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Volumn 36, Issue , 2016, Pages 12-17

Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know

Author keywords

ER stress; mTOR; oxidative stress; plasma cells; RIDD; TSC; UPR

Indexed keywords

IMMUNOGLOBULIN; MAMMALIAN TARGET OF RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

EID: 84959116980     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-016-0246-9     Document Type: Review
Times cited : (28)

References (47)
  • 2
    • 0027484157 scopus 로고
    • Different assembly species of IgM are directed to distinct degradation sites along the secretory pathway
    • COI: 1:CAS:528:DyaK3sXmtVWns78%3D, PID: 8226961
    • Rabinovich E, Bar-Nun S, Amitay R, Shachar I, Gur B, Taya M, Haimovich J Different assembly species of IgM are directed to distinct degradation sites along the secretory pathway. J Biol Chem. 1993;268:24145–8.
    • (1993) J Biol Chem , vol.268 , pp. 24145-24148
    • Rabinovich, E.1    Bar-Nun, S.2    Amitay, R.3    Shachar, I.4    Gur, B.5    Taya, M.6    Haimovich, J.7
  • 3
    • 34948899397 scopus 로고    scopus 로고
    • Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
    • COI: 1:CAS:528:DC%2BD2sXhtFWiu7rO, PID: 17805346
    • Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C, Sitia R Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 2007;26:4177–88.
    • (2007) EMBO J , vol.26 , pp. 4177-4188
    • Anelli, T.1    Ceppi, S.2    Bergamelli, L.3    Cortini, M.4    Masciarelli, S.5    Valetti, C.6    Sitia, R.7
  • 4
    • 70349456510 scopus 로고    scopus 로고
    • Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing
    • COI: 1:CAS:528:DC%2BD1MXhtFaju77I, PID: 19749764
    • Martincic K, Alkan SA, Cheatle A, Borghesi L, Milcarek C Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat Immunol. 2009;10:1102–9.
    • (2009) Nat Immunol , vol.10 , pp. 1102-1109
    • Martincic, K.1    Alkan, S.A.2    Cheatle, A.3    Borghesi, L.4    Milcarek, C.5
  • 5
    • 82555190936 scopus 로고    scopus 로고
    • The genetic network controlling plasma cell differentiation
    • COI: 1:CAS:528:DC%2BC3MXhsVOrurzK, PID: 21924923
    • Nutt SL, Taubenheim N, Hasbold J, Corcoran LM, Hodgkin PD The genetic network controlling plasma cell differentiation. Semin Immunol. 2011;23:341–9.
    • (2011) Semin Immunol , vol.23 , pp. 341-349
    • Nutt, S.L.1    Taubenheim, N.2    Hasbold, J.3    Corcoran, L.M.4    Hodgkin, P.D.5
  • 7
    • 33745182931 scopus 로고    scopus 로고
    • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    • COI: 1:CAS:528:DC%2BD28XlvFGjsbs%3D, PID: 16767092
    • Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K, Dalla-Favera R Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006;7:773–82.
    • (2006) Nat Immunol , vol.7 , pp. 773-782
    • Klein, U.1    Casola, S.2    Cattoretti, G.3    Shen, Q.4    Lia, M.5    Mo, T.6    Ludwig, T.7    Rajewsky, K.8    Dalla-Favera, R.9
  • 9
    • 23444459544 scopus 로고
    • a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
    • Turner Jr CA, Mack DH, Davis MM Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell. 1994;77:297–306.
    • (1994) Cell , vol.77 , pp. 297-306
    • Turner, C.A.1    Mack, D.H.2    Blimp, D.M.M.3
  • 10
    • 40049086212 scopus 로고    scopus 로고
    • Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6
    • COI: 1:CAS:528:DC%2BD1cXis1Glu74%3D, PID: 18256039
    • Ochiai K, Muto A, Tanaka H, Takahashi S, Igarashi K Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int Immunol. 2008;20:453–60.
    • (2008) Int Immunol , vol.20 , pp. 453-460
    • Ochiai, K.1    Muto, A.2    Tanaka, H.3    Takahashi, S.4    Igarashi, K.5
  • 11
    • 78649688039 scopus 로고    scopus 로고
    • Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch
    • COI: 1:CAS:528:DC%2BC3cXht1yqurrI, PID: 20953163
    • Muto A, Ochiai K, Kimura Y, Itoh-Nakadai A, Calame KL, Ikebe D, Tashiro S, Igarashi K Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J. 2010;29:4048–61.
    • (2010) EMBO J , vol.29 , pp. 4048-4061
    • Muto, A.1    Ochiai, K.2    Kimura, Y.3    Itoh-Nakadai, A.4    Calame, K.L.5    Ikebe, D.6    Tashiro, S.7    Igarashi, K.8
  • 12
    • 79960725899 scopus 로고    scopus 로고
    • Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation
    • COI: 1:CAS:528:DC%2BC3MXpt1yhsb0%3D, PID: 21674482
    • Alinikula J, Nera KP, Junttila S, Lassila O Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation. Eur J Immunol. 2011;41:2404–13.
    • (2011) Eur J Immunol , vol.41 , pp. 2404-2413
    • Alinikula, J.1    Nera, K.P.2    Junttila, S.3    Lassila, O.4
  • 13
    • 80053369081 scopus 로고    scopus 로고
    • Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response
    • COI: 1:CAS:528:DC%2BC3MXht1aitr%2FE, PID: 21852455
    • Gardner BM, Walter P Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science. 2011;333:1891–4.
    • (2011) Science , vol.333 , pp. 1891-1894
    • Gardner, B.M.1    Walter, P.2
  • 14
    • 84919797456 scopus 로고    scopus 로고
    • Lipid-dependent regulation of the unfolded protein response
    • COI: 1:CAS:528:DC%2BC2MXislGmtg%3D%3D, PID: 25543896
    • Volmer R, Ron D Lipid-dependent regulation of the unfolded protein response. Curr Opin Cell Biol. 2015;33:67–73.
    • (2015) Curr Opin Cell Biol , vol.33 , pp. 67-73
    • Volmer, R.1    Ron, D.2
  • 15
    • 68549092781 scopus 로고    scopus 로고
    • Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
    • COI: 1:CAS:528:DC%2BD1MXhtVahsb3I, PID: 19651891
    • Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009;186:323–31.
    • (2009) J Cell Biol , vol.186 , pp. 323-331
    • Hollien, J.1    Lin, J.H.2    Li, H.3    Stevens, N.4    Walter, P.5    Weissman, J.S.6
  • 16
    • 34147172715 scopus 로고    scopus 로고
    • Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis
    • R. Sriburi, H. Bommiasamy, G.L. Buldak, G.R. Robbins, M. Frank, S. Jackowski, J.W. Brewer, Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis, J Biol Chem, 282 (2007) 7024–7034.
    • (2007) J Biol Chem , vol.282 , pp. 7024-7034
    • Sriburi, R.1    Bommiasamy, H.2    Buldak, G.L.3    Robbins, G.R.4    Frank, M.5    Jackowski, S.6    Brewer, J.W.7
  • 17
    • 29244448729 scopus 로고    scopus 로고
    • XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    • COI: 1:CAS:528:DC%2BD2MXhtlanu73P, PID: 16362047
    • Lee AH, Chu GC, Iwakoshi NN, Glimcher LH XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J. 2005;24:4368–80.
    • (2005) EMBO J , vol.24 , pp. 4368-4380
    • Lee, A.H.1    Chu, G.C.2    Iwakoshi, N.N.3    Glimcher, L.H.4
  • 19
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    • COI: 1:CAS:528:DC%2BD3MXktVagsro%3D, PID: 11381086
    • Novoa I, Zeng H, Harding HP, Ron D Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol. 2001;153:1011–22.
    • (2001) J Cell Biol , vol.153 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 20
    • 84949111233 scopus 로고    scopus 로고
    • Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate
    • COI: 1:CAS:528:DC%2BC2MXht1Wqs7bK, PID: 26225772
    • Liu Z, Lv Y, Zhao N, Guan G, Wang J Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate. Cell Death Disease. 2015;6:e1822.
    • (2015) Cell Death Disease , vol.6
    • Liu, Z.1    Lv, Y.2    Zhao, N.3    Guan, G.4    Wang, J.5
  • 21
    • 0032693671 scopus 로고    scopus 로고
    • Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    • COI: 1:CAS:528:DyaK1MXntlyrsLs%3D, PID: 10564271
    • Haze K, Yoshida H, Yanagi H, Yura T, Mori K Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell. 1999;10:3787–99.
    • (1999) Mol Biol Cell , vol.10 , pp. 3787-3799
    • Haze, K.1    Yoshida, H.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 22
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    • COI: 1:CAS:528:DC%2BD38XhvFKgs7s%3D, PID: 11850408
    • Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002;16:452–66.
    • (2002) Genes Dev , vol.16 , pp. 452-466
    • Lee, K.1    Tirasophon, W.2    Shen, X.3    Michalak, M.4    Prywes, R.5    Okada, T.6    Yoshida, H.7    Mori, K.8    Kaufman, R.J.9
  • 24
    • 67349176043 scopus 로고    scopus 로고
    • XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
    • COI: 1:CAS:528:DC%2BD1MXlt1GmtLw%3D, PID: 19407814
    • Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009;28:1624–36.
    • (2009) EMBO J , vol.28 , pp. 1624-1636
    • Hu, C.C.1    Dougan, S.K.2    McGehee, A.M.3    Love, J.C.4    Ploegh, H.L.5
  • 25
    • 84866551237 scopus 로고    scopus 로고
    • High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency
    • COI: 1:CAS:528:DC%2BC38XhtlOmurbE, PID: 22925926
    • Taubenheim N, Tarlinton DM, Crawford S, Corcoran LM, Hodgkin PD, Nutt SL High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency. J Immunol. 2012;189:3328–38.
    • (2012) J Immunol , vol.189 , pp. 3328-3338
    • Taubenheim, N.1    Tarlinton, D.M.2    Crawford, S.3    Corcoran, L.M.4    Hodgkin, P.D.5    Nutt, S.L.6
  • 26
    • 77951252041 scopus 로고    scopus 로고
    • Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response
    • COI: 1:CAS:528:DC%2BC3cXktlSitLw%3D, PID: 19898960
    • Ma Y, Shimizu Y, Mann MJ, Jin Y, Hendershot LM Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response. Cell Stress Chaperones. 2010;15:281–93.
    • (2010) Cell Stress Chaperones , vol.15 , pp. 281-293
    • Ma, Y.1    Shimizu, Y.2    Mann, M.J.3    Jin, Y.4    Hendershot, L.M.5
  • 27
    • 78851469165 scopus 로고    scopus 로고
    • Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling
    • COI: 1:CAS:528:DC%2BC3MXpvFCjsA%3D%3D, PID: 21268018
    • Goldfinger M, Shmuel M, Benhamron S, Tirosh B Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling. Eur J Immunol. 2011;41:491–502.
    • (2011) Eur J Immunol , vol.41 , pp. 491-502
    • Goldfinger, M.1    Shmuel, M.2    Benhamron, S.3    Tirosh, B.4
  • 29
    • 84896048275 scopus 로고    scopus 로고
    • Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells
    • COI: 1:CAS:528:DC%2BC3sXhvFOmurfM, PID: 24242955
    • Benhamron S, Hadar R, Iwawaky T, So JS, Lee AH, Tirosh B Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells. Eur J Immunol. 2014;44:867–76.
    • (2014) Eur J Immunol , vol.44 , pp. 867-876
    • Benhamron, S.1    Hadar, R.2    Iwawaky, T.3    So, J.S.4    Lee, A.H.5    Tirosh, B.6
  • 30
    • 84859258173 scopus 로고    scopus 로고
    • On the redox control of B lymphocyte differentiation and function
    • COI: 1:CAS:528:DC%2BC38XkvVSqsLk%3D, PID: 22229488
    • Bertolotti M, Sitia R, Rubartelli A On the redox control of B lymphocyte differentiation and function. Antioxid Redox Signal. 2012;16:1139–49.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1139-1149
    • Bertolotti, M.1    Sitia, R.2    Rubartelli, A.3
  • 32
    • 84879300138 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXptVOlu7o%3D, PID: 23729400
    • Vincenz L, Jager R, O’Dwyer M, Samali A Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma. Mol Cancer Ther. 2013;12:831–43.
    • (2013) Mol Cancer Ther , vol.12 , pp. 831-843
    • Vincenz, L.1    Jager, R.2    O’Dwyer, M.3    Samali, A.4
  • 34
    • 84934287525 scopus 로고    scopus 로고
    • Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma
    • PID: 25945832
    • Raninga PV, Di Trapani G, Vuckovic S, Bhatia M, Tonissen KF Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma. Oncotarget. 2015;6:15410–24.
    • (2015) Oncotarget , vol.6 , pp. 15410-15424
    • Raninga, P.V.1    Di Trapani, G.2    Vuckovic, S.3    Bhatia, M.4    Tonissen, K.F.5
  • 35
    • 0037332128 scopus 로고    scopus 로고
    • Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion
    • PID: 12594951
    • van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R, Braakman I, Heck AJ Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity. 2003;18:243–53.
    • (2003) Immunity , vol.18 , pp. 243-253
    • van Anken, E.1    Romijn, E.P.2    Maggioni, C.3    Mezghrani, A.4    Sitia, R.5    Braakman, I.6    Heck, A.J.7
  • 38
    • 84963978877 scopus 로고    scopus 로고
    • Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses
    • PID: 26586568
    • Arnold J, Murera D, Arbogast F, Fauny JD, Muller S, Gros F Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses. Cell Death Differ. 2015. doi:10.1038/cdd.2015.149.
    • (2015) Cell Death Differ
    • Arnold, J.1    Murera, D.2    Arbogast, F.3    Fauny, J.D.4    Muller, S.5    Gros, F.6
  • 39
    • 84934342481 scopus 로고    scopus 로고
    • KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models
    • PID: 26109433
    • Riz I, Hawley TS, Hawley RG KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget. 2015;6:14814–31.
    • (2015) Oncotarget , vol.6 , pp. 14814-14831
    • Riz, I.1    Hawley, T.S.2    Hawley, R.G.3
  • 41
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: the mTOR network in metabolism and signalling crosstalk
    • COI: 1:CAS:528:DC%2BC2cXivFagtrk%3D, PID: 24556838
    • Shimobayashi M, Hall MN Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol. 2014;15:155–62.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 42
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and −2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • COI: 1:CAS:528:DC%2BD38XotVKmsLY%3D, PID: 12271141
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J Tuberous sclerosis complex-1 and −2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002;99:13571–6.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 44
    • 84920025530 scopus 로고    scopus 로고
    • mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion
    • COI: 1:CAS:528:DC%2BC2MXhslKktrc%3D, PID: 25332234
    • Benhamron S, Pattanayak SP, Berger M, Tirosh B mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion. Mol Cell Biol. 2015;35:153–66.
    • (2015) Mol Cell Biol , vol.35 , pp. 153-166
    • Benhamron, S.1    Pattanayak, S.P.2    Berger, M.3    Tirosh, B.4


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