Brain mitochondrial drug delivery: Influence of drug physicochemical properties

Pharmaceutical Research

Volumn 28, Issue 11, 2011, Pages 2833-2847

  Durazo, Shelley A ^a   Kadam, Rajendra S ^a   Drechsel, Derek ^a   Patel, Manisha ^a   Kompella, Uday B ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Brain delivery; Lipophilicity; Membrane potential; Mitochondrial delivery; Polar surface area

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL FRACTIONATION; CELL MEMBRANE DEPOLARIZATION; CELL TRANSPORT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ADRENAL CORTEX HORMONES; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR TARGETED THERAPY; PHYSICOCHEMICAL PHENOMENA; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; SOFTWARE;

EID: 84856220542     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0532-4     Document Type: Article

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