Substrate channeling between the human dihydrofolate reductase and thymidylate synthase

Protein Science

Volumn 25, Issue 1, 2016, Pages 79-86

  Wang, Nuo ^a   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bifunctional DHFR TS; dihydrofolate reductase; electrostatic channeling; folate; metabolon; one carbon metabolism; substrate channeling; thymidylate synthase

Indexed keywords

DIHYDROFOLATE REDUCTASE; MULTIENZYME COMPLEX; THYMIDYLATE SYNTHASE; FOLIC ACID; PROTEIN BINDING; THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE;

ARTICLE; CONTROLLED STUDY; HUMAN; IN VIVO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STATIC ELECTRICITY; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; SOFTWARE; SURFACE PROPERTY;

BIOCATALYSIS; FOLIC ACID; HUMANS; MOLECULAR DOCKING SIMULATION; MULTIENZYME COMPLEXES; PROTEIN BINDING; SOFTWARE; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; SURFACE PROPERTIES; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 84959237862     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2720     Document Type: Article

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