Tequila regulates insulin-like signaling and extends life span in drosophila melanogaster

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 12, 2015, Pages 1461-1469

  Huang, Cheng Wen ^a,b   Wang, Horng Dar ^b,c,d   Bai, Hua ^e   Wu, Ming Shiang ^f   Yen, Jui Hung ^g   Tatar, Marc ^e   Fu, Tsai Feng ^h   Wang, Pei Yu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Institute of Biotechnology   (Taiwan)

^c Institute of Systems Neuroscience   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e BROWN UNIVERSITY   (United States)

^f NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^g INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h NATIONAL CHI NAN UNIVERSITY   (Taiwan)

Author keywords

Aging; Glucose homeostasis; Longevity; Neurotrypsin

Indexed keywords

DROSOPHILA PROTEIN; INSULIN; SERINE PROTEINASE; SIGNAL PEPTIDE; TEQUILA PROTEIN, DROSOPHILA;

ANIMAL; DROSOPHILA MELANOGASTER; FEMALE; LIFE EXPECTANCY; LONGEVITY; MALE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIFE EXPECTANCY; LONGEVITY; MALE; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 84959327891     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glv094     Document Type: Article

References (29)

1. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 2000;289:2126-2128. doi:10.1126/science.289.5487.2126
2. Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430:686-689. doi:10.1038/nature02789
3. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the benefcial actions of calorie restriction. Proc Natl Acad Sci USA. 2006;103:7901-7905. doi:10.1073/pnas.0600161103
4. Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol. 2001;11:213-221. doi:10.1016/S0960-9822(01)00068-9
5. Garelli A, Gontijo AM, Miguela V, Caparros E, Dominguez M. Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Science. 2012;336:579-582. doi:10.1126/science.1216735
6. Colombani J, Andersen DS, Léopold P. Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science. 2012;336:582-585. doi:10.1126/science.1216689
7. Rulifson EJ, Kim SK, Nusse R. Ablation of insulin-producing neurons in fies: growth and diabetic phenotypes. Science. 2002;296:1118-1120. doi:10.1126/science.1070058
8. Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulinlike signals. Science. 2003;299:1346-1351. doi:10.1126/science.1081447
9. Houthoofd K, Braeckman BP, Johnson TE, Vanfeteren JR. Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp Gerontol. 2003;38:947-954. doi:10.1016/S0531-5565(03)0161-X
10. Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L. Dietary restriction in long-lived dwarf fies. Science. 2002;296:319. doi:10.1126/sci-ence.1069366
11. Min KJ, Yamamoto R, Buch S, Pankratz M, Tatar M. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell. 2008;7:199-206. doi:10.1111/j.1474-9726.2008.00373.x
12. Giannakou ME, Goss M, Partridge L. Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell. 2008;7:187-198. doi:10.1111/j.1474-9726.2007.00362.x
13. Munier AI, Medzhitov R, Janeway CA Jr, Doucet D, Capovilla M, Lagueux M. graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol. 2004;34:1025-1035. doi:10.1016/j.ibmb.2003.09.009
14. Chen C-C, Wu J-K, Lin H-W, et al. Visualizing long-term memory formation in two neurons of the Drosophila brain. Science. 2012;335:678-685. doi:10.1126/science.1212735
15. Didelot G, Molinari F, Tchénio P, et al. Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila. Science. 2006;313:851-853. doi:10.1126/science.1127215
16. Plaçais PY, Preat T. To favor survival under food shortage, the brain disables costly memory. Science. 2013;339:440-442. doi:10.1126/science.1226018
17. Wang P-Y, Neretti N, Whitaker R, et al. Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci USA. 2009;106:9262-9267. doi:10.1073/pnas.0904115106
18. Lin WS, Chen JY, Wang JC, et al. The anti-aging effects of Ludwigia octo-valvis on Drosophila melanogaster and SAMP8 mice. Age. 2014;36:689-703. doi:10.1007/s11357-013-9606-z
19. Chou HJ, Lai DM, Huang CW, McLennan IS, Wang HD, Wang PY. BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS One. 2013;8:e58441. doi:10.1371/journal.pone.0058441
20. Wang P-Y, Koishi K, McGeachie AB, et al. Mullerian inhibiting substance acts as a motor neuron survival factor in vitro. Proc Natl Acad Sci USA. 2005;102:16421-16425. doi:10.1073/pnas.0508304102
21. Bai H, Kang P, Tatar M. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. Aging Cell. 2012;11:978-985. doi:10.1111/acel.12000
22. Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL. Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fy. Cell Metab. 2005;1:145-152. doi:10.1016/j. cmet.2005.01.005
23. Wang CT, Chen YC, Wang YY, et al. Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. Aging Cell. 2012;11:93-103. doi:10.1111/j.1474-9726.2011.00762.x
24. Liu YL, Lu WC, Brummel TJ, et al. Reduced expression of alpha-1, 2-mannosidase I extends lifespan in Drosophila melanogaster and Cae-norhabditis elegans. Aging Cell. 2009;8:370-379. doi:10.1111/j.1474-9726.2009.00471.x
25. Broughton SJ, Piper MD, Ikeya T, et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci USA. 2005;102:3105-3110. doi:10.1073/pnas.0405775102
26. Haselton A, Sharmin E, Schrader J, Sah M, Poon P, Fridell YW. Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance. Cell Cycle. 2010;9:3063-3071. doi:10.4161/cc.9.15.12458
27. Smeekens SP, Montag AG, Thomas G, et al. Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci USA. 1992;89:8822-8826.
28. Libert S, Chao Y, Chu X, Pletcher SD. Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell. 2006;5:533-543. doi:10.1111/j.1474-9726.2006.00251.x
29. Danielli A, Loukeris TG, Lagueux M, Müller HM, Richman A, Kafatos FC. A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae. Proc Natl Acad Sci USA. 2000;97:7136-7141. doi:10.1073/pnas.97.13.7136