Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′- dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-dioleoyl-3- trimethylammonium propane (DOTAP): Prolonged liposome retention mediates stronger Th1 responses

Molecular Pharmaceutics

Volumn 8, Issue 1, 2011, Pages 153-161

  Henriksen Lacey, Malou ^a   Christensen, Dennis ^b   Bramwell, Vincent W ^a   Lindenstrøm, Thomas ^b   Agger, Else Marie ^b   Andersen, Peter ^b   Perrie, Yvonne ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

Adjuvant; DC Chol; DDA; Depot effect; DOTAP; TDB; Vaccine

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 3BETA [N (N',N' DIMETHYLAMINOETHANE)CARBOMYL] CHOLESTEROL; BCG VACCINE; CHOLESTEROL DERIVATIVE; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; IMMUNOMODULATING AGENT; LIPOSOME; TREHALOSE; TREHASOLE 6,6' DIBEHENATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL INFILTRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; INJECTION SITE; LYMPH NODE; MONOCYTE; MOUSE; NONHUMAN; POPLITEAL LYMPH NODE; PRIORITY JOURNAL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; CHOLESTEROL; FATTY ACIDS, MONOUNSATURATED; FEMALE; LIPOSOMES; MICE; MICE, INBRED C57BL; QUATERNARY AMMONIUM COMPOUNDS; VACCINES;

EID: 79952968002     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100208f     Document Type: Article

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