Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes

Reproductive Toxicology

Volumn 22, Issue 1, 2006, Pages 102-110

  Andric, Nebojsa L ^a   Kostic, Tatjana S ^a   Zoric, Sonja N ^a   Stanic, Bojana D ^a   Andric, Silvana A ^a   Kovacevic, Radmila Z ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

17 HSD; CYP enzymes; EROD; Polychlorinated biphenyls; PROD; Pyralene; Testosterone

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2B1; ETHOXYRESORUFIN DEETHYLASE; LIVER ENZYME; MESSENGER RNA; OIL; PENTOXYRESORUFIN O DEETHYLASE; POLYCHLORINATED BIPHENYL; PROGESTERONE; PYRALENE; TESTOSTERONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANDROGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CONVALESCENCE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; EXPECTATION; GENE DISRUPTION; LIVER CELL; LONG TERM EXPOSURE; MALE; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; RAT; RNA TRANSCRIPTION; STEROIDOGENESIS; TESTIS; XENOBIOTIC METABOLISM;

EID: 33745508184     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.12.002     Document Type: Article

References (43)

1. Hansen L.G. Metabolism and metabolites. The ortho side of PCBs. Occurrence, disposition (1999), Kluwer Academic Publishers, London pp. 81-101
2. Taniyasu S., Kannan K., Holoubek I., Ansorgova A., Horii Y., Hanari N., et al. Isomer-specific analysis of chlorinated biphenyls, naphthalenes and dibenzofurans in Delor: polychlorinated biphenyl preparations from the former Czechoslovakia. Environ Pollut 126 (2003) 169-178
3. Kania-Korwel I., Ludewig G., Robertson L.W., Hornbuckle K.C., Peck A., Espandiari P., et al. Biochemical effects of an environmental Chlorofen mixture in comparison with Aroclor 1254 in rats. Organohalogen Compd 66 (2004) 2985-2992
4. Andric S.A., Kostic T.S., Dragisic S., Andric N.L., Stojilkovic S.S., and Kovacevic R.Z. Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis. Environ Health Perspect 108 (2000) 955-959
5. Andric N.L., Andric S.A., Zoric S.N., Kostic T.S., Stojilkovic S.S., and Kovacevic R.Z. Parallelism and dissociation in the action of an Aroclor 1260-based transformer fluid on testicular steroidogenesis and antioxidant enzymes. Toxicology 194 (2003) 65-75
6. Bandiera S.M. Cytochrome P450 enzymes as biomarkers of PCB exposure and modulation of toxicity. In: Robertson P.L.W., and Hansen L.G. (Eds). Recent advances in the environmental toxicology and health effects (2001), The University Press of Kentucky, Kentucky 185-192
7. Heinrich-Hirsch B., Chahoud I., Grote K., Hartmann J., and Mathar W. Tissue distribution, toxicokinetics and induction of hepatic drug metabolizing enzymes in male rats after a single s.c. dose of 3,4,3′,4′-tetrachlorobiphenyls (PCB-77). Chemosphere 34 (1997) 1523-1534
8. Madra S., Mann F., Francis J.E., Manson M.M., and Smith A.G. Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor1254). Toxicol Appl Pharmacol 136 (1996) 79-86
9. Ngui J.S., and Bandiera S.M. Induction of hepatic CYP2B is more sensitive indicator of exposure to Aroclor 1260 than CYP1A in male rats. Toxicol Appl Pharmacol 161 (1999) 160-170
10. Ptak A., Ludewig G., Lehmler H.J., Wojtowicz A.K., Robertson L.W., and Gregoraszczuk E.L. Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture. Reprod Toxicol 20 (2005) 57-64
11. Meerts I.A., Hoving S., van den Berg J.H., Weijers B.M., Swarts H.J., van der Beek E.M., et al. Effects of in utero exposure to 4-hydroxy-2,3,3′,4′,5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. Toxicol Sci 82 (2004) 259-267
12. Lai K.P., Wong M.H., and Wong C.K. Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells. J Endocrinol 185 (2005) 519-527
13. Fukuzawa N.H., Ohsako S., Wu Q., Sakaue M., Fujii-Kuriyama Y., Baba T., et al. Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse. Mol Cell Endocrinol 221 (2004) 87-96
14. Ruangwises S., Bestervelt L.L., Piper D.W., Nolan C.J., and Piper W.N. Human chorionic gonadotropin treatment prevents depressed 17 alpha-hydroxylase/C17-20 lyase activities and serum testosterone concentrations in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats. Biol Reprod 45 (1991) 143-150
15. Roman B.L., Pollenz R.S., and Peterson R.E. Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Ah receptor and ARNT expression, CYP1A1 induction: Ah receptor down regulation. Toxicol Appl Pharmacol 150 (1998) 228-239
16. Mandal P.K., McDaniel L.R., Prough R.A., and Clark B.J. 7,12-Dimethylbenz(a)anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1. Toxicol Appl Pharmacol 175 (2001) 200-208
17. Fukuzawa N.H., Ohsako S., Nagano R., Sakaue M., Baba T., Aoki Y., et al. Effects of 3,3′,4,4′,5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Toxicol In Vitro 17 (2003) 1-11
18. Erickson M.D. Analytical chemistry of PCBs (1997), Lewis Publisher, New York pp. 25-35
19. Bradford M.M. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
20. Kostic T.S., Andric S.A., Maric D., and Kovacevic R.Z. Inhibitory effects of stress-activated nitric oxide on antioxidant enzymes and testicular steroidogenesis. J Steroid Biochem Mol Biol 75 (2000) 299-306
21. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., and Mayer R.T. Ethoxy, pentoxy, and benzyloxyphenoxazones and homologues: a series of substrate to distinguish between different induced cytochromes P450. Biochem Pharmacol 48 (1985) 923-936
22. Seglen P.O. Preparation of rat liver cells. Exp Cells Res 82 (1973) 391-398
23. Kovacevic R., and Sarac M. Bromocryptine-induced inhibition of hydroxylase/lyase activity in adult male rat Leydig cells. J Steroid Biochem Mol Biol 46 (1993) 841-845
24. Dasmahapatra A.K., Wimpee BAB, Trewin A.L., and Hutz R.J. 3,7,8-Tetrachlorodibenzo-p-dioxin increases steady-state estrogen receptor-beta mRNA levels after CYP1A1 and CYP1B1 induction in rat granulosa cells in vitro. Mol Cell Endocrinol 182 (2001) 39-48
25. Toritsuka N., Nonogaki Y., Hori Y., Sawada S., Shoun H., and Motooka S. Well maintained expression of CYP genes in sandwich-culturing hepatocytes: quantitative analysis using real-time PCR method. Res Commun Mol Pathol Pharmacol 110 (2001) 311-318
26. Dasmahapatra A.K., Wimpee B.A.B., Trewin A.L., Wimpe C.F., Ghorai J.K., and Hutz R.J. Demonstration of 2,3,7,8-tetrachlorodibenzo-p-dioxin attenuation of P450 steroidogenic enzyme mRNA in rat granulosa cell in vitro by competitive reverse transcription-polymerase chain reaction assay. Mol Cell Endocrinol 164 (2000) 5-18
27. Sakaue M., Ishimura R., Kurosawa S., Fukazawa N.H., Kurohmaru M., Hayashi Y., et al. Administration of estradiol-3-benzoate down regulates the expression of testicular steroidogenic enzyme genes for testosterone production in the adult rat. J Vet Med Sci 64 (2002) 107-113
28. Kostic T.S., Andric S.A., and Stojilkovic S.S. Spontaneous and receptor-controlled soluble guanylyl cyclase activity in anterior pituitary cells. Mol Endocrinol 15 (2001) 1010-1022
29. Vojinovic-Miloradov M., Adamov J., Sekulic P., Buzarov D., and Jovetic S. POPs after the Kosovo war. Organohalogen Compd 59 (2002) 86-90
30. Frame G.M., Cochran J.W., and Bowadt S.S. Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC system optimized for comprehensive, quantitative, congener-specific analysis. J High Resol Chromatogr 19 (1996) 657-668
31. Kim K.S., Hirai Y., Kato M., Urano K., and Masunaga S. Detailed PCB congener patterns in incinerator flue gas and commercial PCB formulations (Kanechlor). Chemosphere 55 (2004) 539-553
32. Rushneck D.R., Beliveau A., Fowler B., Hamilton C., Hoover D., Kaye K., et al. Concentrations of dioxin-like PCB congeners in unweathered Aroclors by HRGC/HRMS using EPA Method 1668A. Chemosphere 54 (2004) 79-87
33. Akingbemi B.T., Ge R., Klinefelter G.R., Gunsalus G.L., and Hardy M.P. A metabolite of methoxychlor 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat Leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. Biol Reprod 62 (2000) 571-578
34. Akingbemi B.T., Youker R.T., Sottas C.M., Ge R., Katz E., Klinefelter G.R., et al. Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biol Reprod 65 (2001) 1252-1259
35. Akingbemi B.T., Sottas C.M., Koulova A.I., Klinefelter G.R., and Hardy M.P. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145 (2004) 592-603
36. Murugesan P., Kanagaraj P., Yuvaraj S., Balasubramanian K., Aruldhas M.M., and Arunakaran J. The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reprod Toxicol 20 (2005) 117-126
37. Andric S.A., Kostic T.S., Stojilkovic S.S., and Kovacevic R.Z. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248. Biol Reprod 62 (2000) 1882-1888
38. Cooke G.M., Price C.A., and Oko R.J. Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum androgens and steroidogenic enzyme activities in the male reproductive tract. J Steroid Mol Biol 67 (1998) 347-354
39. Laurenzana E.M., Balasubramanian G., Weis C., Blaydes B., Newbold R.R., and Delclos K.B. Effects of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal and adult rats. Chem Biol Interact 139 (2002) 23-41
40. Germolec D.R., Henry E.C., Maronpot R., Foley J.F., Adams N.H., Gasiewicz T.A., et al. Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Toxicol Appl Pharmacol 137 (1996) 57-66
41. Korkalainen M., Tuomisto J., and Pohjanvirta R. Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in TCDD-sensitive and a TCDD-resistent rat strain. Biochem Biophys Res Commun 315 (2004) 123-131
42. Yamamoto J., Ihara K., Nakayama H., Hikino S., Satoh K., Kubo N., et al. Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells. Life Sci 74 (2004) 1039-1049
43. Hilscherova K., Jones P.D., Gracia T., Newsted J.L., Zhang X., Sanderson J.T., et al. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol Sci 81 (2004) 78-89