-
1
-
-
67650726486
-
Multiple myeloma
-
Raab MS, Podar K, Breitkreutz I, Richardson PG, Anderson KC. Multiple myeloma. Lancet. 2009; 374: 324-339.
-
(2009)
Lancet
, vol.374
, pp. 324-339
-
-
Raab, M.S.1
Podar, K.2
Breitkreutz, I.3
Richardson, P.G.4
Anderson, K.C.5
-
2
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal S, Mehta J, Desikan R, Ayers D, Roberson P, Eddlemon P, Munshi N, Anaissie E, Wilson C, Dhodapkar M, Zeddis J, Barlogie B. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999; 341: 1565-1571.
-
(1999)
N Engl J Med
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
Ayers, D.4
Roberson, P.5
Eddlemon, P.6
Munshi, N.7
Anaissie, E.8
Wilson, C.9
Dhodapkar, M.10
Zeddis, J.11
Barlogie, B.12
-
3
-
-
33750607347
-
A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
-
Richardson PG, Blood E, Mitsiades CS, Jagannath S, Zeldenrust SR, Alsina M, Schlossman RL, Rajkumar SV, Desikan KR, Hideshima T, Munshi NC, Kelly-Colson K, Doss D, McKenney ML, Gorelik S, Warren D, et al. A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood. 2006; 108: 3458-3464.
-
(2006)
Blood
, vol.108
, pp. 3458-3464
-
-
Richardson, P.G.1
Blood, E.2
Mitsiades, C.S.3
Jagannath, S.4
Zeldenrust, S.R.5
Alsina, M.6
Schlossman, R.L.7
Rajkumar, S.V.8
Desikan, K.R.9
Hideshima, T.10
Munshi, N.C.11
Kelly-Colson, K.12
Doss, D.13
McKenney, M.L.14
Gorelik, S.15
Warren, D.16
-
4
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, Goldschmidt H, Reece D, San-Miguel JF, Blade J, Boccadoro M, Cavenagh J, Dalton WS, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005; 352: 2487-2498.
-
(2005)
N Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
Harousseau, J.L.7
Ben-Yehuda, D.8
Lonial, S.9
Goldschmidt, H.10
Reece, D.11
San-Miguel, J.F.12
Blade, J.13
Boccadoro, M.14
Cavenagh, J.15
Dalton, W.S.16
-
5
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
6
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat. 2004; 7: 97-110.
-
(2004)
Drug Resist Updat
, vol.7
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
7
-
-
33748165596
-
Reactive oxygen species in cancer cells: live by the sword, die by the sword
-
Schumacker PT. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell. 2006; 10: 175-176.
-
(2006)
Cancer Cell
, vol.10
, pp. 175-176
-
-
Schumacker, P.T.1
-
8
-
-
84892366219
-
The thioredoxin antioxidant system
-
Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med. 2014; 66: 75-87.
-
(2014)
Free Radic Biol Med
, vol.66
, pp. 75-87
-
-
Lu, J.1
Holmgren, A.2
-
9
-
-
0034703631
-
Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions
-
Das KC, Das CK. Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions. Biochem Biophys Res Commun. 2000; 277: 443-447.
-
(2000)
Biochem Biophys Res Commun
, vol.277
, pp. 443-447
-
-
Das, K.C.1
Das, C.K.2
-
10
-
-
19444375216
-
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
-
Rhee SG, Chae HZ, Kim K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med. 2005; 38: 1543-1552.
-
(2005)
Free Radic Biol Med
, vol.38
, pp. 1543-1552
-
-
Rhee, S.G.1
Chae, H.Z.2
Kim, K.3
-
11
-
-
43549109795
-
Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine
-
Kim HY, Kim JR. Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine. Biochem Biophys Res Commun. 2008; 371: 490-494.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 490-494
-
-
Kim, H.Y.1
Kim, J.R.2
-
12
-
-
0242321235
-
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter
-
Bloomfield KL, Osborne SA, Kennedy DD, Clarke FM, Tonissen KF. Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter. Gene. 2003; 319: 107-116.
-
(2003)
Gene
, vol.319
, pp. 107-116
-
-
Bloomfield, K.L.1
Osborne, S.A.2
Kennedy, D.D.3
Clarke, F.M.4
Tonissen, K.F.5
-
13
-
-
0030936568
-
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
-
Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A. 1997; 94: 3633-3638.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 3633-3638
-
-
Hirota, K.1
Matsui, M.2
Iwata, S.3
Nishiyama, A.4
Mori, K.5
Yodoi, J.6
-
14
-
-
0030695172
-
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo
-
Baker A, Payne CM, Briehl MM, Powis G. Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res. 1997; 57: 5162-5167.
-
(1997)
Cancer Res
, vol.57
, pp. 5162-5167
-
-
Baker, A.1
Payne, C.M.2
Briehl, M.M.3
Powis, G.4
-
15
-
-
0042807630
-
The thioredoxin-thioredoxin reductase system: over-expression in human cancer
-
Lincoln DT, Ali Emadi EM, Tonissen KF, Clarke FM. The thioredoxin-thioredoxin reductase system: over-expression in human cancer. Anticancer Res. 2003; 23: 2425-2433.
-
(2003)
Anticancer Res
, vol.23
, pp. 2425-2433
-
-
Lincoln, D.T.1
Ali Emadi, E.M.2
Tonissen, K.F.3
Clarke, F.M.4
-
16
-
-
28544450990
-
High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer
-
Kim SJ, Miyoshi Y, Taguchi T, Tamaki Y, Nakamura H, Yodoi J, Kato K, Noguchi S. High thioredoxin expression is associated with resistance to docetaxel in primary breast cancer. Clin Cancer Res. 2005; 11: 8425-8430.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8425-8430
-
-
Kim, S.J.1
Miyoshi, Y.2
Taguchi, T.3
Tamaki, Y.4
Nakamura, H.5
Yodoi, J.6
Kato, K.7
Noguchi, S.8
-
17
-
-
84865690949
-
Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma
-
Li C, Thompson MA, Tamayo AT, Zuo Z, Lee J, Vega F, Ford RJ, Pham LV. Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma. Oncotarget. 2012; 3: 314-326.
-
(2012)
Oncotarget
, vol.3
, pp. 314-326
-
-
Li, C.1
Thompson, M.A.2
Tamayo, A.T.3
Zuo, Z.4
Lee, J.5
Vega, F.6
Ford, R.J.7
Pham, L.V.8
-
18
-
-
79551594518
-
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma
-
Iwasawa S, Yamano Y, Takiguchi Y, Tanzawa H, Tatsumi K, Uzawa K. Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma. Oncol Rep. 2011; 25: 637-644.
-
(2011)
Oncol Rep
, vol.25
, pp. 637-644
-
-
Iwasawa, S.1
Yamano, Y.2
Takiguchi, Y.3
Tanzawa, H.4
Tatsumi, K.5
Uzawa, K.6
-
19
-
-
79960017291
-
Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells
-
Liu JJ, Liu Q, Wei HL, Yi J, Zhao HS, Gao LP. Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells. Pharmazie. 2011; 66: 440-444.
-
(2011)
Pharmazie
, vol.66
, pp. 440-444
-
-
Liu, J.J.1
Liu, Q.2
Wei, H.L.3
Yi, J.4
Zhao, H.S.5
Gao, L.P.6
-
20
-
-
0031906550
-
Signal transduction through NF-kappa B
-
May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today. 1998; 19: 80-88.
-
(1998)
Immunol Today
, vol.19
, pp. 80-88
-
-
May, M.J.1
Ghosh, S.2
-
21
-
-
0033596127
-
Control of apoptosis by Rel/NF-kappaB transcription factors
-
Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 1999; 18: 6910-6924.
-
(1999)
Oncogene
, vol.18
, pp. 6910-6924
-
-
Barkett, M.1
Gilmore, T.D.2
-
22
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, Dave S, Hurt EM, Tan B, Zhao H, Stephens O, Santra M, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007; 12: 115-130.
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
Dave, S.11
Hurt, E.M.12
Tan, B.13
Zhao, H.14
Stephens, O.15
Santra, M.16
-
23
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer. 2002; 2: 927-937.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 927-937
-
-
Hideshima, T.1
Anderson, K.C.2
-
24
-
-
34547598337
-
Multiple myeloma: lusting for NF-kappaB
-
Gilmore TD. Multiple myeloma: lusting for NF-kappaB. Cancer Cell. 2007; 12: 95-97.
-
(2007)
Cancer Cell
, vol.12
, pp. 95-97
-
-
Gilmore, T.D.1
-
25
-
-
0035958517
-
The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications
-
Hideshima T, Chauhan D, Schlossman R, Richardson P, Anderson KC. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene. 2001; 20: 4519-4527.
-
(2001)
Oncogene
, vol.20
, pp. 4519-4527
-
-
Hideshima, T.1
Chauhan, D.2
Schlossman, R.3
Richardson, P.4
Anderson, K.C.5
-
26
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, Munshi N, Dang L, Castro A, Palombella V, Adams J, Anderson KC. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002; 277: 16639-16647.
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
Munshi, N.7
Dang, L.8
Castro, A.9
Palombella, V.10
Adams, J.11
Anderson, K.C.12
-
27
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Zeldenrust SR, Dingli D, Russell SJ, Lust JA, Greipp PR, Kyle RA, Gertz MA. Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008; 111: 2516-2520.
-
(2008)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
Lacy, M.Q.4
Hayman, S.R.5
Buadi, F.K.6
Zeldenrust, S.R.7
Dingli, D.8
Russell, S.J.9
Lust, J.A.10
Greipp, P.R.11
Kyle, R.A.12
Gertz, M.A.13
-
28
-
-
84897437312
-
The resistance mechanisms of proteasome inhibitor bortezomib
-
Lu S, Wang J. The resistance mechanisms of proteasome inhibitor bortezomib. Biomark Res. 2013; 1: 13.
-
(2013)
Biomark Res
, vol.1
, pp. 13
-
-
Lu, S.1
Wang, J.2
-
29
-
-
0026715172
-
Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62
-
Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 1992; 20: 3821-3830.
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 3821-3830
-
-
Matthews, J.R.1
Wakasugi, N.2
Virelizier, J.L.3
Yodoi, J.4
Hay, R.T.5
-
30
-
-
0032493647
-
Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds
-
Gromer S, Arscott LD, Williams CH, Jr., Schirmer RH, Becker K. Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J Biol Chem. 1998; 273: 20096-20101.
-
(1998)
J Biol Chem
, vol.273
, pp. 20096-20101
-
-
Gromer, S.1
Arscott, L.D.2
Williams, C.H.3
Schirmer, R.H.4
Becker, K.5
-
31
-
-
0032055646
-
Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides
-
Kirkpatrick DL, Kuperus M, Dowdeswell M, Potier N, Donald LJ, Kunkel M, Berggren M, Angulo M, Powis G. Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem Pharmacol. 1998; 55: 987-994.
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 987-994
-
-
Kirkpatrick, D.L.1
Kuperus, M.2
Dowdeswell, M.3
Potier, N.4
Donald, L.J.5
Kunkel, M.6
Berggren, M.7
Angulo, M.8
Powis, G.9
-
32
-
-
84907919427
-
Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide
-
Tan Y, Bi L, Zhang P, Wang F, Lin F, Ni W, Wu J, Jiang L. Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide. Int J Clin Exp Pathol. 2014; 7: 4765-4773.
-
(2014)
Int J Clin Exp Pathol
, vol.7
, pp. 4765-4773
-
-
Tan, Y.1
Bi, L.2
Zhang, P.3
Wang, F.4
Lin, F.5
Ni, W.6
Wu, J.7
Jiang, L.8
-
33
-
-
84891939128
-
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis
-
You BR, Shin HR, Park WH. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis. Int J Oncol. 2014; 44: 301-308.
-
(2014)
Int J Oncol
, vol.44
, pp. 301-308
-
-
You, B.R.1
Shin, H.R.2
Park, W.H.3
-
34
-
-
38549132452
-
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance
-
Matsui W, Wang Q, Barber JP, Brennan S, Smith BD, Borrello I, McNiece I, Lin L, Ambinder RF, Peacock C, Watkins DN, Huff CA, Jones RJ. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008; 68: 190-197.
-
(2008)
Cancer Res
, vol.68
, pp. 190-197
-
-
Matsui, W.1
Wang, Q.2
Barber, J.P.3
Brennan, S.4
Smith, B.D.5
Borrello, I.6
McNiece, I.7
Lin, L.8
Ambinder, R.F.9
Peacock, C.10
Watkins, D.N.11
Huff, C.A.12
Jones, R.J.13
-
35
-
-
77950819906
-
NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction
-
Rushworth SA, Bowles KM, Raninga P, MacEwan DJ. NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. Cancer Res. 2010; 70: 2973-2983.
-
(2010)
Cancer Res
, vol.70
, pp. 2973-2983
-
-
Rushworth, S.A.1
Bowles, K.M.2
Raninga, P.3
MacEwan, D.J.4
-
36
-
-
0028867742
-
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
-
Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem. 1995; 270: 24995-25000.
-
(1995)
J Biol Chem
, vol.270
, pp. 24995-25000
-
-
Singh, S.1
Aggarwal, B.B.2
-
37
-
-
84862846436
-
Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1
-
Hong YS, Hong SW, Kim SM, Jin DH, Shin JS, Yoon DH, Kim KP, Lee JL, Heo DS, Lee JS, Kim TW. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. Int J Oncol. 2012; 41: 76-82.
-
(2012)
Int J Oncol
, vol.41
, pp. 76-82
-
-
Hong, Y.S.1
Hong, S.W.2
Kim, S.M.3
Jin, D.H.4
Shin, J.S.5
Yoon, D.H.6
Kim, K.P.7
Lee, J.L.8
Heo, D.S.9
Lee, J.S.10
Kim, T.W.11
-
38
-
-
84868503037
-
Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells
-
Selimovic D, Porzig BB, El-Khattouti A, Badura HE, Ahmad M, Ghanjati F, Santourlidis S, Haikel Y, Hassan M. Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells. Cell Signal. 2013; 25: 308-318.
-
(2013)
Cell Signal
, vol.25
, pp. 308-318
-
-
Selimovic, D.1
Porzig, B.B.2
El-Khattouti, A.3
Badura, H.E.4
Ahmad, M.5
Ghanjati, F.6
Santourlidis, S.7
Haikel, Y.8
Hassan, M.9
-
39
-
-
84919455991
-
Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines
-
Wang F, Lin F, Zhang P, Ni W, Bi L, Wu J, Jiang L. Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines. Oncol Rep. 2015; 33: 967-973.
-
(2015)
Oncol Rep
, vol.33
, pp. 967-973
-
-
Wang, F.1
Lin, F.2
Zhang, P.3
Ni, W.4
Bi, L.5
Wu, J.6
Jiang, L.7
-
40
-
-
85017733693
-
PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner
-
You BR, Shin HR, Han BR, Park WH. PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner. Tumour Biol. 2014.
-
(2014)
Tumour Biol
-
-
You, B.R.1
Shin, H.R.2
Han, B.R.3
Park, W.H.4
-
41
-
-
84879123031
-
A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers
-
Baker AF, Adab KN, Raghunand N, Chow HH, Stratton SP, Squire SW, Boice M, Pestano LA, Kirkpatrick DL, Dragovich T. A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers. Invest New Drugs. 2013; 31: 631-641.
-
(2013)
Invest New Drugs
, vol.31
, pp. 631-641
-
-
Baker, A.F.1
Adab, K.N.2
Raghunand, N.3
Chow, H.H.4
Stratton, S.P.5
Squire, S.W.6
Boice, M.7
Pestano, L.A.8
Kirkpatrick, D.L.9
Dragovich, T.10
-
42
-
-
79953784421
-
A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination
-
Ramanathan RK, Abbruzzese J, Dragovich T, Kirkpatrick L, Guillen JM, Baker AF, Pestano LA, Green S, Von Hoff DD. A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination. Cancer Chemother Pharmacol. 2011; 67: 503-509.
-
(2011)
Cancer Chemother Pharmacol
, vol.67
, pp. 503-509
-
-
Ramanathan, R.K.1
Abbruzzese, J.2
Dragovich, T.3
Kirkpatrick, L.4
Guillen, J.M.5
Baker, A.F.6
Pestano, L.A.7
Green, S.8
Von Hoff, D.D.9
-
43
-
-
84900019686
-
Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia
-
Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, Wiestner A, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res. 2014; 74: 2520-2532.
-
(2014)
Cancer Res
, vol.74
, pp. 2520-2532
-
-
Fiskus, W.1
Saba, N.2
Shen, M.3
Ghias, M.4
Liu, J.5
Gupta, S.D.6
Chauhan, L.7
Rao, R.8
Gunewardena, S.9
Schorno, K.10
Austin, C.P.11
Maddocks, K.12
Byrd, J.13
Melnick, A.14
Huang, P.15
Wiestner, A.16
-
44
-
-
84908212007
-
Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells
-
Park N, Chun YJ. Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells. J Toxicol Environ Health A. 2014; 77: 1467-1476.
-
(2014)
J Toxicol Environ Health A
, vol.77
, pp. 1467-1476
-
-
Park, N.1
Chun, Y.J.2
-
45
-
-
84874742657
-
Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells
-
Kim NH, Park HJ, Oh MK, Kim IS. Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells. BMB Rep. 2013; 46: 59-64.
-
(2013)
BMB Rep
, vol.46
, pp. 59-64
-
-
Kim, N.H.1
Park, H.J.2
Oh, M.K.3
Kim, I.S.4
-
46
-
-
3242772761
-
Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro
-
Kim IS, Jin JY, Lee IH, Park SJ. Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro. Br J Pharmacol. 2004; 142: 749-755.
-
(2004)
Br J Pharmacol
, vol.142
, pp. 749-755
-
-
Kim, I.S.1
Jin, J.Y.2
Lee, I.H.3
Park, S.J.4
-
47
-
-
70449095882
-
Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity
-
Honeggar M, Beck R, Moos PJ. Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity. Toxicol Appl Pharmacol. 2009; 241: 348-355.
-
(2009)
Toxicol Appl Pharmacol
, vol.241
, pp. 348-355
-
-
Honeggar, M.1
Beck, R.2
Moos, P.J.3
-
48
-
-
0347986778
-
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
-
Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest. 2003; 112: 1395-1406.
-
(2003)
J Clin Invest
, vol.112
, pp. 1395-1406
-
-
Yamamoto, M.1
Yang, G.2
Hong, C.3
Liu, J.4
Holle, E.5
Yu, X.6
Wagner, T.7
Vatner, S.F.8
Sadoshima, J.9
-
49
-
-
77952311188
-
Thioredoxin and thioredoxin reductase: current research with special reference to human disease
-
Holmgren A, Lu J. Thioredoxin and thioredoxin reductase: current research with special reference to human disease. Biochem Biophys Res Commun. 2010; 396: 120-124.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 120-124
-
-
Holmgren, A.1
Lu, J.2
-
50
-
-
80054074183
-
Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells
-
Farina AR, Cappabianca L, DeSantis G, Di Ianni N, Ruggeri P, Ragone M, Merolle S, Tonissen KF, Gulino A, Mackay AR. Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells. FEBS Lett. 2011; 585: 3328-3336.
-
(2011)
FEBS Lett
, vol.585
, pp. 3328-3336
-
-
Farina, A.R.1
Cappabianca, L.2
DeSantis, G.3
Di Ianni, N.4
Ruggeri, P.5
Ragone, M.6
Merolle, S.7
Tonissen, K.F.8
Gulino, A.9
Mackay, A.R.10
-
51
-
-
79955974540
-
Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications
-
Jakubikova J, Adamia S, Kost-Alimova M, Klippel S, Cervi D, Daley JF, Cholujova D, Kong SY, Leiba M, Blotta S, Ooi M, Delmore J, Laubach J, Richardson PG, Sedlak J, Anderson KC, et al. Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. Blood. 2011; 117: 4409-4419.
-
(2011)
Blood
, vol.117
, pp. 4409-4419
-
-
Jakubikova, J.1
Adamia, S.2
Kost-Alimova, M.3
Klippel, S.4
Cervi, D.5
Daley, J.F.6
Cholujova, D.7
Kong, S.Y.8
Leiba, M.9
Blotta, S.10
Ooi, M.11
Delmore, J.12
Laubach, J.13
Richardson, P.G.14
Sedlak, J.15
Anderson, K.C.16
-
52
-
-
34250306257
-
Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
-
Ho MM, Ng AV, Lam S, Hung JY. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res. 2007; 67: 4827-4833.
-
(2007)
Cancer Res
, vol.67
, pp. 4827-4833
-
-
Ho, M.M.1
Ng, A.V.2
Lam, S.3
Hung, J.Y.4
-
53
-
-
34548596706
-
Side population cells isolated from mesenchymal neoplasms have tumor initiating potential
-
Wu C, Wei Q, Utomo V, Nadesan P, Whetstone H, Kandel R, Wunder JS, Alman BA. Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res. 2007; 67: 8216-8222.
-
(2007)
Cancer Res
, vol.67
, pp. 8216-8222
-
-
Wu, C.1
Wei, Q.2
Utomo, V.3
Nadesan, P.4
Whetstone, H.5
Kandel, R.6
Wunder, J.S.7
Alman, B.A.8
-
54
-
-
0034795256
-
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
-
Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 2001; 7: 1028-1034.
-
(2001)
Nat Med
, vol.7
, pp. 1028-1034
-
-
Zhou, S.1
Schuetz, J.D.2
Bunting, K.D.3
Colapietro, A.M.4
Sampath, J.5
Morris, J.J.6
Lagutina, I.7
Grosveld, G.C.8
Osawa, M.9
Nakauchi, H.10
Sorrentino, B.P.11
-
55
-
-
84874633096
-
Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells
-
Nara M, Teshima K, Watanabe A, Ito M, Iwamoto K, Kitabayashi A, Kume M, Hatano Y, Takahashi N, Iida S, Sawada K, Tagawa H. Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells. PLoS One. 2013; 8: e56954.
-
(2013)
PLoS One
, vol.8
-
-
Nara, M.1
Teshima, K.2
Watanabe, A.3
Ito, M.4
Iwamoto, K.5
Kitabayashi, A.6
Kume, M.7
Hatano, Y.8
Takahashi, N.9
Iida, S.10
Sawada, K.11
Tagawa, H.12
-
56
-
-
0029938958
-
Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines
-
Yamada M, Tomida A, Yoshikawa H, Taketani Y, Tsuruo T. Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. Clin Cancer Res. 1996; 2: 427-432.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 427-432
-
-
Yamada, M.1
Tomida, A.2
Yoshikawa, H.3
Taketani, Y.4
Tsuruo, T.5
-
57
-
-
79951844220
-
Bortezomib induces nuclear translocation of IkappaBalpha resulting in gene-specific suppression of NF-kappaB-dependent transcription and induction of apoptosis in CTCL
-
Juvekar A, Manna S, Ramaswami S, Chang TP, Vu HY, Ghosh CC, Celiker MY, Vancurova I. Bortezomib induces nuclear translocation of IkappaBalpha resulting in gene-specific suppression of NF-kappaB-dependent transcription and induction of apoptosis in CTCL. Mol Cancer Res. 2011; 9: 183-194.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 183-194
-
-
Juvekar, A.1
Manna, S.2
Ramaswami, S.3
Chang, T.P.4
Vu, H.Y.5
Ghosh, C.C.6
Celiker, M.Y.7
Vancurova, I.8
-
58
-
-
0036624741
-
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications
-
Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, Munshi N, Treon SP, Anderson KC. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood. 2002; 99: 4079-4086.
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.7
Treon, S.P.8
Anderson, K.C.9
-
59
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001; 61: 3071-3076.
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.J.4
Elliott, P.J.5
Adams, J.6
Anderson, K.C.7
-
60
-
-
84855204408
-
Bortezomib resistance in a myeloma cell line is associated to PSMbeta5 overexpression and polyploidy
-
Balsas P, Galan-Malo P, Marzo I, Naval J. Bortezomib resistance in a myeloma cell line is associated to PSMbeta5 overexpression and polyploidy. Leuk Res. 2012; 36: 212-218.
-
(2012)
Leuk Res
, vol.36
, pp. 212-218
-
-
Balsas, P.1
Galan-Malo, P.2
Marzo, I.3
Naval, J.4
-
61
-
-
42249109833
-
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib
-
Nerini-Molteni S, Ferrarini M, Cozza S, Caligaris-Cappio F, Sitia R. Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib. Br J Haematol. 2008; 141: 494-503.
-
(2008)
Br J Haematol
, vol.141
, pp. 494-503
-
-
Nerini-Molteni, S.1
Ferrarini, M.2
Cozza, S.3
Caligaris-Cappio, F.4
Sitia, R.5
-
62
-
-
84857997426
-
Cycling hypoxia up-regulates thioredoxin levels in human MDA-MB-231 breast cancer cells
-
Karlenius TC, Shah F, Di Trapani G, Clarke FM, Tonissen KF. Cycling hypoxia up-regulates thioredoxin levels in human MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun. 2012; 419: 350-355.
-
(2012)
Biochem Biophys Res Commun
, vol.419
, pp. 350-355
-
-
Karlenius, T.C.1
Shah, F.2
Di Trapani, G.3
Clarke, F.M.4
Tonissen, K.F.5
-
63
-
-
33748373173
-
The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure
-
Osborne SA, Hawkes HJ, Baldwin BL, Alexander KA, Svingen T, Clarke FM, Tonissen KF. The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure. Biochem J. 2006; 398: 269-277.
-
(2006)
Biochem J
, vol.398
, pp. 269-277
-
-
Osborne, S.A.1
Hawkes, H.J.2
Baldwin, B.L.3
Alexander, K.A.4
Svingen, T.5
Clarke, F.M.6
Tonissen, K.F.7
-
64
-
-
58149181985
-
Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes
-
Rushworth SA, MacEwan DJ, O'Connell MA. Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol. 2008; 181: 6730-6737.
-
(2008)
J Immunol
, vol.181
, pp. 6730-6737
-
-
Rushworth, S.A.1
MacEwan, D.J.2
O'Connell, M.A.3
-
65
-
-
53649092133
-
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation
-
Cox AG, Brown KK, Arner ES, Hampton MB. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochem Pharmacol. 2008; 76: 1097-1109.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 1097-1109
-
-
Cox, A.G.1
Brown, K.K.2
Arner, E.S.3
Hampton, M.B.4
-
66
-
-
79959590587
-
Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
-
Xie Z, Bi C, Cheong LL, Liu SC, Huang G, Zhou J, Yu Q, Chen CS, Chng WJ. Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. PLoS One. 2011; 6: e21583.
-
(2011)
PLoS One
, vol.6
-
-
Xie, Z.1
Bi, C.2
Cheong, L.L.3
Liu, S.C.4
Huang, G.5
Zhou, J.6
Yu, Q.7
Chen, C.S.8
Chng, W.J.9
|