IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 1, 2016, Pages 200-209.e8

  Humblet Baron, Stéphanie ^a,b   Franckaert, Dean ^a,b   Dooley, James ^a,b   Bornschein, Simon ^a,b   Cauwe, Bénédicte ^a,b   Schönefeldt, Susann ^a,b   Bossuyt, Xavier ^b,d   Matthys, Patrick ^c   Baron, Frédéric ^e   Wouters, Carine ^b,d   Liston, Adrian ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

familial hemophagocytic lymphohistiocytosis; IL 2; immune homeostasis; lymphocytic choriomeningitis virus; perforin; Regulatory T cells

Indexed keywords

CD103 ANTIGEN; CD69 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; PERFORIN; STAT5 PROTEIN;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARENAVIRUS INFECTION; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HEMOPHAGOCYTIC SYNDROME; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MONOCYTE; MOUSE; NEGATIVE FEEDBACK; NEUTROPHIL COUNT; NONHUMAN; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRAL CLEARANCE; YOUNG ADULT; ANIMAL; DISEASE MODEL; GENETICS; HOMEOSTASIS; IMMUNOLOGY; IMMUNOMODULATION; KNOCKOUT MOUSE; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; METABOLISM; PHYSIOLOGY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; HOMEOSTASIS; HUMANS; IMMUNOMODULATION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MICE; MICE, KNOCKOUT; PERFORIN; T-LYMPHOCYTES, REGULATORY;

EID: 84959278184     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.12.1314     Document Type: Article

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