingarden, A.R.2    Sadowsky, M.J.3    Khoruts, A.4
  • 62
    • 84954543513 scopus 로고    scopus 로고
    • Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: A randomized clinical trial
    • Lee, C. H., et al. Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial. JAMA 315, 142-149 (2016
    • (2016) JAMA , vol.315 , pp. 142-149
    • Lee, C.H.1
  • 63
    • 84874737205 scopus 로고    scopus 로고
    • High-Throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria
    • Hamilton, M. J., Weingarden, A. R., Unno, T., Khoruts, A.,&Sadowsky, M. J. High-Throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes 4, 125-135 (2013
    • (2013) Gut Microbes , vol.4 , pp. 125-135
    • Hamilton, M.J.1    Weingarden, A.R.2    Unno, T.3    Khoruts, A.4    Sadowsky, M.J.5
  • 64
    • 84963679952 scopus 로고    scopus 로고
    • Long-Term follow up study of fecal microbiota transplantation for severe and/or complicated Clostridium difficile infection: A multicenter experience
    • Aroniadis, O. C., et al. Long-Term follow up study of fecal microbiota transplantation for severe and/or complicated Clostridium difficile infection: a multicenter experience. J. Clin. Gastroenterol. http://dx.doi.org/10.1097/MCG.0000000000000374 (2015
    • (2015) J. Clin. Gastroenterol
    • Aroniadis, O.C.1
  • 65
    • 84937214310 scopus 로고    scopus 로고
    • Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection
    • Hirsch, B. E., et al. Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection. BMC Infect. Dis. 15, 191 (2015
    • (2015) BMC Infect. Dis , vol.15 , pp. 191
    • Hirsch, B.E.1
  • 66
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • Youngster, I., et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312, 1772-1778 (2014
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1
  • 67
    • 84947125813 scopus 로고    scopus 로고
    • Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead
    • Borody, T., Fischer, M., Mitchell, S.,&Campbell, J. Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead. Expert Rev. Gastroenterol. Hepatol. 9, 1379-1391 (2015
    • (2015) Expert Rev. Gastroenterol. Hepatol , vol.9 , pp. 1379-1391
    • Borody, T.1    Fischer, M.2    Mitchell, S.3    Campbell, J.4
  • 69
    • 84868158515 scopus 로고    scopus 로고
    • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
    • Lawley, T. D., et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog. 8, e1002995 (2012
    • (2012) PLoS Pathog , vol.8 , pp. e1002995
    • Lawley, T.D.1
  • 70
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie, C. G., et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205-208 (2015
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 71
    • 82955233474 scopus 로고    scopus 로고
    • Treating Clostridium difficile infection with fecal microbiota transplantation
    • Bakken, J. S., et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol. Hepatol. 9, 1044-1049 (2011
    • (2011) Clin. Gastroenterol. Hepatol , vol.9 , pp. 1044-1049
    • Bakken, J.S.1
  • 72
    • 84881148330 scopus 로고    scopus 로고
    • Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts
    • Schwartz, M., Gluck, M.,&Koon, S. Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts. Am. J. Gastroenterol. 108, 1367 (2013
    • (2013) Am. J. Gastroenterol , vol.108 , pp. 1367
    • Schwartz, M.1    Gluck, M.2    Koon, S.3
  • 73
    • 84894234528 scopus 로고    scopus 로고
    • Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn's disease and recurrent Clostridium difficile infection
    • Quera, R., Espinoza, R., Estay, C.,&Rivera, D. Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn's disease and recurrent Clostridium difficile infection. J. Crohns Colitis 8, 252-253 (2014
    • (2014) J. Crohns Colitis , vol.8 , pp. 252-253
    • Quera, R.1    Espinoza, R.2    Estay, C.3    Rivera, D.4
  • 74
    • 84903894091 scopus 로고    scopus 로고
    • Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients
    • Kelly, C. R., et al. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am. J. Gastroenterol. 109, 1065-1071 (2014
    • (2014) Am. J. Gastroenterol , vol.109 , pp. 1065-1071
    • Kelly, C.R.1
  • 75
    • 84953849261 scopus 로고    scopus 로고
    • Fatal aspiration pneumonia as a complication of fecal microbiota transplant
    • Baxter, M., Ahmad, T., Colville, A.,&Sheridan, R. Fatal aspiration pneumonia as a complication of fecal microbiota transplant. Clin. Infect. Dis. 61, 136-137 (2015
    • (2015) Clin. Infect. Dis , vol.61 , pp. 136-137
    • Baxter, M.1    Ahmad, T.2    Colville, A.3    Sheridan, R.4
  • 76
    • 84880601378 scopus 로고    scopus 로고
    • Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection
    • De Leon, L. M., Watson, J. B.,&Kelly, C. R. Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin. Gastroenterol. Hepatol. 11, 1036-1038 (2013
    • (2013) Clin. Gastroenterol. Hepatol , vol.11 , pp. 1036-1038
    • De Leon, L.M.1    Watson, J.B.2    Kelly, C.R.3
  • 77
    • 84978328160 scopus 로고    scopus 로고
    • Weight gain after fecal microbiota transplantation
    • Alang, N.,&Kelly, C. R. Weight gain after fecal microbiota transplantation. Open Forum Infect. Dis. 2, ofv004 (2015
    • (2015) Open Forum Infect. Dis , vol.2 , pp. ofv004
    • Alang, N.1    Kelly, C.R.2
  • 78
    • 0032574193 scopus 로고    scopus 로고
    • Primary symptomless colonisation by Clostridium difficile and decreased risk of subsequent diarrhoea
    • Shim, J. K., Johnson, S., Samore, M. H., Bliss, D. Z.,&Gerding, D. N. Primary symptomless colonisation by Clostridium difficile and decreased risk of subsequent diarrhoea. Lancet 351, 633-636 (1998
    • (1998) Lancet , vol.351 , pp. 633-636
    • Shim, J.K.1    Johnson, S.2    Samore, M.H.3    Bliss, D.Z.4    Gerding, D.N.5
  • 79
    • 0347950950 scopus 로고    scopus 로고
    • Prevention of fatal Clostridium difficile-Associated disease during continuous administration of clindamycin in hamsters
    • Merrigan, M. M., Sambol, S. P., Johnson, S.,&Gerding, D. N. Prevention of fatal Clostridium difficile-Associated disease during continuous administration of clindamycin in hamsters. J. Infect. Dis. 188, 1922-1927 (2003
    • (2003) J. Infect. Dis , vol.188 , pp. 1922-1927
    • Merrigan, M.M.1    Sambol, S.P.2    Johnson, S.3    Gerding, D.N.4
  • 80
    • 0037115014 scopus 로고    scopus 로고
    • Colonization for the prevention of Clostridium difficile disease in hamsters
    • Sambol, S. P., Merrigan, M. M., Tang, J. K., Johnson, S.,&Gerding, D. N. Colonization for the prevention of Clostridium difficile disease in hamsters. J. Infect. Dis. 186, 1781-1789 (2002
    • (2002) J. Infect. Dis , vol.186 , pp. 1781-1789
    • Sambol, S.P.1    Merrigan, M.M.2    Tang, J.K.3    Johnson, S.4    Gerding, D.N.5
  • 81
    • 0035915688 scopus 로고    scopus 로고
    • Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea
    • Kyne, L., Warny, M., Qamar, A.,&Kelly, C. P. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 357, 189-193 (2001
    • (2001) Lancet , vol.357 , pp. 189-193
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 82
    • 67349114409 scopus 로고    scopus 로고
    • Toxin B is essential for virulence of Clostridium difficile
    • Lyras, D., et al. Toxin B is essential for virulence of Clostridium difficile. Nature 458, 1176-1179 (2009
    • (2009) Nature , vol.458 , pp. 1176-1179
    • Lyras, D.1
  • 83
    • 84904467481 scopus 로고    scopus 로고
    • Antibodies for treatment of Clostridium difficile infection
    • Humphreys, D. P.,&Wilcox, M. H. Antibodies for treatment of Clostridium difficile infection. Clin. Vaccine Immunol. 21, 913-923 (2014
    • (2014) Clin. Vaccine Immunol , vol.21 , pp. 913-923
    • Humphreys, D.P.1    Wilcox, M.H.2
  • 84
    • 0031057477 scopus 로고    scopus 로고
    • Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract
    • Kelly, C. P., et al. Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract. Antimicrob. Agents Chemother. 41, 236-241 (1997
    • (1997) Antimicrob. Agents Chemother , vol.41 , pp. 236-241
    • Kelly, C.P.1
  • 85
    • 0033027528 scopus 로고    scopus 로고
    • Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine
    • Warny, M., et al. Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut 44, 212-217 (1999
    • (1999) Gut , vol.44 , pp. 212-217
    • Warny, M.1
  • 86
    • 34249813402 scopus 로고    scopus 로고
    • Clostridium difficile-Associated diarrhoea: Bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses
    • Numan, S. C., Veldkamp, P., Kuijper, E. J., van den Berg, R. J.,&van Dissel, J. T. Clostridium difficile-Associated diarrhoea: bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses. Gut 56, 888-889 (2007
    • (2007) Gut , vol.56 , pp. 888-889
    • Numan, S.C.1    Veldkamp, P.2    Kuijper, E.J.3    Van Den Berg, R.J.4    Van Dissel, J.T.5
  • 87
    • 50549086810 scopus 로고    scopus 로고
    • A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-Associated diarrhoea: Efficacy and safety data of a prematurely interrupted trial
    • Mattila, E., et al. A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-Associated diarrhoea: efficacy and safety data of a prematurely interrupted trial. Scand. J. Infect. Dis. 40, 702-708 (2008
    • (2008) Scand. J. Infect. Dis , vol.40 , pp. 702-708
    • Mattila, E.1
  • 88
    • 84926665081 scopus 로고    scopus 로고
    • Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection
    • Sponseller, J. K., et al. Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection. J. Infect. Dis. 211, 1334-1341 (2015
    • (2015) J. Infect. Dis , vol.211 , pp. 1334-1341
    • Sponseller, J.K.1
  • 89
    • 84880899231 scopus 로고    scopus 로고
    • Hyperimmune bovine colostrum for treatment of GI infections: A review and update on Clostridium difficile
    • Steele, J., Sponseller, J., Schmidt, D., Cohen, O.,&Tzipori, S. Hyperimmune bovine colostrum for treatment of GI infections: a review and update on Clostridium difficile. Hum. Vaccin. Immunother. 9, 1565-1568 (2013
    • (2013) Hum. Vaccin. Immunother , vol.9 , pp. 1565-1568
    • Steele, J.1    Sponseller, J.2    Schmidt, D.3    Cohen, O.4    Tzipori, S.5
  • 90
    • 77951852492 scopus 로고    scopus 로고
    • Bovine colostrum in the management of nonorganic failure to thrive: A randomized clinical trial
    • Panahi, Y., et al. Bovine colostrum in the management of nonorganic failure to thrive: a randomized clinical trial. J. Pediatr. Gastroenterol. Nutr. 50, 551-554 (2010
    • (2010) J. Pediatr. Gastroenterol. Nutr , vol.50 , pp. 551-554
    • Panahi, Y.1
  • 91
    • 0030763467 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy for severe Clostridium difficile colitis
    • Salcedo, J., et al. Intravenous immunoglobulin therapy for severe Clostridium difficile colitis. Gut 41, 366-370 (1997
    • (1997) Gut , vol.41 , pp. 366-370
    • Salcedo, J.1
  • 92
    • 79151476267 scopus 로고    scopus 로고
    • Intravenous immunoglobulin for the treatment of Clostridium difficile infection: A review
    • Abougergi, M. S.,&Kwon, J. H. Intravenous immunoglobulin for the treatment of Clostridium difficile infection: a review. Dig. Dis. Sci. 56, 19-26 (2011
    • (2011) Dig. Dis. Sci , vol.56 , pp. 19-26
    • Abougergi, M.S.1    Kwon, J.H.2
  • 93
    • 74849098405 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against Clostridium difficile toxins
    • Lowy, I., et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N. Engl. J. Med. 362, 197-205 (2010
    • (2010) N. Engl. J. Med , vol.362 , pp. 197-205
    • Lowy, I.1
  • 94
    • 84871775506 scopus 로고    scopus 로고
    • Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease
    • Steele, J., Mukherjee, J., Parry, N.,&Tzipori, S. Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease. J. Infect. Dis. 207, 323-330 (2013
    • (2013) J. Infect. Dis , vol.207 , pp. 323-330
    • Steele, J.1    Mukherjee, J.2    Parry, N.3    Tzipori, S.4
  • 97
    • 84922789313 scopus 로고    scopus 로고
    • The prospect for vaccines to prevent Clostridium difficile infection
    • Ghose, C.,&Kelly, C. P. The prospect for vaccines to prevent Clostridium difficile infection. Infect. Dis. Clin. North Am. 29, 145-162 (2015
    • (2015) Infect. Dis. Clin. North Am. , vol.29 , pp. 145-162
    • Ghose, C.1    Kelly, C.P.2
  • 98
    • 84861975931 scopus 로고    scopus 로고
    • Clostridium difficile: Development of a novel candidate vaccine
    • Foglia, G., Shah, S., Luxemburger, C.,&Pietrobon, P. J. Clostridium difficile: development of a novel candidate vaccine. Vaccine 30, 4307-4309 (2012
    • (2012) Vaccine , vol.30 , pp. 4307-4309
    • Foglia, G.1    Shah, S.2    Luxemburger, C.3    Pietrobon, P.J.4
  • 99
    • 20244383137 scopus 로고    scopus 로고
    • Clostridium difficile toxoid vaccine in recurrent C difficile-Associated diarrhea
    • Sougioultzis, S., et al. Clostridium difficile toxoid vaccine in recurrent C. difficile-Associated diarrhea. Gastroenterology 128, 764-770 (2005
    • (2005) Gastroenterology , vol.128 , pp. 764-770
    • Sougioultzis, S.1
  • 100
    • 84857793535 scopus 로고    scopus 로고
    • Phase i dose finding studies of an adjuvanted Clostridium difficile toxoid vaccine
    • Greenberg, R. N., Marbury, T. C., Foglia, G.,&Warny, M. Phase I dose finding studies of an adjuvanted Clostridium difficile toxoid vaccine. Vaccine 30, 2245-2249 (2012
    • (2012) Vaccine , vol.30 , pp. 2245-2249
    • Greenberg, R.N.1    Marbury, T.C.2    Foglia, G.3    Warny, M.4
  • 103
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01887912?term=NCT01887912&rank=1 (2015
    • (2015) ClinicalTrials.gov [Online]
  • 104
    • 84879819430 scopus 로고    scopus 로고
    • A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile
    • Donald, R. G., et al. A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile. Microbiology 159, 1254-1266 (2013
    • (2013) Microbiology , vol.159 , pp. 1254-1266
    • Donald, R.G.1
  • 105
    • 84861661669 scopus 로고    scopus 로고
    • A novel fusion protein containing the receptor binding domains of C difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models
    • Tian, J. H., et al. A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models. Vaccine 30, 4249-4258 (2012
    • (2012) Vaccine , vol.30 , pp. 4249-4258
    • Tian, J.H.1
  • 106
    • 79959449569 scopus 로고    scopus 로고
    • Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B
    • Permpoonpattana, P., et al. Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B. Infect. Immun. 79, 2295-2302 (2011
    • (2011) Infect. Immun , vol.79 , pp. 2295-2302
    • Permpoonpattana, P.1
  • 107
    • 34247178951 scopus 로고    scopus 로고
    • Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile
    • Pechine, S., et al. Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile. Vaccine 25, 3946-3954 (2007
    • (2007) Vaccine , vol.25 , pp. 3946-3954
    • Pechine, S.1
  • 108
    • 84899988599 scopus 로고    scopus 로고
    • Development of a recombinant toxin fragment vaccine for Clostridium difficile infection
    • Karczewski, J., et al. Development of a recombinant toxin fragment vaccine for Clostridium difficile infection. Vaccine 32, 2812-2818 (2014
    • (2014) Vaccine , vol.32 , pp. 2812-2818
    • Karczewski, J.1
  • 109
    • 85006223114 scopus 로고    scopus 로고
    • Concomitant medical conditions and therapies preclude accurate classification of children with severe or severe complicated Clostridium difficile infection
    • Kociolek, L. K., Patel, S. J., Shulman, S. T.,&Gerding, D. N. Concomitant medical conditions and therapies preclude accurate classification of children with severe or severe complicated Clostridium difficile infection. J. Pediatric Infect. Dis. Soc. 4, e139-e142 (2014
    • (2014) J. Pediatric Infect. Dis. Soc , vol.4 , pp. e139-e142
    • Kociolek, L.K.1    Patel, S.J.2    Shulman, S.T.3    Gerding, D.N.4


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