Validation of biomarkers in cardiotoxicity induced by Periplocin on neonatal rat cardiomyocytes using UPLC-Q-TOF/MS combined with a support vector machine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 123, Issue , 2016, Pages 179-185

  Li, Aizhu ^a   Guo, Xuejun ^a   Xie, Jiabin ^a   Liu, Xinyu ^a   Zhang, Zhenzhu ^a   Li, Yubo ^a   Zhang, Yanjun ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Biomarkers; Cardiotoxicity; Metabolomics; Periplocin; SVM; UPLC Q TOF MS

Indexed keywords

ACETYLCARNITINE; ALANINE; ASPARTIC ACID; BIOLOGICAL MARKER; CARDIAC GLYCOSIDE; CARNITINE; CITRIC ACID; DICARBOXYLIC ACID; GLUTAMIC ACID; GLUTAMINE; GLYOXYLIC ACID; INDOLEACRYLIC ACID; ISOLEUCINE; LEUCINE; PANTOTHENIC ACID; PERIPLOCIN; PROLINE; PYROGLUTAMIC ACID; TRYPTOPHAN; UNCLASSIFIED DRUG; AMINO ACID; HERBACEOUS AGENT; SAPONIN;

AMINO ACID METABOLISM; ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONCENTRATION PROCESS; CONTROLLED STUDY; COREX PERIPLOCAE; DRUG SAFETY; ENERGY METABOLISM; HEART MUSCLE CELL; METABOLOMICS; NEWBORN; NONHUMAN; PERIPLOCA; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPHINGOLIPID METABOLISM; SUPPORT VECTOR MACHINE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS; ADVERSE EFFECTS; ANIMAL; CARDIAC MUSCLE CELL; CHINESE MEDICINE; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID METABOLISM; MASS SPECTROMETRY; METABOLISM; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT;

AMINO ACIDS; ANIMALS; ANIMALS, NEWBORN; BIOMARKERS; CARDIOTOXICITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; ENERGY METABOLISM; LIPID METABOLISM; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SUPPORT VECTOR MACHINE;

EID: 84959182553     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2016.02.014     Document Type: Article

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