Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism

Reproductive Biology and Endocrinology

Volumn 7, Issue , 2009, Pages

  Aquila, Saveria ^a   Guido, Carmela ^a   Middea, Emilia ^a   Perrotta, Ida ^a   Bruno, Rosalinda ^a   Pellegrino, Michele ^a   Andò, Sebastiano ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACROSIN; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CALCITRIOL RECEPTOR; CALCIUM; GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; ACYL COENZYME A DEHYDROGENASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; RNA;

ARTICLE; CALCIUM CELL LEVEL; CELL METABOLISM; CELL STIMULATION; CONTROLLED STUDY; ENDOCRINOLOGY; ENZYME ACTIVITY; FERTILIZATION; GAMETE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; PARACRINE SIGNALING; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPERM; SPERMATOZOON MOTILITY; WESTERN BLOTTING; ADULT; BIOSYNTHESIS; CELL SEPARATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; GERM CELL; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; SPERMATOZOON;

ACROSIN; ACYL-COA DEHYDROGENASE; ADULT; BLOTTING, WESTERN; CALCITRIOL; CALCIUM; CELL SEPARATION; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; GERM CELLS; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; LIPASE; MALE; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SPERM MOTILITY; SPERMATOZOA; TRIGLYCERIDES;

EID: 72549100959     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-7-140     Document Type: Article

References (60)

1. Zehnder D, Bland R, Walker EA, Bradwell AR, Howie AJ, Hewison M, Stewart PM. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney. J Am Soc Nephrol 1999, 10:2465-2473.
2. Sunn KL, Cock TA, Crofts LA, Eisman JA, Gardiner EM. Novel N-Terminal Variant of Human VDR. Mol Endocrinol 2001, 15:1599-1609. 10.1210/me.15.9.1599, 11518809.
3. Jurutka PW, Whitfield GK, Hsieh JC, Thompson PD, Haussler CA, Haussler MR. Molecular Nature of the Vitamin D Receptor and its Role in Regulation of Gene Expression. End & Metab Disorders 2001, 2:203-216.
4. Nemere I, Yoshimoto Y, Norman AW. Calcium transport in perfused duodena from normal chicks: enhancement within 14 minutes of exposure to 1α,25-dihydroxyvitamin D3. Endocrinology 1984, 115:1476-1483. 10.1210/endo-115-4-1476, 6548181.
5. Norman AW, Okamura WH, Hammond MW, Bishop JE, Dormanen MC, Bouillon R, Van Baelen H, Ridall AL, Daane E, Khoury R. Comparison of 6-s-cis and 6-s-trans locked analogs of 1,25(OH)2-vitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis nor 6-s-trans locked analogs are preferred for genomic biological responses. Mol Endocrinol 1997, 11:1518-1531. 10.1210/me.11.10.1518, 9280067.
6. Kadowaki S, Norman AW. Time-course study of insulin secretion after 1α,25-dihydroxyvitamin D3 administration. Endocrinology 1985, 117:1765-1771. 10.1210/endo-117-5-1765, 3899614.
7. Kajikawa M, Ishida H, Fujimoto S, Mukai E, Nishimura M, Fujita J, Tsuura Y, Okamoto Y, Norman AW, Seino Y. An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic β-cells through nongenomic signal transduction. Endocrinology 1999, 140:4706-4712. 10.1210/en.140.10.4706, 10499529.
8. Rebsamen MC, Sun J, Norman AW, Liao JK. 1α,25-Dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase. Circ Res 2002, 91:17-24. 10.1161/01.RES.0000025269.60668.0F, 12114317.
9. Gniadecki R. Activation of Raf-mitogen-activated protein kinase signaling pathway by 1α,25-dihydroxyvitamin D3 in normal human keratinocytes. J Invest Dermatol 1996, 106:1212-1217. 10.1111/1523-1747.ep12348498, 8752659.
10. Massheimer V, Boland R, De Boland AR. Rapid 1,25(OH)2-vitamin D3 stimulation of calcium uptake by rat intestinal cells involves a dihydropyridine-sensitive cAMP-dependent pathway. Cell Signal 1994, 3:299-304.
11. Buitrago C, Gonzalez PV, Russo DB, Boland R. Activation of RAF-1 through RAS and PKC mediates 1,25(OH)2D3 regulation of the map kinase pathway in muscle cells. J Biol Chem 2002, 278:2199-2205. 10.1074/jbc.M205732200, 12417593.
12. Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem Cell Biol 1995, 105:7-15.
13. Habib FK, Maddy SQ, Gelly KJ. Characterisation of receptors for 1,25-dihydroxyvitamin D3 in the human testis. Steroid Biochem 1990, 35:195-199.
14. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology 2006, 68:1345-1349. 10.1016/j.urology.2006.09.011, 17169662.
15. Aquila S, Guido C, Perrotta I, Tripepi S, Nastro A, Andò S. Human sperm anatomy: ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. J Anat 2008, 213:555-564.
16. Kwiecinksi GG, Petrie GI, DeLuca HF. 1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats. Am J Physil 1989, 256:483-487.
17. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia, and growth retardation after weaning. Nat Genet 1997, 16:391-396. 10.1038/ng0897-391, 9241280.
18. Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, Rago V, Andò S. Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway. J Clin Endocrinol Metab 2004, 89:1443-1451. 10.1210/jc.2003-031681, 15001646.
19. El-Hefnawy T, Manna PR, Luconi M, Baldi E, Slotte PJ. Huhtaniemi: Progesterone Action in a Murine Leydig Tumor Cell Line (mLTC-1), Possibly through a Nonclassical Receptor Type. Endocrinology 2000, 141:247-255. 10.1210/en.141.1.247, 10614645.
20. Grunewald S, Paasch U, Glander HJ, Anderegg U. Mature human spermatozoa do not transcribe novel RNA. Andrologia 2005, 37:69-71. 10.1111/j.1439-0272.2005.00656.x, 16026427.
21. Aquila S, Gentile M, Middea E, Catalano S, Morelli C, Pezzi V, Andò S. Leptin Secretion by Human Ejaculated Spermatozoa. J Clin Endocrinol Metab 2005, 90:4753-4761. 10.1210/jc.2004-2233, 15944217.
22. World Health Organization Laboratory manual for the examination of human semen and sperm-cervical mucus interactions. 1999, Cambridge UK Cambridge University Press, 4.
23. Aquila S, Sisci D, Gentile M, Middea E, Siciliano L, Andò S. Human Ejaculated Spermatozoa Contain Active P450 Aromatase. J Clin Endocrinol Metab 2002, 87:3385-3390. 10.1210/jc.87.7.3385, 12107254.
24. Diesing D, Cordes T, Fischer D, Diedrich K, Friedrich M. Vitamin D--metabolism in the human breast cancer cell line MCF-7. Anticancer Res 2006, 26:2755-2759.
25. Ovsiannikov AI, Kon'kov SA, Gurkalo VK. Measurement of calcium content in the blood and other biological fluids by Arsenazo III complexone. Klin Lab Diagn 1999, 1:16-18.
26. Aquila S, Guido C, Laezza C, Santoro A, Pezzi V, Panza S, Andò S, Bifulco M. A new role of anandamide in human sperm: focus on metabolism. J Cell Physiol 2009, 221:147-153. 10.1002/jcp.21837, 19492411.
27. Kennedy WP, Kaminski JM, Ven HH, Jeyendran RS, Reid DS, Blackwell J, Bielfeld P, Zaneveld LJ. A simple, clinical assay to evaluate the acrosin activity of human spermatozoa. J Androl 1989, 10:221-231.
28. Aquila S, Sisci D, Gentile M, Carpino A, Middea E, Catalano S, Rago V, Andò S. Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm. Hum Reprod 2003, 18:1650-1659. 10.1093/humrep/deg340, 12871877.
29. Aquila S, Bonofiglio D, Gentile M, Middea E, Gabriele S, Belmonte M, Catalano S, Pellegrino M, Andò S. Peroxisome proliferator-activated receptor (PPAR)gamma is expressed by human spermatozoa: its potential role on the sperm physiology. J Cell Physiol 2006, 209:977-986. 10.1002/jcp.20807, 16972250.
30. Lehman TC, Hale DE, Bhala A, Thorpe C. An acyl-coenzyme A dehydrogenase assay utilizing the ferricenium ion. Anal Biochem 1990, 186:280-284. 10.1016/0003-2697(90)90080-S, 2363500.
31. Panteghini M, Bonora R, Pagani F. Measurement of pancreatic lipase activity in serum by a kinetic colorimetric assay using a new chromogenic substrate. Ann Clin Biochem 2001, 38:365-370. 10.1258/0004563011900876, 11471878.
32. Mork Hansen C, Rohde L, Madsen MW, Hansen D, Colston KW, Pirianov G, Holm PK, Binderup L. MCF-7/VDR A new vitamin D resistant cell line. J Cell Biochem 2001, 82:3.
33. Leman ES, Arlotti JA, Dhir R, Getzenberg RH. Vitamin D and androgen regulation of prostatic growth. J Cell Biochem 2003, 90:138-147. 10.1002/jcb.10605, 12938163.
34. Lou YR, Laaksi I, Syvala H, Blauer M, Tammela TLJ, Ylikomi T, Tuohimaa P. 25-Hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells. Faseb J 2004, 18:332-334.
35. Banerjee P, Chatterjee M. Antiproliferative role of vitamin D and its analogs--a brief overview. Mol Cell Biochem 2003, 253:247-254. 10.1023/A:1026072118217, 14619976.
36. Kong LJ, Yang YY, Wang GL. CatSper and sperm hyperactivation. Zhonghua Nan Ke Xue 2007, 13:164-167.
37. Peacock M. Vitamin D receptor gene alleles and osteoporosis: a contrasting view. J Bone Miner Res 1995, 10:1294-1297.
38. Reichel H, Koeffler HP, Norman AW. The role of the vitamin D endocrinesystem in health and disease. N Engl J Med 1989, 320:980-991.
39. Nangia AK, Butcher JL, Konety BR, Vietmeie BN, Getzenberg RH. Association of vitamin D receptors with the nuclear matrix of human and rat genitourinary tissues. Steroid Biochem 1998, 66:241-246.
40. Norman AW, Mizwicki MT, Norman DP. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 2004, 3:27-41. 10.1038/nrd1283, 14708019.
41. Aquila S, Middea E, Catalano S, Marsico S, Lanzino M, Casaburi I, Barone I, Bruno R, Zupo S, Andò S. Human sperm express a functional androgen receptor: effects on PI3K/AKT pathway. Hum Reprod 2007, 22:2594-2605. 10.1093/humrep/dem243, 17656415.
42. Florman HM, Arnoult C, Kazam IG, Li C, O'Toole CM. A perspective on the control of mammalian fertilization by egg-activated ion channels in sperm: a tale of two channels. Biol Reprod 1998, 59:12-16. 10.1095/biolreprod59.1.12, 9674987.
43. Suarez SS, Ho HC. Hyperactivation of mammalian sperm. Cell Mol Biol 2003, 49:351-356.
44. Steinberg D. Prostaglandins as adrenergic antagonists. Ann N Y Acad Sci 1967, 139:897-909. 10.1111/j.1749-6632.1967.tb41259.x, 4292400.
45. Mita M, Yasumasu I, Nakamura M. Energy metabolism of spermatozoa of the sand dollar Clypeaster japonicus: the endogenous substrate and ultrastructural correlates. J Biochem 1994, 116:108-113.
46. Zhang L, Lookene A, Wu G, Olivecrona G. Calcium triggers folding of lipoprotein lipase into active dimers. J Biol Chem 2005, 280:42580-42591. 10.1074/jbc.M507252200, 16179346.
47. Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J 2001, 15:2751-2753.
48. Schrager S. Dietary Calcium Intake and Obesity. J Am Board Fam Practice 2005, 18:205-210.
49. Suarez SS, Dai X. Intracellular calcium reaches different levels of elevation in hyperactivated and acrosome-reacted hamster sperm. Mol Reprod Dev 1995, 42:325-333. 10.1002/mrd.1080420310, 8579847.
50. Dube C, Tardif S, LeClerc P, Bailey JL. The importance of calcium in the appearance of p32, a boar sperm tyrosine phosphoprotein, during in vitro capacitation. J Androl 2003, 24:727-733.
51. Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006, 147:5542-5548. 10.1210/en.2006-0946, 16946007.
52. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185. 10.1016/0092-8674(95)90401-8, 7834738.
53. Castoria G, Lombardi M, Barone MV, Bilancio A, Di Domenico M, Bottero D, Vitale F, Migliaccio A, Auricchio F. Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action. J Cell Biol 2003, 161:547-556. 10.1083/jcb.200211099, 2172930, 12743104.
54. Uotani S, Bjørbaek C, Tornøe J, Flier J. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 1999, 48:279-286. 10.2337/diabetes.48.2.279, 10334302.
55. Friedrich M, Villena-Heinsen C, Axt-Fliedner R, Meyberg R, Tilgen W, Schmidt W, Reichrath J. Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue. Anticancer Res 2002, 22:183-186.
56. Evans KN, Bulmer JN, Kilby MD, Hewison M. Vitamin D and placental-decidual function. J Soc Gynecol Investig 2004, 11:263-271. 10.1016/j.jsgi.2004.02.002, 15219879.
57. Becker S, Cordes T, Diesing D, Diedrich K, Friedrich M. Expression of 25 hydroxyvitamin D3-1alpha-hydroxylase in human endometrial tissue. J Steroid Biochem Mol Biol 2007, 103:771-775. 10.1016/j.jsbmb.2006.12.075, 17236759.
58. Yildirim BN, Abban G, Rota S, Jetten A. Immunohistochemical Detection and Distribution Cornifin and Vitamin D Receptor Expression in Vaginal Epithelium Treated With Vitamin. D3. J Turkish-German Gynecol Assoc 2007, 8:33-37.
59. Pérez-López FR. Sunlight, the vitamin D endocrine system, and their relationships with gynaecologic cancer. Maturitas 2008, 59:101-113. 10.1016/j.maturitas.2007.12.007, 18289805.
60. Teilmann SC, Clement CA, Thorup J, Byskov AG, Christensen ST. Expression and localization of the progesterone receptor in mouse and human reproductive organs. J Endocrinol 2006, 191:525-535. 10.1677/joe.1.06565, 17170211.