Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced Colitis

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Chen, Zhiqi ^a   Yu, Kai ^a   Zhu, Fang ^a   Gorczynski, Reginald ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD200 ANTIGEN; CD200 RECEPTOR; CYTOKINE; DEXTRAN SULFATE; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR FOXP3; ANTIGENS, CD200; CD200 RECEPTOR, MOUSE; DOXYCYCLINE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD3+ T LYMPHOCYTE; CELL INFILTRATION; CELL ISOLATION; COLITIS; COLON; CYTOKINE PRODUCTION; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPLANT; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; INFLAMMATORY BOWEL DISEASE; INTESTINE PROTECTION; KNOCKOUT MOUSE; MACROPHAGE; MONONUCLEAR CELL; MOUSE; NEUTROPHIL; NONHUMAN; PROPHYLAXIS; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; TRANSGENIC MOUSE; WEIGHT REDUCTION; WILD TYPE MOUSE; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; CHRONIC DISEASE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; TRANSCRIPTION INITIATION;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD; CHRONIC DISEASE; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; DOXYCYCLINE; FEMALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRANSCRIPTIONAL ACTIVATION;

EID: 84959019451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0146681     Document Type: Article

References (58)

1. Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007; 117: 514-521. PMID: 17332878
2. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol. 2008; 8: 458-466. doi: 10.1038/nri2340 PMID: 18500230
3. Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007; 448: 427-434. PMID: 17653185
4. Khor B, Gardet A, Xavier, RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011; 474: 3017-317
5. Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011; 140: 1756-1767. doi: 10.1053/j.gastro.2011.02.016 PMID: 21530742
6. Fuchs A, Colonna M. Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract. Curr Opin Gastroenterol. 2013; 29: 581-587. doi: 10.1097/MOG. 0b013e328365d339 PMID: 24100718
7. Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010; 464: 1371-1375. doi: 10.1038/nature08949 PMID: 20393462
8. Li X, Chen G, Li Y, Wang R, Wang L, Lin Z et al. Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease. Clin Immunol. 2010; 134: 169-177. doi: 10.1016/j.clim. 2009.09.012 PMID: 19913460
9. Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. J Immunol. 2004; 172: 7744-7749. PMID: 15187158
10. Gorczynski RM, Chen Z, Fu XM, Zeng H. Increased expression of the novel molecule OX-2 is involved in prolongation of murine renal allograft survival. Transplantation. 1998; 65: 1106-1114. PMID: 9583873
11. Clark DA, Keil A, Chen Z, Markert U, Manuel J, Gorczynski RM. Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2). Am J Reprod Immunol. 2003; 50: 187-195. PMID: 14629022
12. Kretz-Rommel A, Qin F, Dakappagari N, Ravey EP, McWhirter J, Oltean D, Ravey E et al. CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy. J Immunol. 2007; 178: 5595-5605. PMID: 17442942
13. Wong KK, Brenneman F, Chesney A, Spaner DE, Gorczynski RM. Soluble CD200 is critical to engraft chronic lymphocytic leukemia cells in immunocompromised mice. Cancer Res. 2012; 72: 4931-4943. doi: 10.1158/0008-5472.CAN-12-1390 PMID: 22875025
14. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R,Zurawski SM et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 2000; 290: 1768-1771. PMID: 11099416
15. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick ADConstitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol. 2002; 161: 1669-1677. PMID: 12414514
16. Gorczynski RM, Chen Z, Yu K, Hu J. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Clin Immunol. 2001; 101: 328-334. PMID: 11726225
17. Chitnis T, Imitola J, Wang Y, Elyaman W, Chawla P, Sharuk M et al. Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. Am J Pathol. 2007; 170: 1695-1712. PMID: 17456775
18. Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat Protoc. 2007; 2: 541-546. PMID: 17406617
19. Yu K, Chen Z, Wang S, Gorczynski R. Decreased alloreactivity using donor cells from mice expressing a CD200 transgene under control of a tetracycline-inducible promoter. Transplantation. 2005; 80: 394-401. PMID: 16082336
20. Gorczynski RM, Chen Z, He W, Khatri I, Sun Y, Yu K et al. Expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts. J Immunol. 2009; 183: 1560-1568. doi: 10.4049/jimmunol.0900200 PMID: 19592654
21. Boudakov I, Liu J, Fan N, Gulay P, Wong K, Gorczynski RM. Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-Alpha and mixed leukocyte culture responses by CD200. Transplantation. 2007; 84: 251-257. PMID: 17667818
22. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990; 98: 694-702. PMID: 1688816
23. Dunay IR, Renato A, DaMatta RA, Fux B, Presti R, Greco S, Colonna M, Sibley LD. Gr1+ (Ly6C+) Inflammatory Monocytes are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii Immunity 2008; 29: 306-317 doi: 10.1016/j.immuni.2008.05.019 PMID: 18691912
24. Rivollier A, He J, Kole A, Valatas V, and Kelsall BL. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon J Exp Med. 2012; 209: 139-155 doi: 10.1084/jem.20101387 PMID: 22231304
25. Geem D, Medina-Contreras O, Kim W, Huang CS, Denning TL. Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine. J. Vis. Exp. (63: ), e4040, doi: 10.3791/4040 (2012) PMID: 22644046
26. Stevceva L, Pavli P, Husband AJ, Doe WF. The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it. BMC Clin Pathol. 2001; 1: 3. PMID: 11580872
27. Grobeta P, Doser K, Falk W, Obermeier F, Hofmann C. IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflamm Bowel Dis. 2012; 18: 1900-1909. doi: 10.1002/ibd.22900 PMID: 22508383
28. Gorczynski RM, Cattral MS, Chen Z, Hu J, Lei J, Min WP et al. An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo-And xenograft survival. J Immunol. 1999; 163: 1654-1660. PMID: 10415071
29. Bradford E. Berndt BE, Zhang M, Chen G-H, Huffnagle GB, Kao JY The Role of Dendritic Cells in the Development of Acute Dextran Sulfate Sodium Colitis J Immunol 2007 179:6255-6262 PMID: 17947701
30. Walker JA, Barlow JL, McKenzie AN. Innate lymphoid cells-how did we miss them? Nat Rev Immunol. 2013; 13: 75-87. doi: 10.1038/nri3349 PMID: 23292121
31. Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology. 2008; 135: 552-567. doi: 10.1053/j.gastro.2008.04.037 PMID: 18598698
32. Yu K, Chen Z, Khatri I, Gorczynski RM. CCR4 dependent migration of Foxp3+ Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients. Immunol Lett. 2011; 141: 116-122. doi: 10.1016/j.imlet.2011.09.002 PMID: 21945175
33. Perse M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol 2012; 2012: 718617. doi: 10.1155/2012/718617 PMID: 22665990
34. Szebeni B, Veres G, Dezsofi A, Rusai K, Vannay A, Mraz M et al. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin Exp Immunol. 2008; 151: 34-41. PMID: 17991289
35. Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M et al. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006; 7: 868-874. PMID: 16829963
36. Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity. 2010; 32: 379-391. doi: 10.1016/j.immuni.2010.03.003 PMID: 20303296
37. Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010; 59: 1192-1199. doi: 10.1136/gut.2009.197822 PMID: 20442201
38. Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009; 15: 341-352. doi: 10.1002/ibd.20753 PMID: 18942757
39. Pizarro TT, Cominelli F. Cytokine therapy for Crohn's disease: advances in translational research. Annu Rev Med. 2007; 58: 433-444. PMID: 17217333
40. Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR. New pathogenic paradigms in inflammatory bowel disease. Inflamm Bowel Dis. 2012; 18: 368-371. doi: 10.1002/ibd.21735 PMID: 21538717
41. Kim YS, Lee MH, Ju AS, Rhee KJ. Th17 responses are not induced in dextran sodium sulfate model of acute colitis. Immune Netw. 2011; 11: 416-419. doi: 10.4110/in.2011.11.6.416 PMID: 22346784
42. Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009; 58: 1629-1636. doi: 10.1136/gut.2009.182170 PMID: 19740775
43. Melgar S, Karlsson L, Rehnstrom E, Karlsson A, Utkovic H, Jansson L et al. Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease. Int Immunopharmacol. 2008; 8: 836-844. doi: 10.1016/j.intimp.2008.01.036 PMID: 18442787
44. Melgar S, Engstrom K, Jagervall A, Martinez V. Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice. Stress. 2008; 11: 348-362. doi: 10.1080/10253890701820166 PMID: 18666024
45. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal micromicrobiota by toll-like receptors is required for intestinal homeostasis. Cell. 2004; 118: 229-241. PMID: 15260992
46. Heimesaat MM, Fischer A, Siegmund B, Kupz A, Niebergall J, Fuchs D et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One. 2007; 2: e662. PMID: 17653282
47. Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol. 2005; 288: G1055-1065. PMID: 15826931
48. Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R et al. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol. 2005; 40: 16-23. PMID: 15692785
49. Bain CC, Mowat AM. CD200 receptor and macrophage function in the intestine. Immunobiology. 2012; 217: 643-651. doi: 10.1016/j.imbio.2011.11.004 PMID: 22204814
50. Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1994; 1: 553-562. PMID: 7600284
51. Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK. Regulatory role of mature B cells in a murine model of inflammatory bowel disease Int. Immunol. 2000; 12: 597-605.
52. Vadasz Z, Haj T, Kessel A, Toubi E. B-regulatory cells in autoimmunity and immune mediated inflammation. FEBS Lett. 2013; 587:2074-2078. doi: 10.1016/j.febslet.2013.05.023 PMID: 23707422
53. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005; 6: 345-352. PMID: 15785760
54. Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P et al. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut. 2006; 55: 671-680. PMID: 16162681
55. Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol. 2010; 30: 80-89. doi: 10.1007/s10875-009-9345-1 PMID: 19936899
56. Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity. 2009; 30: 636-645. doi: 10.1016/j.immuni.2009.04.010 PMID: 19464986
57. Yuan Q, Bromley SK, Means TK, Jones KJ, Hayashi F, Bhan AK et al. CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med. 2007; 204: 1327-1334. PMID: 17548518
58. Eijkelkamp N, Heijnen CJ, Lucas A, Premont RT, Elsenbruch S, Schedlowski M et al. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut. 2007; 56: 847-854. PMID: 17229795