-
1
-
-
73449088379
-
Vaccines: the fourth century
-
S.A.Plotkin Vaccines: the fourth century. Clin Vaccine Immunol. 2009;16(12):1709–1719. doi:10.1128/CVI.00290-09.
-
(2009)
Clin Vaccine Immunol
, vol.16
, Issue.12
, pp. 1709-1719
-
-
Plotkin, S.A.1
-
2
-
-
84951566775
-
Prospects for a globally effective HIV-1 vaccine
-
J.L.Excler, M.L.Robb, J.H.Kim. Prospects for a globally effective HIV-1 vaccine. Vaccine. 2015;33(Suppl 4):D4–D12. doi:10.1016/j.vaccine.2015.03.059.
-
(2015)
Vaccine
, vol.33
, pp. D4-D12
-
-
Excler, J.L.1
Robb, M.L.2
Kim, J.H.3
-
4
-
-
0013961951
-
Influence of antigens on release of free fatty acids from Arlacel A (mannide monooleate)
-
M.C.Hardegree, M.Pittman. Influence of antigens on release of free fatty acids from Arlacel A (mannide monooleate). Proc Soc Exp Biol Med. 1966;123(1):179–184.
-
(1966)
Proc Soc Exp Biol Med
, vol.123
, Issue.1
, pp. 179-184
-
-
Hardegree, M.C.1
Pittman, M.2
-
5
-
-
84922398714
-
Adjuvants for vaccines to drugs of abuse and addiction
-
C.R.Alving, G.R.Matyas, O.Torres, et al. Adjuvants for vaccines to drugs of abuse and addiction. Vaccine. 2014;32(42):5382–5389.
-
(2014)
Vaccine
, vol.32
, Issue.42
, pp. 5382-5389
-
-
Alving, C.R.1
Matyas, G.R.2
Torres, O.3
-
6
-
-
84906785463
-
Designing and building the next generation of improved vaccine adjuvants
-
L.A.Brito, D.T.O’Hagan. Designing and building the next generation of improved vaccine adjuvants. J Control Release. 2014;190:563–579.• Places the development of liposome-based adjuvants in the greater context of the development of commercial vaccine adjuvants.
-
(2014)
J Control Release
, vol.190
, pp. 563-579
-
-
Brito, L.A.1
O’Hagan, D.T.2
-
7
-
-
3142657967
-
Influenza virosomes as an efficient system for adjuvanted vaccine delivery
-
R.Glück, C.Moser, I.C.Metcalfe. Influenza virosomes as an efficient system for adjuvanted vaccine delivery. Expert Opin Biol Ther. 2004;4(7):1139–1145. doi:10.1517/14712598.4.7.1139.
-
(2004)
Expert Opin Biol Ther
, vol.4
, Issue.7
, pp. 1139-1145
-
-
Glück, R.1
Moser, C.2
Metcalfe, I.C.3
-
8
-
-
84880897333
-
Influenza virosomes as vaccine adjuvant and carrier system
-
C.Moser, M.Müller, M.D.Kaeser, et al. Influenza virosomes as vaccine adjuvant and carrier system. Expert Rev Vaccines. 2013;12(7):779–791.•• Detailed review of history of intellectual property development and clinical use of virosome adjuvant/antigen technology, particularly as it relates to influenza virus.
-
(2013)
Expert Rev Vaccines
, vol.12
, Issue.7
, pp. 779-791
-
-
Moser, C.1
Müller, M.2
Kaeser, M.D.3
-
9
-
-
79955086319
-
Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems
-
N.Garçon, M.Van Mechelen. Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines. 2011;10(4):471–486.• Summary of the GSK liposome vaccine technology.
-
(2011)
Expert Rev Vaccines.
, vol.10
, Issue.4
, pp. 471-486
-
-
Garçon, N.1
Van Mechelen, M.2
-
11
-
-
84864924172
-
Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines
-
C.R.Alving, M.Rao, N.J.Steers, et al. Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Rev Vaccines. 2012;11(6):733–744.•• Detailed review of history, intellectual properties, and activities of lipid A, MPLA, and liposomes containing lipid A.
-
(2012)
Expert Rev Vaccines
, vol.11
, Issue.6
, pp. 733-744
-
-
Alving, C.R.1
Rao, M.2
Steers, N.J.3
-
12
-
-
84857785011
-
Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens
-
D.S.Watson, A.N.Endsley, L.Huang. Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens. Vaccine. 2012;30(13):2256–2272.• Detailed review that includes a summary of preclinical research and clinical development of various types of liposomes as adjuvants.
-
(2012)
Vaccine
, vol.30
, Issue.13
, pp. 2256-2272
-
-
Watson, D.S.1
Endsley, A.N.2
Huang, L.3
-
13
-
-
84880675799
-
A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvant
-
Y.Perrie, E.Kastner, R.Kaur, et al. A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvant. Hum Vaccin Immunother. 2013;9(6):1374–1381.• Provides a reasoned algorithm for the initiation and development of cationic liposomal adjuvants.
-
(2013)
Hum Vaccin Immunother
, vol.9
, Issue.6
, pp. 1374-1381
-
-
Perrie, Y.1
Kastner, E.2
Kaur, R.3
-
14
-
-
84926435038
-
Liposomes as vaccine delivery systems: a review of the recent advances
-
R.A.Schwendener. Liposomes as vaccine delivery systems: a review of the recent advances. Ther Adv Vaccines. 2014;2(6):159–182. doi:10.1177/2051013614541440.
-
(2014)
Ther Adv Vaccines
, vol.2
, Issue.6
, pp. 159-182
-
-
Schwendener, R.A.1
-
15
-
-
85012373035
-
Diffusion of univalent ions across the lamellae of swollen phospholipids
-
A.D.Bangham, M.M.Standish, J.C.Watkins. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13(1):238–252.• Original description of liposomes.
-
(1965)
J Mol Biol.
, vol.13
, Issue.1
, pp. 238-252
-
-
Bangham, A.D.1
Standish, M.M.2
Watkins, J.C.3
-
16
-
-
0014360953
-
Membrane models with phospholipids
-
A.D.Bangham. Membrane models with phospholipids. Prog Biophys Mol Biol. 1968;18:29–95.
-
(1968)
Prog Biophys Mol Biol
, vol.18
, pp. 29-95
-
-
Bangham, A.D.1
-
17
-
-
0021982417
-
Lipid polymorphism: the molecular basis of nonbilayer phases
-
S.M.Gruner, P.R.Cullis, M.J.Hope, et al. Lipid polymorphism: the molecular basis of nonbilayer phases. Annu Rev Biophys Biophys Chem. 1985;14:211–238. doi:10.1146/annurev.bb.14.060185.001235.
-
(1985)
Annu Rev Biophys Biophys Chem
, vol.14
, pp. 211-238
-
-
Gruner, S.M.1
Cullis, P.R.2
Hope, M.J.3
-
18
-
-
0000427542
-
The physical states of lipids: solids, mesomorphic states, and liquids
-
Small D.M., (ed), New York: Plenum
-
D.M.Small. The physical states of lipids: solids, mesomorphic states, and liquids. In: D.M.Small, editor. The physical chemical of lipids. From alkanes to phospholipids. New York: Plenum; 1986. p. 43–87.• Comprehensive and authoritative description of the biophysical characteristics and chemistry of liposomal lipids.
-
(1986)
The physical chemical of lipids. From alkanes to phospholipids
, pp. 43-87
-
-
Small, D.M.1
-
19
-
-
0014284131
-
Phospholipid spherules (liposomes) as a model for biological membranes
-
G.Sessa, G.Weissmann. Phospholipid spherules (liposomes) as a model for biological membranes. J Lipid Res. 1968;9(3):310–318.
-
(1968)
J Lipid Res
, vol.9
, Issue.3
, pp. 310-318
-
-
Sessa, G.1
Weissmann, G.2
-
20
-
-
84975146008
-
Method of producing high-aqueous volume multilamellar vesicles
-
D.F.H.Wallach. Method of producing high-aqueous volume multilamellar vesicles. US4855090. 1989.
-
(1989)
US4855090
-
-
Wallach, D.F.H.1
-
21
-
-
0029872916
-
Adjuvant properties of non-phospholipid liposomes (Novasomes) in experimental animals for human vaccine antigens
-
R.K.Gupta, C.L.Varanelli, P.Griffin, et al. Adjuvant properties of non-phospholipid liposomes (Novasomes) in experimental animals for human vaccine antigens. Vaccine. 1996;14(3):219–225.
-
(1996)
Vaccine
, vol.14
, Issue.3
, pp. 219-225
-
-
Gupta, R.K.1
Varanelli, C.L.2
Griffin, P.3
-
22
-
-
28144437548
-
Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6ʹ-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses
-
J.Davidsen, I.Rosenkrands, D.Christensen, et al. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6ʹ-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim Biophys Acta. 2005;1718(1–2):22–31.
-
(2005)
Biochim Biophys Acta.
, vol.1718
, Issue.1-2
, pp. 22-31
-
-
Davidsen, J.1
Rosenkrands, I.2
Christensen, D.3
-
23
-
-
52349119606
-
Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
-
E.M.Agger, I.Rosenkrands, J.Hansen, et al. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PLoS One. 2008;3(9):e3116. doi:10.1371/journal.pone.0003116.
-
(2008)
PLoS One
, vol.3
, Issue.9
, pp. e3116
-
-
Agger, E.M.1
Rosenkrands, I.2
Hansen, J.3
-
24
-
-
84915751154
-
A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human
-
J.T.Van Dissel, S.A.Joosten, S.T.Hoff, et al. A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human. Vaccine. 2014;32(52):7098–7107.
-
(2014)
Vaccine
, vol.32
, Issue.52
, pp. 7098-7107
-
-
Van Dissel, J.T.1
Joosten, S.A.2
Hoff, S.T.3
-
25
-
-
9344271546
-
Immunity in response to particulate antigen-delivery systems
-
T.Storni, T.M.Kündig, G.Senti, et al. Immunity in response to particulate antigen-delivery systems. Adv Drug Deliv Rev. 2005;57(3):333–355. doi:10.1016/j.addr.2004.09.008.
-
(2005)
Adv Drug Deliv Rev
, vol.57
, Issue.3
, pp. 333-355
-
-
Storni, T.1
Kündig, T.M.2
Senti, G.3
-
26
-
-
84921057150
-
Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate
-
Z.Beck, G.R.Matyas, C.R.Alving. Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate. Biochim Biophys Acta. 2015;1848(3):775–780. doi:10.1016/j.bbamem.2014.12.005.
-
(2015)
Biochim Biophys Acta
, vol.1848
, Issue.3
, pp. 775-780
-
-
Beck, Z.1
Matyas, G.R.2
Alving, C.R.3
-
27
-
-
84943454535
-
Differential immune responses to HIV-1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21
-
Epub ahead of print
-
Z.Beck, G.R.Matyas, R.Jalah, et al. Differential immune responses to HIV-1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21. Vaccine. 2015;pii: S0264-410X(15)01244-X. doi:10.1016/j.vaccine.2015.09.001. Epub ahead of print.• Description of physical characteristics and adjuvant properties of ALF and ALFQ.
-
(2015)
Vaccine
-
-
Beck, Z.1
Matyas, G.R.2
Jalah, R.3
-
28
-
-
84975100914
-
Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
-
R.Glück, R.Mischler Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them. Publication number WO 92/19267. 1992.
-
(1992)
Publication number WO 92/19267
-
-
Glück, R.1
Mischler, R.2
-
29
-
-
0026808892
-
Immunopotentiating reconstituted influenza virosomes (IRIVs) and other adjuvants for improved presentation of small antigens
-
R.Glück. Immunopotentiating reconstituted influenza virosomes (IRIVs) and other adjuvants for improved presentation of small antigens. Vaccine. 1992;10(13):915–919.• Original description of virosome adjuvant technology.
-
(1992)
Vaccine
, vol.10
, Issue.13
, pp. 915-919
-
-
Glück, R.1
-
30
-
-
0029190259
-
Liposomal presentation of antigens for human vaccines
-
R.Glück. Liposomal presentation of antigens for human vaccines. Pharm Biotechnol. 1995;6:325–345.
-
(1995)
Pharm Biotechnol
, vol.6
, pp. 325-345
-
-
Glück, R.1
-
31
-
-
0037435877
-
Immunostimulating reconstituted influenza virosomes
-
Feb
-
R.Zurbriggen. Immunostimulating reconstituted influenza virosomes. Vaccine. 2003 Feb 14;21(9–10):921–924.
-
(2003)
Vaccine
, vol.21
, Issue.9-10
, pp. 921-924
-
-
Zurbriggen, R.1
-
32
-
-
67649341977
-
Eleven years of inflexal V-a virosomal adjuvanted influenza vaccine
-
C.Herzog, K.Hartmann, V.Künzi, et al. Eleven years of inflexal V-a virosomal adjuvanted influenza vaccine. Vaccine. 2009;27(33):4381–4387. doi:10.1016/j.vaccine.2009.05.029.
-
(2009)
Vaccine
, vol.27
, Issue.33
, pp. 4381-4387
-
-
Herzog, C.1
Hartmann, K.2
Künzi, V.3
-
33
-
-
9244234954
-
Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
-
D.Felnerova, J.F.Viret, R.Glück, et al. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr Opin Biotechnol. 2004;15(6):518–529. doi:10.1016/j.copbio.2004.10.005.
-
(2004)
Curr Opin Biotechnol
, vol.15
, Issue.6
, pp. 518-529
-
-
Felnerova, D.1
Viret, J.F.2
Glück, R.3
-
34
-
-
84975121411
-
-
Available from:, Sep
-
S.A.Mymetics [Internet]. 2015. [cited 2015 Sep23]. Available from: http://www.mymetics.com/
-
-
-
Mymetics, S.A.1
-
35
-
-
84860764098
-
Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice
-
T.Kamphuis, T.Meijerhof, T.Stegmann, et al. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS One. 2012;7(5):e36812. doi:10.1371/journal.pone.0036812.
-
(2012)
PLoS One
, vol.7
, Issue.5
, pp. e36812
-
-
Kamphuis, T.1
Meijerhof, T.2
Stegmann, T.3
-
36
-
-
84887167187
-
A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats
-
T.Kamphuis, T.Stegmann, T.Meijerhof, et al. A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats. Influenza Other Respir Viruses. 2013;7(6):1227–1236.
-
(2013)
Influenza Other Respir Viruses
, vol.7
, Issue.6
, pp. 1227-1236
-
-
Kamphuis, T.1
Stegmann, T.2
Meijerhof, T.3
-
37
-
-
0026703035
-
A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two weeks
-
M.Just, R.Berger, H.Dreschsler, et al. A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two weeks. Vaccine. 1992;10(11):737–739.
-
(1992)
Vaccine
, vol.10
, Issue.11
, pp. 737-739
-
-
Just, M.1
Berger, R.2
Dreschsler, H.3
-
38
-
-
0028008770
-
Inactivated virosome hepatitis A vaccine
-
L.Loutan, P.Bovier, B.Althaus, et al. Inactivated virosome hepatitis A vaccine. Lancet. 1994;343(8893):322–324.
-
(1994)
Lancet
, vol.343
, Issue.8893
, pp. 322-324
-
-
Loutan, L.1
Bovier, P.2
Althaus, B.3
-
39
-
-
0028244249
-
Immunogenicity of new virosome influenza vaccine in elderly people
-
R.Glück, R.Mischler, B.Finkel, et al. Immunogenicity of new virosome influenza vaccine in elderly people. Lancet. 1994;344(8916):160–163.
-
(1994)
Lancet
, vol.344
, Issue.8916
, pp. 160-163
-
-
Glück, R.1
Mischler, R.2
Finkel, B.3
-
40
-
-
22544449912
-
Clinical experience with inactivated, virosomal influenza vaccine
-
I.A.De Bruijn, J.Nauta, W.C.Cramer, et al. Clinical experience with inactivated, virosomal influenza vaccine. Vaccine. 2005;23(Suppl 1):S39–49.
-
(2005)
Vaccine
, vol.23
, pp. S39-S49
-
-
De Bruijn, I.A.1
Nauta, J.2
Cramer, W.C.3
-
41
-
-
0028822890
-
Virosomes as carriers for combined vaccines
-
B.Mengiardi, R.Berger, M.Just, et al. Virosomes as carriers for combined vaccines. Vaccine. 1995;13(14):1306–1315.
-
(1995)
Vaccine
, vol.13
, Issue.14
, pp. 1306-1315
-
-
Mengiardi, B.1
Berger, R.2
Just, M.3
-
42
-
-
84908461841
-
Matrix M™ adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man
-
G.K.Pedersen, H.Sjursen, J.K.Nøstbakken, et al. Matrix M™ adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man. Hum Vaccin Immunother. 2014;10(8):2408–2416.
-
(2014)
Hum Vaccin Immunother
, vol.10
, Issue.8
, pp. 2408-2416
-
-
Pedersen, G.K.1
Sjursen, H.2
Nøstbakken, J.K.3
-
43
-
-
0027080416
-
Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
-
R.Glück, R.Mischler, S.Brantschen, et al. Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A. J Clin Invest. 1992;90(6):2491–2495.
-
(1992)
J Clin Invest
, vol.90
, Issue.6
, pp. 2491-2495
-
-
Glück, R.1
Mischler, R.2
Brantschen, S.3
-
44
-
-
0037146955
-
Inflexal V a trivalent virosome subunit influenza vaccine: production
-
R.Mischler, I.C.Metcalfe. Inflexal V a trivalent virosome subunit influenza vaccine: production. Vaccine. 2002;20 Suppl 5:B17–23.
-
(2002)
Vaccine
, vol.20 Suppl 5
, pp. B17-B23
-
-
Mischler, R.1
Metcalfe, I.C.2
-
45
-
-
84874711999
-
Effectiveness of adjuvanted seasonal influenza vaccines (Inflexal V ® and Fluad ®) in preventing hospitalization for influenza and pneumonia in the elderly: a matched case-control study
-
R.Gasparini, D.Amicizia, P.L.Lai, et al. Effectiveness of adjuvanted seasonal influenza vaccines (Inflexal V ® and Fluad ®) in preventing hospitalization for influenza and pneumonia in the elderly: a matched case-control study. Hum Vaccin Immunother. 2013;9(1):144–152.
-
(2013)
Hum Vaccin Immunother
, vol.9
, Issue.1
, pp. 144-152
-
-
Gasparini, R.1
Amicizia, D.2
Lai, P.L.3
-
46
-
-
84929850029
-
Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults
-
H.Lal, A.L.Cunningham, O.Godeaux, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015;372(22):2087–2096.
-
(2015)
N Engl J Med
, vol.372
, Issue.22
, pp. 2087-2096
-
-
Lal, H.1
Cunningham, A.L.2
Godeaux, O.3
-
47
-
-
20044362219
-
Towards an RTS, S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research
-
D.G.HeppnerJr, K.E.Kester, C.F.Ockenhouse, et al. Towards an RTS, S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine. 2005;23(17–18):2243–2250.
-
(2005)
Vaccine
, vol.23
, Issue.17-18
, pp. 2243-2250
-
-
Heppner, D.G.1
Kester, K.E.2
Ockenhouse, C.F.3
-
48
-
-
77954762106
-
The RTS, S malaria vaccine
-
S.Casares, T.D.Brumeanu, T.L.Richie. The RTS, S malaria vaccine. Vaccine. 2010;28(31):4880–4894. doi:10.1016/j.vaccine.2010.05.033.
-
(2010)
Vaccine
, vol.28
, Issue.31
, pp. 4880-4894
-
-
Casares, S.1
Brumeanu, T.D.2
Richie, T.L.3
-
49
-
-
0023037366
-
Effectiveness of liposomes as potential carriers of vaccines: applications to cholera toxin and human malaria sporozoite antigen
-
C.R.Alving, R.L.Richards, J.Moss, et al. Effectiveness of liposomes as potential carriers of vaccines: applications to cholera toxin and human malaria sporozoite antigen. Vaccine. 1986;4(3):166–172.• Original description of use of liposomes containing MPLA for malaria vaccine.
-
(1986)
Vaccine
, vol.4
, Issue.3
, pp. 166-172
-
-
Alving, C.R.1
Richards, R.L.2
Moss, J.3
-
50
-
-
0023818238
-
Liposomes, lipid A, and aluminum hydroxide enhance the immune response to a synthetic malaria sporozoite antigen
-
R.L.Richards, M.D.Hayre, W.T.Hockmeyer, et al. Liposomes, lipid A, and aluminum hydroxide enhance the immune response to a synthetic malaria sporozoite antigen. Infect Immun. 1988;56(3):682–686.
-
(1988)
Infect Immun
, vol.56
, Issue.3
, pp. 682-686
-
-
Richards, R.L.1
Hayre, M.D.2
Hockmeyer, W.T.3
-
51
-
-
0023140735
-
Developing a human malaria sporozoite vaccine
-
J.F.Young, W.R.Ballou, W.T.Hockmeyer. Developing a human malaria sporozoite vaccine. Microb Pathog. 1987;2(4):237–240.
-
(1987)
Microb Pathog
, vol.2
, Issue.4
, pp. 237-240
-
-
Young, J.F.1
Ballou, W.R.2
Hockmeyer, W.T.3
-
52
-
-
0023254214
-
Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine
-
W.R.Ballou, S.L.Hoffman, J.A.Sherwood, et al. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet. 1987;1(8545):1277–1281.
-
(1987)
Lancet
, vol.1
, Issue.8545
, pp. 1277-1281
-
-
Ballou, W.R.1
Hoffman, S.L.2
Sherwood, J.A.3
-
53
-
-
0026571596
-
Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy
-
L.F.Fries, D.M.Gordon, R.L.Richards, et al. Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy. Proc Natl Acad Sci U S A. 1992;89(1):358–362.•• The first phase I liposome human vaccine clinical trial. It describes the safety of nonpyrogenic liposomes containing 2.2 mg of MPLA as an adjuvant for a malaria vaccine containing a recombinant protein with a repeat sequence of CSP.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, Issue.1
, pp. 358-362
-
-
Fries, L.F.1
Gordon, D.M.2
Richards, R.L.3
-
54
-
-
84975147081
-
Vaccine compositions comprising a Saponin adjuvant
-
August
-
P.Vandepapeliere Vaccine compositions comprising a Saponin adjuvant. US patent application 20110206758. August 25, 2011.• US patent application publication that contains a detailed description of the composition and preparation of AS01B.
-
(2011)
US patent application 20110206758
-
-
Vandepapeliere, P.1
-
55
-
-
0026033441
-
Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
-
C.R.Kensil, U.Patel, M.Lennick, et al. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol. 1991;146(2):431–437.•• Original description of QS21 as an adjuvant.
-
(1991)
J Immunol.
, vol.146
, Issue.2
, pp. 431-437
-
-
Kensil, C.R.1
Patel, U.2
Lennick, M.3
-
56
-
-
77952540334
-
Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results
-
C.W.Cluff. Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol. 2010;667:111–123. doi:10.1007/978-1-4419-1603-7_10.
-
(2010)
Adv Exp Med Biol
, vol.667
, pp. 111-123
-
-
Cluff, C.W.1
-
57
-
-
84954387067
-
Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys
-
Epub ahead of print
-
N.Garçon, J.Silvano, C.F.Kuper, et al. Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys. J Appl Toxicol. 2015. doi:10.1002/jat.3167. Epub ahead of print
-
(2015)
J Appl Toxicol.
-
-
Garçon, N.1
Silvano, J.2
Kuper, C.F.3
-
58
-
-
84922378414
-
Nonclinical reproductive and developmental safety evaluation of the MAGE-A3 cancer immunotherapeutic, a therapeutic vaccine for cancer treatment
-
E.Destexhe, D.Stannard, O.K.Wilby, et al. Nonclinical reproductive and developmental safety evaluation of the MAGE-A3 cancer immunotherapeutic, a therapeutic vaccine for cancer treatment. Reprod Toxicol. 2015;51:90–105. doi:10.1016/j.reprotox.2014.12.009.
-
(2015)
Reprod Toxicol
, vol.51
, pp. 90-105
-
-
Destexhe, E.1
Stannard, D.2
Wilby, O.K.3
-
59
-
-
84936934979
-
Effects of adjuvant systems on the cardiovascular and respiratory functions in telemetered conscious dogs and anaesthetised rats
-
L.Segal, V.Roger, C.Williams, et al. Effects of adjuvant systems on the cardiovascular and respiratory functions in telemetered conscious dogs and anaesthetised rats. Regul Toxicol Pharmacol. 2015;73(1):116–125.
-
(2015)
Regul Toxicol Pharmacol
, vol.73
, Issue.1
, pp. 116-125
-
-
Segal, L.1
Roger, V.2
Williams, C.3
-
61
-
-
0024844843
-
Immunogenicity of liposomal malaria sporozoite antigen in monkeys: adjuvant effects of aluminium hydroxide and non-pyrogenic liposomal lipid A
-
R.L.Richards, G.M.SwartzJr, C.Schultz, et al. Immunogenicity of liposomal malaria sporozoite antigen in monkeys: adjuvant effects of aluminium hydroxide and non-pyrogenic liposomal lipid A. Vaccine. 1989;7(6):506–512.
-
(1989)
Vaccine
, vol.7
, Issue.6
, pp. 506-512
-
-
Richards, R.L.1
Swartz, G.M.2
Schultz, C.3
-
62
-
-
0027173808
-
Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants
-
C.R.Alving. Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology. 1993;187(3–5):430–446. doi:10.1016/S0171-2985(11)80355-4.
-
(1993)
Immunobiology
, vol.187
, Issue.3-5
, pp. 430-446
-
-
Alving, C.R.1
-
63
-
-
0035898945
-
Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21
-
D.C.Waite, E.W.Jacobson, F.A.Ennis, et al. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine. 2001;19(28–29):3957–3967.
-
(2001)
Vaccine
, vol.19
, Issue.28-29
, pp. 3957-3967
-
-
Waite, D.C.1
Jacobson, E.W.2
Ennis, F.A.3
-
64
-
-
34047189362
-
Humoral and cell-mediated immune responsesof humans to inactivated influenza vaccine with or without QS21 adjuvant
-
I.Mbawuike, Y.Zang, R.B.Couch. Humoral and cell-mediated immune responsesof humans to inactivated influenza vaccine with or without QS21 adjuvant. Vaccine. 2007;25(17):3263–3269. doi:10.1016/j.vaccine.2007.01.073.
-
(2007)
Vaccine
, vol.25
, Issue.17
, pp. 3263-3269
-
-
Mbawuike, I.1
Zang, Y.2
Couch, R.B.3
-
65
-
-
0019449884
-
Isolation of a nontoxic lipid A fraction containing tumor regression activity
-
K.Takayama, E.Ribi, J.L.Cantrell. Isolation of a nontoxic lipid A fraction containing tumor regression activity. Cancer Res. 1981;41(7):2654–2657.• Original description of monophosphoryl lipid A.
-
(1981)
Cancer Res
, vol.41
, Issue.7
, pp. 2654-2657
-
-
Takayama, K.1
Ribi, E.2
Cantrell, J.L.3
-
66
-
-
0020056981
-
Preparation and antitumor activity of nontoxic lipid A
-
E.Ribi, K.Amano, J.L.Cantrell, et al. Preparation and antitumor activity of nontoxic lipid A. Cancer Immunol Immunother. 1982;12:91–96. doi:10.1007/BF00205365.
-
(1982)
Cancer Immunol Immunother
, vol.12
, pp. 91-96
-
-
Ribi, E.1
Amano, K.2
Cantrell, J.L.3
-
67
-
-
0020367633
-
Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium
-
N.Qureshi, K.Takayama, E.Ribi. Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium. J Biol Chem. 1982;257(19):11808–11815.•• Detailed purification of monophosphoryl lipid A.
-
(1982)
J Biol Chem.
, vol.257
, Issue.19
, pp. 11808-11815
-
-
Qureshi, N.1
Takayama, K.2
Ribi, E.3
-
68
-
-
0029023980
-
Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity
-
C.R.Alving. Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity. Ann N Y Acad Sci. 1995;754:143–152.
-
(1995)
Ann N Y Acad Sci
, vol.754
, pp. 143-152
-
-
Alving, C.R.1
-
69
-
-
18744364924
-
Design and selection of vaccine adjuvants: animal models and human trials
-
C.R.Alving. Design and selection of vaccine adjuvants: animal models and human trials. Vaccine. 2002;20(Suppl 3):S56–S64.
-
(2002)
Vaccine
, vol.20
, pp. S56-S64
-
-
Alving, C.R.1
-
70
-
-
1342333037
-
Oil-in-water liposomal emulsions for vaccine delivery
-
G.R.Matyas, J.M.Muderhwa, C.R.Alving. Oil-in-water liposomal emulsions for vaccine delivery. Methods Enzymol. 2003;373:34–50. doi:10.1016/S0076-6879(03)73003-1.
-
(2003)
Methods Enzymol
, vol.373
, pp. 34-50
-
-
Matyas, G.R.1
Muderhwa, J.M.2
Alving, C.R.3
-
71
-
-
78751575656
-
Highly effective generic adjuvant systems for orphan or poverty-related vaccines
-
M.Rao, K.K.Peachman, Q.Li, et al. Highly effective generic adjuvant systems for orphan or poverty-related vaccines. Vaccine. 2011;29(5):873–877.
-
(2011)
Vaccine
, vol.29
, Issue.5
, pp. 873-877
-
-
Rao, M.1
Peachman, K.K.2
Li, Q.3
-
72
-
-
0029422476
-
Selection of potent immunological adjuvants for vaccine construction
-
M.J.McElrath. Selection of potent immunological adjuvants for vaccine construction. Semin Cancer Biol. 1995;6(6):375–385.
-
(1995)
Semin Cancer Biol
, vol.6
, Issue.6
, pp. 375-385
-
-
McElrath, M.J.1
-
73
-
-
19144370919
-
Safety, immunogenicity, and efficacy of plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes
-
D.G.Heppner, D.M.Gordon, M.Gross, et al. Safety, immunogenicity, and efficacy of plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes. J Infect Dis. 1996;174(2):361–366.
-
(1996)
J Infect Dis
, vol.174
, Issue.2
, pp. 361-366
-
-
Heppner, D.G.1
Gordon, D.M.2
Gross, M.3
-
74
-
-
84855354748
-
Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide
-
W.D.Zollinger, J.G.Babcock, E.E.Moran, et al. Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide. Vaccine. 2012;30(4):712–721.
-
(2012)
Vaccine
, vol.30
, Issue.4
, pp. 712-721
-
-
Zollinger, W.D.1
Babcock, J.G.2
Moran, E.E.3
-
75
-
-
0345549227
-
Intramuscular fate and local effects of liposomes as carriers for drugs and vaccines
-
Shek P.N., (ed), Singapore: Harwood Academic Publishers
-
F.L.Richards, J.R.Hailey, J.E.Egan, et al. Intramuscular fate and local effects of liposomes as carriers for drugs and vaccines. In: P.N.Shek, editor. Liposomes in biomedical applications. Singapore: Harwood Academic Publishers; 1995. p. 167–178.
-
(1995)
Liposomes in biomedical applications
, pp. 167-178
-
-
Richards, F.L.1
Hailey, J.R.2
Egan, J.E.3
-
76
-
-
0024370352
-
Retention of bacterial lipopolysaccharide at the site of subcutaneous injection
-
T.Yokochi, Y.Inoue, J.Yokoo, et al. Retention of bacterial lipopolysaccharide at the site of subcutaneous injection. Infect Immun. 1989;57(6):1786–1791.
-
(1989)
Infect Immun
, vol.57
, Issue.6
, pp. 1786-1791
-
-
Yokochi, T.1
Inoue, Y.2
Yokoo, J.3
-
77
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
S.Rerks-Ngarm, P.Pitisuttithum, S.Nitayaphan, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361(23):2209–2220.
-
(2009)
N Engl J Med
, vol.361
, Issue.23
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
Pitisuttithum, P.2
Nitayaphan, S.3
-
78
-
-
34547473731
-
Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice
-
A.Muhs, D.T.Hickman, M.Pihlgren, et al. Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice. Proc Natl Acad Sci U S A. 2007;104(23):9810–9815.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.23
, pp. 9810-9815
-
-
Muhs, A.1
Hickman, D.T.2
Pihlgren, M.3
-
79
-
-
84975151031
-
-
Sep, Available from:
-
AC Immune technology [Internet]. 2015 [cited 2015 Sep 25]. Available from: http://www.acimmune.com/
-
(2015)
-
-
-
80
-
-
76749160185
-
Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen
-
M.Henriksen-Lacey, V.W.Bramwell, D.Christensen, et al. Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen. J Control Release. 2010;142(2):180–186.
-
(2010)
J Control Release
, vol.142
, Issue.2
, pp. 180-186
-
-
Henriksen-Lacey, M.1
Bramwell, V.W.2
Christensen, D.3
-
81
-
-
77953961068
-
Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response
-
M.Henriksen-Lacey, D.Christensen, V.W.Bramwell, et al. Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response. J Control Release. 2010;145(2):102–108.
-
(2010)
J Control Release
, vol.145
, Issue.2
, pp. 102-108
-
-
Henriksen-Lacey, M.1
Christensen, D.2
Bramwell, V.W.3
-
82
-
-
80052209319
-
The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
-
M.Henriksen-Lacey, A.Devitt, Y.Perrie. The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production. J Control Release. 2011;154(2):131–137. doi:10.1016/j.jconrel.2011.05.019.
-
(2011)
J Control Release
, vol.154
, Issue.2
, pp. 131-137
-
-
Henriksen-Lacey, M.1
Devitt, A.2
Perrie, Y.3
-
83
-
-
79952968002
-
Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N’,N’-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses
-
M.Henriksen-Lacey, D.Christensen, V.W.Bramwell, et al. Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N’,N’-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses. Mol Pharm. 2011;8(1):153–161.
-
(2011)
Mol Pharm
, vol.8
, Issue.1
, pp. 153-161
-
-
Henriksen-Lacey, M.1
Christensen, D.2
Bramwell, V.W.3
-
84
-
-
84857913863
-
Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses
-
R.Kaur, V.W.Bramwell, D.J.Kirby, et al. Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses. J Control Release. 2012;158(1):72–77.
-
(2012)
J Control Release
, vol.158
, Issue.1
, pp. 72-77
-
-
Kaur, R.1
Bramwell, V.W.2
Kirby, D.J.3
-
85
-
-
84870242847
-
Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response
-
R.Kaur, V.W.Bramwell, D.J.Kirby, et al. Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response. J Control Release. 2012;164(3):331–337. doi:10.1016/j.jconrel.2012.07.012.
-
(2012)
J Control Release
, vol.164
, Issue.3
, pp. 331-337
-
-
Kaur, R.1
Bramwell, V.W.2
Kirby, D.J.3
-
86
-
-
84925755151
-
Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study
-
E.Kastner, M.J.Hussain, V.W.Bramwell, et al. Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study. J Pharm Pharmacol. 2015;67(3):450–463.
-
(2015)
J Pharm Pharmacol
, vol.67
, Issue.3
, pp. 450-463
-
-
Kastner, E.1
Hussain, M.J.2
Bramwell, V.W.3
-
87
-
-
84937527091
-
ISCOMATRIX™ adjuvant promotes epitope spreading and antibody affinity maturation of influenza A H7N9 virus like particle vaccine that correlate with virus neutralization in humans
-
K.Y.Chung, E.M.Coyle, D.Jani, et al. ISCOMATRIX™ adjuvant promotes epitope spreading and antibody affinity maturation of influenza A H7N9 virus like particle vaccine that correlate with virus neutralization in humans. Vaccine. 2015;33(32):3953–3962.
-
(2015)
Vaccine
, vol.33
, Issue.32
, pp. 3953-3962
-
-
Chung, K.Y.1
Coyle, E.M.2
Jani, D.3
-
88
-
-
84861806285
-
Adjuvanted influenza vaccines
-
N.Principi, S.Esposito. Adjuvanted influenza vaccines. Hum Vaccin Immunother. 2012;8(1):59–66. doi:10.4161/hv.8.1.18011.
-
(2012)
Hum Vaccin Immunother
, vol.8
, Issue.1
, pp. 59-66
-
-
Principi, N.1
Esposito, S.2
-
89
-
-
80053645706
-
Evaluation of a virosomal H5N1 vaccine formulated with Matrix M™ adjuvant in a phase I clinical trial
-
R.J.Cox, G.Pedersen, A.S.Madhun, et al. Evaluation of a virosomal H5N1 vaccine formulated with Matrix M™ adjuvant in a phase I clinical trial. Vaccine. 2011;29(45):8049–8059.
-
(2011)
Vaccine
, vol.29
, Issue.45
, pp. 8049-8059
-
-
Cox, R.J.1
Pedersen, G.2
Madhun, A.S.3
-
90
-
-
84875818500
-
Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial
-
I.Leroux-Roels, S.Forgus, F.De Boever, et al. Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial. Vaccine. 2013;31(17):2196–2206.
-
(2013)
Vaccine
, vol.31
, Issue.17
, pp. 2196-2206
-
-
Leroux-Roels, I.1
Forgus, S.2
De Boever, F.3
-
91
-
-
84889091707
-
A randomized, controlled dose-finding Phase II study of the M72/AS01 candidate tuberculosis vaccine in healthy PPD-positive adults
-
J.Montoya, J.A.Solon, S.R.Cunanan, et al. A randomized, controlled dose-finding Phase II study of the M72/AS01 candidate tuberculosis vaccine in healthy PPD-positive adults. J Clin Immunol. 2013;33(8):1360–1375.
-
(2013)
J Clin Immunol
, vol.33
, Issue.8
, pp. 1360-1375
-
-
Montoya, J.1
Solon, J.A.2
Cunanan, S.R.3
|