Immune tolerance: Are regulatory T cell subsets needed to explain suppression of autoimmunity?

BioEssays

Volumn 34, Issue 7, 2012, Pages 569-575

  Tian, Lei ^a   Humblet Baron, Stephanie ^a,b   Liston, Adrian ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Autoimmunity; Chemokines; Foxp3; Regulatory T cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERFERON REGULATORY FACTOR 4; PROTEIN BCL 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; AUTOIMMUNITY; CELL MIGRATION; EFFECTOR CELL; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MICROENVIRONMENT; NONHUMAN; PARSIMONY ANALYSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; AUTOIMMUNITY; CELL LINEAGE; CELL MOVEMENT; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; INTERFERON REGULATORY FACTORS; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION, GENETIC;

EID: 84862336315     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201100180     Document Type: Article

References (44)

1. Sakaguchi S, Wing K, Miyara M. 2007. Regulatory T cells - a brief history and perspective. Eur J Immunol 37: S116- 23.
2. Shevach EM. 2009. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30: 636- 45.
3. Chaudhry A, Rudra D, Treuting P, Samstein RM, et al. 2009. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326: 986- 91.
4. Chung Y, Tanaka S, Chu F, Nurieva RI, et al. 2011. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17: 983- 8.
5. Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, et al. 2009. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10: 595- 602.
6. Linterman MA, Pierson W, Lee SK, Kallies A, et al. 2011. Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17: 975- 82.
7. Zheng Y, Chaudhry A, Kas A, deRoos P, et al. 2009. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458: 351- 6.
8. Tian L, Altin JA, Makaroff LE, Franckaert D, et al. 2011. Foxp3 regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood 118: 1845- 53.
9. Zhu J, Paul WE. 2010. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev 238: 247- 62.
10. Vinuesa CG, Cyster JG. 2011. How T cells earn the follicular rite of passage. Immunity 35: 671- 80.
11. Breitfeld D, Ohl L, Kremmer E, Ellwart J, et al. 2000. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545- 52.
12. Chtanova T, Tangye SG, Newton R, Frank N, et al. 2004. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 173: 68- 78.
13. Schaerli P, Willimann K, Lang AB, Lipp M, et al. 2000. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192: 1553- 62.
14. Lim HW, Hillsamer P, Kim CH. 2004. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest 114: 1640- 9.
15. Alexander CM, Tygrett LT, Boyden AW, Wolniak KL, et al. 2011. T regulatory cells participate in the control of germinal centre reactions. Immunology 133: 452- 68.
16. Wollenberg I, Agua-Doce A, Hernandez A, Almeida C, et al. 2011. Regulation of the germinal center reaction by foxp3+ follicular regulatory T cells. J Immunol 187: 4553- 60.
17. Szabo SJ, Kim ST, Costa GL, Zhang X, et al. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655- 69.
18. Lord GM, Rao RM, Choe H, Sullivan BM, et al. 2005. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106: 3432- 9.
19. Erhardt A, Wegscheid C, Claass B, Carambia A, et al. 2011. CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis. J Immunol 186: 5284- 93.
20. Oo YH, Weston CJ, Lalor PF, Curbishley SM, et al. 2010. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol 184: 2886- 98.
21. Hasegawa H, Inoue A, Kohno M, Lei J, et al. 2008. Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Gene Ther 15: 171- 82.
22. Lu LF, Boldin MP, Chaudhry A, Lin LL, et al. 2010. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142: 914- 29.
23. Takahashi R, Nishimoto S, Muto G, Sekiya T, et al. 2011. SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production. J Exp Med 208: 2055- 67.
24. Oldenhove G, Bouladoux N, Wohlfert EA, Hall JA, et al. 2009. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31: 772- 86.
25. Zheng J, Liu Y, Qin G, Lam KT, et al. 2011. Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway. Eur J Immunol 41: 128- 39.
26. Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, et al. 2011. GATA3 controls Foxp3 regulatory T cell fate during inflammation in mice. J Clin Invest 121: 4503- 15.
27. Lohoff M, Mittrucker HW, Prechtl S, Bischof S, et al. 2002. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci USA 99: 11808- 12.
28. Rengarajan J, Mowen KA, McBride KD, Smith ED, et al. 2002. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 195: 1003- 12.
29. Brustle A, Heink S, Huber M, Rosenplanter C, et al. 2007. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 8: 958- 66.
30. Soler D, Chapman TR, Poisson LR, Wang L, et al. 2006. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol 177: 6940- 51.
31. Cretney E, Xin A, Shi W, Minnich M, et al. 2011. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol 12: 304- 11.
32. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, et al. 2008. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322: 271- 5.
33. Cote-Sierra J, Foucras G, Guo L, Chiodetti L, et al. 2004. Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci USA 101: 3880- 5.
34. Singh N, Chandler PR, Seki Y, Baban B, et al. 2007. Role of CD28 in fatal autoimmune disorder in scurfy mice. Blood 110: 1199- 206.
35. Nasta F, Corinti S, Bonura A, Colombo P, et al. 2007. CTLA-4 regulates allergen response by modulating GATA-3 protein level per cell. Immunology 121: 62- 70.
36. Bettelli E, Korn T, Oukka M, Kuchroo VK. 2008. Induction and effector functions of T(H)17 cells. Nature 453: 1051- 7.
37. Wang C, Kang SG, Lee J, Sun Z, et al. 2009. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol 2: 173- 83.
38. Yamazaki T, Yang XO, Chung Y, Fukunaga A, et al. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181: 8391- 401.
39. Turner JE, Paust HJ, Steinmetz OM, Peters A, et al. 2010. CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 21: 974- 85.
40. Kitamura K, Farber JM, Kelsall BL. 2010. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype. J Immunol 185: 3295- 304.
41. Chaudhry A, Samstein RM, Treuting P, Liang Y, et al. 2011. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 34: 566- 78.
42. Maynard CL, Harrington LE, Janowski KM, Oliver JR, et al. 2007. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol 8: 931- 41.
43. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, et al. 2008. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28: 546- 58.
44. Huber S, Gagliani N, Esplugues E, O'Connor W, Jr, et al. 2011. Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34: 554- 65.