Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: Results from a pilot study

Reproductive Biology and Endocrinology

Volumn 13, Issue 1, 2015, Pages

  Tartagni, Massimo ^a   Matteo, Maria ^b   Baldini, Domenico ^c   Tartagni, Mario V ^c   Alrasheed, Hala ^c   De Salvia, Maria A ^a   Loverro, Giuseppe ^a   Montagnani, Monica ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b Ospedali Riuniti di Foggia   (Italy)

^c Centro di Fecondazione Medicalmente Assistita MoMo Fertilife   (Italy)

Author keywords

Hypovitaminosis D; Male infertility; Pregnancy rate; Vitamin D

Indexed keywords

ESTROGEN; GLUCOSE; PROSTATE SPECIFIC ANTIGEN; VITAMIN D;

ADULT; ARTICLE; BODY MASS; CHILDBIRTH; COITUS; CONTROLLED STUDY; DISEASE DURATION; ESTROGEN BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFERTILITY THERAPY; MALE; MALE INFERTILITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; OVARY FOLLICLE; OVULATION INDUCTION; PILOT STUDY; PREGNANCY RATE; REPRODUCTIVE SUCCESS; SEMEN ANALYSIS; SEXUAL ABSTINENCE; SEXUAL INTERCOURSE; SPERMATOZOON MOTILITY; SPONTANEOUS ABORTION; TIME TO PREGNANCY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; BLOOD; INFERTILITY; PHYSIOLOGY; PREGNANCY; SPERMATOZOON COUNT;

ADULT; COITUS; FEMALE; HUMANS; INFERTILITY; MALE; OVULATION INDUCTION; PILOT PROJECTS; PREGNANCY; PREGNANCY RATE; SPERM COUNT; SPERM MOTILITY; VITAMIN D;

EID: 84959095589     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/s12958-015-0126-9     Document Type: Article

References (52)

1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.
2. Holick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public Health Rev. 2010;32:267-83.
3. Wacker M, Holick MF. Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5(1):111-48.
4. Zheng Y, Zhu J, Zhou M, Cui L, Yao W, Liu Y. Meta-analysis of long-term vitamin D supplementation on overall mortality. PLoS One. 2013;8(12):e82109.
5. Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology. 2014;83(10):920-8.
6. Grober U, Reichrath J, Holick MF. Live longer with vitamin D? Nutrients. 2015;7(3):1871-80.
7. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376(9736):180-8.
8. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6.
9. Lips P. Vitamin D physiology. Prog Biophys Mol Biol. 2006;92(1):4-8.
10. Ashwell M, Stone EM, Stolte H, Cashman KD, Macdonald H, Lanham-New S, et al. UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status. Br J Nutr. 2010;104(4):603-11.
11. DeLuca HF. The kidney as an endocrine organ for the production of 1,25-dihydroxyvitamin D 3, a calcium-mobilizing hormone. N Engl J Med. 1973;289(7):359-65.
12. Bouillon R, Okamura WH, Norman AW. Structure-function relationships in the vitamin D endocrine system. Endocr Rev. 1995;16(2):200-57.
13. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, et al. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res. 1998;13(3):325-49.
14. Brot C, Vestergaard P, Kolthoff N, Gram J, Hermann AP, Sorensen OH. Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr. 2001;86 Suppl 1:S97-103.
15. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69(5):842-56.
16. NCT01304927 CgI. Vitamin D Supplementation and Male Infertility: The Copenhagen Bone-Gonadal Study a Double Blinded Randomized Clinical Trial. 2011. https://clinicaltrials.gov/
17. Diehl JW, Chiu MW. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatol Ther. 2010;23(1):48-60.
18. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr. 2008;88(6):1519-27.
19. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807-20.
20. Spiro A, Buttriss JL. Vitamin D: an overview of vitamin D status and intake in Europe. Nutr Bull. 2014;39(4):322-50.
21. Lippi G, Nouvenne A, Ticinesi A, Bonelli P, Salvagno GL, Cervellin G, et al. The burden of vitamin D deficiency in a Mediterranean country without a policy of food fortification. Acta Biomed. 2015;86(1):59-62.
22. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology. 2006;68(6):1345-9.
23. Luk J, Torrealday S, Neal Perry G, Pal L. Relevance of vitamin D in reproduction. Hum Reprod. 2012;27(10):3015-27.
24. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet. 1997;16(4):391-6.
25. Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. J Nutr. 1989;119(5):741-4.
26. Sun W, Chen L, Zhang W, Wang R, Goltzman D, Miao D. Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice. Am J Physiol Endocrinol Metab. 2015;308(1):E51-62.
27. Nangia AK, Hill O, Waterman MD, Schwender CE, Memoli V. Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. J Urol. 2007;178(3 Pt 1):1092-6.
28. Blomberg Jensen M. Vitamin D and male reproduction. Nat Rev Endocrinol. 2014;10(3):175-86.
29. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726-76.
30. Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011;26(3):455-7.
31. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
32. Committee ADAA-PP. Standards of medical care in diabetes-2015: summary of revisions and position statement. Diabetes Care. 2015;38 Suppl 1:S1-93.
33. Organization WH. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization, Department of Reproductive Health and Research; 2010. p. 1-287.
34. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16(3):231-45.
35. Melis GB, Paoletti AM, Strigini F, Menchini Fabris F, Canale D, Fioretti P. Pharmacologic induction of multiple follicular development improves the success rate of artificial insemination with husband's semen in couples with male-related or unexplained infertility. Fertil Steril. 1987;47(3):441-5.
36. (WHO) WHO. Infertility. 2013.
37. Bonde JP, Ernst E, Jensen TK, Hjollund NH, Kolstad H, Henriksen TB, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet. 1998;352(9135):1172-7.
38. Sun W, Xie H, Ji J, Zhou X, Goltzman D, Miao D. Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus. Am J Physiol Endocrinol Metab. 2010;299(6):E928-35.
39. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol. 2012;28(12):965-8.
40. Fischer D, Schroer A, Ludders D, Cordes T, Bucker B, Reichrath J, et al. Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births. Clin Exp Obstet Gynecol. 2007;34(2):80-4.
41. Vanni VS, Vigano P, Somigliana E, Papaleo E, Paffoni A, Pagliardini L, et al. Vitamin D and assisted reproduction technologies: current concepts. Reprod Biol Endocrinol. 2014;12:47.
42. Melis GB, Strigini F, Mais V, Paoletti AM, Olivieri L, Antinori D, et al. Critical reappraisal of the clinical effectiveness of different methods of assisted fertilization. J Endocrinol Invest. 1990;13(3):263-74.
43. Mascarenhas L, Khastgir G, Davies WA, Lee S. Superovulation and timed intercourse: can it provide a reasonable alternative for those unable to afford assisted conception? Hum Reprod. 1994;9(1):67-70.
44. Aquila S, Guido C, Perrotta I, Tripepi S, Nastro A, Ando S. Human sperm anatomy: ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. J Anat. 2008;213(5):555-64.
45. Aquila S, Guido C, Middea E, Perrotta I, Bruno R, Pellegrino M, et al. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reprod Biol Endocrinol. 2009;7:140.
46. Hamden K, Carreau S, Jamoussi K, Miladi S, Lajmi S, Aloulou D, et al. 1Alpha,25 dihydroxyvitamin D3: therapeutic and preventive effects against oxidative stress, hepatic, pancreatic and renal injury in alloxan-induced diabetes in rats. J Nutr Sci Vitaminol (Tokyo). 2009;55(3):215-22.
47. Polidoro L, Properzi G, Marampon F, Gravina GL, Festuccia C, Di Cesare E, et al. Vitamin D protects human endothelial cells from H(2)O(2) oxidant injury through the Mek/Erk-Sirt1 axis activation. J Cardiovasc Transl Res. 2013;6(2):221-31.
48. Asemi Z, Samimi M, Tabassi Z, Shakeri H, Esmaillzadeh A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr. 2013;143(9):1432-8.
49. Check JH, Katsoff D, Check ML. Some semen abnormalities may cause infertility by impairing implantation rather than fertilization. Med Hypotheses. 2001;56(5):653-7.
50. Denker HW. Implantation: a cell biological paradox. J Exp Zool. 1993;266(6):541-58.
51. Daniels R, Kinis T, Serhal P, Monk M. Expression of the myotonin protein kinase gene in preimplantation human embryos. Hum Mol Genet. 1995;4(3):389-93.
52. Howarth B, Alliston CW, Ulberg LC. Importance of uterine environment on rabbit sperm prior to fertilization. J Anim Sci. 1965;24:1027-32.