The role of adiponectin in cardiometabolic diseases: Effects of nutritional interventions

Journal of Nutrition

Volumn 146, Issue 2, 2016, Pages 422S-426S

  Lopez Jaramillo, Patricio ^a  

^a UNIVERSIDAD DE SANTANDER   (Colombia)

Author keywords

Adiponectin; Aged garlic extract; Cardiovascular disease; Diabetes mellitus; Metabolic syndrome; Nutritional interventions; Visceral fat

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CANOLA OIL; DOCOSAHEXAENOIC ACID; GARLIC EXTRACT; GLUCOKINASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; OMEGA 3 FATTY ACID; ADIPOQ PROTEIN, HUMAN; PLANT EXTRACT;

ABDOMINAL OBESITY; ADIPOCYTE; ALCOHOL CONSUMPTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY FAT DISTRIBUTION; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CORONARY ARTERY DISEASE; CORONARY RISK; DIABETIC PATIENT; DIET THERAPY; END STAGE RENAL DISEASE; ETHNIC DIFFERENCE; GENETIC REGULATION; GLUCONEOGENESIS; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HORMONE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOADIPONECTINEMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MALNUTRITION; MEDITERRANEAN DIET; METABOLIC DISORDER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL DEFICIENCY; OBESITY; PATHOGENESIS; PISTACHIO; PROADIPOCYTE; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; COMPLICATION; GARLIC; METABOLISM; PISTACIA;

ADIPONECTIN; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIET, MEDITERRANEAN; FATTY ACIDS, OMEGA-3; GARLIC; HUMANS; INTRA-ABDOMINAL FAT; METABOLIC SYNDROME X; OBESITY; PISTACIA; PLANT EXTRACTS;

EID: 84959264632     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.202432     Document Type: Article

References (73)

1. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995;270:26746-9.
2. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-703.
3. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai M, Matsuzawa Y, Funahashi T. Adiponectin as a biomarker of the metabolic syndrome. Circ J 2004;68:975-81.
4. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 2012;425:560-4.
5. Spranger J, Kroke A, Möhlig M, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361:226-8.
6. Laughlin GA, Barrett-Connor E, May S, Langenberg C. Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study. Am J Epidemiol 2007;165:164-74.
7. Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, et al. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 2004;43:1318-23.
8. Hong SJ, Park CG, Seo HS, Oh DJ, Ro YM. Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index. Blood Press 2004;13:236-42.
9. Schulze MB, Shai I, Rimm EB, Li T, Rifai N, Hu FB. Adiponectin and future coronary heart disease events among men with type 2 diabetes. Diabetes 2005;54:534-9.
10. Zoccali C, Mallamaci F, Tripepi G, Benedetto FA, Cutrupi S, Parlongo S, Malatino LS, Bonanno G, Seminara G, Rapisarda F, et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 2002;13:134-41.
11. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004;291:1730-37.
12. Robinson K, Prins J, Venkatesh B. Clinical review: Adiponectin biology and its role in inflammation and critical illness. Crit Care 2011;15:221.
13. Tian F, Luo R, Zhao Z, Wu Y, Ban Dj. Blockade of the RAS increases plasma adiponectin in subjects with metabolic syndrome and enhances differentiation and adiponectin expression of human preadipocytes. Exp Clin Endocrinol Diabetes 2010;118:258-65.
14. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, Kumada M, Ohashi K, Okamoto Y, Nishizawa H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003;42:231-4.
15. Hattori Y, Suzuki M, Hattori S, Kasai K. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 2003;46:1543-9.
16. Moncada S, Higgs EA, Hodson HF, Knowles RG, López-Jaramillo P, McCall T, Palmer RMJ, Radomski MW, Rees DD, Schultz R. The L-arginine:nitric oxide pathway. J Cardiovasc Pharmacol 1991;17: Suppl 3:S1-9.
17. Shinmura K, Tamaki K, Saito K, Nakano Y, Tobe T, Bolli R. Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 2007;116:2809-17.
18. Chiva-Blanch G, Magraner E, Condines X, Valderas-Martínez P, Roth I, Arranz S, Casas R, Navarro M, Hervas A, Sisó A, et al. Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: A randomized feeding trial. Nutr Metab Cardiovasc Dis 2014;pii:S0939-4753(14)00251-8.
19. Gray B, Steyn F, Davies PS, Vitetta L. Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. Eur J Clin Nutr 2013;67:1234-42.
20. Baril-Gravel L, Labonté ME, Couture P, Vohl MC, Charest A, Guay V, Jenkins DA, Connelly PW, West S, Kris-Etherton PM, et al. Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: A randomized crossover controlled intervention trial. Nutr Metab Cardiovasc Dis 2015;25:52-9.
21. Haidari F, Mohammadshahi M, Borsi SH, Haghighizadeh MH, Malgard S. Comparison of essential fatty acid intakes and serum levels of inflammatory factors between asthmatic and healthy adults: a casecontrol study. Iran J Allergy Asthma Immunol 2014;13:335-42.
22. de Luis D, Izaola O, de la Fuente B, Aller R. Effect of l-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery. Nutr Hosp 2014;30:870-5.
23. Schwingshackl L, Hoffmann G. Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis 2014;24:929-39.
24. Monfort-Pires M, Folchetti LD, Previdelli AN, Siqueira-Catania A, de Barros CR, Ferreira SR. Healthy Eating Index is associated with certain markers of inflammation and insulin resistance but not with lipid profile in individuals at cardiometabolic risk. Appl Physiol Nutr Metab 2014;39:497-502.
25. Gulati S, Misra A, Pandey RM, Bhatt SP, Saluja S. Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a 24-wk, randomized control trial. Nutrition 2014;30:192-7.
26. Barona J, Blesso CN, Andersen CJ, Park Y, Lee J, Fernandez ML. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012;4:1945-57.
27. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC, Jr. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640-5.
28. Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, Rinfret S, Schiffrin EL, Eisenberg MJ. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010;56:1113-32.
29. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA 2002;287:356-9.
30. Rivlin RS. Historical perspective on the use of garlic. J Nutr 2001;131:951S-4S.
31. Borek C. Antioxidant health effects of aged garlic extract. J Nutr 2001;131:1010S-5S.
32. Gómez-Arbeláez D, Lahera V, Oubiña P, Valero-Muñoz M, de Las Heras N, Rodríguez Y, García RG, Camacho PA, López-Jaramillo P. Aged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover study. Mediators Inflamm 2013;2013:285795.
33. Keophiphath M, Priem F, Jacquemond-Collet I, Clement K, Lacasa D. 1, 2-Vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr 2009;139:2055-60.
34. Xi W, Satoh H, Kase H, Suzuki K, Hattori Y. Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: vasorelaxation in response to globular adiponectin. Biochem Biophys Res Commun 2005;332:200-5.
35. Razny U, Kiec-Wilk B, Wator L, Polus A, Dyduch G, Solnica B, MaleckiM, Tomaszewska R, Cooke JP, Dembinska-Kiec A. Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance. Cardiovasc Diabetol 2011;10:68.
36. Weiss N, Papatheodorou L, Morihara N, Hilge R, Ide N. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. J Ethnopharmacol 2013;145:162-7.
37. Lawlor DA, Ebrahim S, Davey Smith G. Sex matters: secular and geographical trends in sex differences in coronary heart disease mortality. BMJ 2001;323:541-5.
38. Lawlor DA, Smith GD, Leon DA, Sterne JA, Ebrahim S. Secular trends in mortality by stroke subtype in the 20th century: a retrospective analysis. Lancet 2002;360:1818-23.
39. López-Jaramillo P, Pradilla LP, Castillo VR, Lahera V. Socioeconomic pathology as a cause of regional differences in the prevalence of metabolic syndrome and pregnancy-induced hypertension. Rev Esp Cardiol 2007;60:168-78.
40. Lopez-Jaramillo P, Lahera V, Lopez-Lopez J. Epidemic of cardiometabolic diseases: A Latin American point of view. Ther Adv Cardiovasc Dis 2011;5:119-31.
41. Morimoto Y, Conroy SM, Ollberding NJ, Kim Y, Lim U, Cooney RV, Franke AA, Wilkens LR, Hernandez BY, Goodman MT, et al. Ethnic differences in serum adipokines and C-reactive protein levels: the multiethnic cohort study. Int J Obes (Lond) 2014;38:1416-22.
42. Sulistyoningrum DC. 1, Gasevic D, Lear SA, Ho J, Mente A, Devlin AM. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol 2013;12:170.
43. Munch-Andersen T, Sorensen K, Aachmann-Andersen NJ, Aksglaede L, Juul A, Helge JW. Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children. Int J Circumpolar Health 2013 Aug 7 (Epub ahead of print; DOI: 10.3402/ijch. v72i0.21458).
44. RosenbaumM, Fennoy I, Accacha S, Altshuler L, Carey DE, Holleran S, Rapaport R, Shelov SP, Speiser PW, Ten S, et al. Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children. Obesity (Silver Spring) 2013;21:2081-90.
45. Anand SS, Tarnopolsky M, Rashid S, Schulze KM, Desai D, Mente A, Rao S, Yusuf S, Gerstein HC, Sharma AM. Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE). PLoS ONE 2011;6:e22112.
46. Hales CN, Barker D. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992;35:595-601.
47. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 2005;85:571-633.
48. Ravelli AC, van der Meulen J, Osmond C, Barker D, Bleker O. Obesity at the age of 50 years in men and women exposed to famine prenatally. Am J Clin Nutr 1999;70:811-6.
49. Painter RC, de Rooij SR, Bossuyt PM, Simmers TA, Osmond C, Barker DJ, Bleker OP, Roseboom TJ. Early onset of coronary artery disease after prenatal exposure to Dutch famine. Am J Clin Nutr 2006;84:322-7.
50. de Rooij SR, Painter RC, Roseboom TJ, Phillis DI, Osmond C, Barker DJ, Tanck MW, Michels RP, Bossuyt PM, Bleker OP. Glucose tolerance at age 59 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine. Diabetologia 2006;49:637-43.
51. Gallou-Kabani C, Junien C. Nutritional epigenomics of metabolic syndrome. New perspective against the epidemic. Diabetes 2005; 54:1899-906.
52. García-Cardona MC, Huang F, García-Vivas JM, López-Camarillo C, Del Río Navarro BE, Navarro Olivos E, Hong-Chong E, Bolaños-Jiménez F, Marchat LA. DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance. Int J Obes (Lond) 2014;38:1457-65.
53. Matthiesen CF, Blache D, Thomsen PD, Hansen NE, Tauson AH. Effect of late gestation low protein supply to mink (Mustela vison) dams on reproductive performance and metabolism of dam and offspring. Arch Anim Nutr 2010;64:56-76.
54. Khalyfa A, Mutskov V, Carreras A, Khalyfa AA, Hakim F, Gozal D. Sleep fragmentation during late gestation induces metabolic perturbations and epigenetic changes in adiponectin gene expression in male adult offspring mice. Diabetes 2014;63:3230-41.
55. López-Jaramillo P, Velandia-Carrillo C, Alvarez-Camacho J, Cohen DD, Sánchez-Solano T, Castillo-Lopez G. Inflammation and hypertension: are there regional differences? Int J Hypertens 2013;2013: 492094.
56. Simão AN, Lozovoy MA, Bahls LD, Morimoto HK, Simão TN, Matsuo T, Dichi I. Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role of adiponectin and nitric oxide. Br J Nutr 2012;108:1435-42.
57. Hung J, McQuillan BM, Thompson PL, Beilby JP. Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity. Int J Obes (Lond) 2008;32:772-9.
58. Soebijanto N, Waspadji S. Adiponectin levels and its role in insulin resistance among adult women with metabolic syndrome. Acta Med Indones 2010;42:187-91.
59. Stern MP, Gaskill SP, Hazuda HP, Gardner LI, Haffner SM. Does obesity explain excess prevalence of diabetes among Mexican Americans? Results of the San Antonio Heart Study. Diabetologia 1983;24:272-7.
60. Gardner LI, Jr., Stern MP, Haffner SM, Gaskill SP, Hazuda HP, Relethford JH, Eifler CW. Prevalence of diabetes in Mexican Americans. Relationship to percent of gene pool derived from native American sources. Diabetes 1984;33:86-92.
61. Mather KJ, Funahashi T, Matsuzawa Y, Edelstein S, Bray GA, Kahn SE, Crandall J, Marcovina S, Goldstein B, Goldberg R. Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program. Diabetes 2008;57:980-6.
62. Pereira RI, Wang CC, Hosokawa P, Dickinson LM, Chonchol M, Krantz MJ, Steiner JF, Bessesen DH, Havranek EP, Long CS. Circulating adiponectin levels are lower in Latino versus non-Latino white patients at risk for cardiovascular disease, independent of adiposity measures. BMC Endocr Disord 2011;11:13.
63. Hulver MW, Saleh O, MacDonald KG, Pories WJ, Barakat HA. Ethnic differences in adiponectin levels. Metabolism 2004;53:1-3.
64. Henneman P, Aulchenko YS, Frants RR, van Dijk KW, Oostra BA, van Duijn CM. Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: the Erasmus Rucphen Family study. J Med Genet 2008;45:572-7.
65. Gao M, Ding D, Huang J, Qu Y, Wang Y, Huang Q. Association of genetic variants in the adiponectin gene with metabolic syndrome: A case-control study and a systematic meta-analysis in the Chinese population. PLoS ONE 2013;8:e58412.
66. Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmeier EM, et al. Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 2009;58:984-91.
67. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprêtre F, Dupont S, et al. Singlenucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002;11: 2607-14.
68. Ong KL, Li M, Tso AW, Xu A, Cherny SS, Sham PC, Tse HF, Lam TH, Cheung BM, Lam KS.; Investigators of the Hong Kong Cardiovascular Risk Factor Prevalence Study. Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol 2010;163:251-7.
69. Han LY, Wu QH, Jiao ML, Hao YH, Liang LB, Gao LJ, Legge DG, Quan H, Zhao MM, Ning N, et al. Associations between singlenucleotide polymorphisms (+45T.G, +276G.T, 211377C.G, 211391G. A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetologia 2011;54:2303-14.
70. Yang Y, Zhang F, Ding R, Wang Y, Lei H, Hu D. Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects. Thromb Res 2012;130: 58-64.
71. Mente A, Meyre D, Lanktree MB, Heydarpour M. A. Davis AD, Miller R, Gerstein H, Hegele RA, Yusuf S, Anand SS, for the SHARE and SHARE-AP Investigators. Causal relationship between adiponectin and metabolic traits: A Mendelian randomization study in a multiethnic population. PLoS ONE 2013;8:e66808.
72. Klünder-Klünder M, Flores-Huerta S, Garcia-Macedo R, Peralta-Romero J, Cruz M. Adiponectin in eutrophic and obese children as a biomarker to predic metabolic syndrome and each of its components. BMC Public Health 2013;13:88.
73. Okada-Iwabu M, Yamuchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Shirouza M, Ogata H, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013;503:493-9.