Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

Genome Medicine

Volumn 8, Issue 1, 2016, Pages

  Godoy Lozano, Elizabeth Ernestina ^a   Téllez Sosa, Juan ^a   Sánchez González, Gilberto ^a   Sámano Sánchez, Hugo ^a   Aguilar Salgado, Andrés ^a   Salinas Rodríguez, Aarón ^a   Cortina Ceballos, Bernardo ^a   Vivanco Cid, Héctor ^b   Hernández Flores, Karina ^b   Pfaff, Jennifer M ^c   Kahle, Kristen M ^c   Doranz, Benjamin J ^c   Gómez Barreto, Rosa Elena ^a   Valdovinos Torres, Humberto ^a   López Martínez, Irma ^d   Rodriguez, Mario H ^a   Martínez Barnetche, Jesús ^a  

^a INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^b UNIVERSIDAD VERACRUZANA   (Mexico)

^c Integral Molecular Inc   (United States)

^d Instituto Nacional de Diagnostico y Referencia Epidemiologicos   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

ADULT; ANTIBODY SECRETING CELL; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; DENGUE; DISEASE SEVERITY; DNA SEQUENCE; FEMALE; GENE FREQUENCY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; HUMAN CELL; IGHV1 18 GENE; IGHV1 2 GENE; IGHV1 69 GENE; IMMUNE RESPONSE; MALE; MEMORY CELL; NONHUMAN; PLASMABLAST; PRIMARY INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECONDARY INFECTION; SOMATIC HYPERMUTATION; VIRUS GENE; VIRUS NEUTRALIZATION; ACUTE DISEASE; ADOLESCENT; B LYMPHOCYTE; BIOLOGY; CLASSIFICATION; CLUSTER ANALYSIS; COMPLEMENTARITY DETERMINING REGION; DENGUE VIRUS; GENE EXPRESSION PROFILING; GENETICS; GERMINAL CENTER; HIGH THROUGHPUT SEQUENCING; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MUTATION; POSITION WEIGHT MATRIX; PROTEIN MOTIF; SEROTYPE; VIROLOGY; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ADULT; AMINO ACID MOTIFS; B-LYMPHOCYTES; CLUSTER ANALYSIS; COMPLEMENTARITY DETERMINING REGIONS; COMPUTATIONAL BIOLOGY; DENGUE; DENGUE VIRUS; FEMALE; GENE EXPRESSION PROFILING; GERMINAL CENTER; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; MUTATION; POSITION-SPECIFIC SCORING MATRICES; SEROGROUP; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; YOUNG ADULT;

EID: 84959172253     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-016-0276-1     Document Type: Article

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