Replitase: Complete machinery for DNA synthesis

Journal of Cellular Physiology

Volumn 209, Issue 3, 2006, Pages 711-717

  Murthy, Shalini ^a   Reddy, G Prem Veer ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CELL NUCLEUS DNA; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; MULTIENZYME COMPLEX; MULTIPROTEIN COMPLEX; REPLITASE; UNCLASSIFIED DRUG;

ALLOSTERISM; CANCER CELL; CANCER GROWTH; CANCER THERAPY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CELL VIABILITY; COMPLEX FORMATION; DNA REPLICATION; DNA SYNTHESIS; GENOME SIZE; HORMONAL REGULATION; HUMAN; KINETICS; MAMMAL CELL; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE TRANSPORT; PRIORITY JOURNAL; PROKARYOTE; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; SEDIMENTATION; SHORT SURVEY; TIME;

ANIMALS; CELL CYCLE; DNA REPLICATION; MALE; MULTIENZYME COMPLEXES; NUCLEOSIDES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN;

EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 33750499731     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20842     Document Type: Short Survey

References (77)

1. Alberts BM. 1987. Prokaryotic DNA replication mechanisms. Philos Trans R Soc Lond B Biol Sci 317:395-420.
2. Allen JE, Reddy GP, Lasser GW, Mathews CK. 1980. T4 ribonucleotide reductase. Physical and kinetic linkage to other enzymes of deoxyribonucleotide biosynthesis. J Biol Chem 255:7583-7588.
3. Aparicio OM, Stout AM, Bell SP. 1999. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci USA 96:9130-9135.
4. Applegren N, Hickey RJ, Kleinschmidt AM, Zhou Q, Coll J, Wills P, Swaby R, Wei Y, Quan JY, Lee MY, et al. 1995. Further characterization of the human cell multiprotein DNA replication complex. J Cell Biochem 59:91-107.
5. Ashman CR, Reddy GP, Davidson RL. 1981. Bromodeoxyuridine mutagenesis, ribonucleotide reductase activity, and deoxyribonucleotide pools in hydroxyurea-resistant mutants. Somatic Cell Genet 7:751-768.
6. Ayusawa D, Shimizu K, Koyama H, Takeishi K. Seno T. 1983. Unusual aspects of human thymidylate synthase in mouse cells introduced by DNA-mediated gene transfer. J Biol Chem 258:48-53.
7. Bai VU, Cifuentes E, Menon M, Barrack ER, Reddy GP. 2005. Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase. J Cell Physiol 204:381-387.
8. Baril EF, Baril B, Elford H, Luftig R. 1974. DNA polymerases and a possible multienzyme complex for DNA synthesis in eukaryotes. In: Kolber AR, Kohiyama M, editors. Mechanisms and regulation of DNA replication. New York: Plenum Press, pp 275-291.
9. Bechtel PE, Hickey HJ, Schnaper L, Sekowski JW, Long BJ, Freund R, Liu N, Rodriguez-Valenzuela C, Malkas LH. 1998. A unique form of proliferating cell nuclear antigen is present in malignant breast cells. Cancer Res 58:3264-3269.
10. Cao QP, McGrath CA, Baril EF, Quesenberry PJ, Reddy GP. 1995. The 68 kDa calmodulin-binding protein is tightly associated with the multiprotein DNA polymerase alpha-primase complex in HeLa cells. Biochemistry 34:3878-3883.
11. Cardoso MC, Leonhardt H, Nadal-Ginard B, 1993. Reversal of terminal differentiation and control of DNA replication: Cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74:979-992.
12. Chao J, Leach M, Karam J. 1977. In vivo functional interaction between DNA polymerase and dCMP-hydroxymethylase of bacteriophage T4. J Virol 24:557-563.
13. Chiba P, Bacon PE, Cory JG. 1984. Studies directed toward testing the "channeling" hypothesis-ribonucleotides-DNA in leukemia L1210 cells. Biochem Biophys Res Commun 123:656-662.
14. Chiu CS, Cook KS, Greenberg GR. 1982. Characteristics of a bacteriophage T4-induced complex synthesizing deoxyribonucleotides. J Biol Chem 257:15087-15097.
15. Cifuentes E, Croxen R, Menon M, Barrack ER, Reddy GP. 2003. Synchronized prostate cancer cells for studying androgen regulated events in cell cycle progression from G1 into S phase. J Cell Physiol 195:337-345.
16. Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379:180-182.
17. Coll JM, Sekowski JW, Hickey RJ, Schnaper L, Yue W, Brodie AM, Uitto L, Syvaoja JE, Malkas LH. 1996. The human breast cell DNA synthesome: Its purification from tumor tissue and cell culture. Oncol Res 8:435-447.
18. DePamphilis ML. 1988. Transcriptional elements as components of eukaryotic origins of DNA replication. Cell 52:635-638.
19. Dhar V, Skoultchi AI, Schildkraut CL. 1989. Activation and repression of a beta-globin gene in cell hybrids is accompanied by a shift in its temporal replication. Mol Cell Biol 9:3524-3532.
20. Engstrom Y, Rozell B. 1988. Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase. EMBO J 7:1615-1620.
21. Engstrom Y, Rozell B, Hansson HA, Stemme S, Thelander L. 1984. Localization of ribonucleotide reductase in mammalian cells. EMBO J 3:863-867.
22. Firshein W. 1972. The DNA-membrane fraction of Pneumococcus contains a DNA replication complex. J Mol Biol 70:383-397.
23. Fridland A. 1973. DNA precursors in eukaryotic cells. Nat New Biol 243:105-107.
24. Frouin I, Montecucco A, Biamonti G, Hubscher U, Spadari S, Maga G. 2002. Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. EMBO J 21:2485-2495.
25. Harvey G, Pearson CK. 1988. Search for multienzyme complexes of DNA precursor pathways in uninfected mammalian cells and in cells infected with herpes simplex virus type I. J Cell Physiol 134:25-36.
26. Hozak P, Cook PR. 1994. Replication factories. Trends Cell Biol 4:48-52.
27. Hozak P, Hassan AB, Jackson DA, Cook PR. 1993. Visualization of replication factories attached to nucleoskeleton. Cell 73:361-373.
28. Hozak P, Jackson DA, Cook PR. 1994. Replication factories and nuclear bodies: The ultrastructural characterization of replication sites during the cell cycle. J Cell Sci 107:2191-2202.
29. Hubscher U, Maga G, Spadari S. 2002. Eukaryotic DNA polymerases. Annu Rev Biochem 71:133-163.
30. Infante AA, Nauta R, Gilbert S, Hobart P, Firshein W. 1973. DNA synthesis in developing sea urchins: Role of a DNA-nuclear membrane complex. Nat New Biol 242:5-8.
31. Jallepalli PV, Kelly TJ. 1996. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev 10:541-552.
32. Jaumot M, Grana X, Giordano A, Reddy GP, Agell N, Bachs O. 1994. Cyclin/cdk2 complexes in the nucleus of HeLa cells. Biochem Biophys Res Commun 203:1527-1534.
33. Jiang W, Wells NJ, Hunter T. 1999. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc Natl Acad Sci USA 96:6193-6198.
34. Kim J, Wheeler LJ, Shen R, Mathews CK. 2005. Protein-DNA interactions in the T4 dNTP synthetase complex dependent on gene 32 single-stranded DNA-binding protein. Mol Microbiol 55:1502-1514.
35. Kornberg A. 1982. Supplement to DNA replication. San Francisco: W.H.Freeman and Company.
36. Leonhardt H, Page AW, Weier HU, Bestor TH. 1992. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71:865-873.
37. Li A, Blow JJ. 2001. The origin of CDK regulation. Nat Cell Biol 3:E182-E184.
38. Lin S, Hickey RJ, Malkas LH. 1997. The isolation of a DNA synthesome from human leukemia cells. Leuk Res 21:501-512.
39. Liu X, Zhou B, Xue L, Shih J, Tye K, Qi C, Yen Y. 2005. The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells. Biochem Pharmacol 70:1288-1297.
40. Maga G, Hubscher U. 1996. DNA replication machinery: Functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer. Biochemistry 35:5764-5777.
41. Malkas LH, Hickey RJ, Li C, Pedersen N, Baril EF. 1990. A 21S enzyme complex from HeLa cells that functions in simian virus 40 DNA replication in vitro. Biochemistry 29:6362-6374.
42. Mathews CK, North TW, Reddy GP. 1978. Multienzyme complexes in DNA precursor biosynthesis. Adv Enzyme Regul 17:133-156.
43. Mathews CK, Moen LK, Wang Y, Sargent RG. 1988. Intracellular organization of DNA precursor biosynthetic enzymes. Trends Biochem Sci 13:394-397.
44. Moen LK, Howell ML, Lasser GW, Mathews CK. 1988. T4 phage deoxyribonucleoside triphosphate synthetase: Purification of an enzyme complex and identification of gene products required for integrity. J Mol Recognit 1:48-57.
45. Nicander B, Reichard P. 1983. Dynamics of pyrimidine deoxynucleoside triphosphate pools in relationship to DNA synthesis in 3T6 mouse fibroblasts. Proc Natl Acad Sci USA 80:1347-1351.
46. Nicander B, Reichard P. 1985. Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts. J Biol Chem 260:5376-5381.
47. Noguchi H, Reddy GP, Pardee AB. 1983. Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell 32:443-451.
48. Pardee AB. 2002. Regulation, restriction, and reminiscences. J Biol Chem 277:26709-26716.
49. Plucinski TM, Fager RS, Reddy GP. 1990. Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition. Mol Pharmacol 38:114-120.
50. Reddy GP. 1982. Catalytic function on thymidylate synthase is continued to S phase due to its association with replitase. Biochem Biophys Res Commun 109:908-915.
51. Reddy GP. 1989. Compartmentation of deoxypyrimidine nucleotides for nuclear DNA replication in S phase mammalian cells. J Mol Recognit 2:75-83.
52. Reddy GP. 1991. Regulation of DNA replication and S phase. In: Stein GS, Baserga R, Giordano A, Denhardt DT, editors. The molecular basis of cellcycle and growth control. New York: Wiley-Liss. pp 80-154.
53. Reddy GP. 1994. Cell cycle: Regulatory events in G1 → S transition of mammalian cells. J Cell Biochem 54:379-386.
54. Reddy GP, Fager RS. 1993. Replitase: A complex integrating dNTP synthesis and DNA replication. Crit Rev Eukaryot Gene Expr 3:255-277.
55. Reddy GP, Mathews CK. 1978. Functional Compartmentation of DNA precursors in T4 phage-infected bacteria. J Biol Chem 253:3461-3467.
56. Reddy GP, Pardee AB. 1980. Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci USA 77:3312-3316.
57. Reddy GP, Pardee AB. 1982. Coupled ribonucleoside diphosphate reduction, channeling, and incorporation into DNA of mammalian cells. J Biol Chem 257:12526-12531.
58. Reddy GP, Pardee AB. 1983. Inhibitor evidence for allosteric interaction in the replitase multienzyme complex. Nature 304:86-88.
59. Reddy GP, Singh A, Stafford ME, Mathews CK. 1977. Enzyme associations in T4 phage DNA precursor synthesis. Proc Natl Acad Sci USA 74:3152-3156.
60. Reddy GP, Reed WC, Deacon DH, Quesenberry PJ. 1992a. Growth factor-dependent proliferative stimulation of hematopoietic cells is associated with the modulation of cytoplasmic and nuclear 68-Kd calmodulin-binding protein. Blood 79:1946-1955.
61. Reddy GP, Reed WC, Sheehan E, Sacks DB. 1992b. Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells. Biochemistry 31:10426-10430.
62. Reddy GP, Cifuentes E, Bai U, Menon M, Barrack ER. 2004. Onset of DNA synthesis and S phase. In: Stein GS, Pardee AB, editors. Cell cycle and growth control: Biomolecular regulation and cancer, 2nd edition. Hoboken, NJ: John Wiley & Sons Inc. pp 149-200.
63. Sclafani RA, Fangman WL. 1984. Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK. Proc Natl Acad Sci USA 81:5821-5825.
64. Selig S, Okumura K, Ward DC, Cedar H. 1992. Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J 11:1217-1225.
65. Shearman CW, Kalf GF. 1977. DNA replication by a membrane-DNA complex from rat liver mitochondria. Arch Biochem Biophys 182:573-586.
66. Sikorska M, Brewer LM, Youdale T, Richards R, Whitfield JF, Houghten RA, Walker PR. 1990. Evidence that mammalian ribonueleotide reductase is a nuclear membrane associated glycoprotein. Biochem Cell Biol 68:880-888.
67. Srere PA. 1987. Complexes of sequential metabolic enzymes. Annu Rev Biochem 56:89-124.
68. Subramanyam C, Honn SC, Reed WC, Reddy GP. 1990. Nuclear localization of 68 kDa calmodulin-binding protein is associated with the onset of DNA replication. J Cell Physiol 144:423-428.
69. Tubo RA, Berezney R. 1987. Identification of 100 and 150 S DNA polymerase alpha-primase megacomplexes solubilized from the nuclear matrix of regenerating rat liver. J Biol Chem 262:5857-5865.
70. Vishwanatha JK, Coughlin SA, Wesolowski-Owen M, Baril EF. 1986. A multiprotein form of DNA polymerase alpha from HeLa cells. Resolution of its associated catalytic activities. J Biol Chem 261:6619-6628.
71. Walter J, Newport J. 2000. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell 5:617-627.
72. Wheeler L, Wang Y, Mathews CK. 1992. Specific associations of T4 bacteriophage proteins with immobilized deoxycytidylate hydroxymethylase. J Biol Chem 267:7664-7670.
73. Wheeler LJ, Ray NB, Ungermann C, Hendricks SP, Bernard MA, Hanson ES, Mathews CK. 1996. T4 phage gene 32 protein as a candidate organizing factor for the deoxyribonucleoside triphosphate synthetase complex. J Biol Chem 271:11156-11162.
74. Wickremasinghe RG, Yaxley JC, Hoffbrand AV. 1982. Solubilization and partial characterization of a multienzyme complex of DNA synthesis from human lymphoblastoid cells. Eur J Biochem 126:589-596.
75. Wickremasinghe RG, Yaxley JC, Hoffbrand AV. 1983. Gel filtration of a complex of DNA polymerase and DNA precursor-synthesizing enzymes from a human lymphoblastoid cell line. Biochim Biophys Acta 740:243-248.
76. Yamashita T, Arens M, Green M. 1977. Adenovirus deoxyribonucleic acid replication. Isolation of a soluble replication system and analysis of the in vitro DNA product. J Biol Chem 252:7940-7946.
77. Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ. 2002. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 62:1008-1013.