Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Maeda, Keiko ^a   Enomoto, Atsushi ^a   Hara, Akitoshi ^a   Asai, Naoya ^a   Kobayashi, Takeshi ^a   Horinouchi, Asuka ^a   Maruyama, Shoichi ^a   Ishikawa, Yuichi ^b   Nishiyama, Takahiro ^b   Kiyoi, Hitoshi ^b   Kato, Takuya ^c   Ando, Kenju ^a   Weng, Liang ^a   Mii, Shinji ^a   Asai, Masato ^a   Mizutani, Yasuyuki ^a   Watanabe, Osamu ^a   Hirooka, Yoshiki ^a   Goto, Hidemi ^a   Takahashi, Masahide ^a  

^a Department of Pathology ^*  (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN; ISLR PROTEIN, HUMAN; MEMBRANE PROTEIN;

3T3-L1 CELL LINE; ADIPOSE TISSUE; ANIMAL; BONE; BONE DEVELOPMENT; CELL COUNT; CELL DIFFERENTIATION; CYTOLOGY; EMBRYOLOGY; FIBROBLAST; GENE EXPRESSION; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; OSTEOBLAST; PERICYTE; STROMA CELL;

3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; BIOMARKERS; BONE AND BONES; BONE DEVELOPMENT; CELL COUNT; CELL DIFFERENTIATION; FIBROBLASTS; GENE EXPRESSION; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; MEMBRANE GLYCOPROTEINS; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; OSTEOBLASTS; PERICYTES; STROMAL CELLS;

EID: 84959336177     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22288     Document Type: Article

References (58)

1. Friedenstein, A. J., Chailakhjan, R. K. & Lalykina, K. S. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3, 393-403 (1970).
2. Bianco, P. "Mesenchymal" stem cells. Annu Rev Cell Dev Biol 30, 677-704 (2014).
3. Caplan, A. I. Mesenchymal stem cells. J Orthop Res 9, 641-650 (1991).
4. Nombela-Arrieta, C., Ritz, J. & Silberstein, L. E. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol 12, 126-131 (2011).
5. Bianco, P. & Robey, P. G. Skeletal stem cells. Development 142, 1023-1027 (2015).
6. Sacchetti, B. et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131, 324-336 (2007).
7. Méndez-Ferrer, S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829-834 (2010).
8. Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G. & Morrison, S. J. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168 (2014).
9. Morrison, S. J. & Scadden, D. T. The bone marrow niche for haematopoietic stem cells. Nature 505, 327-334 (2014).
10. Mendelson, A. & Frenette, P. S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med 20, 833-846 (2014).
11. Kfoury, Y. & Scadden, D. T. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell 16, 239-253 (2015).
12. Sugiyama, T., Kohara, H., Noda, M. & Nagasawa, T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25, 977-988 (2006).
13. Ding, L., Saunders, T. L., Enikolopov, G. & Morrison, S. J. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481, 457-462 (2012).
14. Caplan, A. I. & Correa, D. The MSC: an injury drugstore. Cell Stem Cell 9, 11-15 (2011).
15. Wang, Y., Chen, X., Cao, W. & Shi, Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol 15, 1009-1016 (2014).
16. da Silva Meirelles, L., Chagastelles, P. C. & Nardi, N. B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119, 2204-2213 (2006).
17. Crisan, M. et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301-313 (2008).
18. Caplan, A. I. All MSCs are pericytes? Cell Stem Cell 3, 229-230 (2008).
19. Murray, I. R. et al. Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci 71, 1353-1374 (2014).
20. Armulik, A., Genove, G. & Betsholtz, C. Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 21, 193-215 (2011).
21. Lv, F.-J., Tuan, R. S., Cheung, K. & Leung, V. Y. Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells 32, 1408-1419 (2014).
22. Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317 (2006).
23. Morikawa, S. et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 206, 2483-2496 (2009).
24. Worthley, D. L. et al. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 160, 269-284 (2015).
25. Greenbaum, A. et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 495, 227-230 (2013).
26. Bara, J. J., Richards, R. G., Alini, M. & Stoddart, M. J. Concise review: bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: Implications for basic research and the clinic. Stem Cells 32, 1713-1723 (2014).
27. Nagasawa, A. et al. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). Genomics 44, 273-279 (1997).
28. Dolan, J. et al. The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 8, 320 (2007).
29. Mandai, K. et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63, 614-627 (2009).
30. Mandai, K., Reimert, D. V. & Ginty, D. D. Linx mediates interaxonal interactions and formation of the internal capsule. Neuron 83, 93-103 (2014).
31. Homma, S., Shimada, T., Hikake, T. & Yaginuma, H. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns 9, 1-26 (2009).
32. Jansen, B. J. et al. Functional differences between mesenchymal stem cell populations are reflected by their transcriptome. Stem Cells Dev 19, 481-490 (2010).
33. Hsieh, J.-Y., Fu, Y.-S., Chang, S.-J., Tsuang, Y.-H. & Wang, H.-W. Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Wharton's jelly of umbilical cord. Stem Cells Dev 19, 1895-1910 (2010).
34. Yamada, Y., Fujimoto, A., Ito, A., Yoshimi, R. & Ueda, M. Cluster analysis and gene expression profiles: a cDNA microarray systembased comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells (hMSCs) for tissue engineering cell therapy. Biomaterials 27, 3766-3781 (2006).
35. Kapur, S. K. & Katz, A. J. Review of the adipose derived stem cell secretome. Biochimie 95, 2222-2228 (2013).
36. Huang, T. S. et al. Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2. Stem Cells 26, 1186-1201 (2008).
37. Chambers, S. M. et al. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell 1, 578-591 (2007).
38. Yin, H., Price, F. & Rudnicki, M. A. Satellite cells and the muscle stem cell niche. Physiol Rev 93, 23-67 (2011).
39. Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 12, 143-52 (2010).
40. Long, F. Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol 13, 27-38 (2012).
41. Rosen, E. D. & MacDougald, O. A. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885-896 (2006).
42. Wozniak, M. A. & Chen, C. S. Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol 10, 34-43 (2009).
43. Simion, C., Cedano-Prieto, M. E. & Sweeney, C. The LRIG family: enigmatic regulators of growth factor receptor signaling. Endocr Relat Cancer 21, R431-R443 (2014).
44. Powell, A. E. et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149, 146-158 (2012).
45. Xu, Y. et al. LRIG1 extracellular domain: Structure and function analysis. J Mol Biol 427, 1934-1948 (2015).
46. Wong, V. W. et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 14, 401-408 (2012).
47. Senapedis, W. T., Kennedy, C. J., Boyle, P. M. & Silver, P. A. Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell 22, 1791-1805 (2011).
48. Teixeira, C. C. et al. Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem 285, 31055-31065 (2010).
49. Rached, M.-T. et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 11, 147-160 (2010).
50. Walter, K. et al. Overexpression of Smoothened activates the Sonic Hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin Cancer Res 16, 1781-1789 (2010).
51. Allinen, M. et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6, 17-32 (2004).
52. Cabrera, S. et al. Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycininduced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 304, L593-L601 (2013).
53. Patel, M. J. et al. Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine. J Cell Biochem 101, 587-599 (2007).
54. Stephens, A. S. & Morrison, N. A. Novel target genes of RUNX2 transcription factor and 1, 25-dihydroxyvitamin D3. J Cell Biochem 115, 1594-1608 (2014).
55. Yoon, I. K. et al. Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology. Exp Gerontol 39, 1369-1378 (2004).
56. de Wit, J., Hong, W., Luo, L. & Ghosh, A. Role of leucine-rich repeat proteins in the development and function of neural circuits. Annu Rev Cell Dev Biol 27, 697-729 (2011).
57. Winkler, E. A., Bell, R. D. & Zlokovic, B. V. Central nervous system pericytes in health and disease. Nat Neurosci 14, 1398-1405 (2011).
58. Karow, M. Mountaineering pericytes-A universal key to tissue repair? BioEssays 35, 771-774 (2013).