Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

Journal of Clinical Investigation

Volumn 117, Issue 2, 2007, Pages 407-418

  Humblet Baron, Stephanie ^a,b   Sather, Blythe ^a,c   Anover, Stephanie ^a   Becker Herman, Shirly ^a   Kasprowicz, Debora J ^c   Khim, Socheath ^a   Nguyen, Thuc ^a   Hudkins Loya, Kelly ^a   Alpers, Charles E ^a   Ziegler, Steve F ^a,c   Ochs, Hans ^a   Torgerson, Troy ^a   Campbell, Daniel J ^a,c   Rawlings, David J ^a,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c BENAROYA RESEARCH INSTITUTE   (United States)

^d SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; TRANSCRIPTION FACTOR FOXP3; WISKOTT ALDRICH SYNDROME PROTEIN;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL HOMING; CLINICAL OBSERVATION; CONTROLLED STUDY; DOWN REGULATION; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOPATHOLOGY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WISKOTT ALDRICH SYNDROME;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; CELL DIFFERENTIATION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HOMEOSTASIS; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MUTATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 33846850600     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI29539     Document Type: Article

References (35)

1. Sullivan, K.E., Mullen, C.A., Blaese, R.M., and Winkelstein, J.A. 1994. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J. Pediatr. 125:876-885.
2. Thrasher, A.J. 2002. WASp in immune-system organization and function. Nat. Rev. Immunol. 2:635-646.
3. Imai, K., et al. 2004. Clinical course of patients with WASP gene mutations. Blood. 103:456-464.
4. Dupuis-Girod, S., et al. 2003. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics. 111:e622-e627.
5. Burns, S., Cory, G.O., Vainchenker, W., and Thrasher, A.J. 2004. Mechanisms of WASp-mediated hematologic and immunologic disease. Blood. 104:3454-3462.
6. Schurman, S.H., and Candotti, F. 2003. Autoimmunity in Wiskott-Aldrich syndrome. Curr. Opin. Rheumatol. 15:446-453.
7. Fontenot, J.D., Gavin, M.A., and Rudensky, A.Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
8. Sakaguchi, S., and Sakaguchi, N. 2005. Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int. Rev. Immunol. 24:211-226.
9. Snapper, S.B., et al. 1998. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 9:81-91.
10. Zhang, J., et al. 1999. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190:1329-1342.
11. Strom, T.S., Li, X., Cunningham, J.M., and Nienhuis, A.W. 2002. Correction of the murine Wiskott-Aldrich syndrome phenotype by hematopoietic stem cell transplantation. Blood. 99:4626-4628.
12. Borchers, A., Ansari, A.A., Hsu, T., Kono, D.H., and Gershwin, M.E. 2000. The pathogenesis of autoimmunity in New Zealand mice. Semin. Arthritis Rheum. 29:385-399.
13. Lacout, C., et al. 2003. A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. Blood. 102:1282-1289.
14. Setoguchi, R., Hori, S., Takahashi, T., and Sakaguchi, S. 2005. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723-735.
15. Fisson, S., et al. 2003. Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J. Exp. Med. 198:737-746.
16. Huehn, J., and Hamann, A. 2005. Homing to suppress: address codes for Treg migration. Trends Immunol. 26:632-636.
17. Lehmann, J., et al. 2002. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc. Natl. Acad. Sci. U. S. A. 99:13031-13036.
18. Huehn, J., et al. 2004. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J. Exp. Med. 199:303-313.
19. Siegmund, K., et al. 2005. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood. 106:3097-3104.
20. Suffia, I., Reckling, S.K., Salay, G., and Belkaid, Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J. Immunol. 174:5444-5455.
21. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., and Rudensky, A.Y. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6:1142-1151.
22. Salomon, B., et al. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:431-440.
23. Sakaguchi, S. 2004. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531-562.
24. Snapper, S.B., et al. 2005. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J. Leukoc. Biol. 77:993-998.
25. Westerberg, L., et al. 2005. Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. Blood. 105:1144-1152.
26. Lim, H.W., Hillsamer, P., Banham, A.H., and Kim, C.H. 2005. Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J. Immunol. 175:4180-4183.
27. Bystry, R.S., Aluvihare, V., Welch, K.A., Kallikourdis, M., and Betz, A.G. 2001. B cells and professional APCs recruit regulatory T cells via CCL4. Nat. Immunol. 2:1126-1132.
28. Fields, M.L., et al. 2005. CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response. J. Immunol. 175:4255-4264.
29. Wada, T., et al. 2001. Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc. Natl. Acad. Sci. U. S. A. 98:8697-8702.
30. Ariga, T., et al. 2001. Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome. J. Immunol. 166:5245-5249.
31. Wada, T., et al. 2004. Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family. Blood. 104:1270-1272.
32. Zhou, B., et al. 2005. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6:1047-1053.
33. Knibbs, R.N., et al. 1998. Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts. J. Immunol. 161:6305-6315.
34. Zhu, Q., et al. 1997. Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype. Blood. 90:2680-2689.
35. Taneda, S., et al. 2001. Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice. Am. J. Pathol. 159:2355-2369.