Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response

Journal of Controlled Release

Volumn 164, Issue 3, 2012, Pages 331-337

  Kaur, Randip ^a   Bramwell, Vincent W ^a   Kirby, Daniel J ^a   Perrie, Yvonne ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Adjuvant; DDA; Liposomes; Polyethylene glycol; TDB; Vaccine

Indexed keywords

ADJUVANT; ANIONIC LIPOSOMES; ANTIBODY RESPONSE; BIODISTRIBUTIONS; CATIONIC VESICLES; CLEARANCE RATES; DISTRIBUTION PROFILES; IMMUNE CELLS; LYMPH NODE; PEGYLATION; PHARMACOKINETIC PROFILES; SMALL UNILAMELLAR VESICLE; T-CELL RESPONSE; TDB; VESICLE SIZE;

DIGITAL DIFFERENTIAL ANALYZERS; LIPOSOMES; POLYETHYLENE GLYCOLS; SYNCHROTRONS; VACCINES;

MOLECULAR BIOLOGY;

ADJUVANT; LIPOSOME; MACROGOL; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOPLASM VESICLE; DRUG DISTRIBUTION; DRUG FORMULATION; FEMALE; INJECTION SITE; LIPOSOMAL DELIVERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CATIONS; CELL PROLIFERATION; CYTOKINES; DRUG CARRIERS; FEMALE; GLYCOLIPIDS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; LIPOSOMES; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; QUATERNARY AMMONIUM COMPOUNDS; RECOMBINANT FUSION PROTEINS; SPLEEN; SURFACE PROPERTIES; T-LYMPHOCYTES; TUBERCULOSIS VACCINES;

EID: 84870242847     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.012     Document Type: Conference Paper

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