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Volumn 8, Issue 6, 2013, Pages

Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CYTOSINE; GLUCOSE; GUANINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

EID: 84879491823     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066808     Document Type: Article
Times cited : (55)

References (69)
  • 1
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF, (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-26749.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 2
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, et al. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 98: 2005-2010.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.5
  • 3
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Terauchi, Y.4    Kubota, N.5
  • 4
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473-2476.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Maeda, K.4    Kuriyama, H.5
  • 5
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, et al. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86: 1930-1935.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3    Hotta, K.4    Matsuzawa, Y.5
  • 6
    • 2542473288 scopus 로고    scopus 로고
    • Hypoadiponectinemia is an independent risk factor for hypertension
    • Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, et al. (2004) Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43: 1318-1323.
    • (2004) Hypertension , vol.43 , pp. 1318-1323
    • Iwashima, Y.1    Katsuya, T.2    Ishikawa, K.3    Ouchi, N.4    Ohishi, M.5
  • 7
    • 0036075053 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations in women with dyslipidemia
    • Matsubara M, Maruoka S, Katayose S, (2002) Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 87: 2764-2769.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2764-2769
    • Matsubara, M.1    Maruoka, S.2    Katayose, S.3
  • 9
    • 0842269790 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    • Yamamoto Y, Hirose H, Saito I, Nishikai K, Saruta T, (2004) Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population. J Clin Endocrinol Metab 89: 87-90.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 87-90
    • Yamamoto, Y.1    Hirose, H.2    Saito, I.3    Nishikai, K.4    Saruta, T.5
  • 10
    • 43449091901 scopus 로고    scopus 로고
    • Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations
    • Wildman RP, Mancuso P, Wang C, Kim M, Scherer PE, et al. (2008) Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations. Int J Obes (Lond) 32: 740-748.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 740-748
    • Wildman, R.P.1    Mancuso, P.2    Wang, C.3    Kim, M.4    Scherer, P.E.5
  • 11
    • 0037031088 scopus 로고    scopus 로고
    • Adiponectin and development of type 2 diabetes in the Pima Indian population
    • Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, et al. (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360: 57-58.
    • (2002) Lancet , vol.360 , pp. 57-58
    • Lindsay, R.S.1    Funahashi, T.2    Hanson, R.L.3    Matsuzawa, Y.4    Tanaka, S.5
  • 12
    • 34249298701 scopus 로고    scopus 로고
    • Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study
    • Chow WS, Cheung BM, Tso AW, Xu A, Wat NM, et al. (2007) Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension 49: 1455-1461.
    • (2007) Hypertension , vol.49 , pp. 1455-1461
    • Chow, W.S.1    Cheung, B.M.2    Tso, A.W.3    Xu, A.4    Wat, N.M.5
  • 13
    • 33846221186 scopus 로고    scopus 로고
    • Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study
    • Laughlin GA, Barrett-Connor E, May S, Langenberg C, (2007) Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study. Am J Epidemiol 165: 164-174.
    • (2007) Am J Epidemiol , vol.165 , pp. 164-174
    • Laughlin, G.A.1    Barrett-Connor, E.2    May, S.3    Langenberg, C.4
  • 14
    • 0036788294 scopus 로고    scopus 로고
    • Low plasma adiponectin concentrations do not predict weight gain in humans
    • Vozarova B, Stefan N, Lindsay RS, Krakoff J, Knowler WC, et al. (2002) Low plasma adiponectin concentrations do not predict weight gain in humans. Diabetes 51: 2964-2967.
    • (2002) Diabetes , vol.51 , pp. 2964-2967
    • Vozarova, B.1    Stefan, N.2    Lindsay, R.S.3    Krakoff, J.4    Knowler, W.C.5
  • 15
    • 77953065694 scopus 로고    scopus 로고
    • Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits
    • Henneman P, Aulchenko YS, Frants RR, Zorkoltseva IV, Zillikens MC, et al. (2010) Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits. Diabetes Care 33: 908-913.
    • (2010) Diabetes Care , vol.33 , pp. 908-913
    • Henneman, P.1    Aulchenko, Y.S.2    Frants, R.R.3    Zorkoltseva, I.V.4    Zillikens, M.C.5
  • 16
    • 82255179403 scopus 로고    scopus 로고
    • Shared genetic variance between the features of the metabolic syndrome: heritability studies
    • Povel CM, Boer JM, Feskens EJ, (2011) Shared genetic variance between the features of the metabolic syndrome: heritability studies. Mol Genet Metab 104: 666-669.
    • (2011) Mol Genet Metab , vol.104 , pp. 666-669
    • Povel, C.M.1    Boer, J.M.2    Feskens, E.J.3
  • 17
    • 0033580457 scopus 로고    scopus 로고
    • Organization of the gene for gelatin-binding protein (GBP28)
    • Saito K, Tobe T, Minoshima S, Asakawa S, Sumiya J, et al. (1999) Organization of the gene for gelatin-binding protein (GBP28). Gene 229: 67-73.
    • (1999) Gene , vol.229 , pp. 67-73
    • Saito, K.1    Tobe, T.2    Minoshima, S.3    Asakawa, S.4    Sumiya, J.5
  • 18
    • 18644369745 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
    • Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, et al. (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11: 2607-26014.
    • (2002) Hum Mol Genet , vol.11 , pp. 2607-26014
    • Vasseur, F.1    Helbecque, N.2    Dina, C.3    Lobbens, S.4    Delannoy, V.5
  • 19
    • 74749102353 scopus 로고    scopus 로고
    • Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
    • Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, et al. (2010) Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 208: 412-420.
    • (2010) Atherosclerosis , vol.208 , pp. 412-420
    • Heid, I.M.1    Henneman, P.2    Hicks, A.3    Coassin, S.4    Winkler, T.5
  • 20
    • 84855393631 scopus 로고    scopus 로고
    • Population-specific coding variant underlies genome-wide association with adiponectin level
    • Croteau-Chonka DC, Wu Y, Li Y, Fogarty MP, Lange LA, et al. (2012) Population-specific coding variant underlies genome-wide association with adiponectin level. Hum Mol Genet 21: 463-471.
    • (2012) Hum Mol Genet , vol.21 , pp. 463-471
    • Croteau-Chonka, D.C.1    Wu, Y.2    Li, Y.3    Fogarty, M.P.4    Lange, L.A.5
  • 21
    • 84860562410 scopus 로고    scopus 로고
    • Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation
    • Warren LL, Li L, Nelson MR, Ehm MG, Shen J, et al. (2012) Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation. Diabetes 61: 1297-1301.
    • (2012) Diabetes , vol.61 , pp. 1297-1301
    • Warren, L.L.1    Li, L.2    Nelson, M.R.3    Ehm, M.G.4    Shen, J.5
  • 22
    • 77957750180 scopus 로고    scopus 로고
    • Adiponectin concentrations: a genome-wide association study
    • Jee SH, Sull JW, Lee JE, Shin C, Park J, et al. (2010) Adiponectin concentrations: a genome-wide association study. Am J Hum Genet 87: 545-552.
    • (2010) Am J Hum Genet , vol.87 , pp. 545-552
    • Jee, S.H.1    Sull, J.W.2    Lee, J.E.3    Shin, C.4    Park, J.5
  • 23
    • 78649476050 scopus 로고    scopus 로고
    • Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    • Wu Y, Li Y, Lange EM, Croteau-Chonka DC, Kuzawa CW, et al. (2010) Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet 19: 4955-4964.
    • (2010) Hum Mol Genet , vol.19 , pp. 4955-4964
    • Wu, Y.1    Li, Y.2    Lange, E.M.3    Croteau-Chonka, D.C.4    Kuzawa, C.W.5
  • 24
    • 74249100913 scopus 로고    scopus 로고
    • A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    • Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, et al. (2009) A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 5: e1000768.
    • (2009) PLoS Genet , vol.5
    • Richards, J.B.1    Waterworth, D.2    O'Rahilly, S.3    Hivert, M.F.4    Loos, R.J.5
  • 25
    • 84859238629 scopus 로고    scopus 로고
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    • Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, et al. (2012) Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 8: e1002607.
    • (2012) PLoS Genet , vol.8
    • Dastani, Z.1    Hivert, M.F.2    Timpson, N.3    Perry, J.R.4    Yuan, X.5
  • 26
    • 64649104152 scopus 로고    scopus 로고
    • Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data
    • Laumen H, Saningong AD, Heid IM, Hess J, Herder C, et al. (2009) Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 58: 984-991.
    • (2009) Diabetes , vol.58 , pp. 984-991
    • Laumen, H.1    Saningong, A.D.2    Heid, I.M.3    Hess, J.4    Herder, C.5
  • 27
    • 77955343146 scopus 로고    scopus 로고
    • Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
    • Ong KL, Li M, Tso AW, Xu A, Cherny SS, et al. (2010) Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol 163: 251-257.
    • (2010) Eur J Endocrinol , vol.163 , pp. 251-257
    • Ong, K.L.1    Li, M.2    Tso, A.W.3    Xu, A.4    Cherny, S.S.5
  • 28
    • 80054680992 scopus 로고    scopus 로고
    • Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis
    • Han LY, Wu QH, Jiao ML, Hao YH, Liang LB, et al. (2011) Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetologia 54: 2303-2314.
    • (2011) Diabetologia , vol.54 , pp. 2303-2314
    • Han, L.Y.1    Wu, Q.H.2    Jiao, M.L.3    Hao, Y.H.4    Liang, L.B.5
  • 29
    • 84862777070 scopus 로고    scopus 로고
    • Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects
    • Yang Y, Zhang F, Ding R, Wang Y, Lei H, et al. (2012) Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects. Thromb Res 130: 58-64.
    • (2012) Thromb Res , vol.130 , pp. 58-64
    • Yang, Y.1    Zhang, F.2    Ding, R.3    Wang, Y.4    Lei, H.5
  • 30
    • 12144285794 scopus 로고    scopus 로고
    • Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
    • Anand SS, Yusuf S, Vuksan V, Devanesen S, Teo KK, et al. (2000) Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE). Lancet 356: 279-284.
    • (2000) Lancet , vol.356 , pp. 279-284
    • Anand, S.S.1    Yusuf, S.2    Vuksan, V.3    Devanesen, S.4    Teo, K.K.5
  • 31
    • 0035818328 scopus 로고    scopus 로고
    • Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP)
    • Anand SS, Yusuf S, Jacobs R, Davis AD, Yi Q, et al. (2001) Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the Study of Health Assessment and Risk Evaluation in Aboriginal Peoples (SHARE-AP). Lancet 358: 1147-1153.
    • (2001) Lancet , vol.358 , pp. 1147-1153
    • Anand, S.S.1    Yusuf, S.2    Jacobs, R.3    Davis, A.D.4    Yi, Q.5
  • 32
    • 7844251181 scopus 로고    scopus 로고
    • The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators
    • Anand SS, Yusuf S, Vuksan V, Devanesen S, Montague P, et al. (1998) The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators. Can J Cardiol 14: 1349-57.
    • (1998) Can J Cardiol , vol.14 , pp. 1349-1357
    • Anand, S.S.1    Yusuf, S.2    Vuksan, V.3    Devanesen, S.4    Montague, P.5
  • 34
    • 0020680990 scopus 로고
    • A peroxidase-coupled method for the colorimetric determination of serum triglycerides
    • McGowan MW, Artiss JD, Strandbergh DR, Zak B, (1983) A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 29: 538-542.
    • (1983) Clin Chem , vol.29 , pp. 538-542
    • McGowan, M.W.1    Artiss, J.D.2    Strandbergh, D.R.3    Zak, B.4
  • 35
    • 0015349667 scopus 로고
    • Simple automated determination of serum or plasma glucose by a hexokinase-glucose-6 -phosphate dehydrogenase method
    • Neeley WE, (1972) Simple automated determination of serum or plasma glucose by a hexokinase-glucose-6-phosphate dehydrogenase method. Clin Chem 18: 509-515.
    • (1972) Clin Chem , vol.18 , pp. 509-515
    • Neeley, W.E.1
  • 36
    • 0022396983 scopus 로고
    • Comparison of improved precipitation methods for quantification of high-density lipoprotein cholesterol
    • Warnick GR, Nguyen T, Albers AA, (1985) Comparison of improved precipitation methods for quantification of high-density lipoprotein cholesterol. Clin Chem 31: 217-222.
    • (1985) Clin Chem , vol.31 , pp. 217-222
    • Warnick, G.R.1    Nguyen, T.2    Albers, A.A.3
  • 37
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS, (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 38
    • 0036425092 scopus 로고    scopus 로고
    • The assessment of insulin resistance in man
    • Wallace TM, Matthews DR, (2002) The assessment of insulin resistance in man. Diabet Med 19: 527-534.
    • (2002) Diabet Med , vol.19 , pp. 527-534
    • Wallace, T.M.1    Matthews, D.R.2
  • 39
    • 56349155783 scopus 로고    scopus 로고
    • Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
    • Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, et al. (2008) Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3: e3583.
    • (2008) PLoS One , vol.3
    • Keating, B.J.1    Tischfield, S.2    Murray, S.S.3    Bhangale, T.4    Price, T.S.5
  • 40
    • 79951677811 scopus 로고    scopus 로고
    • C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization
    • Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, et al. (2011) C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond) 35: 300-308.
    • (2011) Int J Obes (Lond) , vol.35 , pp. 300-308
    • Timpson, N.J.1    Nordestgaard, B.G.2    Harbord, R.M.3    Zacho, J.4    Frayling, T.M.5
  • 41
    • 70349980881 scopus 로고    scopus 로고
    • The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    • Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, et al. (2009) The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet 18: 4081-4088.
    • (2009) Hum Mol Genet , vol.18 , pp. 4081-4088
    • Beer, N.L.1    Tribble, N.D.2    McCulloch, L.J.3    Roos, C.4    Johnson, P.R.5
  • 42
    • 84856733126 scopus 로고    scopus 로고
    • Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
    • Rees MG, Wincovitch S, Schultz J, Waterstradt R, Beer NL, et al. (2012) Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk. Diabetologia 55: 114-122.
    • (2012) Diabetologia , vol.55 , pp. 114-122
    • Rees, M.G.1    Wincovitch, S.2    Schultz, J.3    Waterstradt, R.4    Beer, N.L.5
  • 43
    • 50949132578 scopus 로고    scopus 로고
    • The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population
    • Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, et al. (2008) The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 57: 2253-2257.
    • (2008) Diabetes , vol.57 , pp. 2253-2257
    • Vaxillaire, M.1    Cavalcanti-Proença, C.2    Dechaume, A.3    Tichet, J.4    Marre, M.5
  • 44
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
    • (2007) Am J Hum Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5
  • 45
    • 33846781527 scopus 로고    scopus 로고
    • The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity
    • Petrone A, Zavarella S, Caiazzo A, Leto G, Spoletini M, et al. (2006) The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring) 14: 1498-1504.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1498-1504
    • Petrone, A.1    Zavarella, S.2    Caiazzo, A.3    Leto, G.4    Spoletini, M.5
  • 46
    • 77749254629 scopus 로고    scopus 로고
    • Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance
    • Ferguson JF, Phillips CM, Tierney AC, Pérez-Martínez P, Defoort C, et al. (2010) Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 91: 794-801.
    • (2010) Am J Clin Nutr , vol.91 , pp. 794-801
    • Ferguson, J.F.1    Phillips, C.M.2    Tierney, A.C.3    Pérez-Martínez, P.4    Defoort, C.5
  • 47
  • 48
    • 38949127024 scopus 로고    scopus 로고
    • Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?
    • Ebrahim S, Davey Smith G, (2008) Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet 123: 15-33.
    • (2008) Hum Genet , vol.123 , pp. 15-33
    • Ebrahim, S.1    Davey Smith, G.2
  • 49
    • 55949098381 scopus 로고    scopus 로고
    • Adiponectin is associated with lipid profile and insulin sensitivity in French adolescents
    • Wagner A, Simon C, Oujaa M, Platat C, Schweitzer B, et al. (2008) Adiponectin is associated with lipid profile and insulin sensitivity in French adolescents. Diabetes Metab 34: 465-471.
    • (2008) Diabetes Metab , vol.34 , pp. 465-471
    • Wagner, A.1    Simon, C.2    Oujaa, M.3    Platat, C.4    Schweitzer, B.5
  • 50
    • 0036349010 scopus 로고    scopus 로고
    • Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population
    • Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, et al. (2002) Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 103: 137-145.
    • (2002) Clin Sci (Lond) , vol.103 , pp. 137-145
    • Yamamoto, Y.1    Hirose, H.2    Saito, I.3    Tomita, M.4    Taniyama, M.5
  • 51
    • 0345275792 scopus 로고    scopus 로고
    • Adiponectin in a native Canadian population experiencing rapid epidemiological transition
    • Hanley AJ, Connelly PW, Harris SB, Zinman B, (2003) Adiponectin in a native Canadian population experiencing rapid epidemiological transition. Diabetes Care 26: 3219-3225.
    • (2003) Diabetes Care , vol.26 , pp. 3219-3225
    • Hanley, A.J.1    Connelly, P.W.2    Harris, S.B.3    Zinman, B.4
  • 52
    • 57049139958 scopus 로고    scopus 로고
    • Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study
    • Goropashnaya AV, Herron J, Sexton M, Havel PJ, Stanhope KL, et al. (2009) Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism 58: 22-29.
    • (2009) Metabolism , vol.58 , pp. 22-29
    • Goropashnaya, A.V.1    Herron, J.2    Sexton, M.3    Havel, P.J.4    Stanhope, K.L.5
  • 53
    • 0037135523 scopus 로고    scopus 로고
    • Disruption of adiponectin causes insulin resistance and neointimal formation
    • Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863-25866.
    • (2002) J Biol Chem , vol.277 , pp. 25863-25866
    • Kubota, N.1    Terauchi, Y.2    Yamauchi, T.3    Kubota, T.4    Moroi, M.5
  • 54
    • 9144263120 scopus 로고    scopus 로고
    • A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity
    • Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, et al. (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145: 367-383.
    • (2004) Endocrinology , vol.145 , pp. 367-383
    • Combs, T.P.1    Pajvani, U.B.2    Berg, A.H.3    Lin, Y.4    Jelicks, L.A.5
  • 55
    • 0037462684 scopus 로고    scopus 로고
    • Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    • Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, et al. (2003) Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278: 2461-2468.
    • (2003) J Biol Chem , vol.278 , pp. 2461-2468
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Imai, Y.4    Shimozawa, N.5
  • 56
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, et al. (2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117: 2621-2637.
    • (2007) J Clin Invest , vol.117 , pp. 2621-2637
    • Kim, J.Y.1    van de Wall, E.2    Laplante, M.3    Azzara, A.4    Trujillo, M.E.5
  • 57
  • 58
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-95.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5
  • 59
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE, (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-953.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 60
    • 33847336953 scopus 로고    scopus 로고
    • The glucose clamp reveals an association between adiponectin gene polymorphisms and insulin sensitivity in obese subjects
    • Buzzetti R, Petrone A, Zavarella S, Zampetti S, Spoletini M, et al. (2007) The glucose clamp reveals an association between adiponectin gene polymorphisms and insulin sensitivity in obese subjects. Int J Obes (Lond) 31: 424-428.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 424-428
    • Buzzetti, R.1    Petrone, A.2    Zavarella, S.3    Zampetti, S.4    Spoletini, M.5
  • 61
    • 51049119223 scopus 로고    scopus 로고
    • Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men
    • Perez-Martinez P, Lopez-Miranda J, Cruz-Teno C, Delgado-Lista J, Jiménez-Gómez Y, et al. (2008) Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr 138: 1609-1614.
    • (2008) J Nutr , vol.138 , pp. 1609-1614
    • Perez-Martinez, P.1    Lopez-Miranda, J.2    Cruz-Teno, C.3    Delgado-Lista, J.4    Jiménez-Gómez, Y.5
  • 62
    • 84860625807 scopus 로고    scopus 로고
    • Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population
    • Karmelić I, Lovrić J, Božina T, Ljubić H, Vogrinc Ž, et al. (2012) Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population. Arch Med Res 43: 145-153.
    • (2012) Arch Med Res , vol.43 , pp. 145-153
    • Karmelić, I.1    Lovrić, J.2    Božina, T.3    Ljubić, H.4    Vogrinc, Ž.5
  • 65
    • 77958187338 scopus 로고    scopus 로고
    • Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    • Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, et al. (2010) Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care 33: 1629-1634.
    • (2010) Diabetes Care , vol.33 , pp. 1629-1634
    • Mente, A.1    Razak, F.2    Blankenberg, S.3    Vuksan, V.4    Davis, A.D.5
  • 66
    • 29144494451 scopus 로고    scopus 로고
    • The relationship between insulin sensitivity and serum adiponectin levels in three population groups
    • Ferris WF, Naran NH, Crowther NJ, Rheeder P, van der Merwe L, et al. (2005) The relationship between insulin sensitivity and serum adiponectin levels in three population groups. Horm Metab Res 37: 695-701.
    • (2005) Horm Metab Res , vol.37 , pp. 695-701
    • Ferris, W.F.1    Naran, N.H.2    Crowther, N.J.3    Rheeder, P.4    van der Merwe, L.5
  • 67
    • 79956119046 scopus 로고    scopus 로고
    • Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population
    • Khoo CM, Sairazi S, Taslim S, Gardner D, Wu Y, et al. (2011) Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population. Diabetes Care 34: 1120-1126.
    • (2011) Diabetes Care , vol.34 , pp. 1120-1126
    • Khoo, C.M.1    Sairazi, S.2    Taslim, S.3    Gardner, D.4    Wu, Y.5
  • 68
    • 84880255967 scopus 로고    scopus 로고
    • Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population
    • (Lond). In press
    • Robiou-du-Pont S, Bonnefond A, Yengo L, Vaillant E, Lobbens S, et al. (2012) Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int J Obes (Lond). In press.
    • (2012) Int J Obes
    • Robiou-du-Pont, S.1    Bonnefond, A.2    Yengo, L.3    Vaillant, E.4    Lobbens, S.5
  • 69
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3    Monda, K.L.4    Thorleifsson, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.