A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis

Journal of Experimental Medicine

Volumn 212, Issue 10, 2015, Pages 1571-1587

  Wu, Ling ^a   Chen, Xing ^a   Zhao, Junjie ^a,b   Martin, Bradley ^a,b   Zepp, Jarod A ^a,b   Ko, Jennifer S ^a   Gu, Chunfang ^a   Cai, Gang ^c   Ouyang, Wenjun ^d   Sen, Ganes ^a   Stark, George R ^a   Su, Bing ^c,e   Vines, Charlotte M ^f   Tournier, Cathy ^g   Hamilton, Thomas A ^a   Vidimos, Allison ^a   Gastman, Brian ^a   Liu, Caini ^a   Li, Xiaoxia ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d GENENTECH INC   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS AT EL PASO   (United States)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACT1 PROTEIN; CYCLIN D1; GAMMA INTERFERON RECEPTOR 1; INTERLEUKIN 11; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17C; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; MYC PROTEIN; PROTEIN; PROTEIN P63; SIX TRANSMEMBRANE EPITHELIAL ANTIGEN OF THE PROSTATE 4; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 4; UNCLASSIFIED DRUG; MAP3K3 PROTEIN, MOUSE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TIARP PROTEIN, MOUSE; TRAF3IP2 PROTEIN, MOUSE; TRAF4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPIDERMIS HYPERPLASIA; GENE EXPRESSION; INTRACELLULAR SIGNALING; KERATINOCYTE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; ANIMAL; C57BL MOUSE; FEEDBACK SYSTEM; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; FEEDBACK, PHYSIOLOGICAL; HUMANS; INTERLEUKIN-17; KERATINOCYTES; MAP KINASE KINASE KINASE 3; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 7; PHOSPHOPROTEINS; RECEPTORS, INTERLEUKIN-17; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TNF RECEPTOR-ASSOCIATED FACTOR 4; TRANS-ACTIVATORS;

EID: 84959339548     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150204     Document Type: Article

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