Endocrine-disrupting chemicals and oil and natural gas operations: Potential environmental contamination and recommendations to assess complex environmental mixtures

Environmental Health Perspectives

Volumn 124, Issue 3, 2016, Pages 256-264

  Kassotis, Christopher D ^a   Tillitt, Donald E ^b   Lin, Chung Ho ^c   McElroy, Jane A ^c   Nagel, Susan C ^d  

^a DUKE UNIVERSITY   (United States)

^b Jackson Field Research Station   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ALKANE; ALKENE; ANDROGEN; BENZENE; CYTOCHROME P450; ENDOCRINE DISRUPTOR; ESTROGEN; ETHYLBENZENE; FORMALDEHYDE; GROUND WATER; HEAVY METAL; HORMONE; HORMONE RECEPTOR; HYDROCARBON; NAPHTHALENE; NATURAL GAS; OIL; SILICON DIOXIDE; TOLUENE; XYLENE; PETROLEUM; WATER POLLUTANT;

BIOASSAY; BIOAVAILABILITY; CHEMICAL COMPOSITION; CONGENITAL MALFORMATION; HEALTH IMPACT ASSESSMENT; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; INFERTILITY; NEOPLASM; NOTE; OCCUPATIONAL EXPOSURE; OFFSHORE OIL INDUSTRY; OIL SPILL; POLLUTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; WASTE WATER RECYCLING; WATER CONTAMINATION; ADVERSE EFFECTS; CHEMISTRY; ENVIRONMENT; ENVIRONMENTAL MONITORING; OIL AND GAS FIELD; PROCEDURES; WATER POLLUTANT; WATER POLLUTION; WATER SUPPLY;

ENDOCRINE DISRUPTORS; ENVIRONMENT; ENVIRONMENTAL MONITORING; GROUNDWATER; HUMANS; OIL AND GAS FIELDS; PETROLEUM; WATER POLLUTANTS, CHEMICAL; WATER POLLUTION, CHEMICAL; WATER SUPPLY;

EID: 84959314112     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1409535     Document Type: Note

References (134)

1. Andric NL, Kostic TS, Zoric SN, Stanic BD, Andric SA, Kovacevic RZ. 2006. Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes. Reprod Toxicol 22:102-110.
2. Anzenbacher P, Anzenbacherová E. 2001. Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 58:737-747.
3. Bamberger M, Oswald RE. 2012. Impacts of gas drilling on human and animal health. New Solut 22:51-77.
4. Bamberger M, Oswald RE. 2014. Unconventional oil and gas extraction and animal health. Environ Sci Process Impacts 16:1860-1865.
5. Bamberger M, Oswald RE. 2015. Long-term impacts of unconventional drilling operations on human and animal health. J Environ Sci Health A Tox Hazard Subst Environ Eng 50:447-459.
6. Bellanger M, Demeneix B, Grandjean P, Zoeller RT, Trasande L. 2015. Neurobehavioral deficits, diseases and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100:1256-1266.
7. Bergman Å, Heindel JJ, Jobling S, Kidd KA, Zoeller RT, eds. 2013. State of the Science of Endocrine Disrupting Chemicals-2012. World Health Organization. Available: http://apps.who.int/iris/ bitstream/10665/78101/1/9789241505031_eng. pdf?ua=1[accessed 25 February 2015].
8. Bertin MJ, Moeller P, Guillette LJ Jr, Chapman RW. 2013. Using machine learning tools to model complex toxic interactions with limited sampling regimes. Environ Sci Technol 47:2728-2736.
9. Braga O, Smythe GA, Schafer AI, Feitz AJ. 2005. Steroid estrogens in primary and tertiary wastewater treatment plants. Water Sci Technol 52:273-278.
10. Brantley SL, Yoxtheimer D, Arjmand S, Grieve P, Vidic R, Pollak J, et al. 2014. Water resource impacts during unconventional shale gas development: the Pennsylvania experience. Int J Coal Geol 126:140-156.
11. Brown DR, Lewis C, Weinberger BI. 2015. Human exposure to unconventional natural gas development: a public health demonstration of periodic high exposure to chemical mixtures in ambient air. J Environ Sci Health A Tox Hazard Subst Environ Eng 50:460-472.
12. Brown D, Weinberger B, Lewis C, Bonaparte H. 2014. Understanding exposure from natural gas drilling puts current air standards to the test. Rev Environ Health 29:277-292.
13. Burgess RM, Ho KT, Brack W, Lamoree M. 2013. Effects-directed analysis (EDA) and toxicity identification evaluation (TIE): complementary but different approaches for diagnosing causes of environmental toxicity. Environ Toxicol Chem 32:1935-1945.
14. Burton GA Jr, Basu N, Ellis BR, Kapo KE, Entrekin S, Nadelhoffer K. 2014. Hydraulic "fracking": are surface water impacts an ecological concern? Environ Toxicol Chem 33:1679-1689.
15. Campbell CG, Borglin SE, Green FB, Grayson A, Wozei E, Stringfellow WT. 2006. Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: a review. Chemosphere 65:1265-1280.
16. Cargouët M, Perdiz D, Mouatassim-Souali A, TamisierKarolak S, Levi Y. 2004. Assessment of river contamination by estrogenic compounds in Paris area (France). Sci Total Environ 324:55-66.
17. Clean Water Act of 1972. 1972. Public Law 92-500.
18. Colborn T, Kwiatkowski C, Schultz K, Bachran M. 2011. Natural gas operations from a public health perspective. Hum Ecol Risk Assess 17:1039-1056.
19. Colborn T, Schultz K, Herrick L, Kwiatkowski C. 2014. An exploratory study of air quality near natural gas operations. Hum Ecol Risk Assess 20:86-105.
20. Cordier S, Bergeret A, Goujard J, Ha MC, Aymé S, Bianchi F, et al. 1997. Congenital malformation and maternal occupational exposure to glycol ethers. Occupational Exposure and Congenital Malformations Working Group. Epidemiology 8:355-363.
21. Darrah TH, Vengosh A, Jackson RB, Warner NR, Poreda RJ. 2014. Noble gases identify the mechanisms of fugitive gas contamination in drinkingwater wells overlying the Marcellus and Barnett Shales. Proc Natl Acad Sci USA 111:14076-14081.
22. Deutch J, Holditch S, Krupp F, McGinty K, Tierney S, Yergin D, et al. 2011. The Secretary of the Energy Board Shale Gas Production Subcommittee Ninety Day Report. Washington, DC:U.S. Department of Energy. Available: http://energy.gov/sites/ prod/files/Final_90_day_Report.pdf [accessed 25 February 2015].
23. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. 2009. Endocrinedisrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30:293-342.
24. DiGiulio DC, Wilkin RT, Miller C, Oberley G. 2011. Draft Investigation of Ground Water Contamination near Pavillion, Wyoming. EPA 600/R-00/000. Ada, OK:U.S. Environmental Protection Agency, Office of Research and Development, National Risk Mangement Reserch Laboratory. Available: http:// www.epa.gov/sites/production/files/documents/ EPA_ReportOnPavillion_Dec-8-2011.pdf [accessed 25 February 2015].
25. Eastern Research Group/Sage Environmental Consulting. 2011. City of Fort Worth Natural Gas Air Quality Study. Final Report. Available: http:// fortworthtexas.gov/uploadedFiles/Gas_Wells/ AirQualityStudy_final.pdf [accessed 1 July 2015].
26. Esswein EJ, Breitenstein M, Snawder J, Kiefer M, Sieber WK. 2013. Occupational exposures to respirable crystalline silica during hydraulic fracturing. J Occup Environ Hyg 10:347-356.
27. Esswein EJ, Snawder J, King B, Breitenstein M, Alexander-Scott M, Kiefer M. 2014. Evaluation of some potential chemical exposure risks during flowback operations in unconventional oil and gas extraction: preliminary results. J Occup Environ Hyg 11:D174-D184.
28. Ethridge S. 2010. Texas Commission on Environmental Quality Interoffice Memorandum to Mark R. Vickery, P.G. Health Effects Review of Barnett Shale Formation Area Monitoring Projects, including Phase I (August 24-28, 2009), Phase II (October 9-16, 2009), and Phase III (November 16-20, 2009): Volatile Organic Compound (VOCs), Reduced Sulfur Compounds (RSC), Oxides of Nitrogen (NOx), and Infrared (IR) Camera Monitoring, Document No. BS0912-FR. Available: http://www.tceq.state. tx.us/assets/public/implementation/barnett_ shale/2010.01.27-healthEffects-BarnettShale.pdf [accessed 4 July 2015].
29. Ferrar KJ, Kriesky J, Christen CL, Marshall LP, Malone SL, Sharma RK, et al. 2013a. Assessment and longitudinal analysis of health impacts and stressors perceived to result from unconventional shale gas development in the Marcellus Shale region. Int J Occup Environ Health 19:104-112.
30. Ferrar KJ, Michanowicz DR, Christen CL, Mulcahy N, Malone SL, Sharma RK. 2013b. Assessment of effluent contaminants from three facilities discharging Marcellus Shale wastewater to surface waters in Pennsylvania. Environ Sci Technol 47:3472-3481.
31. Ferrer I, Thurman EM. 2015. Chemical constituents and analytical approaches for hydraulic fracturing waters. Trends Environ Anal Chem 5:18-25.
32. Filer D, Patisaul HB, Schug T, Reif D, Thayer K. 2014. Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II. Curr Opin Pharmacol 19:145-152.
33. Fontenot BE, Hunt LR, Hildenbrand ZL, Carlton DD Jr, Oka H, Walton JL, et al. 2013. An evaluation of water quality in private drinking water wells near natural gas extraction sites in the Barnett Shale formation. Environ Sci Technol 47:10032-10040.
34. Fryzek J, Pastula S, Jiang X, Garabrant DH. 2013. Childhood cancer incidence in Pennsylvania counties in relation to living in counties with hydraulic fracturing sites. J Occup Environ Med 55:796-801.
35. Gauger KJ, Giera S, Sharlin DS, Bansal R, Iannacone E, Zoeller RT. 2007. Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ Health Perspect 115:1623-1630; doi:10.1289/ehp.10328.
36. Gayrard V, Lacroix MZ, Collet SH, Viguié C, BousquetMelou A, Toutain PL, et al. 2013. High bioavailability of bisphenol A from sublingual exposure. Environ Health Perspect 121:951-956; doi:10.1289/ ehp.1206339.
37. Gilmore KR, Hupp RL, Glathar J. 2014. Transport of hydraulic fracturing water and wastes in the Susquehanna River Basin, Pennsylvania. J Environ Eng (New York) 140: B4013002; doi:10.1061/(ASCE) EE.1943-7870.0000810.
38. Grant CJ, Weimer AB, Marks NK, Perow ES, Oster JM, Brubaker KM, et al. 2015. Marcellus and mercury: assessing potential impacts of unconventional natural gas extraction on aquatic ecosystems in northwestern Pennsylvania. J Environ Sci Health A Tox Hazard Subst Environ Eng 50:482-500.
39. Gross SA, Avens HJ, Banducci AM, Sahmel J, Panko JM, Tvermoes BE. 2013. Analysis of BTEX groundwater concentrations from surface spills associated with hydraulic fracturing operations. J Air Waste Manag Assoc 63:424-432.
40. Hansen BH, Altin D, Vang SH, Nordtug T, Olsen AJ. 2008. Effects of naphthalene on gene transcription in Calanus finmarchicus(Crustacea: Copepoda). Aquat Toxicol 86:157-165.
41. Harkness JS, Dwyer GS, Warner NR, Parker KM, Mitch WA, Vengosh A. 2015. Iodide, bromide, and ammonium in hydraulic fracturing and oil and gas wastewaters: environmental implications. Environ Sci Technol 49:1955-1963.
42. Harvey TG, Matheson TW, Pratt KC. 1984. Chemical class separation of organics in shale oil by thinlayer chromatography. Anal Chem 56:1277-1281.
43. Hauser R, Skakkebaek NE, Hass U, Toppari J, Juul A, Andersson AM, et al. 2015. Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100:1267-1277.
44. He Y, Wiseman SB, Hecker M, Zhang X, Wang N, Perez LA, et al. 2011. Effect of ozonation on the estrogenicity and androgenicity of oil sands processaffected water. Environ Sci Technol 45:6268-6274.
45. Helmig D, Thompson CR, Evans J, Boylan P, Hueber J, Park JH. 2014. Highly elevated atmospheric levels of volatile organic compounds in the Uintah Basin, Utah. Environ Sci Technol 48:4707-4715.
46. Hormann AM, vom Saal FS, Nagel SC, Stahlhut RW, Moyer CL, Ellersieck MR, et al. 2014. Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioative and urine total levels of bisphenol A (BPA). PloS One 9:e110509; doi:10.1371/journal.pone.0110509.
47. Hunt A, Ferguson J. 2014. Health Costs in the European Union: How Much is Related to EDCs? Health and Environment Alliance (HEAL). Available: http:// env-health.org/IMG/pdf/18062014_final_health_ costs_in_the_european_union_how_much_is_ realted_to_edcs-2.pdf [accessed 25 February 2015].
48. Ingraffea AR, Wells MT, Santoro RL, Shonkoff SB. 2014. Assessment and risk analysis of casing and cement impairment in oil and gas wells in Pennsylvania, 2000-2012. Proc Natl Acad Sci USA 111:10955-10960.
49. Jackson RB, Vengosh A, Darrah TH, Warner NR, Down A, Poreda RJ, et al. 2013. Increased stray gas abundance in a subset of drinking water wells near Marcellus shale gas extraction. Proc Natl Acad Sci USA 110:11250-11255.
50. Kahrilas GA, Blotevogel J, Stewart PS, Borch T. 2015. Biocides in hydraulic fracturing fluids: a critical review of their usage, mobility, degradation, and toxicity. Environ Sci Technol 49:16-32.
51. Kassotis CD, Tillitt DE, Davis JW, Hormann AM, Nagel SC. 2014. Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region. Endocrinology 155:897-907.
52. Kell S. 2011. State Oil and Gas Agency Groundwater Investigations and their Role in Advancing Regulatory Reforms. A Two-State Review: Ohio and Texas. Groundwater Protection Council. Available: https://fracfocus.org/sites/default/files/ publications/state_oil__gas_agency_groundwater_ investigations_optimized.pdf [accessed 25 February 2015].
53. Knag AC, Verhaegen S, Ropstad E, Mayer I, Meier S. 2013. Effects of polar oil related hydrocarbons on steroidogenesis in vitroin H295R cells. Chemosphere 92:106-115.
54. Kortenkamp A, Scholze M, Ermler S. 2014. Mind the gap: can we explain declining male reproductive health with known antiandrogens? Reproduction 147:515-527.
55. Lee DS, Herman JD, Elsworth D, Kim HT, Lee HS. 2011. A critical evaluation of unconventional gas recovery from the Marcellus shale, northeastern United States. KSCE J Civil Eng15:679-687.
56. Legler J, Fletcher T, Govarts E, Porta M, Blumberg B, Heindel JJ, et al. 2015. Obesity, diabetes, and associated costs of exposure to endocrinedisrupting chemicals in the European Union. J Clin Endocrinol Metab 100:1278-1288.
57. Lester Y, Ferrer I, Thurman EM, Sitterley KA, Korak JA, Aiken G, et al. 2015. Characterization of hydraulic fracturing flowback water in Colorado: implications for water treatment. Sci Total Environ 512-513:637-644.
58. Leusch FD, de Jager C, Levi Y, Lim R, Puijker L, Sacher F, et al. 2010. Comparison of five in vitro bioassays to measure estrogenic activity in environmental waters. Environ Sci Technol 44:3853-3860.
59. Li H, Carlson KH. 2014. Distribution and origin of groundwater methane in the Wattenberg oil and gas field of northern Colorado. Environ Sci Technol 48:1484-1491.
60. Liscio C, Abdul-Sada A, Al-Salhi R, Ramsey MH, Hill EM. 2014. Methodology for profiling antiandrogen mixtures in river water using multiple passive samplers and bioassay-directed analyses. Water Res 57:258-269.
61. Macey GP, Breech R, Chernaik M, Cox C, Larson D, Thomas D, et al. 2014. Air concentrations of volatile compounds near oil and gas production: a community-based exploratory study. Environ Health 13:82; doi:10.1186/1476-069X-13-82.
62. Maguire-Boyle SJ, Barron AR. 2014. Organic compounds in produced waters from shale gas wells. Environ Sci Process Impacts 16:2237-2248.
63. Markowitz JS, Donovan JL, DeVane CL, Taylor RM, Ruan Y, Wang JS, et al. 2003. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 290:1500-1504.
64. Maule AL, Makey CM, Benson EB, Burrows IJ, Scammell MK. 2013. Disclosure of hydraulic fracturing fluid chemical additives: analysis of regulations. New Solut 23:167-187.
65. Mauter MS, Alvarez PJ, Burton A, Cafaro DC, Chen W, Gregory KB, et al. 2014. Regional variation in water-related impacts of shale gas development and implications for emerging international plays. Environ Sci Technol 45:8298-8306.
66. McKenzie LM, Guo R, Witter RZ, Savitz DA, Newman LS, Adgate JL. 2014. Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ Health Perspect 122:412-417; doi:10.1289/ehp.1306722.
67. McKenzie LM, Witter RZ, Newman LS, Adgate JL. 2012. Human health risk assessment of air emissions from development of unconventional natural gas resources. Sci Total Environ 424:79-87.
68. Mokry BJ. 2010. Summary of Investigation into the Occurrence of Cancer, Zip Codes 75022 and 75028, Flower Mound, Denton County, Texas, 1998-2007, 2007-2009. Department of State Health Services Texas Cancer Registry. Available: https:// www.dshs.state.tx.us/epitox/consults/flower_ mound32010.doc [accessed 27 February 2015].
69. Moore CW, Zielinska B, Pétron G, Jackson RB. 2014. Air impacts of increased natural gas acquisition, processing, and use: a critical review. Environ Sci Technol 48:8349-8359.
70. Naylor LH. 1999. Reporter gene technology: the future looks bright. Biochem Pharmacol 58:749-757.
71. Nishihara T, Nishikawa JI, Kanayama T, Dakeyama F, Saito K, Imagawa M, et al. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J Health Sci 46:282-298.
72. Olsson IM. 2014. The Cost of Inaction-A Socioeconomic Analysis of Costs Linked to Effects of Endocrine Disrupting Substances on Male Reproductive Health. Copenhagaen, Denmark:Nordic Council of Ministers. Available: http://norden.diva-portal.org/smash/get/ diva2:763442/FULLTEXT04.pdf [accessed 21 February 2015].
73. Orem W, Tatu C, Varonka M, Lerch H, Bates A, Engle M, et al. 2014. Organic substances in produced and formation water from unconventional natural gas extraction in coal and shale. Int J Coal Geol 126:20-31.
74. Orton F, Rosivatz E, Scholze M, Kortenkamp A. 2012. Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides. Environ Health Perspect 120:1578-1584; doi:10.1289/ehp.1205391.
75. Osborn SG, Vengosh A, Warner NR, Jackson RB. 2011. Methane contamination of drinking water accompanying gas-well drilling and hydraulic fracturing. Proc Natl Acad Sci USA 108:8172-8176; doi:10.1073/pnas.1100682108.
76. Papoulias DM, Velasco AL. 2013. Histopathological analysis of fish from Acorn Fork Creek, Kentucky, exposed to hydraulic fracturing fluid releases. Southeast Nat 12:92-111.
77. Payne J, Rajapakse N, Wilkins M, Kortenkamp A. 2000. Prediction and assessment of the effects of mixtures of four xenoestrogens. Environ Health Perspect 108:983-987.
78. Pollino CA, Georgiades E, Holdway DA. 2009. Physiological changes in reproductively active rainbowfish (Melanotaenia fluviatilis) following exposure to naphthalene. Ecotoxicol Environ Saf 72:1265-1270.
79. Rabinowitz PM, Slizovskiy IB, Lamers V, Trufan SJ, Holford TR, Dziura JD, et al. 2015. Proximity to natural gas wells and reported health status: results of a household survey in Washington County, Pennsylvania. Environ Health Perspect 123:21-26; doi:10.1289/ehp.1307732.
80. Rajapakse N, Silva E, Kortenkamp A. 2002. Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. Environ Health Perspect 110:917-921.
81. Richter CA, Martyniuk CJ, Annis ML, Brumbaugh WG, Chasar LC, Denslow ND, et al. 2014. Methylmercuryinduced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides). Gen Comp Endocrinol 203:215-224.
82. Riedl J, Rotter S, Faetsch S, Schmitt-Jansen M, Altenburger R. 2013. Proposal for applying a component-based mixture approach for ecotoxicological assessment of fracturing fluids. Environ Earth Sci 70:3907-3920.
83. Rostkowski P, Horwood J, Shears JA, Lange A, Oladapo FO, Besselink HT, et al. 2011. Bioassay-directed identification of novel antiandrogenic compounds in bile of fish exposed to wastewater effluents. Environ Sci Technol 45:10660-10667.
84. Roy AA, Adams PJ, Robinson AL. 2014. Air pollutant emissions from the development, production, and processing of Marcellus Shale natural gas. J Air Waste Manag Assoc 64:19-37.
85. Rozell DJ, Reaven SJ. 2012. Water pollution risk associated with natural gas extraction from the Marcellus Shale. Risk Anal 32:1382-1393.
86. Safe Drinking Water Act of 1974. 1974. Public Law 93-523.
87. Schaeffer E, Bernhardt C. 2014. Fracking's Toxic Loophole. Thanks to the "Halliburton Loophole," Hydraulic Fracturing Companies Are Injecting Chemicals More Toxic than Diesel. Environmental Integrity Project. Available: http://environmentalintegrity.org/ wp-content/uploads/FRACKINGS-TOXIC-LOOPHOLE. pdf [accessed 25 February 2015].
88. Schriks M, van Leerdam JA, van der Linden SC, van der Burg B, van Wezel AP, de Voogt P. 2010. High-resolution mass spectrometric identification and quantification of glucocorticoid compounds in various wastewaters in the Netherlands. Environ Sci Technol 44:4766-4774.
89. Schug TT, Abagyan R, Blumberg B, Collins TJ, Crews D, DeFur PL, et al. 2013. Designing endocrine disruption out of the next generation of chemicals. Green Chem 15:181-198.
90. Shonkoff SB, Hays J, Finkel ML. 2014. Environmental public health dimensions of shale and tight gas development. Environ Health Perspect 122:787-795; doi:10.1289/ehp.1307866.
91. Silva E, Rajapakse N, Kortenkamp A. 2002. Something from "nothing"-eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36:1751-1756.
92. Slizovskiy IB, Conti LA, Trufan SJ, Reif JS, Lamers VT, Stowe MH, et al. 2015. Reported health conditions in animals residing near natural gas wells in southwestern Pennsylvania. J Environ Sci Health A Tox Hazard Subst Environ Eng 50:473-481.
93. Soraghan M. 2014. Oil and Gas: Spills up 17 Percent in U.S. in 2013. EnergyWire (Washington, DC) 12 May. Available: http://www.eenews.net/ stories/1059999364 [accessed 25 February 2015].
94. Soto AM, Maffini MV, Schaeberle CM, Sonnenschein C. 2006. Strengths and weaknesses of in vitroassays for estrogenic and androgenic activity. Best Pract Res Clin Endocrinol Metab 20:15-33.
95. Souther S, Tingley MW, Popescu VD, Hayman DT, Ryan ME, Graves TA, et al. 2014. Biotic impacts of energy development from shale: research priorities and knowledge gaps. Front Ecol Environ 12:330-338.
96. Stacy SL, Brink LL, Larkin JC, Sadovsky Y, Goldstein BD, Pitt BR, et al. 2015. Perinatal outcomes and unconventional natural gas operations in Southwest Pennsylvania. PloS One 10:e0126425; doi:10.1371/ journal.pone.0126425.
97. Steinzor N, Subra W, Sumi L. 2013. Investigating links between shale gas development and health impacts through a community survey project in Pennsylvania. New Solut 23:55-83.
98. Subra W. 2009. Health Survey Results of Current and Former Dish/Clark, Texas Residents. Washington, DC:Earthworks' Oil and Gas Accountability Project. Available: https://www.earthworksaction. org/files/publications/DishTXHealthSurvey_ FINAL_hi.pdf [accessed 22 July 2015].
99. Subra W. 2010. Community Health Survey Results: Pavillion, Wyoming. Washington, DC:Earthworks' Oil and Gas Accountability Project. Available: https://www.earthworksaction.org/files/ publications/PavillionFINALhealthSurvey-201008. pdf [accessed 22 July 2015].
100. Sun Q, Deng S, Huang J, Shen G, Yu G. 2008. Contributors to estrogenic activity in wastewater from a large wastewater treatment plant in Beijing, China. Environ Toxicol Pharmacol 25:20-26.
101. Thomas KV, Balaam J, Hurst MR, Thain JE. 2004. Identification of in vitro estrogen and androgen receptor agonists in North Sea offshore produced water discharges. Environ Toxicol Chem 23:1156-1163.
102. Thomas KV, Langford K, Petersen K, Smith AJ, Tollefsen KE. 2009. Effect-directed identification of naphthenic acids as important in vitro xeno-estrogens and anti-androgens in North Sea offshore produced water discharges. Environ Sci Technol 43:8066-8071.
103. Thomas P, Budiantara L. 1995. Reproductive life history stages sensitive to oil and naphthalene in Atlantic croaker. Mar Environ Res 39:147-150.
104. Thurman EM, Ferrer I, Blotevogel J, Borch T. 2014. Analysis of hydraulic fracturing flowback and produced waters using accurate mass: identification of ethoxylated surfactants. Anal Chem 86:9653-9661.
105. Tice RR, Austin CP, Kavlock RJ, Bucher JR. 2013. Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect 121:756-765; doi:10.1289/ehp.1205784.
106. Tintos A, Gesto M, Alvarez R, Miguez JM, Soengas JL. 2006. Interactive effects of naphthalene treatment and the onset of vitellogenesis on energy metabolism in liver and gonad, and plasma steroid hormones of rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol C Toxicol Pharmacol 144:155-165.
107. Tollefsen KE, Harman C, Smith A, Thomas KV. 2007. Estrogen receptor (ER) agonists and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production platforms. Mar Pollut Bull 54:277-283.
108. Trasande L. 2014. Further limiting bisphenol A in food uses could provide health and economic benefits. Health Aff (Millwood) 33:316-323.
109. Trasande L, Zoeller RT, Hass U, Kortenkamp A, Grandjean P, Myers JP, et al. 2015. Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100:1245-1255.
110. Trimble DC. 2012. Unconventional Oil and Gas Development: Key Environmental and Public Health Requirements. U.S. Government Accountability Office. GAO-12-874. Available: http://www.gao.gov/products/GAO-12-874 [accessed 25 February 2015].
111. U.S. EPA (U.S. Environmental Protection Agency). 2009a. Endocrine Disruptor Screening Program Test Guidelines-OPPTS 890.1100: Amphibian Metamorphosis (Frog). EPA 740-C-09-002. Available: http://www. regulations.gov/#!documentDetail;D=EPA-HQOPPT-2009-0576-0002 [accessed 15 July 2015].
112. U.S. EPA. 2009b. Endocrine Disruptor Screening Program Test Guidelines-OPPTS 890.1350: Fish Short-Term Reproduction Assay. EPA 740-C-09-007. Available: http://www. regulations.gov/#!documentDetail;D=EPA-HQOPPT-2009-0576-0007 [accessed 15 July 2015].
113. U.S. EPA. 2009c. Endocrine Disruptor Screening Program Test Guidelines-OPPTS 890.1500: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Male Rats. EPA 740-C-09-012. Available: http://www. regulations.gov/#!documentDetail;D=EPA-HQOPPT-2009-0576-0010 [accessed 15 July 2015].
114. U.S. EPA. 2015. Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources (External Review Draft). EPA/600/R-15/047. Washington, DC:U.S. EPA. Available: http://cfpub.epa.gov/ncea/hfstudy/ recordisplay.cfm?deid=244651 [accessed 1 August 2015].
115. Vandenberg LN. 2014. Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol A as a case study. Dose Response 12:259-276.
116. Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, et al. 2012. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 33:378-455.
117. Vengosh A, Jackson RB, Warner N, Darrah TH, Kondash A. 2014. A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States. Environ Sci Technol 48:8334-8348.
118. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, et al. 2007. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 24:131-138.
119. vom Saal FS, Welshons WV. 2014. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure. Mol Cell Endocrinol 398:101-113.
120. Warner NR, Christie CA, Jackson RB, Vengosh A. 2013. Impacts of shale gas wastewater disposal on water quality in western Pennsylvania. Environ Sci Technol 47:11849-11857.
121. Warner NR, Darrah TH, Jackson RB, Millot R, Kloppmann W, Vengosh A. 2014. New tracers identify hydraulic fracturing fluids and accidental releases from oil and gas operations. Environ Sci Technol 48:12552-12560.
122. Warner NR, Jackson RB, Darrah TH, Osborn SG, Down A, Zhao K, et al. 2012. Geochemical evidence for possible natural migration of Marcellus Formation brine to shallow aquifers in Pennsylvania. Proc Natl Acad Sci USA 109:11961-11966.
123. Waxman HA, Markey EJ, DeGette D. 2011. Chemicals Used in Hydraulic Fracturing. U.S. House of Representatives. Committee on Energy and Commerce. Minority Staff Report. Available: http://www.conservation.ca.gov/dog/ general_information/Documents/Hydraulic%20 Fracturing%20Report%204%2018%2011.pdf [accessed 25 February 2015].
124. Webb E, Bushkin-Bedient S, Cheng A, Kassotis CD, Balise V, Nagel SC. 2014. Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations. Rev Environ Health 29:307-318.
125. Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM, vom Saal FS. 2003. Large effects from small exposures. I. Mechanisms for endocrinedisrupting chemicals with estrogenic activity. Environ Health Perspect 111:994-1006; doi:10.1289/ ehp.5494.
126. Werner AK, Vink S, Watt K, Jagals P. 2015. Environmental health impacts of unconventional natural gas development: a review of the current strength of evidence. Sci Total Environ 505:1127-1141.
127. Westerhoff P, Yoon Y, Snyder S, Wert E. 2005. Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. Environ Sci Technol 39:6649-6663.
128. Wiseman HJ. 2008. Untested waters: the rise of hydraulic fracturing in oil and gas production and the need to revisit regulation. Fordham Environ Law Rev 20:115-169.
129. Wiseman HJ. 2011. Trade secrets, disclosure, and dissent in a fracturing energy revolution. Columbia Law Rev 111:1-13.
130. Witter R, Stinson K, Sackett H, Putter S, Kinney G, Teitelbaum D, et al. 2008. Potential Exposure-Related Human Health Effects of Oil and Gas Development: A Literature Review (2003-2008). University of Colorado School of Public Health. Available: PDF available: http://docs.nrdc.org/health/files/ hea_08091702b.pdf [accessed 15 July 2015].
131. Wolf Eagle Environmental. 2009. Town of Dish, Texas Ambient Air Monitoring Analysis. Final Report. Available: http://townofdish.com/objects/DISH_-_ final_report_revised.pdf [accessed 22 July 2015].
132. Ziemkiewicz PF, Quaranta JD, Darnell A, Wise R. 2014. Exposure pathways related to shale gas development and procedures for reducing environmental and public risk. J Nat Gas Sci Eng 16:77-84.
133. Zoeller RT, Bergman A, Becher G, Bjerregaard P, Bornman R, Brandt I, et al. 2014. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health 14:118; doi:10.1186/1476-069X-13-118.
134. Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, et al. 2012. Endocrinedisrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology 153:4097-4110.