Structure of the Brd4 et domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 8, 2016, Pages 2086-2091

  Crowe, Brandon L ^a   Larue, Ross C ^a   Yuan, Chunhua ^a   Hess, Sonja ^b   Kvaratskhelia, Mamuka ^a   Foster, Mark P ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

BET family transcription factor; ET binding motif (EBM); NMR; Protein protein interaction; Retroviral integration

Indexed keywords

BRD4 PROTEIN; GAMMA RETROVIRAL INTEGRASE; INTEGRASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; BRD4 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN BINDING; TRANSCRIPTION FACTOR; VIRAL PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CHROMATIN ASSEMBLY AND DISASSEMBLY; EXTRATERMINAL DOMAIN; HYDROPHOBICITY; MURINE LEUKEMIA VIRUS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY; TRANSCRIPTION REGULATION; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; HUMANS; INTEGRASES; LEUKEMIA VIRUS, MURINE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 84959193038     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516813113     Document Type: Article

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