Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt

Molecular Cell

Volumn 54, Issue 3, 2014, Pages 378-391

  Wang, Pingping ^a   Zhou, Zhihong ^a   Hu, Anchang ^a   Pontede Albuquerque, Claudio ^a,b   Zhou, Yu ^a   Hong, Lixin ^c   Sierecki, Emma ^d   Ajiro, Masahiko ^e   Kruhlak, Michael ^e   Harris, Curtis ^e   Guan, Kun Liang ^d   Zheng, Zhi Ming ^e   Newton, Alexandra C ^d   Sun, Peiqing ^c   Zhou, Huilin ^a,b   Fu, Xiang Dong ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d San Diego   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN KINASE B; SRPK1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NEOPLASM; NONHUMAN; PHENOTYPE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEOMICS;

ANIMALS; CARCINOGENESIS; CELL ADHESION; CELL AGING; CELLS, CULTURED; COLONIC NEOPLASMS; ENZYME ACTIVATION; FEMALE; HUMANS; MALE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MICE, NUDE; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR BURDEN;

EID: 84899821715     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.03.007     Document Type: Article

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